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2010 - today

2010

  • Langowski, J. (2010):
    Chromosome conformation by crosslinking: Polymer physics matters.
    Nucleus 1(1): 37-39 [LINK / PDF]
  • F. Aumann, J. Sühnel, S. Diekmann, J. Langowski (2010): 
    Rigid assembly and Monte Carlo models of stable and unstable chromatin structures: the effect of nucleosomal spacing.
    Theor. Chem. Accts. 125(3-6): 217-231; DOI: 10.1007/s00214-009-0561-9 [PDF]
  • Diesinger,P.M., Kunkel,S., Langowski,J., Heermann,D.W. (2010):
    Histone Depletion Facilitates Chromatin Loops on the Kilobasepair Scale.
    Biophysical Journal 99(9), 2995-3001 [PDF]
  • C. Fritsch, J. Langowski (2010):
    Anomalous Diffusion in the Interphase Cell Nucleus: The Effect of Spatial Correlations of Chromatin.
    J. Chem. Phys 133(2), 025101; DOI: 10.1063/1.3435345 [PDF]
  • Bär H, Schopferer M, Sharma S, Hochstein B, Mücke N, Herrmann H, Willenbacher N (2010): 
    Mutations in desmin's carboxy-terminal "tail" domain severely modify filament and network mechanics. 
    Journal of Molecular Biology 397(5): 1188-1198.
  • Braun,K., Dunsch,L., Pipkorn,R., Bock,M., Bäuerle,T., Yang,S.F., Waldeck,W., Wiessler,M. (2010):
    Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics.
    International Journal of Medical Sciences 7(3), 136-146
  • Braun,K., Wiessler,M., Pipkorn,R., Ehemann,V., Bauerle,T., Fleischhacker,H., Müller,G., Lorenz,P., Waldeck,W. (2010):
    A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv "Click Chemistry" targeted to alphavbeta3 integrin for therapy.
    International Journal of Medical Sciences 7(6), 326-339
  • Kapinos,L.E., Schumacher,J., Mücke,N., Machaidze,G., Burkhard,P., Aebi,U., Strelkov,S.V., Herrmann,H. (2010):
    Characterization of the Head-to-Tail Overlap Complexes Formed by Human Lamin A, B1 and B2 "Half-minflamin" Dimers.
    Journal of Molecular Biology 396(3), 719-731
  • Müller,G., Waldeck,W., Braun,K. (2010):
    From green to red - To more dead? Autofluorescent proteins as photosensitizers.
    Journal of Photochemistry and Photobiology / B, Biology 98(1), 95-98
  • Wenzel, N. I., Chavain, N., Wang, Y., Friebolin, W., Maes, L. , Pradines, B., Lanzer, M., Yardley, V., Brun, R., Herold-Mende, C., Biot, C. Tóth, K., Davioud-Charvet, E. (2010): 
    Antimalarial versus Cytotoxic Properties of Dual Drugs Derived From 4-Aminoquinolines and Mannich Bases: Interaction with DNA 
    J. Med. Chem. 53: 3214-3226, DOI: 10.1021/jm9018383 [PDF], paper supplement [PDF]
  • Wiessler, M, Kliem, C, Waldeck, W, Pipkorn, R, Braun, K. (2010):
    The Diels-Alder-Reaction with inverse Electron Demand, a very efficient Click-Reaction Concept for Ligation of variable molecular Partners.
    Int. J. Medic Sci 7(1): 19-28
  • Wiessler M, Waldeck W, Pipkorn R, Kliem C, Lorenz P, Fleischhacker H, Hafner M, Braun K (2010): 
    Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry. 
    Int J Med Sci. 7(4):2 13-23

2011

  • Böhm, V., Gansen, A., Hieb, A., Tóth, K., Andrews, A., Luger, K., Langowski, J. (2011):
    Nucleosomal DNA accessibility governed by the dimer/tetramer interface.
    Nucleic Acids Research DOI: 10.1093/nar/gkq1279 [PDF]
  • Fritsch, C., Langowski, J. (2011):
    Chromosome dynamics, molecular crowding and diffusion in the interphase cell nucleus: A Monte-Carlo lattice simulation study.
    Chromosome Research 19(1): 63-81 [PDF]
  • Mezö G, Herényi L, Habdas J, Majer Z, Mysliwa-Kurdziel B, Tóth K, Csík G (2011):
    Syntheses and DNA binding of new cationic porphyrin-tetrapeptide conjugates. Biophys Chem 155(1):36-44. Epub 2011 Feb 26. [PDF]
  • S. Winheim, A. Hieb, M. Silbermann, E.-M. Surmann, T. Wedig, H. Herrmann, J. Langowski, N. Mücke (2011):
    Deconstructing the Late Phase of Vimentin Assembly by Total Internal Reflection Fluorescence Microscopy (TIRFM). PLoS ONE 6(4): e19202. DOI:10.1371/journal.pone.0019202 [PDF]
  • Brazda, P., Szekeres, T., Bravics, B., Tóth, K., Vamosi, G., Nagy, L. (2011):
    Live-cell fluorescence correlation spectroscopy dissects the role of coregulator exchange and chromatin binding in retinoic acid receptor mobility. Biochemistry 124:3631-3642. DOI: 10.1242/jcs.086082 [PDF]
  • Cs. Szasz, A. Alexa, K. Toth, M. Rakacs, J. Langowski, P. Tompa (2011):
    Protein Disorder Prevails under Crowded Conditions. Biochemistry 50:5834-5844. DOI: 10.1021/bi200365j [PDF]
  • Ungerer, N., Mücke, N., Broecker, J., Keller, S., Frings, S., Möhrlen, F. (2011) 
    Distinct binding properties distinguish LQ-type Calmodulin-binding domains in cyclic nucleotide-gated channels.
    Biochemistry. 50, 3221-3228. DOI: 10.1021/bi200115m
  • Binder, M., Eberle, F., Seitz, S., Mücke, N., Hüber, C.M., Kiani, N., Kaderali, L., Lohmann, V., Dalpke, A., Bartenschlager, R. (2011)
    Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid inducible Gene-I (RIG-I)
    JBC, 286, (31), 27278-27287
  • T. Kühn, T.O. Ihalainen, J. Hyväluoma, N. Dross, S.F. Willman, J. Langowski , M. Vihinen-Ranta, J. Timonen:
    Protein diffusion in mammalian cell cytoplasm. 
    PLoS ONE 6(8), e22962 (2011)
  • M. Biswas, K. Voltz, J.C. Smith, J. Langowski:
    Role of histone tails in nucleosome stability. 
    PLoS Comp Biol 7(12), e1002279 (2011) DOI: 10.1371/journal.pcbi.1002279 [LINK]
  • Wiessler, M; Hennrich, U; Pipkorn, R; Waldeck, W; Cao, L; Peter, J; Ehemann, V; Semmler, W; Lammers, T; Braun, K. Theranostic (2011):
    cRGD-BioShuttle constructs containing Temozolomide- and Cy7 for NIR-imaging and therapy
    Theranostics 1: 381-394
  • Mueller, G; Waldeck, W; Tóth, K; Wiessler; M; Braun, K. (2011):
    Positioning Effects of KilleRed in the Cell correlates with DNA Strand Breaks after Activation with white Light
    Int J Medic Sci 8(2): 97-105
  • Pipkorn, R; Dunsch, L; Wiessler, M; Waldeck, W; Braun, K. (2011):
    A rare earth endo-Nitrite-Cluster-Fullerene-Conjugate useful as an intravital Contrast Agent in MRT? 
    Biopolymers 96: 506-506
  • Pipkorn, R; Wiessler, M; Waldeck, W; Lorenz, P; Muehlhausen, U; Fleischhacker, H; Koch, M; Braun, K. (2011):
    Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-based Monomers
    Int J Medic Sci 8(5): 387-396

2012

  • Jan Buchholz, Jan Wolfgang Krieger, Gábor Mocsár, Balázs Kreith, Edoardo Charbon, György Vámosi, Udo Kebschull, and Jörg Langowski (2012):
    FPGA implementation of a 32x32 autocorrelator array for analysis of fast image series,
    Opt. Express 20, 17767-17782,
    DOI: 10.1364/OE.20.017767 [LINK]
  • Lichtenstern, T., Mücke, N., Aebi, U., Mauermann, M., Herrmann, H. (2012)
    Complex formation and kinetics of filament assembly exhibited by the simple epithelial keratins K8 and K18.
    JSB, 177, 54-62
  • Trokter, M., Mücke,N., Surrey. (2012)
    Reconstitution of the human cytoplasmic dynein complex.
    PNAS, 109, 20895-20900
  • K. Voltz, J. Trylska, J.C. Smith, J. Langowski:
    Unwrapping of Nucleosomal DNA Ends: A Multiscale Molecular Dynamics Study.
    Biophys. J. 102 (4), 849-858; DOI:10.1016/j.bpj.2011.11.4028 (2012)
  • M. Biswas, T. Wocjan, J. Langowski, J.C. Smith:
    DNA bending potentials for loop-mediated nucleosome repositioning.
    Europhys. Lett. 97, 38004; DOI:10.1209/0295-5075/97/38004 (2012)
  • G. Mocsár, B. Kreith, J. Buchholz, J. W. Krieger, J. Langowski, G. Vámosi: 
    Multiplexed multiple-t auto- and cross-correlators on a single FPGA.
    Rev. Sci. Instr. 83, 046101; DOI: 10.1063/1.3700810 (2012)
  • R. Broderick, S. Ramadurai, K. Tóth, D.M. Togashi, A.G. Ryder, J. Langowski, H.-P. Nasheuer:
    Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy.
    PLoS ONE 7(4): e35537. DOI:10.1371/journal.pone.0035537 (2012) 
  • L.R. Gehlen, G. Gruenert, M.B. Jones, C.D. Rodley, J. Langowski, J.M. O’Sullivan:
    Chromosome positioning and the clustering of functionally related loci in yeast is driven by chromosomal interactions. 
    Nucleus 3(4), 1-14 (2012)
  • C. Fritsch, J. Langowski:
    Kinetic lattice Monte Carlo simulation of viscoelastic subdiffusion.
    J. Chem. Phys. 137, 064114 (2012) 
  • Waldeck, W; Heidenreich, E; Mueller, G; Wiessler, M; Braun, K. (2012):
    ROS-mediated Killing Efficiency with visible Light of Bacteria carrying different red Fluorochrome Proteins
    J Photochem Photobiol B 109: 28-33
  • Braun, K; Beining, M; Pipkorn, R; Nokihara, K; Wiessler, M; Boehm, V; Waldeck, W. (2012):
    Mobility and Delivery of the non-viral Drug Delivery & Targeting Platform BioShuttle in living Cells studied with High-Resolution FCS & CLSM Methodologies
    Int J Medic Sci 9(5): 339-352
  • Pipkorn, R; Wiessler, M; Waldeck, W; Hennrich, U; Nokihara, K; Beining, M; Braun, K. (2012):
    Improved Synthesis Strategy for Peptide Nucleic Acids (PNA) appropriate for Cell specific Fluorescence Imaging
    Int J Medic Sci 9(1): 1-10

2013

  • Anand Pratap Singh, Jan Wolfgang Krieger, Jan Buchholz, Edoardo Charbon, Jörg Langowski, Thorsten Wohland (2013):
    The performance of 2D array detectors for light sheet based fluorescence correlation spectroscopy. Opt. Express 21(7), 8652-68. DOI: 10.1364/OE.21.008652
  • A. Gansen, A.R. Hieb, V. Böhm, K. Tóth, J. Langowski: Closing the gap between single-molecule and bulk FRET analysis of nucleosomes. (2013) PLoS ONE 8(4): e57018. DOI:10.1371/journal.pone.0057018
  • M. Biswas, J. Langowski, T.C. Bishop:. Atomistic simulations of nucleosomes. (2013) Wiley Interdisciplinary Reviews: Computational Molecular Science 3(4), 378-392; http://dx.doi.org/10.1002/wcms.1139
  • Orosz A, Mezo G, Herenyi L, Habdas J, Majer Z, Mysliwa-Kurdziel B, Toth K, Csik G (2013): Binding of new cationic porphyrin-tetrapeptide conjugates to nucleoprotein complexes. Biophys Chem 2013, 177-178C:14-23.
  • Szalóki N, Xuan QMD, Szöllosi J, Tóth K, Vámosi G, Bacsó Zs (2013) High throughput FRET analysis of protein-protein interactions by slide-based imaging laser scanning cytometry. Cytometry A 83A, 818-829.
  • Tóth K, Böhm V. Sellmann C, Danner M, Hanne J, Berg M, Barz I, Gansen A, Langowski J (2013) Histone- and DNA sequence-dependent stability of nucleosomes studied by single pair FRET. Cytometry A 83A, 839-846.
  • Waldeck W, Mueller G, Glatting KH, Hotz-Wagenblatt A, Diessl N, Chotewutmonti S, Langowski J, Semmler W, Wiessler M, Braun K (2013) Spatial Localization of Genes Determined by Intranuclear DNA Fragmentation with the Fusion Proteins Lamin KRED and Histone KRED und Visible Light. Int J Med Sci10(9):1136-1148. DOI: 10.7150/ijms.6121
  • J.M.O'Sullivan, M.D. Hendy, T. Pichugina, G. Wake, J. Langowski: The statistical-mechanics of chromosome conformation capture. (2013) Nucleus 4(5), 390-398
  • Braun K, Müller G, Schick M, Bewerunge-Hudler M, Heil O, Wiessler M, Pipkorn R, Semmler W and Waldeck W (2013)
    Expressions Profiling project of human embryonic lung cells exposed to pyrolyzed cigarette smoke IJPSR,4(11):4203-4222. 
  • Manfred Wiessler, Waldemar Waldeck, Ruediger Pipkorn, Peter Lorenz, Jürgen Debus, Hans-Hermann Schrenk, and Klaus Braun (2013) The Diels-Alder-reaction with inverse-electron-demand - a review of an efficient & attractive click-reaction concept IJPSR, 4(10): 3678-3698. 
  • Pipkorn R, Rawer S, Wiessler M, Waldeck W, Koch M, Schrenk HH, Braun K. SPPS resins impact the PNA-syntheses' improvement. (2013) Int J Med Sci. 10(3):331-7. DOI: 10.7150/ijms.5374

