Publications

Research Publications (since establishment of the group in 2013)

Schmidt T.T., Sharma S, Reyes G.X., Gries K., Gross M., Zhao B., Yuan J.H., Wade R., Chabes A., Hombauer H (2018). A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance. .Nucleic Acids Res. doi: 10.1093/nar/gky1154.

Schmidt T.T., Reyes G., Gries K., Ceylan C.Ü., Sharma S., Meurer M., Knop M., Chabes A., Hombauer H (2017). Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis. Proc Natl Acad Sci U S A 114(22):E4442-E4451. doi: 10.1073/pnas.1618714114.

Goellner, E. M., C. E. Smith, C. S. Campbell, H. Hombauer, A. Desai, C. D. Putnam and R. D. Kolodner (2014). PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair. Mol Cell 55(2): 291-304.

Campbell, C. S., H. Hombauer, A. Srivatsan, N. Bowen, K. Gries, A. Desai, C. D. Putnam and R. D. Kolodner (2014). Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae. PLoS Genet 10(5): e1004327.

Jaehnig, E. J., D. Kuo, H. Hombauer, T. G. Ideker and R. D. Kolodner (2013). Checkpoint kinases regulate a global network of transcription factors in response to DNA damage. Cell Rep 4(1): 174-188.

Smith, C. E., M. L. Mendillo, N. Bowen, H. Hombauer, C. S. Campbell, A. Desai, C. D. Putnam and R. D. Kolodner (2013). Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. PLoS Genet 9(10): e1003869.

 

Reviews

Schmidt, T. T. and H. Hombauer (2016). Visualization of mismatch repair complexes using fluorescence microscopy. DNA Repair (Amst) 38: 58-67.

Reyes, G. X., T. T. Schmidt, R. D. Kolodner and H. Hombauer (2015). New insights into the mechanism of DNA mismatch repair. Chromosoma 124(4): 443-462.

 

Research Publications (before 2013)

Hombauer, H., A. Srivatsan, C. D. Putnam and R. D. Kolodner (2011). Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication. Science 334(6063): 1713-1716.

Hombauer, H., C. S. Campbell, C. E. Smith, A. Desai and R. D. Kolodner (2011). Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates. Cell 147(5): 1040-1053.

Cantagrel, V., D. J. Lefeber, B. G. Ng, Z. Guan, J. L. Silhavy, S. L. Bielas, L. Lehle, H. Hombauer, M. Adamowicz, E. Swiezewska, A. P. De Brouwer, P. Blumel, J. Sykut-Cegielska, S. Houliston, D. Swistun, B. R. Ali, W. B. Dobyns, D. Babovic-Vuksanovic, H. van Bokhoven, R. A. Wevers, C. R. Raetz, H. H. Freeze, E. Morava, L. Al-Gazali and J. G. Gleeson (2010). SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142(2): 203-217.

Enserink, J. M., H. Hombauer, M. E. Huang and R. D. Kolodner (2009). Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae. J Cell Biol 185(3): 423-437.

Hombauer, H., D. Weismann, I. Mudrak, C. Stanzel, T. Fellner, D. H. Lackner and E. Ogris (2007). Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. PLoS Biol 5(6): e155.

Mostafaie, N., W. Rossmanith, H. Hombauer, T. Dechat, T. Raffelsberger, K. Bauer, B. Worofka, E. Kittl, J. Hofmann, M. Hejtman, W. Kirchmeyr, W. Schreiber, S. Weissgram, S. Jungwirth, P. Fischer, R. Bittner and K. Huber (2004). Mitochondrial genotype and risk for Alzheimer's disease: cross-sectional data from the Vienna-Transdanube-Aging "VITA" study. J Neural Transm 111(9): 1155-1165.

Yeong, F. M., H. Hombauer, K. S. Wendt, T. Hirota, I. Mudrak, K. Mechtler, T. Loregger, A. Marchler-Bauer, K. Tanaka, J. M. Peters and E. Ogris (2003). Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A. Curr Biol 13(23): 2058-2064.

Fellner, T., D. H. Lackner, H. Hombauer, P. Piribauer, I. Mudrak, K. Zaragoza, C. Juno and E. Ogris (2003). A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. Genes Dev 17(17): 2138-2150.

Hombauer, H. and J. J. Minguell (2000). Selective interactions between epithelial tumour cells and bone marrow mesenchymal stem cells. Br J Cancer 82(7): 1290-1296.

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