Research Publications (since establishment of the group in 2013)

Schmidt T.T, Sharma S, Reyes G.X., Wagner T, Kolodziejczak A, Luke B, Hofer A, Chabes A, Hombauer H. Inactivation of the folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio. Nucleic Acids Res, 2019 pii: gkz1006. doi: 10.1093/nar/gkz1006

Schmidt T.T., Sharma S, Reyes G.X., Gries K., Gross M., Zhao B., Yuan J.H., Wade R., Chabes A., Hombauer H (2018). A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance. .Nucleic Acids Res. doi: 10.1093/nar/gky1154.

Schmidt T.T., Reyes G., Gries K., Ceylan C.Ü., Sharma S., Meurer M., Knop M., Chabes A., Hombauer H (2017). Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis. Proc Natl Acad Sci U S A 114(22):E4442-E4451. doi: 10.1073/pnas.1618714114.

Goellner, E. M., C. E. Smith, C. S. Campbell, H. Hombauer, A. Desai, C. D. Putnam and R. D. Kolodner (2014). PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair. Mol Cell 55(2): 291-304.

Campbell, C. S., H. Hombauer, A. Srivatsan, N. Bowen, K. Gries, A. Desai, C. D. Putnam and R. D. Kolodner (2014). Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae. PLoS Genet 10(5): e1004327.

Jaehnig, E. J., D. Kuo, H. Hombauer, T. G. Ideker and R. D. Kolodner (2013). Checkpoint kinases regulate a global network of transcription factors in response to DNA damage. Cell Rep 4(1): 174-188.

Smith, C. E., M. L. Mendillo, N. Bowen, H. Hombauer, C. S. Campbell, A. Desai, C. D. Putnam and R. D. Kolodner (2013). Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. PLoS Genet 9(10): e1003869.



Schmidt, T. T. and H. Hombauer (2016). Visualization of mismatch repair complexes using fluorescence microscopy. DNA Repair (Amst) 38: 58-67.

Reyes, G. X., T. T. Schmidt, R. D. Kolodner and H. Hombauer (2015). New insights into the mechanism of DNA mismatch repair. Chromosoma 124(4): 443-462.


Research Publications (before 2013)

Hombauer, H., A. Srivatsan, C. D. Putnam and R. D. Kolodner (2011). Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication. Science 334(6063): 1713-1716.

Hombauer, H., C. S. Campbell, C. E. Smith, A. Desai and R. D. Kolodner (2011). Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates. Cell 147(5): 1040-1053.

Cantagrel, V., D. J. Lefeber, B. G. Ng, Z. Guan, J. L. Silhavy, S. L. Bielas, L. Lehle, H. Hombauer, M. Adamowicz, E. Swiezewska, A. P. De Brouwer, P. Blumel, J. Sykut-Cegielska, S. Houliston, D. Swistun, B. R. Ali, W. B. Dobyns, D. Babovic-Vuksanovic, H. van Bokhoven, R. A. Wevers, C. R. Raetz, H. H. Freeze, E. Morava, L. Al-Gazali and J. G. Gleeson (2010). SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142(2): 203-217.

Enserink, J. M., H. Hombauer, M. E. Huang and R. D. Kolodner (2009). Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae. J Cell Biol 185(3): 423-437.

Hombauer, H., D. Weismann, I. Mudrak, C. Stanzel, T. Fellner, D. H. Lackner and E. Ogris (2007). Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. PLoS Biol 5(6): e155.

Mostafaie, N., W. Rossmanith, H. Hombauer, T. Dechat, T. Raffelsberger, K. Bauer, B. Worofka, E. Kittl, J. Hofmann, M. Hejtman, W. Kirchmeyr, W. Schreiber, S. Weissgram, S. Jungwirth, P. Fischer, R. Bittner and K. Huber (2004). Mitochondrial genotype and risk for Alzheimer's disease: cross-sectional data from the Vienna-Transdanube-Aging "VITA" study. J Neural Transm 111(9): 1155-1165.

Yeong, F. M., H. Hombauer, K. S. Wendt, T. Hirota, I. Mudrak, K. Mechtler, T. Loregger, A. Marchler-Bauer, K. Tanaka, J. M. Peters and E. Ogris (2003). Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A. Curr Biol 13(23): 2058-2064.

Fellner, T., D. H. Lackner, H. Hombauer, P. Piribauer, I. Mudrak, K. Zaragoza, C. Juno and E. Ogris (2003). A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. Genes Dev 17(17): 2138-2150.

Hombauer, H. and J. J. Minguell (2000). Selective interactions between epithelial tumour cells and bone marrow mesenchymal stem cells. Br J Cancer 82(7): 1290-1296.

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