Dynamics of Chromosomes

Which physical processes govern cell nuclei? On scales from individual genomic loci up to whole chromosomes, the motion of chromatin reflects properties of cell nuclei such as viscoelasticity, molecular crowdedness, specific and unspecific interactions, and the folding of chromatin into higher-order structures.

In this project, the diffusive motion of chromatin fibers is simulated together with fluorescence-based detection techniques (FCSSPIM). This allows for a comparison of experimental results with theoretical models of dynamic chromatin fibers. To represent the fibers in this simulation, we use a lattice polymer model which provides realistic dynamics over several orders of magnitude in time, all at relatively low computational cost.

Lattice representation of chromatin fibers forming chromosomes in a cell nucleus

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