2014

  • Jan Wolfgang Krieger, Anand Pratap Singh,, Christoph S. Garbe, Thorsten Wohland and Jörg Langowski (2014):
    Dual-Color Fluorescence Cross-Correlation Spectroscopy on a Single Plane Illumination Microscope (SPIM-FCCS),
    Opt. Express22(3), 2358-2375, DOI: 10.1364/OE.22.002358, supplementary information [PDF]
  • J. Langowski: Watering down a theory. Comment on "Fluctuations in the DNA double helix: A critical review" by Frank-Kamenetskii and Prakash. (2014) Physics of Life Reviewshttp://dx.doi.org/10.1016/j.plrev.2014.03.011
  • Peter Brazda, Jan Krieger, Bence Daniel, David Jonas, Tibor Szekeres, Jörg Langowski, Katalin Tóth, Laszlo Nagy and György Vámosi: Ligand binding shifts highly mobile RXR to chromatin-bound state in a coactivator-dependent manner as revealed by single cell imaging. (2014) Molecular and Cellular Biology34(7): 1234-1245. DOI: 10.1128/MCB.01097-13
  • A.R. Hieb, A. Gansen, V. Böhm, J. Langowski: The conformational state of the nucleosome entry-exit site modulates TATA-box specific TBP binding. (2014) Nucl. Acids Res., http://dx.doi.org/10.1093/nar/gku423 
  • A.L. Olins, N. Ishaque, S. Chotewutmontri, J. Langowski, D.E. Olins: Retrotransposon Alu is enriched in the epichromatin of HL-60 cells. (2014) Nucleus 5(3)http://dx.doi.org/10.4161/nucl.29141
  • J. Erler, R. Zhang, L. Petridis, X. Cheng, J.C. Smith, J. Langowski: The role of histone tails in the nucleosome: A computational study. (2014) Biophys. J. 107(12), 2911-22. doi:10.1016/j.bpj.2014.10.065
  • Pawelzyk P, Mücke N, Herrmann H, Willenbacher N: Attractive interactions among intermediate filaments determine network mechanics in vitro. (2014) PLoS ONE 9 (4), e93194. 
  • Q.-M. Doan-Xuan, N. Szalóki, K. Tóth, J. Szöllösi, Z. Bacsó and G. Vámosi: FRET Imaging by Laser Scanning Cytometry on Large Populations of Adherent Cells. (2014) Curr. Protoc. Cytom. 70, 2.23:2.23.1-2.23.29. 
  • Jortzik E, Farhadi M, Ahmadi R, Tóth K, Lohr J, Helmke BM, Kehr S, Unterberg A, Ott I, Gust R, Deborde V, Davioud-Charvet E, Réau R, Becker K, Herold-Mende C. Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: Chemical synthesis, mechanistic studies, and effectiveness in vivo. (2014) Biochim Biophys Acta.1844(8):1415-26. DOI: 10.1016/j.bbapap.2014.01.006
  • Braun,K., Hotz-Wagenblatt,A., Wiessler,M., Pipkorn,R., Komljenoviç,D., Semmler,W., Waldeck,W.: Cigarette Smoke Extracts induce and repress Genes in human embryonic Lung Cells. (2014) Int. J. Pharm. Sci. Res.5(3).
  • Braun,K., Wiessler,M., Komljenovic,D., Schrenk,H.H., Lorenz,P., Fleischhacker,H., Waldeck,W., Pipkorn,R.: Amide-based Disulfide Building Blocks for the Enlargement of the Solid Phase Peptide Synthesis for Molecular Diagnostics and Imaging. (2014) Pharmaceutical Regulatory Affairs 3(1), 115-124. 
  • Pipkorn R, Braun K, Wiessler M, Waldeck W, Schrenk HH, Koch M, Semmler W, Komljenovic D:A Peptide & Peptide Nucleic Acid Synthesis Technology for Transporter Molecules and Theranostics - The SPPS. (2014) Int J Med Sci. 11(7):697-706. DOI: 10.7150/ijms.8168
  • C.C. Fritsch: A generalization of the bond fluctuation model to viscoelastic environments. (2014) J. Phys.: Condens. Matter 26, 335101. DOI:10.1088/0953-8984/26/33/335101

2015

  • T. Elbel, J. Langowski: The effect of DNA supercoiling on nucleosome structure and stability. (2015) J Phys Condens Matter 27(6), 064105. DOI:10.1088/0953-8984/27/6/064105
  • A. Gansen, K. Tóth, N. Schwarz, J. Langowski: Opposing roles of H3 and H4 acetylation in the regulation of nucleosome structure – a FRET study. (2015) Nucl Acids Res. 43(3), 1433-43.DOI:10.1093/nar/gku1354
  • A. Pernuš, J. Langowski: Imaging Fos-Jun transcription factor mobility and interaction in live cells by single plane illumination-fluorescence cross correlation spectroscopy. (2015) PLoS One 10(4):e0123070. DOI:10.1371/journal.pone.0123070
  • N. Szalóki, J.W. Krieger, I. Komáromi, K. Tóth, G. Vámosi: Evidence for homodimerization of the c-Fos transcription factor in live cells revealed by FRET, SPIM-FCCS and MD-modeling. (2015) Mol. Cell. Biol. e-pub DOI:10.1128/MCB.00346-15
  • N. Plavner Hazan, T.E. Tomov, R. Tsukanov, M. Liber, Y. Berger, R. Masoud, K. Tóth, J. Langowski, E. Nir: Nucleosome Core Particle Stability and Disassembly and Assembly Kinetics Studied using Single-Molecule Fluorescence. (2015) Biophys. J. 109, 1676-1685 
  • T. Wohland, J. Krieger, A. Singh, N. Bag, C. Garbe, T. Saunders, J. Langowski: Practical Guidelines for Imaging Fluorescence (Cross-) Correlation Spectroscopy in Live Cells and Organisms. (2015) Nature Protocols 10(12), 1948-1974
  • Gaik M, Flemming D, von Appen A, Kastritis P, Mücke N, Fischer J, Stelter P, Ori A, Bui KH, Baßler J, Barbar E, Beck M, Hurt E.: Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold. (2015) J Cell Biol. 208(3):283-97 
  • Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, Cölfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, Díez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, Mücke N, Nagel-Steger L, Narlikar GJ, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT 4th, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P: A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. (2015) PLoS One10(5):e0126420
  • Premchandar A, Kupniewska A, Tarnowski K, Mücke N, Mauermann M, Kaus-Drobek M, Edelman A, Herrmann H, Dadlez M: Analysis of distinct molecular assembly complexes of keratin K8 and K18 by hydrogen-deuterium exchange. (2015) J Struct Biol 192(3):426-40

2016

  • N. Mücke, S. Winheim, H. Merlitz, J. Buchholz, J. Langowski, H. Herrmann: In Vitro Assembly Kinetics of Cytoplasmic Intermediate Filaments: A Correlative Monte Carlo Simulation Study. (2016) PLoS One11(6), e0157451
  • G. Mocsár, J. Volk, D. Rönnlund, J. Widengren, P. Nagy, J. Szöllösi, K. Tóth, C.K. Goldman, S Damjanovich, T.A. Waldmann, A. Bodnár, G. Vámosi: MHC I expression regulates co-clustering and mobility of IL-2/IL-15 receptors in T cells. (2016) Biophysical Journal 111(1), 100-12. DOI: 10.1016/j.bpj.2016.05.044.
  • Vámosi G, Mücke N, Müller G, Krieger JW, Curth U, Langowski J, Tóth K: EGFP oligomers as natural fluorescence and hydrodynamic standards. (2016) Sci Rep.6, 33022. DOI: 10.1038/srep33022.
  • Premchandar A, Mücke N, Poznanski J, Wedig T, Kaus-Drobek M, Herrmann H, Dadlez M: Structural Dynamics of the Vimentin Coiled-Coil Contact Regions involved in Filament Assembly as revealed by Hydrogen-Deuterium Exchange. (2016) J Biol Chem. 291(48):24931-24950 pii: jbc.M116.748145.
  • Komljenovic D, Wiessler M, Waldeck W, Ehemann V, Pipkorn R, Schrenk HH, Debus J, Braun K: NIR-Cyanine Dye Linker: a Promising Candidate for Isochronic Fluorescence Imaging in Molecular Cancer Diagnostics and Therapy Monitoring. (2016) Theranostics 6(1):131-141

2017

  • R. Zhang, J. Erler, J. Langowski: Histone Acetylation Regulates Chromatin Accessibility: Role of H4K16 in Inter-nucleosome Interaction. (2017) Biophysical Journal 112(3):450-459
  • Sauer PV, Timm J, Liu D, Sitbon D, Boeri-Erba E, Velours C, Muecke N, Langowski J, Ochsenbein F, Almouzni G, Panne D: Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1. (2017) eLife 2017(6): e23474
  • Teif VB, Mallm JP, Sharma T, Mark Welch DB, Rippe K, Eils R, Langowski J, Olins AL, Olins DE: Nucleosome repositioning during differentiation of a human myeloid leukemia cell line. (2017) Nucleus 8(2):188-204
  • Hetey S, Boros-Olah B, Kuik-Rozsa T, Li Q, Karanyi Z, Szabo Z, Roszik J, Szaloki N, Vamosi G, Toth K, Szekvolgyi L: Biophysical characterization of histone H3.3 K27M point mutation. (2017) Biochemical and Biophysical Research Communications 490(3):868-875
  • Langowski J: Single plane illumination microscopy as a tool for studying nucleome dynamics. (2017)Methods 123:3-10
  • Schulz EC, Seiler M, Zuliani C, Voigt F, Rybin V, Pogenberg V, Mücke N, Wilmanns M, Gibson TJ, Barabas O: Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq. (2017) Scientific Reports 7(1):9903
  • Lehmann,K., Zhang,R.H., Schwarz,N., Gansen,A., Mücke,N., Langowski,J., Toth,K.: Effects of charge-modifying mutations in histone H2A alpha 3-domain on nucleosome stability assessed by single-pair FRET and MD simulations. (2017) Scientific Reports 7(1):13303
  • Mark Welch DB, Jauch A, Langowski J, Olins AL, Olins DE: Transcriptomes reflect the phenotypes of undifferentiated, granulocyte and macrophage forms of HL-60/S4 cells. (2017) Nucleus 8(2):222-237
  • Rubio-Cosials A, Battistini F, Gansen A, Cuppari A, Bernadó P, Orozco M, Langowski J, Tóth K, Solà M: Protein flexibility and synergy of HMG domains underlie U-turn bending of DNA by TFAM in solution. (2017) Biophysical Journal 11:3743 DOI: 10.1016/j.bpj.2017.11.3743
  • Gould, T.J., Tóth, K., Mücke, N., Langowski, J., Hakusui, A., Olins, A.L., Olins, D.E.: Defining the epichromatin epitope. (2017) Nucleus DOI: 10.1080/19491034.2017.1380141
  • Sawant, M., Schwarz, N., Windoffer, R., Magin,T., Krieger, J., Mücke, N., Obara, B., Jankowski, V., Jankowski, J., Wally, V., Lettner, T., Leube, R.E.: Threonine 150 phosphorylation of keratin 5 is linked to EBS and regulates filament assembly and cell viability. (2017) Journal of Investigative Dermatology pii: S0022-202X(17)33079-8, DOI: 10.1016/j.jid.2017.10.011

2000 - 2009

2000

  • K. Klenin, M. Hammermann, J. Langowski (2000):
    Modelling dynamic light scattering of superhelical DNA.
    Macromolecules 33, 1459-1466
  • M. Wachsmuth, W. Waldeck, J. Langowski (2000):
    Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy. 
    J. Mol. Biol. 298, 677-690 [PDF]
  • M. Hammermann, N. Brun, K.V. Klenin, R. May, K. Tóth, J. Langowski (2000):
    The diameter of the DNA superhelix decreases with salt concentration: SANS measurements and Monte Carlo simulations.
    J. Appl. Cryst. 33, 526-529
  • F. Lankas, J. Sponar, P. Hobza, J. Langowski: (2000)
    Sequence-dependent elastic properties of DNA.
    J. Mol. Biol. 299, 697-712 [PDF]
  • M. Hammermann, K. Tóth, C. Rodemer, W. Waldeck, R. May, J. Langowski (2000):
    Salt-dependent compaction of di-and trinucleosomes studied by small angle neutron scattering.
    Biophys. J. 79, 584-594 [PDF]
  • K. Klenin, J. Langowski: (2000)
    Computation of writhe in superhelical DNA.
    Biopolymers 54, 307-317 [PDF]
  • A. Schulz, J. Langowski, K. Rippe: (2000)
    The effect of the DNA conformation on the rate of NtrC activated transcription of E.coli RNA polymerase.σ54 holoenzyme.
    J. Mol. Biol. 300, 709-725 [PDF]
  • I. Hofmann, N. Mücke, J. Reed, H. Herrmann, J. Langowski (2000): 
    Physical characterization of Plakophilin 1 reconstituted with and without Zinc.
    Eur. Biophys.  J. 267, 4381-4389 [PDF]
  • J. Langowski, C. Mehring, M. Hammermann, K. Klenin, C. Münkel, K. Tóth, G. Wedemann (2000): 
    The genome as a flexible polymer chain: recent results from simulations and experiments.
    In: Genomics and Proteomics Ð functional and computational aspects, ed. S. Suhai; Plenum Press, New York, 121-131.
  • H. Bornfleth, C. Cremer, T. Cremer, S. Dietzel, P. Edelmann, R. Eils, W. Jäger, D. Kienle, G. Kreth, P. Lichter, G. Little, C. Münkel, J. Langowski, I. Solovei, E. H. K. Stelzer, D. Zink:
    Analysis of chromosome territory architecture in the human cell nucleus. Overview of data from a collaborative study.
    In: Genomics and Proteomics - functional and computational aspects, ed. S. Suhai; (2000) Plenum Press, New York, 133-140.
  • J. Langowski, M. Tewes: 
    Determination of DNA-Ligand interaction by fluorescence correlation spectroscopy. 
    In: DNA-Protein interactions: a practical approach, A. Travers and M. Buckle, eds., (2000) Oxford University Press, Oxford.
  • J. Langowski, M. Wachsmuth, K. Rippe, M. Tewes:
    Biomolecular shape and interactions determined by fluorescence correlation spectroscopy.
    In: Energies et forces de l'interaction entre macromolécules biologiques: l'aspect quantitatif, pp. 65-77. Ecole Physique et Chimie du Vivant no. 2 (mai 2000), Publications CNRS, Paris

