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Clinical Epidemiology and Aging Research

Original and Review Articles in 2022 and in Press

Nano, J., Schottker, B., Lin, J. S., Huth, C., Ghanbari, M., Garcia, P. M., . . . , Thorand, B. Novel biomarkers of inflammation, kidney function and chronic kidney disease in the general population. Nephrology Dialysis Transplantation 2022; 37: 1916-1926.

Li, X. W., Delerue, T., Schottker, B., Holleczek, B., Grill, E., Peters, A., . . . , Brenner, H. Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults. Nature Communications 2022; 13: 11.

Perna, L., Trares, K., Perneczky, R., Tato, M., Stocker, H., Mollers, T., . . . , Brenner, H. Risk of Late-Onset Depression and Cognitive Decline: Results From Inflammatory Proteome Analyses in a Prospective Population-Based Cohort Study. American Journal of Geriatric Psychiatry 2022; 30: 689-700.

Mollers, T., Stocker, H., Perna, L., Rujescu, D., Holleczek, B., Schottker, B., Brenner, H. Subjective short-term memory difficulties at ages 50-75 predict dementia risk in a community-based cohort followed over 17 years. Age and Ageing 2022; 51: 10.

Safizadeh, F., Nguyen, T. N. M., Brenner, H., Schottker, B. Association of renin-angiotensin-aldosterone system inhibition with Covid-19 hospitalization and all-cause mortality in the UK biobank. British Journal of Clinical Pharmacology 2022; 88: 2830-2842.

Trares, K., Bhardwaj, M., Perna, L., Stocker, H., Petrera, A., Hauck, S. M., . . . , Schottker, B. Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study. Alzheimers Research & Therapy 2022; 14: 17.

Zhu, A., Kuznia, S., Niedermaier, T., Holleczek, B., Schottker, B., Brenner, H. VITAMIN D-BINDING PROTEIN, TOTAL, "NON-BIOAVAILABLE", BIOAVAILABLE, AND FREE 25-HYDROXYVITAMIN D, AND MORTALITY IN A LARGE POPULATION-BASED COHORT OF OLDER ADULTS. Anticancer Research 2022; 42: 2214-2214.

Zhu, A., Kuznia, S., Niedermaier, T., Holleczek, B., Schottker, B., Brenner, H. DISTRIBUTION AND DETERMINANTS OF VITAMIN D-BINDING PROTEIN, TOTAL, "NON-BIOAVAILABLE" BIOAVAILABLE, AND FREE 25-HYDROXYVITAMIN D CONCENTRATIONS IN A LARGE POPULATIONBASED COHORT OF OLDER ADULTS. Anticancer Research 2022; 42: 2218-2218.

Ponce-de-Leon, M., Linseisen, J., Peters, A., Linkohr, B., Heier, M., Grallert, H., . . . , Meisinger, C. Novel associations between inflammation- related proteins and adiposity: A targeted proteomics approach across four population- based studies. Translational Research 2022; 242: 93-104.

Nguyen, T. N. M., Chen, L. J., Trares, K., Stocker, H., Holleczek, B., Beyreuther, K., . . . , Schottker, B. Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer's disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies. Alzheimers Research & Therapy 2022; 14: 14.

Nguyen, T. N. M., Sha, S., Chen, L. J., Holleczek, B., Brenner, H., Schottker, B. Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: Results from two large cohorts with new-user design. Alimentary Pharmacology & Therapeutics 2022; 56: 251-262.

Peters, A., Greiser, K. H., Gottlicher, S., Ahrens, W., Albrecht, M., Bamberg, F., . . . , German Natl Cohort, N. C. Framework and baseline examination of the German National Cohort (NAKO). European Journal of Epidemiology 2022; 37: 1107-1124.

Zhu, A. N., Kuznia, S., Niedermaier, T., Holleczek, B., Schottker, B., Brenner, H. Vitamin D-binding protein, total, "nonbioavailable," bioavailable, and free 25-hydroxyvitamin D, and mortality in a large population-based cohort of older adults. Journal of Internal Medicine 2022; 292: 463-476.

Zhu, A. N., Kuznia, S., Niedermaier, T., Holleczek, B., Schottker, B., Brenner, H. Consistent Inverse Associations of Total, "Bioavailable", Free, and "Non-Bioavailable" Vitamin D with Incidence of Diabetes among Older Adults with Lower Baseline HbA(1c) (<= 6%) Levels. Nutrients 2022; 14: 13.

