Henri-Jacques Delecluse

Henri-Jacques Delecluse

Henri-Jacques Delecluse


Group leader


+49 6221 424851


+49 6221 424852



Curriculum Vitae


1987               Medical degree. Faculty of Medicine, Lille, France

1988               Residency in Pathology, Lyon, France

1991               M.D. Faculty of Medicine, Lyon, France 

1993               Diploma in Histo and Cytopathology. Full specialist registration

1995               Ph.D. Molecular Biology, University of Lyon, France

Additional qualifications: B.Sc. in Pure Mathematics (Paris, Besancon), M.Sc. in Genetics, Differentiation, Immunology (Lyon)

Professional experience

Since 2012    Director of Inserm-DKFZ Unit U1074

Since 2011    Member of the German Centre for Infection Research (DZIF)

2005-2011     Speaker of the department ‘Infections and Cancer’, DKFZ

Since 2003    Full (C4) professor at the University of Heidelberg, Head of the “Pathogenesis of Virus-associated Tumours” division.

2000-2003     Professor of Molecular Pathology (personal chair), University of Birmingham, UK. Pathology reporting (Hematopathology, Molecular Pathology)

1996-2000     Group leader, Institute for Clinical Molecular Biology, Gene Vectors Department, GSF, Munich, Germany

1995-1996     Lecturer in Pathology, University Hospital B. Franklin, Free University of Berlin, Germany. Pathology reporting (Hematopathology, Molecular Pathology)

1993-1995     Lecturer in Pathology, University Hospital E. Herriot, France. Pathology reporting (Hematopathology, Molecular Pathology)

10 selected publications (2002-2016)

Neuhierl B, Feederle R, Hammerschmidt H & Delecluse HJ. Glycoprotein gp110 of Epstein-Barr virus determines viral tropism and efficiency of infection.PNAS 2002, 99; 15036–15041

TimmsJM, BellA, FlavellJ, MurrayP, RickinsonA, Traverse-GlehenA, BergerF & Delecluse HJ. Target cells of Epstein-Barr-virus (EBV)-positive post-transplant lymphoproliferative disease: similarities to EBV-positive Hodgkin's lymphoma Lancet 2003, 361; 217-23

Shannon-Lowe CD, Neuhierl B, Baldwin G, Rickinson AB, Delecluse HJ. Resting B cells as a transfer vehicle for Epstein-Barr Virus infection of epithelial cells. PNAS 2006,103; 7065-7070

Hutzinger R, Feederle R, Mrazek J, Schiefermeier N, Balwierz PJ, Zavolan M, Polacek N, Delecluse HJ*, Hüttenhofer A*. Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome.
PLoS Pathog. 2009 Aug;5(8):e1000547. *Corresponding authors

Feederle R, Linnstaedt SD, Bannert H, Lips H, Bencun M, Cullen BR, Delecluse HJ. A Viral microRNA cluster strongly potentiates the transforming properties of a Human Herpesvirus. PLoS Pathogens, 2011 PLoS Pathog 7(2): e1001294

Tsai MH, Raykova  A, Klinke O, Bernhardt K, Gärtner K, Leung CS, Geletneky K, Sertel S, Münz C, Feederle R, Delecluse HJ. Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas. Cell Rep. 2013 Oct;5(2):458-70  

Yu X, Ilecka M, Bartlett EJ, Schneidt V, Bhat R, Mautner J, Feederle R, Delecluse HJ. Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells. Blood. 2015 Mar 5;125(10):1601-10.

Lin X., Tsai MH., Shumilov A., Poirey R., Bannert H., Middeldorp JM., Feederle R., Delecluse HJ:: The Epstein-Barr virus BART miRNA cluster of the M81 strain modulates multiple functions in primary B cells. PloS Pathogens 2015.

Bernhardt K, Haar J, Tsai MH, Poirey R, Feederle R, Delecluse HJ. A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog. PLoS Pathog. 2016 Jan 22;12(1):e1005405. doi: 10.1371/journal.ppat.1005405. eCollection 2016 Jan.

Shumilov A, Tsai MH, Schlosser YT, KratzAS, BernhardtK, Fink S, MizaniT, LinX JauchA, MautnerJ, Kopp-SchneiderA, FeederleR, HoffmannI & Delecluse HJ Epstein-Barr virus particles induce centrosome amplification and chromosomal instability. Nature communications 2016, in press

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