2001

  • G. Chirico, M. Collini, K. Tóth, N. Brun, J. Langowski (2001): 
    Rotational dynamics of DNA fragments studied by fluorescence polarization anisotropy.
    Eur. Biophys. J. 29(8), 597-606. [PDF]
  • K. Klenin, J. Langowski (2001):
    Diffusion controlled intrachain reactions of supercoiled DNA: Brownian dynamics simulations.
    Biophys. J. 80(1), 69-74 [PDF]
  • K. Klenin, J. Langowski (2001):
    Kinetics of intrachain reactions of supercoiled DNA: Theory and numerical modeling.
    J. Chem. Phys. 114(12), 5049-5060 [PDF]
  • K. Tóth, N. Brun, J. Langowski (2001):
    Trajectory of nucleosomal linker DNA studied by fluorescence resonance energy transfer.  
    Biochemistry 40, 6921-6928 [PDF]
  • K. Klenin, J. Langowski (2001):
    Intrachain reactions of supercoiled DNA simulated by Brownian dynamics. 
    Biophys. J. 81, 1924-1929 [PDF]
  • Gábor, F., Szolnoki, J, Tóth, K., Fekete, A., Maillard, Ph., Csík, Cs. (2001):
    Photoincduced inactivation of T7 phage sensitized by symmetrically and asymemetrically substituted tetraphenyl porphyrin: comparison of efficiency and mechanism of action.  
    Photochem. Photobiol. 73(3): 304-311.
  • K. Braun, G. Wolber, R. Pipkorn, W. Waldeck, I. Braun, J. Debus. 
    Modular Peptide Carrier For Efficient Drug Delivery and Targeting Into Living Cells
    Proc: Re-Evaluation of Peptide Research for the 21st Century’s 2001 Bioscience Kyoto, Japan; p 12-13
  • R. Pipkorn; K. Braun; W. Waldeck; I. Braun; M. Koch; J. Debus.
    Peptide Carrier For Efficient Drug Transport Into Living Cells.
    Proc: 2nd Int. Peptide Symp. in conjunction with the 17th American Peptide Symp., San Diego, California, 2001; p 692
  • K. Braun, G. Wolber, R. Pipkorn, W. Waldeck, I. Braun, V. Ehemann, A. Eisenmenger, J. Debus.
    The Neutron Capture Therapy - Where to go?
    J Radiat Oncol Biol Phys 177: p. 110; 7. Jahreskongress der Deutschen Gesellschaft für Radioonkologie DEGRO 2001, Hamburg, Germany
  • K. Braun, R. Pipkorn, W. Waldeck, H. Spring, J. Jenne, R. Rastert, G. Müller, I. Braun, V. Ehemann, H. Corban-Wilhelm, G. Greulich, H. Reutner and J. Debus,
    Breakthrough in DNA Delivery for Gene Therapy Protocols: Use of the BioShuttle System and Local Activation of Gene Expression
    Published Date: 06-Nov-2001; Pharma-Transfer Internet Database, London
  • H. Corban-Wilhelm, K. Braun, R. Pipkorn, W. Waldeck, I. Braun*, H. Spring, J. Jenne, R. Rastert, D. Greulich, J. Simiantonakis and J. Debus.
    Biological Gene Delivery and the Local Activation
    6th Int. Symp. BIOLOGICAL THERAPY OF CANCER, 2001 From Basic Research to Clinical Application Munich, Germany, Europ J Cancer 37: (Suppl 3): p 88, 2001
  • Strunz,A.M.,Peschke,P.,Waldeck,W., Ehemann,V.,Kissel,M.,Debus,J.
    Preferential radiosensitazion in p53-mutated human tumour cell lines by pemtoxyfylline-mediated disruption of the G2/M checkpoint control.
    International Journal of Radiation Biology 78 (8): 721-732, 2001.

2002

  • F. Bestvater, T.A. Knoch, J. Langowski, E. Spiess (2002):
    GFP-Walking: Artificial construct conversions caused by simultaneous cotransfection. 
    BioTechniques 32, 844-855.
  • T. Weidemann, M. Wachsmuth, M. Tewes, K. Rippe, J. Langowski (2002):
    Analysis of Ligand Binding by Two-Color Fluorescence Cross-Correlation Spectroscopy. 
    Single Molecules 3, 49-61 [PDF]
  • F. Lankas, T. E. Cheatham III, N. Spačkova, P. Hobza, J. Langowski, J. Šponar (2002):
    Critical effect of the N2 amino group on structure, dynamics and elasticity of DNA polypurine tracts. 
    Biophys. J. 82, 2592-2609 [PDF]
  • G. Wedemann, J. Langowski (2002):
    Computer simulation of the 30-nm chromatin fiber. 
    Biophys. J. 82, 2847-59 [PDF]
  • M. Gumbel, R. Grebe, M. Knapp-Mohammady, G. M. Ullmann, J. Langowski (2002):
    Modellierung biologischer Prozesse. 
    In: Handbuch der Medizinischen Informatik (T. Lehmann & E. Meyer zu Bexten, eds.) Hanser, München 2002.
  • K. Klenin, J. Langowski, A. Vologodskii (2002):
    Computational Analysis of the Chiral Action of Type II DNA Topoisomerases. 
    J. Mol. Biol. 320(2), 359-367. [PDF]
  • I. Hofmann, H. Winter, N. Mücke, J. Langowski, J. Schweizer (2002):
    The in vitro assembly of hair follicle keratins: Comparision of cortex and companion layer keratins. 
    Biol. Chem. 383(9), 1373-81
  • M. Bussiek, K. Klenin, J. Langowski (2002):
    Kinetics of site-site interaction in superhelical DNA. 
    J. Mol. Biol. 322(4), 707-18 [PDF]
  • G. Westphal, S. van den Berg-Stein, K. Braun, T.A. Knoch, M. Dummerling, J. Langowski, J. Debus, E. Friedrich (2002):
    Detection of NGF-receptors TrkA and p75NTR in human tumor cell lines and effect of NGF on the growth characteristic of the UT-7/EPO cell line. 
    J. Exp. Clin. Cancer Res. 21(2), 255-67
  • G. Kreth, P. Edelmann, Ch. Münkel, J. Langowski, C. Cremer (2002):
    Translocation frequencies for X and Y chromosomes predicted by computer simulations of nuclear structure. 
    in: Some Aspects of Chromosome Structure and Functions (Eds. R.C. Sobti, G. Obe, R.S. Athwal) pp. 57 Ð 71. 2002, Narosa Publ. House, New Delhi
  • K. Braun, P. Peschke; R. Pipkorn; S. Lampel; M. Wachsmuth; W. Waldeck; E. Friedrich; J. Debus.
    A biological transporter for the delivery of peptides to the nuclear compartment in living cells.
    J Mol Biol 318: 237-243, 2002
  • R. Pipkorn, W. Waldeck, V. Ehemann, A. Eisenmenger, H. Reutner, D. Greulich, G Wolber, J. Debus, K. Braun, 
    Functional Boron-Peptides for NC Tumor Therapy p-BPA + Neutron Particles-A Key to a Door?
    In: "Innovation & Perspectives in Solid Phase Synthesis & Combinatorial Libraries 2001". Proceedings of the 7th International Symposium, University of Southampton, England, UK. publication due May/June, 2002; Order Code: 7th SPS 2002
  • S. Heckl, J. Debus, J. Jenne, R. Pipkorn, W. Waldeck, H. Spring, R. Rastert, C. W. von der Lieth, K. Braun,
    CNN-Gd enables Cell Nucleus Molecular Imaging of Prostate Cancer Cells - the last 600 nm-.
    Cancer Research, 2002 62: 7018-7024
  • K. Braun, R. Pipkorn, W. Waldeck, S. Heckl, V. Ehemann, G. Wolber, A. Eisenmenger, H. Reutner and J. Debus.
    Neutron Capture Therapy is nothing without cell nucleus directed p-BPA Delivery.
    In: Research and Development in Neutron Capture Therapy; p 145-146. Editors: Sauerwein, W.; Moss, R.; Wittig, A. September 8 2002, Bologna, Italy
  • S. Heckl, J. Debus, R. Pipkorn, R. Rastert, W. Waldeck, G. van Kaick, K. Braun,
    Novel Transporter for Gadolinium enables fast and specific cellular uptake into tumor cells.
    Mol Imag 1(2): 125 (2002) 
  • Pieper, U., Groll, D. H., Wünsch, S.,Gast, F. U.,Speck, C., Mücke, N., Pingoud, A.,
    The GTP-Dependent Restriction Enzyme McrBC from Escherichia coli forms High-Molecular Mass Complexes with DNA and Produces a Cleavage Pattern with a Characteristic 10-Base Pair Repeat.
    Biochemistry. 41 (2002), 5245-5254.

2003

  • M. Wachsmuth, T. Weidemann, G. Müller, W. Waldeck, J. Langowski (2003):
    Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching. 
    Biophys. J. 84, 3353-3363 [PDF]
  • T.P. O'Brien, C. Cremer, M. Grunze, B.B. Knowles, J. Langowski, J. McNally, T. Pederson, J. Politz, A. Pombo, P. Schmidt, R. van Driel (2003):
    Functional Architecture of the Nuclear Genome: Towards establishing the Genome Architecture Consortium. 
    Genome Res. 13, 1029-1041, published online before print, DOI: 10.1101/gr.946403 [PDF]
  • K. Módos, R. Galántai, I. Bardos-Nagy, M. Wachsmuth, K. Tóth, J. Fidy, J. Langowski (2003):
    Maximum-entropy decomposition of fluorescence correlation spectroscopy data: application to liposome-human serum albumin association. 
    Eur. Biophys. J., published online 30.08.2003, DOI: 10.1007/s00249-003-0343-6 [PDF]
  • F. Lankaš, J. Šponar, J. Langowski, T.E. Cheatham III (2003):
    DNA base-pair step deformability inferred from molecular dynamics simulations. 
    Biophys. J., 85(5), 2872-2883 [PDF]
  • J. F. Kepert, K. Fejes Tóth, M. Caudron, N. Mücke, J. Langowski, K. Rippe (2003):
    Conformation of reconstituted mononucleosomes determined by scanning force microscopy in air and in aqueous solution. 
    Biophys. J., 85(6), 4012-22 [PDF]
  • M. Bussiek, N. Mücke, J. Langowski (2003):
    Polylysine-coated mica can be used to observe systematic changes in the supercoiled DNA conformation by scanning force microscopy in solution. 
    Nucl. Acids Res., 31(22), e137 [PDF]
  • Egyeki M, Turoczy G, Majer Z, Toth K, Fekete A, Maillard P, Csik G. (2003) Photosensitized inactivation of T7 phage as surrogate of non-enveloped DNA viruses: efficiency and mechanism of action. 
    Biochim Biophys Acta.;1624(1-3):115-24.
  • Egyeki M, Turoczy G, Toth K, Fekete A, Maillard P, Csik G. (2003):
    Photodynamic inactivation of porphyrin sensitized T7 phages: efficiency and mechanism of action, 
    Acta Pharm Hung. 2003;73(2):97-102
  • Weidemann,T., Wachsmuth,M., Knoch,T.A.,Müller, G.,Waldeck,W.,Langowski,J.
    Counting Nucleosomes in Living Cells with a Combination of Fluorescence Correlation Spectroscopy and Confocal Imaging.
  • K. Braun, G. Wolber, W. Waldeck, R. Pipkorn, J. Jenne, R. Rastert, V.Ehemann, A. Eisenmenger, H. Corban-Wilhelm, I. Braun, S. Heckl, and J. Debus. 
    The Enhancement of Neutron Irradiation of HeLa-S Cervix Carcinoma Cells by Cell-Nucleus-addressed Deca-p-Boronophenylalanine.
    Europ J Med Chem, 2003; 38/6: 587-595
  • R. Pipkorn, W. Waldeck, K. Braun.
    Synthesis and application of functional peptides in the treatment of malignant diseases.
    J. Mol Recognit, 2003; 16(5): 240-247. 
  • S. Heckl, R. Pipkorn, W. Waldeck, H. Spring, J. Jenne, C.-W. von der Lieth, H. Corban-Wilhelm, J. Debus, K. Braun. 
    Intracellular Visualization of Prostate Cancer using Magnetic Resonance Imaging. 
    Cancer Research, 2003 63: 4766-4772.
  • Wachsmuth, M., Weidemann,T.,Müller,G., Waldeck,W., Langowski,J.:
    Fluorescence Fluctuation Microscopy of Molecules between Binding and Diffusion.
    Biophys.J.84, 3353-3363 (2003)
  • R. Pipkorn, K. Braun, W. Waldeck, M. Koch, J. Debus.
    Synthesis and Application of functional Peptides for Therapy of HPV18 positive Cervix Carcinoma Cells.
    Biopolymers 71(3): 73; 2003