Heisser, T., Simon, A., Hapfelmeier, J., Hoffmeister, M., Brenner, H. Treatment Costs of Colorectal Cancer by Sex and Age: Population-Based Study on Health Insurance Data from Germany. Cancers 2022; 14: 12.

Peng, Z. X., Kurz, D., Weiss, J. M., Brenner, H., Rothenbacher, D., Genuneit, J. Latent classes of atopic dermatitis and food allergy development in childhood. Pediatric Allergy and Immunology 2022; 33: 5.

Bhardwaj, M., Schottker, B., Holleczek, B., Benner, A., Schrotz-King, P., Brenner, H. Potential of Inflammatory Protein Signatures for Enhanced Selection of People for Lung Cancer Screening. Cancers 2022; 14: 12.

Fiorito, G., Pedron, S., Ochoa-Rosales, C., McCrory, C., Polidoro, S., Zhang, Y., . . . , Carmeli, C. The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis. Journals of Gerontology Series a-Biological Sciences and Medical Sciences 2022; 77: 1750-1759.

Peng, Z. X., Braig, S., Kurz, D., Weiss, J. M., Weidinger, S., Brenner, H., . . . , Genuneit, J. Trajectory and determinants of agreement between parental and physicians' reports of childhood atopic dermatitis. Pediatric Allergy and Immunology 2022; 33: 8.

Thong, M. S. Y., Doege, D., Weisser, L., Koch-Gallenkamp, L., Bertram, H., Eberle, A., . . . , Arndt, V. Health and life insurance-related problems in very long-term cancer survivors in Germany: a population-based study. Journal of Cancer Research and Clinical Oncology 2022; 148: 155-162.

Yu, H. X., Raut, J. R., Bhardwaj, M., Zhang, Y., Sandner, E., Schottker, B., . . . , Brenner, H. A serum microRNA signature for enhanced selection of people for lung cancer screening. Cancer Communications 2022; 42: 1222-1225.

Xie, K., Perna, L., Schottker, B., Kliegel, M., Brenner, H., Mons, U. Type 2 diabetes mellitus and cognitive decline in older adults in Germany - results from a population-based cohort. Bmc Geriatrics 2022; 22: 9.

Doege, D., Thong, M., Koch-Gallenkamp, L., Bertram, H., Eberle, A., Holleczek, B., . . . , Arndt, V. Clinical and sociodemographic determinants of disease-specific health-related quality of life in long-term breast cancer survivors. Oncology Research and Treatment 2022; 45: 217-217.

Li, X. W., Chang-Claude, J., Hoffmeister, M., Brenner, H., Jansen, L. Risk of Colorectal Cancer Associated With Lifetime Excess Weight. Jama Oncology 2022; 8: 730-737.

Scherer-Trame, S., Jansen, L., Koch-Gallenkamp, L., Arndt, V., Chang-Claude, J., Hoffmeister, M., Brenner, H. Quality of life, distress, and posttraumatic growth 5 years after colorectal cancer diagnosis according to history of inpatient rehabilitation. Journal of Cancer Research and Clinical Oncology 2022; 148: 3015-3028.

Boehlen, F. H., Maatouk, I., Friederich, H. C., Schoettker, B., Brenner, H., Wild, B. Loneliness as a gender-specific predictor of physical and mental health-related quality of life in older adults. Quality of Life Research 2022; 31: 2023-2033.

Park, H. A., Seibold, P., Edelmann, D., Benner, A., Canzian, F., Alwers, E., . . . , Chang-Claude, J. Validation of Genetic Markers Associated with Survival in Colorectal Cancer Patients Treated with Oxaliplatin-Based Chemotherapy. Cancer Epidemiology Biomarkers & Prevention 2022; 31: 352-361.

Zhu, A., Kuznia, S., Boakye, D., Schottker, B., Brenner, H. Vitamin D-Binding Protein, Bioavailable, and Free 25(OH)D, and Mortality: A Systematic Review and Meta-Analysis. Nutrients 2022; 14: 15.

Brenner, H., Li, H. J., Boakye, D., Chen, X. C., Hoffmeister, M. Link Between Obesity and Early-Onset Colorectal Cancers (EOCRC): Importance of Accounting for BMI Trajectories in Early Life. American Journal of Gastroenterology 2022; 117: 812-813.

