Name of the cohort: LISAplus

Official homepage of the study. 

Basic characteristics of the study: LISAplus is a multicentre, population-based prospective birth cohort study aiming to determine the influence of life-style factors, environmental exposures including traffic emissions, and health-related behaviour on the development of the immune system and the incidence of allergic diseases in children. In total, 3,097 healthy, fullterm newborns were recruited between December 1997 and January 1999 (1467 newborns from Munich, 976 from Leipzig, 348 from Wesel, and 306 from Bad Honnef). After birth, venous cord blood was collected and questionnaire data on family history of atopy, parental education, health problems during pregnancy, smoking during pregnancy and exposure to environmental tobacco smoke during pregnancy at home were collected. Follow-up studies with medical examinations were conducted at age 2, 6, 10, and 15 years to specifically address the following research questions: (i) Are regional differences (East/West Germany) in humoral and cellular immune parameters and in the prevalence of allergic diseases detectable in children? (ii) Do exposures early in infancy differ between the study regions (e.g. infections, exposure to allergens, health-related behaviour of the parents)? (iii) What is the quantitative influence of pollutants, and indoor and outdoor allergens on the development of allergies? (iv) What are the genetic influences on allergies and other illnesses of the immune system or respiratory tract? How do genetic factors and environmental factors (nutrition, pollutants) interact?

Category of the cohort: Mature birth cohort.

Kind of biomaterials available in the cohorts, i.e. data collected in the cohorts: Biomarkers and genetic data.

Application process to access the biomaterials: An application can be sent to the LISAplus Principal Investigators.

Cohorts’ data, which can be already used within iMed: Extensive data on risk factors, diseases, genetics and biomarkers can be already applied.

Contact person for the cohort: Dr. Joachim Heinrich (heinrich(at), Helmholtz Zentrum München, Institute of Epidemiology I.

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