2004

  • N. Mücke, L. Kreplak, R. Kirmse, T. Wedig, H. Herrmann, U. Aebi, J. Langowski (2004):
    Assessing the Flexibility of Intermediate Filaments by Atomic Force Microscopy. 
    J. Mol. Biol. 335(5), 1241-1250 [PDF]
  • J. Langowski, H. Schiessel (2004):
    Theory and computational modeling of the 30 nm chromatin fiber. 
    In: Chromatin Structure: State of the Art, eds. S. Leuba & J. Zlatanova, 2004, Elsevier, Amsterdam, pp. 397-420
  • J. Langowski (2004):
    Melting Under Stress (New and Notable Comment on article 'Monte Carlo Simulations of Locally Melted Supercoiled DNAs in 20mM Ionic Strength' by Sucato et al. in the same journal). 
    Biophys. J. 86(5), 2639-40. [PDF]
  • F. Lankaš, J. Šponar, J. Langowski, T.E. Cheatham III (2004):
    DNA deformability at the base-pair level. 
    J. Am. Chem. Soc. 126(13), 4124-5 [PDF]
  • Mücke, N., Wedig, T., Burer, A., Marekov, L. N., Steinert, P. M., Langowski, J., Aebi, U. & Herrmann, H. (2004):
    Molecular and Biophysical Characterization of Assembly-Starter Units of Human Vimentin. 
    Journal of Molecular Biology 340, 97-114. [PDF]
  • Vámosi, G., Bodnár, A.1, Vereb, G, Jenei, A., Goldman, C. K., Dubois, S., Langowski, J., Tóth, K., Mátyus, L., Szöllősi, J., Waldmann, T. A., Damjanovich, S. (2004):
    Molecular vicinity of interleukin-15 and -2 receptor alpha subunits in lipid rafts of T lymphoma cells. 
    Proc. Natl. Acad. Sci. USA 101(30), 11082-87 [PDF]
  • S. Bernacchi, G. Müller, J. Langowski and W. Waldeck (2004):
    Characterization of simian virus 40 on its infectious entry pathway in cells using fluorescence correlation spectroscopy. 
    Biochem. Soc. Trans. 32(5), 746-749 [PDF]
  • K. Klenin, J. Langowski (2004):
    Modeling of intramolecular reactions of polymers: An efficient method based on Brownian dynamics simulation. 
    J. Chem. Phys. 121(10), 4951-60 [PDF]
  • K. Bystricky, P. Heun, L. Gehlen, J. Langowski and S. M. Gasser (2004):
    Analyzing long-range compaction of interphase chromatin in budding yeast by high resolution imaging techniques. 
    Proc. Natl. Acad. Sci. USA 101(47), 16495-500 [PDF]
  • Zupan K, Herenyi L, Toth K, Majer Z, Csik G.(2004): Binding of Cationic Porphyrin to Isolated and Encapsidated Viral DNA Analyzed by Comprehensive Spectroscopic Methods.Biochemistry.;43(28):9151-9159. 
  • K. Braun, V. Ehemann, W. Waldeck, R. Pipkorn, H. Corban-Wilhelm, J. Jenne, L. Gissmann, J. Debus.
    HPV18 E6 and E7 Genes affect Cell Cycle, pRB and p53 of Cervical Tumor Cells and represent prominent Candidates for Intervention by Use Peptide Nucleic Acids (PNAs).
    Cancer Letters, 2004, 209(1):37-49

2005

  • M. Bussiek, K. Tóth, N. Brun, J. Langowski (2005):
    DNA loop formation on nucleosomes shown by in-situ scanning force microscopy of superhelical DNA.
    J. Mol. Biol. 345, 695-706 [PDF]
  • N. Baudendistel, G. Müller, W. Waldeck, P. Angel, J. Langowski (2005):
    Two-Hybrid Fluorescence Cross-Correlation Spectroscopy detects protein-protein interactions in vivo. 
    ChemPhysChem, 6(5), 984-90 [PDF]
  • K.V. Klenin, W. Kusnezow, J. Langowski (2005):
    Kinetics of protein binding in solid-phase immunoassays:  Theory. 
    Journal of Chemical Physics, 122(21), 214715, 11 p. [PDF]
  • S. Bernacchi, E. Ennifar, K. Tóth, P. Walter, J. Langowski, P. Dumas (2005):
    Mechanism of hairpin-duplex conversion for the HIV-1 dimerization initiation site. 
    J. Biol. Chem. 280(48):40112-40121 [PDF]
  • Zupan K, Herenyi L, Toth K, Egyeki M, Csik G (2005):
    Binding of Cationic Porphyrin to Isolated DNA and Nucleoprotein Complex: Quantitative Analysis of Binding Forms under Various Experimental Conditions. 
    Biochemistry 44(45):15000-16006.
  • A. Bodnár, Gy. Vámosi, K. Tóth, A. Jenei, L. Mátyus, S. Damjanovich (2005):
    Non-random patterns of membrane proteins and their roles in transmembrane signaling. 
    In: Biophysical aspects of transmembrane signaling, S. Damjanovich (ed.), Springer (Berlin / Heidelberg / New York), 2005
  • E. Spiess, F. Bestvater, A. Heckel-Pompey, K. Tóth, M. Hacker, G. Stobrawa, T. Feurer, C. Wotzlaw, U. Berchner-Pfannschmidt, T. Porwol, and H. Acker (2005):
    Two-photon excitation and emission spectra of the green fluorescent protein variants ECFP, EGFP and EYFP. 
    J Microsc 217:200-204.
  • A. Resemann, D. Suckau, W. Dormeyer, K. Tóth, M. Schnölzer (2005):
    Top-Down Sequence and Modification Analysis of Histones using reISD and T3-Sequencing. 
    Proc. 53rd ASMS Conference on Mass Spectrometry,.
  • K. Braun, R. Pipkorn, W. Waldeck.
    Development & Characterization of Delivery Systems for therapeutic and diagnostic Compounds to their targeted Cells and Tissues: a Review;
    Current Medicinal Chemistry, 2005; 12: 1841-1858.
  • R. Pipkorn, W. Waldeck, K. Braun.
    The SPPs of bacterial addressed peptides and PNAs overcoming the resistance against antibiotics;
    BIOPOLYMERS 80 (4): 528-528 2005
  • R. Pipkorn, W. Waldeck, K. Braun;
    SPPS of bacterial addressed peptides and PNAs overcoming the resistance against antibiotics;
    Proceedings ‘Understanding Biology Using Peptides’ Ed.: S.E. Blondelle, American Peptide Society, San Diego CA 2005 
  • Wickert, U., Mücke, N., Wedig, T., Müller, S., Aebi, U., Herrmann, H. (2005).
    Characterization of the in vitro co-assembly process of the intermediate filament proteins vimentin and desmin: mixed polymers at all stages of assembly.
    Eur. J. Cell. Biol. 84, 379-391 
  • Mücke, N., Kirmse, R., Wedig, T., Leterrier, J., Kreplak, L. (2005).
    Investigation of the morphology of intermediate filaments adsorbed to different solid supports.
    J. Struct. Biol.150, 268-276 
  • Bär, H., Mücke, N., Kostareva, A., Sjöberg, G., Aebi, U., Herrmann, H. (2005).
    Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages.
    Proc. Natl. Acad. Sci. U S A. 102, 15099-15104 

2006

  • J.C.R. Politz, R.A. Tuft, K.V. Prasanth, N. Baudendistel, K.E. Fogarty, L.M. Lifshitz, J. Langowski, D.L. Spector, T. Pederson (2006):
    Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm.
    Mol. Biol. Cell 17(3):1239-49[PDF]
  • C.-X. Wu (2006):
    Facilitated diffusion of DNA-binding proteins. 
    Phys. Rev. Letters 96, 018104; [PDF]
  • K. Tóth, N. Brun, J. Langowski (2006):
    Chromatin compaction at the mononucleosome level. 
    Biochemistry, 45, 1591-1598 [PDF]
  • J. Langowski (2006):
    Polymer chain models for DNA and chromatin. 
    Eur. Phys. J. E 19(3),241-249 doi:10.1140/epje/i2005-10067-9  [PDF]
  • L. R. Gehlen, A. Rosa, K. Klenin, J. Langowski, S. M. Gasser, K. Bystricky (2006):
    Spatially confined polymer chains: implication of chromatin fiber flexibility and peripheral anchoring on telomere-telomere interaction. 
    J. Phys. Cond. Matter 18, S245-S252 doi:10.1088/0953-8984/18/14/S09 [PDF]
  • M. Egyeki, K. Tóth, W. Waldeck, P. Schmezer, J. Langowski, G. Csík (2006):
    DNA damaging capability of hematoporphyrin derivative towards DNAs of various accessibilities. 
    J. Photochem. Photobiol. 84(2), 119-127; doi:10.1016/j.jphotobiol.2006.02.005 [PDF]
  • F. Aumann, F. Lankas, M. Caudron, J. Langowski (2006):
    Monte-Carlo simulations of chromatin stretching. 
    Phys. Rev. E 73(4), 041927; q-bio.BM/0509024 on arXiv.org [PDF]
  • H. Merlitz, K.V. Klenin, C.-X. Wu, J. Langowski (2006):
    Facilitated diffusion of DNA-binding proteins: Efficient simulation with the method of excess collisions (MEC). 
    J. Chem. Phys. 124(13),134908; [PDF]
  • J. Langowski, H. Schiessel (2006):
    Chromatin simulations: From DNA to chromatin fibers. 
    in: Computational Studies of DNA and RNA, eds. J. Sponer and F. Lankas, Springer, Berlin/Heidelberg/New York 2006, ISBN 1-4020-4794-0 [PDF]
  • H. Merlitz, K.V. Klenin, C.-X. Wu,  J. Langowski (2006):
    Facilitated diffusion of DNA-binding proteins: Simulation of large systems. 
    J. Chem. Phys. 125(1), 014906;[PDF]
  • M. Bussiek, K. Tóth, N. Schwarz, J. Langowski (2006):
    Trinucleosome compaction studied by fluorescence energy transfer and scanning force microscopy. 
    Biochemistry 45(36),10838-46; DOI: http://dx.doi.org/10.1021/bi060807p [PDF]
  • C.W. Kauth, U. Woehlbier, M. Kern, Z. Mekonnen, R. Lutz, N. Mücke, J. Langowski, H. Bujard (2006):
    Interactions between merozoite surface proteins 1, 6 and 7 of the malaria parasite Plasmodium falciparum. 
    J. Biol. Chem 281(42):31517-27 [PDF]
  • Urig, K. Fritz-Wolf, R. Réau, C. Herold-Mende, K. Tóth, E. Davioud-Charvet, K. Becker (2006):
    Undressing of Phosphine Gold(I) Therapeutic Agents as Irreversible Inhibitors of Human Disulfide Reductases. 
    Angewandte. Chemie, Int. 45:1881-1886
  • Vámosi G, Vereb G, Bodnár A, Tóth K, Baudendistel N, Damjanovich S, Szöllösi J (2006):
    Fluoreszenzresonanz-Energietransfer (FRET).
    In: Sack U, Tarnok A, Rothe G (ed): Zellulare Diagnostik, Grundlagen, Methoden und klinische Anwendungen der Durchflusszytometrie, Basel: Karger, 2006. pp. 120-138
  • Egyeki M, Toth K, Waldeck W, Schmezer P, Langowski J, Csik G.
    DNA damaging capability of hematoporphyrin towards DNAs of various accessibilities.
    J Photochem Photobiol B. 2006 Aug 1;84(2):119-27. Epub 2006 Mar 23.
  • R. Pipkorn; W. Waldeck, K. Braun,
    Delivery of Substances and their Target-specific topical Activation,
    Biochem & Biophys Acta Biomembranes, 2006, 1758(5): 606-610
  • R. Pipkorn, W. Waldeck, H. Spring, J. Jenne, K. Braun.
    Peptide synthesis of trojan horses for plasmid transfer and topical activation;
    J Peptide Science, 2006, S1: 136
  • Schietke, R., Bröhl, D., Wedig, T., Mücke, N., Herrmann, H., Magin, T. (2006).
    Mutations in vimentin disrupt the cytoskeleton in fibroplasts and delay executions of apoptosis. 
    Eur. J. Cell. Biol. 85, 1-10
  • Foeger,N., Wiesel, N., Lotsch, D., Mücke, N., Kreplak, L., Aebi, U., Gruenbaum, Y., Herrmann, H. (2006).
    Solubility properties and specific assembly pathways of the B-type lamin from Caenorhabditis elegans.
    J. Struct. Biol. 155, 340-350
  • Bär, H., Mücke, N., Ringler, P., Müller, S.A., Kreplak, L., Katus, H.A., Aebi, U., Herrmann, H (2006).
    Impact of Disease Mutations on the Desmin Filament Assembly Process. 
    J. Mol. Biol. 360, 1031-1042
  • Sokolova, A., Kreplak, L. Wedig, T., Mücke, N., Svergun, D., Herrmann, H., Aebi, U., Strelkov, S. (2006).
    Monitoring intermediate filament assembly by small-angle x-ray scattering reveals the molecular architecture of assembly intermediates. 
    Proc. Natl. Acad. Sci. U S A. 103, 16206-16211