Zhao, Z. T., Zhu, A. N., Bhardwaj, M., Schrotz-King, P., Brenner, H. Fecal microRNAs, Fecal microRNA Panels, or Combinations of Fecal microRNAs with Fecal Hemoglobin for Early Detection of Colorectal Cancer and Its Precursors: A Systematic Review. Cancers 2022; 14: 16.

Raut, J. R., Bhardwaj, M., Niedermaier, T., Miah, K., Schrotz-King, P., Brenner, H. Assessment of a Serum Microrna Risk Score for Colorectal Cancer among Participants of Screening Colonoscopy at Various Stages of Colorectal Carcinogenesis. Cells 2022; 11: 10.

Doege, D., Thong, M. S. Y., Koch-Gallenkamp, L., Bertram, H., Eberle, A., Holleczek, B., . . . , Arndt, V. Clinical and sociodemographic determinants of disease-specific health-related quality of life in long-term breast cancer survivors. Journal of Cancer Research and Clinical Oncology 2022; 148: 3461-3473.

Kuznia, S., Czock, D., Kopp-Schneider, A., Caspari, R., Fischer, H., Laetsch, D. C., . . . , Schottker, B. Efficacy and Safety of a Personalized Vitamin D-3 Loading Dose Followed by Daily 2000 IU in Colorectal Cancer Patients with Vitamin D Insufficiency: Interim Analysis of a Randomized Controlled Trial. Nutrients 2022; 14: 15.

Salem, A. A., Trares, K., Kohl, M., Jansen, E., Brenner, H., Schottker, B. Long-term effects of smoking on serum concentrations of oxidative stress biomarkers: Results of a large, population-based cohort study. Environmental Research 2022; 204: 7.

Chen, L. J., Nguyen, T. N. M., Laetsch, D. C., Chang-Claude, J., Hoffmeister, M., Brenner, H., Schottker, B. Association of Comedication Quality With Chemotherapy-Related Adverse Drug Reactions and Survival in Older Colorectal Cancer Patients. Journals of Gerontology Series a-Biological Sciences and Medical Sciences 2022; 77: 1009-1019.

Chen, L. J., Nguyen, T. N. M., Chang-Claude, J., Hoffmeister, M., Brenner, H., Schottker, B. Incorporation of functional status, frailty, comorbidities and comedication in prediction models for colorectal cancer survival. International Journal of Cancer 2022; 151: 539-552.

Niedermaier, T., Balavarca, Y., Gies, A., Weigl, K., Guo, F., Alwers, E., . . . , Brenner, H. Variation of Positive Predictive Values of Fecal Immunochemical Tests by Polygenic Risk Score in a Large Screening Cohort. Clinical and Translational Gastroenterology 2022; 13: 8.

Chen, X. C., Hoffmeister, M., Brenner, H. Red and Processed Meat Intake, Polygenic Risk Score, and Colorectal Cancer Risk. Nutrients 2022; 14: 12.

Gao, X., Huang, N. H., Jiang, M. J., Holleczek, B., Schottker, B., Huang, T., Brenner, H. Mortality and morbidity risk prediction for older former smokers based on a score of smoking history: evidence from UK Biobank and ESTHER cohorts. Age and Ageing 2022; 51: 10.

Niedermaier, T., Gredner, T., Kuznia, S., Schottker, B., Mons, U., Lakerveld, J., . . . , Consortium, P. E. N. Vitamin D food fortification in European countries: the underused potential to prevent cancer deaths. European Journal of Epidemiology 2022; 37: 309-320.

Sha, S., Brenner, H., Schoettker, B., Nguyen, T. M. N., Kuznia, S., Niedermaier, T., Zhu, A. Real-world evidence for the effectiveness of vitamin D supplementation in the reduction of total and cause-specific mortality. Results from half a million participants of the UK biobank cohort study. Pharmacoepidemiology and Drug Safety 2022; 31: 144-144.

Bhardwaj, M., Schrotz-King, P., Brenner, H. Correlation of Repeat Measurements of 27 Candidate Protein Markers for Colorectal Cancer Screening Taken Three Years and Multiple Freeze-Thaw Cycles Apart. Life-Basel 2022; 12: 13.

Gentiluomo, M., Giaccherini, M., Gao, X., Guo, F., Stocker, H., Schottker, B., . . . , Campa, D. Genome-wide association study of mitochondrial copy number. Human Molecular Genetics 2022; 31: 1346-1355.

Pulte, D., Jansen, L., Brenner, H. Incidence and survival estimates for patients with myelodysplastic syndrome in the early 21st century: no evidence of improvement over time. Leukemia & Lymphoma 2022; 63: 1964-1969.

