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The evolution of brain tumors

Scientists from the German Cancer Research Center found in a recent study that only three different genetic alterations drive the early development of malignant glioblastomas. At least one of these three cancer drivers was present in all tumors investigated. However, it is the activation of telomerase that leads to rapid growth. The tumors develop for up to seven years before they become noticeable as symptoms and are diagnosed. However, in contrast to their early development, glioblastomas, which return after therapy, share virtually no concurrent genetic alterations.

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From mirror-image biology to enhanced therapeutic proteins

Scientists from the German Cancer Research Center (DKFZ) have succeeded in reconstructing biomolecules in their mirror-image form. The researchers' goal is to create a mirror-image artificial protein synthesis system. Their aim is to produce mirror-image therapeutic proteins, such as antibodies, which would be protected from biological breakdown in the body and do not provoke any immune response.

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Protein content as a marker for response to therapy in brain cancer

Brain tumors vary widely in how they respond to treatment. However, early assessment of therapy response is essential in order to choose the best possible treatment for the patient. Scientists from the German Cancer Research Center (DKFZ) have now been able to show in a study using non-invasive high-resolution 7-Tesla MRI scans that the protein content of tumors correlates with response to treatment and survival.

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Inflammation signals induce dormancy in aging brain stem cells

In old age, the amount of stem cells in the brains of mice decreases drastically. The remaining ones protect themselves from completely vanishing by entering a state of dormancy, scientists from the German Cancer Research Center (DKFZ) have now reported in "CELL". The old stem cells are hard to awaken, but once reactivated, they are just as potent as young ones. Their dormancy is promoted by inflammatory signals from the stem cells' environment. Anti-inflammatory substances may therefore be a key to awakening the stem cells and stimulating repair processes in the brain in old age.

DKTK

Colon cancer: Different Wnt signaling pathways lead colon cells astray

Signaling molecules in the Wnt family are some of the most essential messengers for continuous regeneration of our stressed colon mucosa. At the same time, "too much" Wnt is a frequent trigger for colon cancer. Wnt is therefore regarded as an important biomarker and treatment target. The cellular response triggered by Wnt can indicate positive or negative disease progression in colon cancer patients. Scientists from the German Cancer Consortium (DKTK) and Goethe University Frankfurt working at Georg Speyer House demonstrated this in a recent study.

1st German Cancer Research Congress

Cancer research in Germany joins forces

At the 1st German Cancer Research Congress, taking place on February 4 and 5 in Heidelberg, around 500 participants meet to exchange knowledge and ideas about what excellent research in Germany can contribute to the fight against the widespread disease of cancer. Anja Karliczek, Federal Minister of Education and Research, and Theresia Bauer, State Minister of Science, Research and the Arts, participated in the opening event on World Cancer Day.

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The development of brain stem cells into new nerve cells and why this can lead to cancer

Stem cells are true "Jacks-of-all-trades" of our bodies, as they can turn into the many different cell types of all organs. This allows the tissues such as muscle or even brain to renew and to heal after injury. This amazing "multipotency" makes stem cells in the adult body key tools for the future of regenerative medicine. Scientists at the German Cancer Research Center (DKFZ) now publish in the journal "Nature" how brain stem cells make the decision to transform into new nerve cells.

Hopp Children's Cancer Center Heidelberg

ERC grant for Stefan Pfister: “We must further advance pediatric cancer research”

KiTZ director Stefan Pfister, professor of pediatric neurooncology at the German Cancer Research Center (DKFZ) and the Heidelberg University Hospital, succeeded in gaining one of the prestigious ERC Consolidator Grants for his project entitled "BRAIN-MATCH". The goal of BRAIN-MATCH is to characterize normal brain development using molecular-biological methods and to compare it with the development of brain cancer. Pfister and his team plan to use the results obtained as a basis for finding new approaches in the treatment of brain cancer in children. The European Research Council (ERC) awards "Consolidator Grants" to support excellent scientists who are expanding their research activities.

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A major step towards digital oncology

New AI infrastructure for cancer research facilitates more complex mathematical models

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