2007

  • W. Waldeck, A. M. Strunz, G. Müller, A. Hotz-Wagenblatt, J. Jenne, J. Langowski, J. Debus, K. Braun (2007):
    Photon and Pentoxyphylline-induced and repressed Genes by differential Analysis and Sequence Similarity Search. 
    Intl. J. Cancer 120(6):1198-207 [PDF]
  • R. Kirmse, S. Portet, N. Mücke, U. Aebi, H. Herrmann, J. Langowski (2007):
    The kinetics of intermediate filament assembly: Evidence for unit-length filament and filament end-to-end annealing as a mechanism for longitudinal growth of filaments.
    J. Biol. Chem. 282(25), 18563-18572, e-pub http://www.jbc.org/cgi/doi/10.1074/jbc.M701063200 [PDF]
  • A. Gansen, F. Hauger, K. Tóth, J. Langowski (2007):
    Single pair FRET of nucleosomes in free diffusion: Optimizing stability and resolution of subpopulations. 
    Anal. Biochem.,368, 193-204, http://dx.doi.org/10.1016/j.ab.2007.04.047 [PDF]
  • A. Wedemeier, H. Merlitz, C.-X. Wu, J. Langowski (2007):
    Modelling diffusional transport in the interphase cell nucleus.
    J. Chem. Phys. 127(4),045102; http://arxiv.org/abs/0704.3551 [PDF]
  • M. Bussiek, G. Müller, W. Waldeck, S. Diekmann, J. Langowski (2007):
    Organization of nucleosome arrays reconstituted with repetitive African green monkey α-satellite DNA as analyzed by atomic force microscopy. 
    Eur. Biophys. J., http://dx.doi.org/10.1007/s00249-007-0166-y [PDF]
  • H. Jin, E.S. Jeng, D.A. Heller, P.V. Jena, T. Ha, R. Kirmse, J. Langowski, M.S. Strano (2007):
    Ion and Thermally Induced DNA Conformational Polymorphism on Single-walled Carbon Nanotubes. 
    Macromolecules, http://dx.doi.org/10.1021/ma070608t [PDF]
  • J. Langowski (2007):
    Chromatin dynamics in silicio. 
    In: NIC Series Volume 36: From Computational Biophysics to Systems Biology (CBSB07), Ulrich H. E. Hansmann, Jan Meinke, Sandipan Mohanty, Olav Zimmermann (Editors), Jülich 2007, ISBN: 978-3-9810843-2-0[PDF]
  • J. Langowski, D. Heermann (2007):
    Computational Modelling of the Chromatin Fiber. 
    Seminars in Cell and Developmental Biology, 18(5), 659-667, http://dx.doi.org/10.1016/j.semcdb.2007.08.011 [PDF]
  • Bussiek M, Müller G, Waldeck W, Diekmann S, Langowski J. 
    Organisation of nucleosomal arrays reconstituted with repetitive African green monkey alpha-satellite DNA as analysed by atomic force microscopy. 
    Eur Biophys J. 2007 Dec;37(1):81-93. Epub 2007 May 15. 
  • Waldeck, W, Strunz, AM, Mueller, G, Hotz-Wagenblatt, A, Jenne, J, Langowski, J, Didinger, B, Debus, J, Braun, K. 
    Induced and repressed genes after irradiation sensitizing by pentoxyphylline.
    Int J Cancer, 2007, 120(6): 1198-1207
  • Braun, K, von Brasch, L, Pipkorn, R, Ehemann, V, Jenne, J, Spring, H, Debus, J, Didinger, B, Rittgen, W, Waldeck, W. 
    BioShuttle-mediated Plasmid Transfer; 
    Int J Medic Sci, 2007, 4(5):267-277
  • Pipkorn, R, Waldeck, W, Jenne, J, Didinger, B, Braun, K.
    Generation, Application & Quantitation of Clamp-BioShuttle-Carriers for Plasmid Delivery into Nuclei of Prostate Cancer Cells; 
    Biochemical Society Transactions, 2007, 35(4):829-832
  • Pipkorn, R, Waldeck, W, Didinger, B, Braun, K.
    BioShuttle mediated Plasmid Transfer – a Way to new genetic Intervention, 
    Biopolymers, 2007, 88(4):536
  • Bär, H., Mücke, N., Katus, H., Aebi, U., Herrmann, H (2007). 
    Assembly defects of desmin disease mutants carrying deletions in the a-helical rod domain are rescued by wild type protein. 
    J. Struct. Biol. 158, 107-115
  • Bär, H., Goudeau, B., Wälde, S., Casteras-Simon, M., Mücke, N., Shatunov, A., Goldberg, Y. P., Clarke, C., Holton, J. L., Eynard, B., Katus, H. A., Fardeau, M., Goldfarb, L., Vicart, P.,0 Herrmann, H. (2007). 
    Conspicuous involvement of desmin tail mutations in diverse cardiac and skeletal myopathies. 
    Hum. Mutat. 28, 4, 374-386

2008

  • J. Rauch, T. Knoch, I. Solovei, K. Teller, S. Stein, K. Buiting, B. Horsthemke, J. Langowski, T. Cremer, M. Hausmann, C. Cremer (2008):
    Light optical precision measurements of the architecture of the Prader-Willi Syndrome imprinting locus in human cell nuclei indicate maximum chromatin condensation changes in the few hundred nanometer range. 
    Differentiation 76(1):66-82, http://dx.doi.org/10.1111/j.1432-0436.2007.00237.x [PDF]
  • C. Hoischen, M. Bussiek, J. Langowski, S. Diekmann (2008):
    E. coli low-copy-number plasmid R1 centromere parC forms a U-shaped complex with its kinetochore binding protein ParR. 
    Nucl.Acids Res. 36(2):607-15, http://dx.doi.org/10.1093/nar/gkm672 [PDF]
  • M. Renz, D. Niederacher, H.-G. Bender. J. Langowski (2008):
    Invasive breast cancer cells exhibit increased mobility of the actin-binding protein CapG. 
    Intl J Cancer 122(7):1476-82 http://dx.doi.org/10.1002/ijc.23215 [PDF]
  • J. Langowski (2008):
    Protein-protein interactions determined by fluorescence correlation spectroscopy. 
    Methods Cell Biol. 85, 471-484 [PDF]
  • A. Wedemeier, T. Zhang, H. Merlitz, C.-X. Wu, J. Langowski (2008):
    The role of chromatin conformations in diffusional transport of chromatin-binding proteins: Cartesian lattice simulations. 
    J. Chem. Phys. 128, 155101 (10 pages), http://dx.doi.org/10.1093/1.2895048 [PDF]
  • A. Gansen, F. Hauger, K. Tóth, J. Langowski (2008):
    Chromatin at the Nanolevel - Toward the analysis of nucleosome remodelling kinetics by single pair spectroscopy. 
    In: Proceedings of the IX. Linz Winter Workshop 2007, Hinterdorfer/Schütz/Pohl (Editors), Schriftenreihe Biophysik, Trauner Verlag, Linz 2008, pp. 69-74  [PDF]
  • K. Voltz, J. Trylska, V. Tozzini, V. Kurkal-Siebert, J. Langowski, J. Smith (2008):
    Coarse-grained force field for the nucleosome from self-consistent multiscaling. 
    J. Comp. Chem. 29, 1429-1439 http://dx.doi.org/10.1002/jcc.20902 [PDF]
  • M. Renz, J. Langowski (2008):
    Dynamics of the CapG actin-binding protein in the cell nucleus studied by FRAP and FCS. 
    Chromosome Research 16:427–437 [PDF]
  • M. G. Poirier, M. Bussiek, J. Langowski, J. Widom (2008):
    Spontaneous access to DNA target sites in folded chromatin fibers. 
    J. Mol. Biol., http://dx.doi.org/10.1016/j.jmb.2008.04.025 [PDF]
  • W. Waldeck, M. Wiessler, V. Ehemann, R. Pipkorn, H. Spring, J. Debus, B. Didinger, G. Mueller, J. Langowski, K. Braun (2008):
    TMZ-BioShuttle--a reformulated temozolomide. 
    Int J Med Sci. 5(5), 273-84 [PDF]
  • K.Zupan,, M. Egyeki, K. Toth , A. Fekete, L. Herenyi , K. Modos, G. Csik (2008):
    Comparison of the effciency and the specificity of DNA-bound and free cationic porphyrin in photodynamic virus inactivation. 
    J. Photochem.Photobiol. B. Biology 90: 105-112.
  • Braun, K, Wiessler, M, Ehemann, V, Pipkorn, R, Spring, H, Debus, J, Didinger, B, Koch, M, Mueller, G, Waldeck, W.
    Treatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder-Ligation chemistry
    Drug Des Devel Ther, 2: 289-301 2008
  • Pipkorn, R, Waldeck, W, von Brasch, L, Didinger, B, Koch, M, Wiessler, M, Braun, K.
    BioShuttle mediated Plasmid Transfer – a Way to new genetic Intervention,
    Int J Chemistry Biotechnology, 26(4): 17-18; 2008
  • Pipkorn, R, Waldeck, W, Didinger, B, Debus, J, Koch, M, Mueller, G, Wiessler, M, Braun, K.
    BioShuttle as a Carrier for Temozolomide Transport into Prostate Cancer Cells. Synthesis & Application,
    J Peptide Science, 14(8): 156, 2008
  • Braun, K, Frank, M, Pipkorn, R, Reed, J, Spring, H, Jenne, J, Didinger, B, Ehemann, V, von der Lieth, CW, Wiessler, M, Waldeck, W.
    HIV-1 Capsid Assembly Inhibitor (CAI) Peptide: Structural Preferences and Delivery into Human Epithelial Lung Cells & Lymphocytes,
    Int. J. Medic Sci 5(5): 230-239, 2008.
  • Waldeck, W, Wiessler, M, Ehemann, V, Pipkorn, P, Spring, H, Debus, J, Didinger, B, Koch, M, Mueller, G, Braun, K.
    TMZ-BioShuttle – a reformulated Temozolomide,
    Int. J. Medic Sci 2008, 5 (5):273-284
  • Pipkorn, R, Waldeck, W, von Brasch, L, Didinger, B, Koch, M, Wiessler, M, Braun, K.
    Genetic interventions by Clamp-PNA-BioShuttle,
    Chimica Oggim Chemistry Today 26(4): 17-18, 2008
  • Vámosi G, Baudendistel N, von der Lieth CW, Szalóki N, Mocsár G, Müller G, Brázda P, Waldeck W, Damjanovich S, Langowski J, Tóth K. 
    Conformation of the c-Fos/c-Jun complex in vivo: a combined FRET, FCCS, and MD-modeling study.
    Biophys J. 2008 Apr 1;94(7):2859-68. Epub 2007 Dec 7. http://dx.doi.org/10.1529/biophysj.107.120766 [PDF]

2009

  • A. Gansen, K. Tóth, N. Schwarz, J. Langowski (2009):
    Structural effects of histone acetylation on mononucleosomes detected by single-pair FRET. 
    J. Phys. Chem. B, 113(9) 2604-2613 [PDF]
  • T. Wocjan, K. Klenin, J. Langowski (2009):
    Dependence of nucleosome unrolling on histone-DNA-interactions assessed by Brownian dynamics simulations. 
    J. Phys. Chem. B 113(9) 2639-2646 [PDF]
  • N. Dross, C. Spriet, M. Zwerger, G. Müller, W. Waldeck, J. Langowski (2009):
    Mapping eGFP oligomer mobility in living cell nuclei. 
    PLoS ONE 4(4): e5041. http://dx.doi.org/10.1371/journal.pone.0005041 [PDF]
  • S. Portet, N. Mücke, R. Kirmse, J. Langowski, M. Beil, H. Herrmann (2009):
    Vimentin intermediate filament formation: In vitro measurement and mathematical modeling of the filament length distribution during assembly. 
    Langmuir 25(15): 8817-23, http://dx.doi.org/10.1021/la900509r [PDF]
  • T.O. Ihalainen, E.A. Niskanen, J. Jylhävä, O. Paloheimo, N. Dross, H. Smolander, J. Langowski. J. Timonen, M. Vihinen-Ranta (2009):
    Parvovirus Induced Alterations in Nuclear Architecture and Dynamics. 
    PLoS ONE 4(6): e5948. http://dx.doi.org/10.1371/journal.pone.0005948 [PDF]
  • F. Aumann, J. Sühnel, S. Diekmann, J. Langowski (2009):
    Spacing of nucleosomal repeat lengths: stable and instable structures in geometrical models and Monte Carlo simulation. 
    Theoretical Chemistry Accounts 125 (3-6), 217-231, http://dx.doi.org/10.1007/s00214-009-0561-9 [PDF]
  • A. Wedemeier, H. Merlitz, C.-X. Wu, J. Langowski (2009):
    How proteins squeeze through polymer networks: a Cartesian lattice study. 
    J. Chem. Phys. 131(6): 064905; http://dx.doi.org/10.1063/1.3205100 [PDF]
  • A. Gansen, A. Valeri, F. Hauger, S. Felekyan, S. Kalinin, K. Tóth, J. Langowski, C. Seidel (2009):
    Nucleosome disassembly intermediates characterized by single-molecule FRET. 
    Proc. Natl. Acad. Sci. USA 11(45), 15308-13. http://dx.doi.org/10.1073/pnas.0903005106 [PDF] paper[PDF] supplement 1[PDF] supplement 2 
  • T. Wocjan, J. Krieger, O. Krichevsky, J. Langowski (2009):
    Dynamics of a fluorophore attached to superhelical DNA: FCS experiments simulated by Brownian dynamics. 
    PhysChemChemPhys, 11 (45), 10671-10681[PDF]
  • N. Mücke, K. Klenin, R. Kirmse, M. Bussiek, H. Herrmann, M. Hafner, J. Langowski (2009):
    Filamentous biopolymers on surfaces: Scanning force microscopy images compared with Brownian dynamics simulations of deposition. 
    PLoS ONE 4(11): e7756; doi:/10.1371/journal.pone.0007756 [PDF]
  • A. Wedemeier, H. Merlitz, J. Langowski (2009):
    Anomalous diffusion in the presence of mobile obstacles. [PDF]
    Europhys. Lett. 88: 38004
  • G. Vámosi, Gy. Vereb. A. Bodnar, K. Tóth, N. Baudendistel, S. Damjánovich, J. Szöllösi (2009):
    Fluorescence Resonance Energy Transfer (FRET). 
    In: Cellular Diagnostics, U. Sack, A. Tárnok & G. Rothe (eds.), Karger, Basel 2009, pp. 141-158 
  • W.Waldeck, R.Pipkorn, B.Korn, G.Müller, M-Schick, K.Toth, M.Wiessler, B.Didinger, K.Braun (2009):
    Transporter molecules influence the gene expression in HeLa cells. 
    Int.J.Med Sci 6(1): 18-27.
  • G. Csík , M. Egyeki , L. Herényi , Zs. Majer , K.Tóth (2009):
    Role of structure-proteins in the porphyrin-DNA interaction 
    J. Photochem.Photobiol. B. Biology 96(3): 207-215
  • W.Waldeck, G.Müller, M.Wiessler,M.Brom, K.Toth, K.Braun (2009):
    Autofluorescent Proteins as Photosensitizer in Eukaryontes 
    Int.J.Med Sci 6(6): 365-373.
  • G. Vamosi, P. Brazda, T. Szekeres, T. Domoszlai, A. Horvath, K. Toth, S. Damjanovich, L.Nagy. (2009):
    Nuclear receptor activation viewed via mobility. 
    Acta Physiologica Hungarica 96(1): 143-144
  • Waldeck, W, Pipkorn, R, Korn, B, Mueller, G, Schick, M, Tóth, K, Didinger, B, Braun, K.
    Transporter Molecules influence the Gene Expression in HeLa Cells
    Int. J. Medic Sci, 6: 18-27, 2009
  • Pipkorn, R, Waldeck, W, Didinger, B, Debus, J, Koch, M, Mueller, G, Langowski, J, Wiessler, M, Braun, K
    Inverse-Electron-Demand Diels-Alder Reaction as a highly efficient chemoselective Ligation Procedure. Synthesis & Function of a BioShuttle for Temozolomide Transport into Prostate Cancer Cells.
    J Peptide Science, 15: 235-241, 2009; IF: 1,8
  • Pipkorn, R, Waldeck, W, Didinger, B, Braun, K,
    BioShuttle mediated plasmid transfer--a way to new genetic intervention.
    Adv Exp Med Biol. 2009; 611: 285-6.
  • Pipkorn, R, Wiessler, M, Waldeck, W, Braun, K.
    TMZ-BioShuttle, an exemplary Drug Reformulation by inverse Diels-Alder Click Chemistry
    BIOPOLYMERS, 92(4): 350-351, 2009
  • Dunsch, L, Bock, M, Wiessler, M, Yang, Pipkorn, R, Debus, J, Waldeck, W, Braun, K.
    Endohedral Nitridcluster-Fullerene-Conjugates As intravital MR-Contrast Agents,
    Electrochem. Soc. 2009; 901: 1246 
  • Mueller, G, Waldeck, W, Braun, K.
    From green to red – more dead? Autofluorescent Proteins as Photosensitizers.
    J Photochem & Photobiol B: Biology, in press, Dec 2009
  • Braun, K, Ehemann, V, Wiessler, M, Pipkorn, R, Didinger, B, Mueller, G, Waldeck, W.
    High-Resolution Flow Cytometry: a suitable Tool for Monitoring aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment.
    Int. J. Medic Sci, 6: 338-347, 2009
  • Schopferer, M., Bär, H., Hochstein, B., Sharma, S., Mücke, N., Herrmann, H., Willenbacher, N. (2009).
    Desmin and Vimentin Intermediate Filament Networks: Their Viscoelastic Properties Investigated by Mechanical Rheometry.
    J. Mol. Biol. 388, 133-143
  • Bär, H., Sharma, S., Kleiner, H., Mücke, N., Zentgraf, H., Katus, H. A., Aebi, U., Herrmann, H. (2009).
    Interference of amino-terminal desmin fragments with desmin filament formation.
    Cell Motil.Cytoskeleton. 1-14, 2009
  • Schädlich, L., Senger, T., Gerlach, B., Mücke, N., Klein, C., Bravo, I. G., Muller, M., Gissmann, L. (2009). 
    Analysis of modified human papillomavirus type 16 L1 capsomeres: the ability to assemble into larger particles correlates with higher immunogenicity.
    J.Virol. 83, (15):7690-7705
  • Sharma, S., Mücke, N., Katus, H.A., Herrmann, H., Bär, H. (2009).
    Disease mutations in the “head” domain of the extra-sarcomeric protein desmin distinctly alter its assembly and network-forming properties.
    J.Mol.Med.87,1207-1219