Niedermaier, T., Guo, F., Weigl, K., Hoffmeister, M., Brenner, H. Combined Performance of Fecal Immunochemical Tests and a Genetic Risk Score for Advanced Neoplasia Detection. Cancer Prevention Research 2022; 15: 543-552.

Gredner, T., Niedermaier, T., Steindorf, K., Brenner, H., Mons, U. Original Research Impact of reducing excess body weight and physical inactivity on cancer incidence in Germany from 2020 to 2050da simulation model. European Journal of Cancer 2022; 160: 215-226.

Chen, X. C., Li, H. J., Guo, F., Hoffmeister, M., Brenner, H. Alcohol consumption, polygenic risk score, and early- and late-onset colorectal cancer risk. Eclinicalmedicine 2022; 49: 12.

Chen, X. C., Li, H. J., Mandic, M., Hoffmeister, M., Brenner, H. Assessment of Body Mass Index, Polygenic Risk Score, and Development of Colorectal Cancer. Jama Network Open 2022; 5: 11.

Li, X. W., Scho, B., Holleczek, B., Brenner, H. Association of longitudinal repeated measurements of frailty index with mortality: Cohort study among. Eclinicalmedicine 2022; 53: 11.

Sha, S., Nguyen, T. M. N., Kuznia, S., Niedermaier, T., Zhu, A., Brenner, H., Schottker, B. REAL-WORLD EVIDENCE FOR THE EFFECTIVENESS OF VITAMIN D SUPPLEMENTATION IN THE REDUCTION OF TOTAL AND CAUSE-SPECIFIC MORTALITY. RESULTS FROM ALMOST HALF A MILLION PARTICIPANTS OF THE UK BIOBANK COHORT STUDY. Anticancer Research 2022; 42: 2209-2209.

Li, H. J., Boakye, D., Chen, X. C., Jansen, L., Chang-Claude, J., Hoffmeister, M., Brenner, H. Associations of Body Mass Index at Different Ages With Early-Onset Colorectal Cancer. Gastroenterology 2022; 162: 1088-+.

Thong, M. S. Y., Boakye, D., Jansen, L., Martens, U. M., Chang-Claude, J., Hoffmeister, M., . . . , Arndt, V. Comorbidities, Rather Than Older Age, Are Strongly Associated With Higher Utilization of Healthcare in Colorectal Cancer Survivors. Journal of the National Comprehensive Cancer Network 2022; 20: 468-+.

Chen, X. C., Ding, J., Li, H. J., Carr, P. R., Hoffmeister, M., Brenner, H. The power of a healthy lifestyle for cancer prevention: the example of colorectal cancer. Cancer Biology & Medicine 2022; 19: 1586-1597.

Eyl, R. E., Thong, M., Carr, P., Jansen, L., Chang-Claude, J., Hoffmeister, M., . . . , Arndt, V. Change towards a healthier lifestyle is associated with better health-related quality of life in long-term colorectal cancer survivors. Oncology Research and Treatment 2022; 45: 214-214.

Schoettker, B., Brenner, H., Kuznia, S. Efficacy and safety of a personalized vitamin d3 loading dose followed by 2000 IU per day to raise serum 25-hydroxyvitamin D levels in colorectal cancer patients with vitamin D insufficiency. Interim analysis of a RCT. Pharmacoepidemiology and Drug Safety 2022; 31: 331-331.

Wannhoff, A., Werner, S., Tao, S., Brenner, H., Gotthardt, D. N. Validation of a genotype-based algorithm that identifies individuals with low, intermediate, and high serum CA19-9 levels in cancer-free individuals and in patients with colorectal cancer. Journal of Gastrointestinal Oncology 2022; 13: 1711-1721.

Schrammen, P. L., Laleh, N. G., Echle, A., Truhn, D., Schulz, V., Brinker, T. J., . . . , Kather, J. N. Weakly supervised annotation-free cancer detection and prediction of genotype in routine histopathology. Journal of Pathology 2022; 256: 50-60.

Brenner, H., Niedermaier, T. POTENTIAL OF VITAMIN D SUPPLEMENTATION OR VITAMIN D FOOD FORTIFICATION FOR PREVENTING CANCER DEATHS IN GERMANYy. Anticancer Research 2022; 42: 2196-2196.

