Open positions

Masters thesis

Lipid signaling in adipose tissue stem cells and metabolism.

We are searching for a highly motivated masters student for the following project.

Previous work has revealed intriguing changes in defined metabolic pathways of sphingolipids in adipose tissue under conditions of metabolic stress. The aim of this project is to dissect the signaling and metabolic effects of these changes in adipose tissue stem cells and adipocytes. To achieve this, the student will manipulate sphingolipid metabolism and signaling pharmacologically and by RNAi, and investigate the consequences for cell function including stem cell differentiation, apoptosis, as well as lipid and carbohydrate metabolism.

Methodology: Primary cell isolation and culture, RNA expression, FACS, cell metabolism assays, lipid analysis.

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