1990 - 1999

1990

  • P. Lindner, H.W. Bewersdorff, R. Heen, P. Sittart, H. Thiel, J. Langowski, R. Oberthür: 
    Drag-reducing surfactant solutions in laminar and turbulent flow investigated by small-angle neutron scattering and light scattering. 
    Prog. Coll. Polym. Sci (1990) 81 , 107-112
  • J. Langowski, R. Bryan (1990): 
    A new maximum entropy algorithm for the analysis of dynamic light-scattering data: Application to particle distributions and DNA internal motions. 
    Progr. Colloid Polym. Sci. 81 , 269
  • S. Krueger, A. Maxwell, J. Langowski, A. Wlodawer, M. Gellert, J. Zaccai: 
    Neutron scattering and hydrodynamic studies of the structure of E. coli Gyrase.  
    J. Mol. Biol. (1990) 211 , 211-220
  • M. Cuillel, B. Cortolezzis, J. Chroboczek, J. Langowski, R. Ruigrok, B. Jacrot: 
    Isolation and characterization of the Protein IIIa from wild type and ts112 Adenovirus 2.    
    Virology (1990) 175 , 222-231

1991

  • J. Langowski, R. Bryan: 
    Dynamic light scattering: data analysis and applications to some biological systems. 
    Proceedings of the European Workshop on "Neutron, X-Ray and Light Scattering as an Investigative Tool for Colloidal and Polymeric Systems", Bombannes, France, 27 May - 2 June, 1990, P. Lindner and T. Zemb (eds), Elsevier, Amsterdam 1991
  • J. Langowski, R. Bryan: 
    Maximum Entropy analysis of photon correlation spectroscopy data using a Bayesian estimate for the regularization parameter.    
    Macromolecules (1991) 24 , 6346-6348 
  • I. Dustin, P. Furrer, A. Stasiak, J. Dubochet, J. Langowski, E. Egelman: 
    Spatial visualization of DNA in solution. 
    J. Struct. Biol. (1991) 107 , 15-21
  • G. Chirico, J. Langowski
    Calcul des propriétés hydrodynamiques de l'ADN par un algorithme de Dynamique Brownienne de deuxième ordre. 
    J. Chimie Physique (1991) 88 , 2561-2566

1992

  • C. Ebel, F. Guinet, J. Langowski, C. Urbanke, J. Gagnon, G. Zaccai: 
    Solution studies of the elongation factor Tu from the extreme halophile Halobacterium marismortui .    
    J. Mol. Biol. (1992) 223 , 361-371
  • G. Chirico, J. Langowski
    Calculating hydrodynamic properties of DNA through a second-order Brownian Dynamics algorithm. 
    Macromolecules (1992) 25 , 769-775
  • O. Coux, H.G. Nothwang, K. Scherrer, W. Bergsma-Schutter, A. Arnberg, P.A. Timmins, J.   Langowski, C. Cohen-Addad: 
    Structure and RNA content of the prosome.
    Febs L. (1992), 300 , 49-55
  • F. Thibault, J. Langowski, R. Leberman: 
    Pre-nucleation crystallization studies on aminoacyl-tRNA-synthetases by dynamic light-scattering. 
    J. Mol. Biol. (1992) 225 , 185-191
  • J. Langowski, W. Kremer, U. Kapp: 
    Dynamic light scattering for study of solution conformation   and dynamics of superhelical DNA.    
    Meth. Enzymology (1992), v. 211 "DNA Structure", eds. D.M.J. Lilley & J.E. Dahlberg, p. 430-448 
  • U. Kapp, J. Langowski
    Preparation of DNA topoisomers by RP-18 high performance liquid chromatography. 
    Anal. Biochem. (1992) 206 , 293-299
  • F. Thibault, J. Langowski, R. Leberman: 
    Optimizing protein crystallization by aggregate size distribution analysis using dynamic light scattering. 
    J. Crystal Growth (1992), 122 , 50-59

1993

  • G. Chirico, U. Kapp, K. Klenin, W. Kremer, J. Langowski
    Ten microseconds in the life of a superhelix.
    J. Math. Chem. (1993) 13 , 33-43; [PDF]
  • A. Timchenko, J. Langowski, I. Serdyuk: 
    Structural changes in 16S RNA from E.coli upon unfolding by urea. 
    Biopolymers (1993) 33 , 1747-1755
  • W. Kremer, K. Klenin, S. Diekmann, J. Langowski
    DNA curvature influences the internal motions of supercoiled DNA. 
    EMBO J. (1993) 12 , 4407-4412

1994

  • G. Chirico, J. Langowski
    Kinetics of DNA supercoiling studied by Brownian Dynamics simulation. 
    Biopolymers (1994) 34 , 415-433
  • J. Langowski, U. Kapp, K. Klenin, A. Vologodskii:
    Solution structure and dynamics of DNA topoisomers. Dynamic light scattering studies and Monte-Carlo simulations. 
    Biopolymers (1994) 34 , 639-646
  • J. Langowski, G. Chirico, U. Kapp: 
    DNA supercoil dynamics studied by dynamic light scattering and Brownian dynamics simulations. 
    In: Structural Biology: The State of the Art. Proceedings of the Eighth Conversation, State University of New York, Albany, NY 1993. Eds. R. H. Sarma & M. H. Sarma, Adenine Press 1994 

1995

  • K. Klenin, M. D. Frank-Kamenetskii, J. Langowski:
    Modulation of intramolecular interactions in superhelical DNA by curved sequences: a Monte-Carlo simulation study. (1995) 
    Biophys. J. , 68 , 81-88
  • E. Valero, S. de Bonis, O. Filhol, R.H. Wade, J. Langowski, E.M. Chambaz, C. Cochet: 
    Quaternary structure of of Casein kinase 2 - Characterization of Multiple Oligomeric States and Relation with Its Catalytic Activity (1995) 
    J. Biol. Chem. 270 , 8345-8352
  • S. Diekmann, J. Langowski (1995): 
    Supercoiling couples DNA curvature to the overall shape and the internal motion of the DNA molecule in solution. 
    TheoChem 336 , 227-234
  • C. Ebel, W. Altekar, G. Krishnan, J. Langowski, C. Urbanke, E. Forest, G. Zaccai (1995): 
    Solution structure of glyceraldehyde-3-phosphate dehydrogenase from Haloarcula vallismortis . 
    Biophys. Chem. 54 , 219-227 
  • K. Rippe, P. H. v. Hippel, J. Langowski (1995): 
    Action at a distance: the effect of DNA looping on the local protein concentration. 
    Trends Biochem.Sci. 20 , 500-506

1996

  • J. Langowski, W.K. Olson, S.C. Pedersen, I. Tobias, T.P. Westcott, Y. Yang (1996): 
    DNA supercoiling, localized bending, and thermal fluctuations. 
    Trends Biochem. Sci. 21 , 50
  • C. Pfannschmidt, A. Schaper, G. Heim, T. M. Jovin and J. Langowski (1996): 
    Sequence-specific labeling of superhelical DNA by triple helix formation and psoralen crosslinking. 
    Nucl. Acids Res., 24 , 1702-1709
  • A. Barge, J. Gagnon, A. Chaffotte, P. Timmins, J. Langowski, R.W.H. Ruigrok, Y. Gaudin (1996):
    Rod-like shape of vesicular stomatitis virus matrix protein. 
    Virology, 219 , 465-470
  • G. Chirico, J. Langowski (1996):
    Brownian dynamics simulations of supercoiled DNA with bent sequences. 
    Biophys. J., 71 , 955-971
  • C. Cremer, C. Münkel, M. Granzow, A. Jauch, S. Dietzel, R. Eils, X.-Y. Guan, P.S. Meltzer, J.M. Trent, J. Langowski, T. Cremer (1996):
    Nuclear architecture and the induction of chromosomal aberrations. 
    Mutation Res. 366 , 97-116.

1997

  • J. Langowski, L. Ehrlich, M. Hammermann, C. Münkel, G. Wedemann: 
    Polymer dynamics of DNA, chromatin and chromosomes, 
    in: Theoretical and computational methods in genome research , ed. S. Suhai, 1997 Plenum Press, New York, pp. 57-72 
  • L. Ehrlich, C. Münkel, G. Chirico, J. Langowski (1997):
    A Brownian dynamics model for the chromatin fiber. 
    CABIOS 13 (3), 271-279
  • G. Längst, T, Schätz, J. Langowski, I. Grummt (1997):
    Structural analysis of mouse rDNA: Coincidence between nuclease hypersensitive sites, DNA curvature and regulatory elements in the intergenic spacer.
    Nucl. Acids Res., 25 , 511-517
  • L. Ehrlich, J. Langowski (1997): 
    Brownian dynamics simulation of chromatin. 
    In: OOCNS'96 - Conference on object oriented computing in the natural sciences, Grenoble 1996, G. Tuparev (ed.)
  • J. Langowski:
    Modelling large DNA molecules: long-range interactions and regulation of transcription. 
    In: Nucleic Acids & Molecular Biology, Vol. 11: Mechanism in Transcription. Eds.: D. Lilley & F. Eckstein, 1997 Springer-Verlag Heidelberg 
  • K. Rippe, N. Mücke, J. Langowski (1997): 
    Superhelix dimensions of a 1868 base pair DNA plasmid determined by scanning force microscopy in air and in aqueous solution.
    Nucl. Acids Res., 25 , 1736-1744
  • K. Rippe, N. Mücke, J. Langowski (1997): 
    Molecules in motion; Imaging DNA with the scanning force microscope in aqueous solutions. 
    BioForum Intl., 1 , 42-44
  • T. Schätz, J. Langowski (1997): 
    Curvature and sequence analysis of eukaryotic promoters. 
    J. Biomolec. Struct. Dyn. , 15 (2), 265-276
  • M. Hammermann, C. Steinmaier, G. Wedemann, G. Chirico, J. Langowski (1997):
    Salt effects on the structure and internal dynamics of superhelical DNAs studied by light scattering and Brownian dynamics.
    Biophys. J. 73 , 2674-2687
  • C. Cremer, H. Bornfleth, J. Bradl, A. Esa, G. Kreth, B. Rinke, R. Eils, C. Münkel, S. Dietzel, M. Granzow, A. Jauch, X.-Y. Guan, P. S. Meltzer, J. M. Trent, L. Trakhtenbrot, D. Zink, J. Langowski, M. Hausmann, T. Cremer (1997): 
    Nuclear architecture and the formation of chromosome aberrations. 
    Radiat. Res. 148 : 513-515.

