Medical Imaging and Radiology - Cancer Prevention

Junior Research Group Medical Imaging and Radiology - Cancer Prevention

PD Dr. Sebastian Bickelhaupt

Diffusion Weighted Imaging (DWI) based magnetic resonance mammography in different CLUT (Color-Lookup-Tables) with depiction of a suspicious breast lesion.
© dkfz.de

Diagnostic imaging is an essential part of modern cancer care, especially in the field of early detection and characterization of malignancies. We elucidate how modern imaging methods such as magnetic resonance imaging (MRI), ultrasound (US) and computed tomography (CT) can be advanced into approaches that do not only allow for reliable early morphologic depiction of cancer suspicious lesions but for their simultaneous quantitative characterization on a microstructural and biophysiological functional level, connecting modern cancer imaging with in cancer (molecular-)biology. A focus is to advance magnetic resonance diffusion weighted imaging (DWI) sequences in order to serve for the dedicated purpose of providing ultrafast, contrast-agent-free imaging-based cancer tests that are both highly reliable, non-invasive, safe and affordable in terms of socioeconomic aspects. With a strong local, national and growing international network we study the translational capabilities of such novel imaging approaches, e.g. with a focus in breast cancer imaging, and work on anticipating the future integration of novel emerging techniques for cancer detection such as liquid biopsy and artificial intelligence algorithms. Together with our interdisciplinary partners in the DKFZ, at the University Hospital Heidelberg, the National Center for Tumor Diseases (NCT), national and international renowned medical centers and industry partners we thus create a highly innovative synergistic scientific environment to advance early cancer detection and cancer imaging for improved cancer care.

Contact

PD Dr. Sebastian Bickelhaupt
Medical Imaging and Radiology - Cancer Prevention (E250)
Tel: +49 6221 42 2603

Selected Publications

  • Bickelhaupt S, Jaeger PF, Laun FB, Lederer W, Daniel H, Kuder TA, Wuesthof L, Paech D, Bonekamp D, Radbruch A, Delorme S, Schlemmer HP, Steudle FH, Maier-Hein KH. Radiomics Based on Adapted Diffusion Kurtosis Imaging Helps to Clarify Most Mammographic Findings Suspicious for Cancer. Radiology. 2018 Jun;287(3):761-770. doi: 10.1148/radiol.2017170273. Epub 2018 Feb 20.
  • Bickelhaupt S, Laun FB, Tesdorff J, Lederer W, Daniel H, Stieber A, Delorme S, Schlemmer HP. Fast and Noninvasive Characterization of Suspicious Lesions Detected at Breast Cancer X-Ray Screening: Capability of Diffusion-weighted MR Imaging with MIPs.. Radiology. 2016 Mar;278(3):689-97. doi: 10.1148/radiol.2015150425. Epub 2015 Sep 29.
  • Bickelhaupt S, Erbel C, Timke C, Wirkner U, Dadrich M, Flechsig P, Tietz A, Pföhler J, Gross W, Peschke P, Hoeltgen L, Katus HA, Gröne HJ, Nicolay NH, Saffrich R, Debus J, Sternlicht MD, Seeley TW, Lipson KE, Huber PE. Effects of CTGF Blockade on Attenuation and Reversal of Radiation-Induced Pulmonary Fibrosis.. J Natl Cancer Inst. 2017 Aug 1;109(8). doi: 10.1093/jnci/djw339.
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