Kuznia, S., Zhu, A., Schottker, B., Brenner, H. EFFICACY OF VITAMIN D3 SUPPLEMENTATION ON CANCER MORTALITY IN THE GENERAL POPULATION AND THE PROGNOSIS OF PATIENTS WITH CANCER: A SYSTEMATIC REVIEW AND INDIVIDUAL PATIENT DATA META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. Anticancer Research 2022; 42: 2202-2203.

Holowatyj, A. N., Ose, J., Gigic, B., Lin, T. D., Ulvik, A., Geijsen, A., . . . , Ulrich, C. M. Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer. American Journal of Clinical Nutrition 2022; 116: 303-313.

Schottker, B., Kuznia, S., Brenner, H. EFFICACY AND SAFETY OF A PERSONALIZED VITAMIN D-3 LOADING DOSE FOLLOWED BY 2,000 IU PER DAY TO RAISE SERUM 25-HYDROXYVITAMIN D IN COLORECTAL CANCER PATIENTS WITH VITAMIN D INSUFFICIENCY. INTERIM ANALYSIS OF A RCT. Anticancer Research 2022; 42: 2209-2210.

Huang, L., Jansen, L., Verhoeven, R. H. A., Ruurda, J. P., Van Eycken, L., De Schutter, H., . . . , Brenner, H. Survival trends of patients with non-metastatic gastric adenocarcinoma in the US and European countries: the impact of decreasing resection rates. Cancer Communications 2022; 42: 648-662.

Schottker, B., Larsen, E. L., Weimann, A., Henriksen, T., Brenner, H., Poulsen, H. E. Associations of urinary metabolites of oxidized DNA and RNA with the incidence of diabetes mellitus using UPLC-MS/MS and ELISA methods. Free Radical Biology and Medicine 2022; 183: 51-59.

Brenner, H., Li, H. J., Hoffmeister, M. The Role of Intestinal Flora and Ethnic Differences in Colorectal Cancer Risk Reply. Gastroenterology 2022; 163: 783-783.

Brenner, H., Hoffmeister, M., Heisser, T. Time to extend screening colonoscopy intervals? If so, by how much and for whom? Findings at 120,000 repeat screening colonoscopies conducted 10 or more years after a negative screening colonoscopy. Cancer Research 2022; 82: 2-3.

Brenner, H., Schottker, B., Niedermaier, T. Vitamin D-3 for reducing mortality from cancer and other outcomes before, during and beyond the COVID-19 pandemic: A plea for harvesting low-hanging fruit. Cancer Communications 2022; 42: 679-682.

Reuter, M., Rigo, M., Formazin, M., Liebers, F., Latza, U., Castell, S., . . . , Dragano, N. Authors' response - Occupation and SARS-CoV-2 infection risk among workers during the first pandemic wave in Germany: potential for bias. Scandinavian Journal of Work Environment & Health 2022; 48: 588-590.

Reuter, M., Rigo, M., Formazin, M., Liebers, F., Latza, U., Castell, S., . . . , Dragano, N. Occupation and SARS-CoV-2 infection risk among 108 960 workers during the first pandemic wave in Germany. Scandinavian Journal of Work Environment & Health 2022; 48: 446-456.

Park, H. A., Edelmann, D., Canzian, F., Harrison, T. A., Hua, X. W., Shi, Q., . . . , Chang-Claude, J. Predictive Polygenic Score for Outcome after First-Line Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients Using Supervised Principal Component Analysis. Cancer Epidemiology Biomarkers & Prevention 2022; 31: 2087-2091.

Ahrens, W., Brenner, H., Flechtner-Mors, M., Harrington, J. M., Hebestreit, A., Kamphuis, C. B. M., . . . , Consortium, P. E. N. Dietary behaviour and physical activity policies in Europe: learnings from the Policy Evaluation Network (PEN). European Journal of Public Health 2022; 32: 114-125.

Saldanha, O. L., Quirke, P., West, N. P., James, J. A., Loughrey, M. B., Grabsch, H. I., . . . , Kather, J. N. Swarm learning for decentralized artificial intelligence in cancer histopathology. Nature Medicine 2022; 28: 1232-+.

Fraszczyk, E., Spijkerman, A. M. W., Zhang, Y., Brandmaier, S., Day, F. R., Zhou, L., . . . , Snieder, H. Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts. Diabetologia 2022; 65: 763-776.