1998

  • C. Pfannschmidt, J. Langowski (1998): 
    Superhelix organization by DNA curvature as measured through site-specific labeling.
    J. Mol. Biol. 275 (4), 601-611
  • H. Merlitz, K. Klenin, K. Rippe, J. Langowski (1998): 
    Looping dynamics of linear DNAs and the effect of DNA curvature. A study by Brownian dynamics simulation. 
    Biophys. J.    74 , 773-779 [PDF]
  • K. Klenin, H. Merlitz, J. Langowski (1998): 
    A Brownian dynamics program for the simulation of linear and circular DNA and other wormlike chain polyelectrolytes. 
    Biophys. J. 74 , 780-788 [PDF]
  • F. W. Sevenich, J. Langowski, V. Weiss, K. Rippe (1998):
    DNA-binding and oligomerization of NtrC studied by fluorescence anisotropy and fluorescence correlation spectroscopy. 
    Nucl. Acids Res. 26 , 1373-1381 
  • C. Münkel, J. Langowski (1998):
    Chromosome structure predicted by a polymer model. 
    Phys. Rev. E 57 , 5888-5896
  • K. Tóth, V. Sauermann, J. Langowski (1998): 
    DNA curvature in solution measured by fluorescence resonance energy transfer. 
    Biochemistry 37 , 8173-8179
  • G. Wedemann, C. Münkel, J. Langowski (1998):
    Kinetics of structural changes in superhelical DNA. 
    Phys. Rev. E 58 , 3537-3546
  • G. Kreth, C. Münkel, J. Langowski, T. Cremer, C. Cremer (1998):
    Chromatin structure and chromosome aberrations: Modelling of damage induced by isotropic and localized irradiation. 
    Mutation Res., 404 , 77-88
  • M. Hammermann, N. Brun, K.V. Klenin, R. May, K. Tóth, J. Langowski (1998):
    Salt-dependent DNA superhelix diameter studied by small-angle neutron scattering and Monte-Carlo simulations. 
    Biophys. J. 75 , 3075-3063  [PDF]
  • A. Schulz, N. Mücke, J. Langowski, K. Rippe (1998): 
    Scanning force microscopy of E.coli RNA polymerase . σ54 holoenzyme complexes with DNA in buffer and in air. 
    J. Mol. Biol. 283 , 821-836.

1999

  • C. Münkel, R. Eils, S. Dietzel, D. Zink, C. Mehring, G. Wedemann, T. Cremer, J. Langowski (1999):
    Compartimentalization of interphase chromosomes observed in simulation and experiment. 
    J. Mol. Biol. 285 , 1053-1065  [PDF]
  • J. Langowski
    Struktur biologischer Makromoleküle in Lösung. 
    In: J. Bille & W. Schlegel (eds.), Medizinische Physik I: Grundlagen , 285-304. (1999) Springer, Heidelberg. 
  • T.A. Knoch, C. Münkel, J. Langowski
    Three-Dimensional Organization of Chromosome Territories and the Human Interphase Nucleus, 
    in: High Performance Computing in Science and Engineering 1999 , Springer, Heidelberg 
  • J. Langowski, M. Hammermann, K. Klenin, K. Tóth:
    Superhelical DNA studied by solution scattering and computer models. 
    In: E.M. Bradbury and S. Pongor (eds.), Structural Biology and Functional Genomics , 73-85. (1999) Kluwer Academic, Dordrecht. 
  • J. Langowski, M. Hammermann, K. Klenin, R.P. May, K. Tóth (1999): 
    Superhelical DNA studied by solution scattering and computer models.
    Genetica 106, 49-55.  [PDF]

1978 - 1989

1978

  • J. Langowski, K. Henco, D. Riesner, H.L. Sänger: 
    Common structural features of different viroids: serial arrangement of double helical sections and internal loops. 
    Nucl. Acids Res. (1978) 5, 1589-1610 [PDF]

1979

  • Tóth, K. (1979) 
    Light scattering of bacterium and virus solutions. (in Hungarian) 
    Study presented at the competition of Young Hungarian Biophysicists, Budapest

1980

  • Langowski, J., Goppelt, M., Maaß, G. & Pingoud, A. M. (1980). 
    Investigations on the mechanism of the cleavage reaction of the restriction endonuclease EcoRI. 
    Hoppe-Seylers Zeitschrift für Physiologische Chemie 361, 293.
  • J. Langowski, A. Pingoud, M. Goppelt, G. Maaß: 
    Inhibition of EcoR1 by polynucleotides. A characterization of the non-specific binding of the enzyme to DNA. 
    Nucl. Acids Res. (1980) 8, 4727-4736 [PDF]
  • G. Maaß, J. Langowski, M. Goppelt, A. Pingoud: 
    DNA binding by restriction endonuclease EcoR1, 
    in: Biological implications of protein-nucleic acid interactions, ed. J. Augustyniak, (1980) Adam Mickiewicz Univ. Press, Poznan, pp. 558-565
  • G. Maaß, J. Langowski, A. Pingoud, C. Urbanke, M. Goppelt: 
    The recognition of specific DNA sequences by restriction endonucleases. Steady state and fast kinetic studies on the cleavage of superhelical DNA by EcoR1.
    Stud. Biophys. (1980) 81, 119-120
  • Tóth, K. , Fekete, A. (1980)
    Effect of microenvironment on the structure of bacteriophage solutions. (Light scattering study). 
    Acta Biochim. Biophys. Acad. Sci. Hung.15, 127

1981

  • D. Shore, J. Langowski, R.L. Baldwin: 
    DNA flexibility studied by covalent closure of short DNA fragments into circles. 
    Proc. Nat. Acad. Sci. USA (1981) 78, 4833-4837 [PDF]
  • J. Langowski, C. Urbanke, A. Pingoud, G. Maaß: 
    Transient cleavage kinetics of the EcoR1 restriction endonuclease measured in a pulsed quench-flow apparatus: enzyme concentration-dependent activity change. 
    Nucl. Acids Res. (1981) 9, 3483-3490 [PDF]
  • M. Goppelt, J. Langowski, A. Pingoud, W. Haupt, C. Urbanke, H. Mayer, G. Maaß: 
    The effect of several nucleic acid binding drugs on the cleavage of d(GGAATTCC) and pBR322 by the EcoR1 restriction endonuclease. 
    Nucl. Acids Res. (1981) 9, 6115-6127
  • Alves, J., Pingoud, A., Langowski, J. & Maass, G. (1981). 
    The endonucleolytic reaction catalyzed by the EcoRI restriction enzyme is inhibited when the enzyme is in excess over substrate. 
    Biophys. Struct. Mech.7, 247-248.

1982

  • J. Alves, A. Pingoud, J. Langowski, C. Urbanke, G. Maaß: 
    Two identical subunits of the EcoR1 restriction endonuclease co-operate in the binding and cleavage of the palindromic substrate. 
    Eur. J. Biochem. (1982) 124, 139-142
  • C. Urbanke, J. Langowski, E. Schuppe: 
    Microprocessor controlled quenched flow apparatus for the study of fast chemical reactions. 
    Z. Anal. Chem. (1982) 311, 364-365
  • J. Langowski, C. Urbanke: 
    A continuous fluorimetric assay for the EcoR1 restriction endonuclease. 
    Z. Anal. Chem. (1982) 311, 367

1983

  • J. Langowski, J. Alves, A. Pingoud, G. Maaß: 
    Does the specific recognition of DNA by the restriction endonuclease EcoR1 involve a linear diffusion step? Investigation of the processivity of the EcoR1 endonuclease. 
    Nucl. Acids Res. (1983) 11, 501-513

1984

  • J. Alves, A. Pingoud, W. Haupt, J. Langowski, G. Maaß, C. Wolf: 
    The influence of sequences adjacent to the recognition site on the cleavage of oligodeoxynucleotides and plasmid DNAs by the EcoR1 endonuclease.
    Eur. J. Biochem. (1984) 140, 83-92
  • J. Langowski, C. Urbanke, E. Schuppe: 
    Construction of a microprocessor controlled pulsed quench-flow apparatus for the study of fast chemical and biochemical reactions. 
    Anal. Biochem. (1984) 142, 91-97

1985

  • Langowski, J. & Giesen, U. (1985). 
    Dynamics of superhelical DNA studied by photon-correlation spectroscopy. 
    Biol. Chem. Hoppe-Seyler 366, 818-818.
  • J. Langowski, B.S. Fujimoto, D. Wemmer, A.S. Benight, G. Drobny, J.H. Shibata, J.M. Schurr: 
    Deformational dynamics and NMR relaxation of supercoiled DNAs. 
    Biopolymers (1985) 24, 1023-1056
  • Schurr, J. M., Shibata, J. H., Wilcoxon, J., Benight, A. S., Langowski, J., Thomas, J. C. & Fujimoto, B. S. (1985). 
    Evidence For 2 Different Global Secondary Structures of Supercoiled Dnas and Buffer-Induced Switching. 
    Biophys. J.47, A16.
  • J. Langowski, A.S. Benight, B.S. Fujimoto, J.M. Schurr, U. Schomburg: 
    Change of conformation and internal dynamics of supercoiled DNA upon binding of E.coli single strand binding protein. 
    Biochemistry (1985) 24, 4022-4028
  • F.U. Gast, J. Langowski, A. Pingoud: 
    Product analysis of in vitro ribosomal protein synthesis for the assessment of kinetic parameters. 
    Anal. Biochem. (1985) 147, 364-368

1986

  • J. Langowski, U. Giesen, Chr. Lehmann: 
    Dynamics of superhelical DNA studied by photon correlation spectroscopy. 
    Biophys. Chem. (1986) 25, 191-200

1987

  • Wu, P. G., Schurr, J. M., Benight, A. S., Langowski, J. & Fujimoto, B. S. (1987). 
    Theory of dynamic light-scattering from rigid double-spirals - a model for supercoiled DNA. 
    Biophys. J. 51, A504.
  • J. Langowski
    Salt effects on internal motions of superhelical and linear DNA. Dynamic light scattering studies. 
    Biophys. Chem. (1987) 27, 263-271
  • A.S. Benight, J. Langowski, P.-G. Wu, J. Wilcoxon, J.H. Shibata, B.S. Fujimoto, N.S. Ribeiro, J.M. Schurr: 
    Structure and Dynamics of Supercoiled DNAs, 
    in: Laser Scattering Spectroscopy of Biological Objects, eds. J. Stepanek, P. Anzenbacher, B. Sedlacek, pp. 407-422 (Elsevier, Amsterdam-Oxford-New York-Tokyo 1987)

1988

  • P. Timmins, J. Langowski, R. Brown: 
    An elongated model of the Xenopus laevis transcription factor IIIA-5S ribosomal RNA complex derived from neutron scattering and hydrodynamic measurements. 
    Nucl. Acids Res. (1988) 16, 8633-8644

1989

  • H.W. Bewersdorff, J. Dohmann, J. Langowski, P. Lindner, A. Maack, R. Oberthür, H. Thiel: 
    SANS- and LS- studies on drag-reducing surfactant solutions. 
    Physica B (1989) 156, 508-511
  • J. Langowski, U. Giesen: 
    Configurational and dynamic properties of different length superhelical DNAs measured by dynamic light scattering. 
    Biophys. Chem. (1989) 34, 9-18
  • J. Langowski, U. Giesen, B. Farago: 
    Studies of the structure and internal motions of supercoiled DNAs using dynamic scattering techniques, 
    in: Proceedings of the 2nd International Conference on Laser Scattering Spectroscopy of Biological Objects, Pécs/Hungary 1988, ed. B. Német, pp. 191-202
  • J. Langowski
    Dynamic light scattering studies of the solution conformation of superhelical DNA. 
    In: Spectroscopy of Biological Molecules - State of the Art, eds. A. Bertoluzza, C. Fagnano, P. Monti, Esculapio, Bologna 1989, pp. 209-211