Echle, A., Laleh, N. G., Quirke, P., Grabsch, H. I., Muti, H. S., Saldanha, O. L., . . . , Kather, J. N. Artificial intelligence for detection of microsatellite instability in colorectal cancer-a multicentric analysis of a pre-screening tool for clinical application. Esmo Open 2022; 7: 12.

Ahearn, T. U., Zhang, H. Y., Michailidou, K., Milne, R. L., Bolla, M. K., Dennis, J., . . . , Investigators, K. C. A. Common variants in breast cancer risk loci predispose to distinct tumor subtypes. Breast Cancer Research 2022; 24: 13.

Rosberg, V., Vishram-Nielsen, J. K. K., Kristensen, A. M. D., Pareek, M., Sehested, T. S. G., Nilsson, P. M., . . . , Olsen, M. H. Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project. Preventive Medicine Reports 2022; 26: 9.

Peduzzi, G., Archibugi, L., Katzke, V., Gentiluomo, M., Capurso, G., Milanetto, A. C., . . . , Campa, D. Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women. Scientific Reports 2022; 12: 8.

Cardoso, R., Guo, F., Heisser, T., De Schutter, H., Van Damme, N., Nilbert, M. C., . . . , Brenner, H. Proportion and stage distribution of screen-detected and non-screen-detected colorectal cancer in nine European countries: an international, population-based study. Lancet Gastroenterology & Hepatology 2022; 7: 711-723.

Laleh, N. G., Muti, H. S., Loeffler, C. M. L., Echle, A., Saldanha, O. L., Mahmood, F., . . . , Kather, J. N. Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology. Medical Image Analysis 2022; 79: 15.

Gorski, M., Rasheed, H., Teumer, A., Thomas, L. F., Graham, S. E., Sveinbjornsson, G., . . . , Lifelines Cohort, S. Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. Kidney International 2022; 102: 624-639.

Hilvo, M., Dhar, I., Laaperi, M., Lysne, V., Sulo, G., Tell, G. S., . . . , Laaksonen, R. Primary cardiovascular risk prediction by LDL-cholesterol in Caucasian middle-aged and older adults: a joint analysis of three cohorts. European Journal of Preventive Cardiology 2022; 29: E128-E137.

Di Castelnuovo, A., Costanzo, S., Bonaccio, M., McElduff, P., Linneberg, A., Salomaa, V., . . . , Iacoviello, L. Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study. Addiction 2022; 117: 312-325.

Wielscher, M., Mandaviya, P. R., Kuehnel, B., Joehanes, R., Mustafa, R., Robinson, O., . . . , Consortium, B. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nature Communications 2022; 13: 14.

Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., . . . , Program, V. A. M. V. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology 2022; 5: 20.

Tanoey, J., Baechle, C., Brenner, H., Deckert, A., Fricke, J., Gunther, K., . . . , Becher, H. Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort. International Journal of Environmental Research and Public Health 2022; 19: 14.

Laleh, N. G., Muti, H. S., Loeffler, C. M. L., Echle, A., Saldanha, O. L., Mahmood, F., . . . , Kather, J. N. Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology' Medical Image Analysis (vol 79, 102474, 2022). Medical Image Analysis 2022; 82: 1.

Archambault, A. N., Jeon, J., Lin, Y., Thomas, M., Harrison, T. A., Bishop, D. T., . . . , Hayes, R. B. Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study. Jnci-Journal of the National Cancer Institute 2022; 114: 528-539.

Dennis, J., Tyrer, J. P., Walker, L. C., Michailidou, K., Dorling, L., Bolla, M. K., . . . , Investigators, K. C. A. Rare germline copy number variants (CNVs) and breast cancer risk. Communications Biology 2022; 5: 15.

Huang, Y. H., Hua, X. W., Labadie, J. D., Harrison, T. A., Dai, J. Y., Lindstrom, S., . . . , Newcomb, P. A. Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex-specific and lifestyle factors specific associations. International Journal of Cancer 2022; 150: 1447-1454.

Gaziano, L., Sun, L., Arnold, M., Bell, S., Cho, K., Kaptoge, S. K., . . . , Di Angelantonio, E. Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses. Circulation 2022; 146: 1507-1517.

Schmid, S., Jiang, M., Brown, M. C., Fares, A., Garcia, M., Soriano, J., . . . , Liu, G. Accounting for EGFR Mutations in Epidemiologic Analyses of Non-Small Cell Lung Cancers: Examples Based on the International Lung Cancer Consortium Data. Cancer Epidemiology Biomarkers & Prevention 2022; 31: 679-687.

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