supervised theses

  • Ursula Giesen: 
    Längenabhängigkeit der Struktur und Dynamik superhelikaler DNA in Lösung. (1986) 
    Diplomarbeit, Fachbereich Chemie, Universität Hannover.
  • François Thibault:
    Application de la diffusion de lumière à la cristallisation des protéines. (1990) 
    Diplomarbeit (frz. DEA), Université Joseph Fourier, Grenoble
  • Werner Kremer:
    Hydrodynamische Charakterisierung von superhelikaler DNA und DNA-Fragmenten mit Sonderstrukturen. (1992) 
    Dissertation, Fakultät für Physik, Universität Göttingen.
  • Laurence Seignovert:
    Aggregation in kristallisierenden und nicht kristallisierenden Proteinlösungen. (1992) 
    Diplomarbeit (frz. DEA), Université Joseph Fourier, Grenoble
  • Carola Steinmaier: 
    Untersuchung von Struktur und Dynamik eines DNA-Plasmids durch Lichtstreuung und Vergleich mit Brownschen Dynamik-Simulationen. (1996) 
    Diplomarbeit, Fakultät für Physik und Astronomie, Ruprecht-Karls-Universität, Heidelberg.
  • Franz Sevenich:
    Untersuchung zur Bindung und Oligomerisierung des NtrC-Proteins an DNA mit Fluoreszenzanisotropie und Fluoreszenzkorrelationsspektroskopie. (1996) 
    Diplomarbeit, Fakultät für Chemie, Ruprecht-Karls-Universität, Heidelberg.
  • Gero Wedemann:
    Simulation der Dynamik von Konformationsübergängen in superhelikaler DNA. (1996) 
    Diplomarbeit, Fakultät für Physik und Astronomie, Ruprecht-Karls-Universität, Heidelberg.
  • Markus Hammermann:
    Struktur und Dynamik von SV-40 DNA und Minichromosomen: Hydrodynamik und Simulationen.(1996) 
    Diplomarbeit, Fakultät für Physik und Astronomie, Ruprecht-Karls-Universität, Heidelberg.
  • Gesine Richter:
    Elektrostatische Effekte auf die Struktur superhelikaler DNA. (1997) 
    Diplomarbeit, Fachbereich Chemie, Universität Hannover.
  • Claus Rodemer:
    In-vitro-Rekonstitution von Nukleosomen auf multimeren DNA-Erkennungssequenzen. (1997) 
    Diplomarbeit, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg.
  • Claudia Pfannschmidt:
    Lokalisierung gekrümmter Sequenzen in superhelikaler DNA. Rasterkraftmikroskopische Untersuchungen an sequenzspezifisch markierten Plasmiden. (1998) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg.
  • Tanja Schätz:
    Analyse von DNA-Krümmung in regulatorischen Sequenzen. (1998) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg.
  • Michael Tewes:
    Aufbau eines Experimentes zur Fluoreszenzkreuzkorrelationsspektroskopie, Erweiterung der theoretischen Grundlagen und biologische Anwendungen. (1998) 
    Dissertation, Fakultät für Physik und Astronomie, Ruprecht-Karls-Universität, Heidelberg.
  • Carsten Mehring:
    Simulation von Chromosomen. (1998) 
    Diplomarbeit, Fakultät für Physik und Astronomie, Ruprecht-Karls-Universität, Heidelberg.
  • Karsten Rippe:
    Regulation der Transkription durch Enhancer. (1999) 
    Habilitationsschrift, Fakultät für Biologie, Ruprecht-Karls-Universität, Heidelberg.
  • Alexandra Schulz:
    Regulation der Transkription aus der Distanz: Untersuchungen an einem prokaryotischen Promotor-Enhancer-System. (1999) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität, Heidelberg.
  • Markus Hammermann:
    Strukturuntersuchungen mit Neutronenkleinwinkelstreuung an superhelikaler DNA und Oligonukleosomen. (1999) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität, Heidelberg.
  • Gero Wedemann:
    Simulation von Struktur und Strukturregulation von Chromatin. (1999) 
    Dissertation, Fachbereich Physik, Gesamthochschule Wuppertal.
  • Ingo Janke:
    Implementierung eines konfokalen Theta-Mikroskops für die Fluoreszenzkorrelationsspektroskopie. (2000) 
    Diplomarbeit, Fakultät für Physik und Astronomie, Ruprecht-Karls-Universität, Heidelberg.
  • Lala Adueva:
    Simulation der elektrostatischen Wechselwirkung von DNA. (2000) 
    Diplomarbeit, Fakultät für Physik und Astronomie, Ruprecht-Karls-Universität, Heidelberg. 
  • Malte Wachsmuth:
    Fluoreszenzfluktuationsmikroskopie: Entwicklung eines Prototyps, Theorie und Messung der Beweglichkeit von Biomolekülen im Zellkern. (2001) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität, Heidelberg. [LINK]
  • Malte Bussiek:
    Einfluss gekrümmter Sequenzen auf Fernwechselwirkungen in superhelikaler DNA. (2001) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg. [LINK]
  • Jan Lubitzki:
    Zeitaufgelöste Fluoreszenzkreuzkorrelationsspektroskopie und Fluoreszenzlebensdauermessungen mittels einer schnellen Elektronik. (2001) 
    Diplomarbeit, Fakultät für Physik und Astronomie, Ruprecht-Karls-Universität, Heidelberg.
  • Thomas Weidemann:
    Quantitative Untersuchung der Verteilung, Mobilität und Bindung von fluoreszenzmarkierten Histonen in vitro und in vivo mit Fluoreszenzfluktuationsmikroskopie. (2002) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg. [LINK]
  • Tobias A. Knoch:
    Approaching the three-dimensional organization of the human genome. (2002) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg. [LINK]
  • Robert Kirmse:
    Rasterkraftmikroskopie von Intermediärfilamenten. (2003) 
    Diplomarbeit, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg.
  • Nicolas Dross:
    Diffusion des rot fluoreszierenden Proteins eqFP611 in lebenden HeLa-Zellkernen in der Interphase. (2004) 
    Diplomarbeit, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg.
  • Lutz Gehlen:
    Untersuchungen zur Mobilität von Chromosomen in Saccharomyces cerevisiae
    (2004) 
    Diplomarbeit, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg.
  • Nina Baudendistel:
    Zwei-Hybrid-Fluoreszenzkreuzkorrelationsspektroskopie: In-vivo-Charakterisierung von Protein-Protein-Wechselwirkungen im AP-1-System. (2004) 
    Dissertation, Fakultät für Chemie, Ruprecht-Karls-Universität Heidelberg. [LINK]
  • Sergiy Mayilo:
    Setup of optics for single molecule spectroscopy. (2005) 
    Masterarbeit, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg
  • Frank Aumann:
    In silicio Streckung und Kompaktierung von Chromatin. (2006) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg[LINK]
  • Susanne Kunkel:
    The ring-closure probability of the 30-nm chromatin fiber.A Monte-Carlo simulation approach.(2007) 
    Diplomarbeit, Fakultät für Mathematik und Informatik, Friedrich-Schiller-Universität Jena
  • Carina Reble:
    Fast video microscopy for the study of metabolic waves in human neutrophiles. (2007) 
    Diplomarbeit, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg 
  • Robert Kirmse:
    Studium der Wachstumskinetik von Intermediärfilamenten mit Hilfe von Vimentin. (2007) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Florian Hauger:
    Fluoreszenzspektroskopische Untersuchungen nukleosomaler Struktur und Dynamik. (2007) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Tabea Elbel:
    Einfluss positiver Superspiralisierung auf die Zugänglichkeit nukleosomaler DNA. (2007) 
    Diplomarbeit, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg
  • Alexander Gansen:
    Chromatin at the Nanolevel: development of a single molecule FRET experiment and analysis of the structure and stability of individual nucleosomes (2008) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Malte Renz:
    Lokalisierung und Dynamik von CapG Protein in Mammakarzinom- und normalen Zellinien mit Hilfe fluoreszenzmikroskopischer Techniken. (2008) 
    Dissertation, Fakultät für Medizin, Universität Düsseldorf
  • Maria Silva Santisteban:
    Chemische Fluoreszenzmarkierung von Histon H3. (2008) 
    Diplomarbeit, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg
  • Annika Wedemeier:
    Diskrete Gittermodelle zur anomalen Diffusion in Polymernetzwerken. (2008) 
    Dissertation, Fakultät für Mathematik und Informatik, Ruprecht-Karls-Universität Heidelberg
  • Sven Dittrich:
    AFM-Untersuchungen zur Krümmung von DNA-Fragmenten. (2009) 
    Diplomarbeit, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg
  • Tillman Kaudse:
    Erweiterung eines Einzelmolekül-FRET-Spektrometers um alternierende Laseranregung und Charakterisierung des Systems. (2009) 
    Diplomarbeit, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg
  • Elrade Rofaani:
    Molecular mechanism of cationic porphyrin in interaction with chromatin: effect of post-translational histone modification. (2009) 
    Erasmus Mundus Master’s thesis, ENS Cachan, Paris
  • Nicolas Dross:
    Mobilität von eGFP-Oligomeren in lebenden Zellkernen. (2009) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Tomasz Wocjan:
    Dynamics of DNA in nucleosomes and plasmids studied by Brownian dynamics (2009) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Marcel Beining:
    Intrazelluläre Dynamik von Bioshuttle-Transportermolekülen. (2010) 
    Masterarbeit, Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg
  • Karine Voltz:
    Insights into the dynamics of the nucleosomes: a multiscale molecular dynamics study (2011) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Christian Fritsch:
    Diffusion Processes in the Interphase Cell Nucleus: Connections between Chromatin Structure, Chromatin Dynamics and Macromolecular Transport. (2011) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Vera Böhm:
    Untersuchungen der Dynamik von Nukleosomen mittels Einzelmolekülfluoreszenz (2011) 
    Dissertation, Fakultät für Chemie, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Anne Rademacher:
    Fluorescence correlation spectroscopy of intermediate filament assembly. (2012) 
    Masterarbeit, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg
  • Stefan Winheim:
    Quantitative Beschreibung der Filamentbildung zytoplasmatischer Intermediärfilament-Proteine (2013) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Niko Schnellbächer:
    Titel (2013) 
    Masterarbeit, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg
  • Sebastian Isbaner:
    Titel (2013) 
    Masterarbeit, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg
  • Katharina Zirngibl:
    Titel (2013) 
    Masterarbeit, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg
  • Jan Krieger:
    Bildgebung von Diffusionsprozessen in lebenden Zellen. (2014) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Tabea Elbel:
    Einfluss lokaler Strukturübergänge auf die Struktur und Dynamik superhelikaler DNA. (2015) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Jan Buchholz:
    Evaluation of single photon avalanche diode arrays for imaging fluorescence correlation spectroscopy : FPGA-based data readout and fast correlation analysis on CPUs, GPUs and FPGAs (2015) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Ruihan Zhang:
    Influence of histone modifications and mutations on nucleosome dynamics:A simulation study.(2016) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Kathrin Lehmann:
    Fluoreszenz-Einzelmolekül-Studien zur Dynamik von Nukleosomen. (2016) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg [LINK]
  • Anja Riedel:
    Titel (2017) 
    Masterarbeit, Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg
  • Lukas Lau:
    Evaluation and Enhancement of a Fluorescence Correlation Spectroscopy Imaging System(2017) 
    Masterarbeit, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg
  • Fereydoon Taheri:
    Long-range dynamics of particles in viscoelastic media using light sheet fluorescence microscopy with correlation spectroscopy (started 2015) 
    Dissertation, Fakultät für Biologie, Ruprecht-Karls-Universität Heidelberg
  • Madhura De:
    Nucleosome dynamics studied by single molecule FRET and computer simulations. (started 2016) 
    Dissertation, Fakultät für Physik, Ruprecht-Karls-Universität Heidelberg

patents

  • M. Tewes, J. Langowski: 
    Fluorescence correlation spectroscopy module for a microscope. 
    European patent no. 0941470 (filed 26.11.1997, granted 24.10.2001)
  • M. Tewes, J. Langowski: 
    Fluorescence correlation spectroscopy process and device, in particular for polychromatic fluorescence correlation spectroscopy. 
    German Patent 19735119 (filed 13.08.1997, granted 20.09.1999); US patent no. 6396580 (28.05.2002); International patent no. WO9909393
  • J. Langowski: 
    Device and method for fluorescence correlation spectroscopy, especially for multicolour fluorescence correlation spectroscopy. 
    German patent application no. 199 07 011.3 (01.03.1999); International patent application WO0049389 (16.02.2000)
  • A. Alonso, W. Waldeck, G. Müller, T.A. Knoch, J. Langowski: 
    DNA sequence and a method for the in vivo marking and the analysis of DNA/chromatin in cells. 
    German patent application 10013204.9 (17.03.2000); International patent application WO0168881 (16.03.2001)
  • M. Wachsmuth, J. Langowski: 
    Fluorescence fluctuation microscope analytical module or scanning module, method for measurement of fluorescence fluctuation and method and device for adjustment of a fluorescence fluctuation microscope. 
    German patent application 10122046.4 (07.05.2001); International patent application no.WO02090947 (07.05.2002)
  • N. Baudendistel, J. Langowski: 
    Screening process for the detection and characterization of protein-protein-interactions in vivo by fluorescence cross correlation spectroscopy. 
    International patent application PCT/EP2005/010714 (05.10.2005)
  • Braun, K, Peschke P, Debus J, Pipkorn R, Waldeck W, Friedrich E: 
    Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen. 
    DP 199 33 492.7-43, DE 101 3300307.2, PCT/DE00/02346, Austral. Pat. 66 839/00, EP 00 954 335.6, Jap. Pat. 2001-510520; US-Pat. 10/0311,505; Can.-Pat. 2,379,346
  • Braun, K, Peschke, P, Pipkorn, R, Waldeck, W, Debus, J.: 
    Modulation der Genexpression durch Oligonukleotid-Analoga in einer Anti-Gen-Strategie. 
    DP199 33 492.7-43.2
  • Braun, K, Waldeck, W, Pipkorn, R, Braun, I, Debus, J : 
    Verfahren zur Entwicklung spezifischer Pharmaka. Individuelles Drug Design zur Genkontrolle an den Rekombinationsloci des BCR/ ABL Fusionsgens. 
    DP10154830.3) (DP101 54 827.3), PCT/DE02/04154, EP 1 444 253
  • Braun, K, Waldeck, W, Pipkorn, R, Braun, I, Debus, J, Jenne, J: 
    Klammer-PNA-Konjugat zum spezifischen Transport thermisch aktivierbarer Nukleinsäuren. 
    DP 101 58 331.1, PCT/DE02/04356
  • Braun, K, Pipkorn, R, Waldeck, W, Braun, I, Debus, J: 
    Konjugate zur Behandlung prokaryontischer Infektionen. 
    DP 102 01 862.6-41
  • Braun K, Waldeck W, Pipkorn R, Braun I, Debus J: 
    Proliferationskontrolle von Human Papillomaviren (HPV 16/18) mittels einer Anti-Gen- Strategie mit Peptid-Nukleinsäuren.
    DP10154831.1, PCT/DE02/04153
  • Braun K, Waldeck W, Pipkorn R, Braun I, Debus J: 
    Genetische Strategien zur Inhibition von HIV. 
    DP10133307.2, PCT/DE02/02564 application at the EPA
  • Braun, K, Waldeck, W, Pipkorn, R, Braun, I, Wolber, G, Debus, J, Ehemann, V.: 
    Neutroneneinfangtherapie (NCT) durch molekulare zellkerngerichtete Transportverfahren.
    DP10154830.3, PCT/DE02/04155
  • Braun, K, Waldeck, W, Pipkorn, R, Heckl, S, Jenne, J Debus, J: 
    Verfahren zur Anreicherung von Substanzen (CTBS) zur MR-Bildgebung mittels organspezifischem Targeting. 
    Eur. Pat. 02 001 506.1
  • Heckl S, Braun K, Waldeck W, Pipkorn R: 
    Conjugate useful for molecular imaging and tumor therapy. ‚Anreicherung bildgebender Substanzen im Zellkern zur Darstellung der Wanderung von Zellen (Cell Tracking) sowie zur Kontrastmittelmarkierung anstelle von Biopsie-Clips in der MRT. 
    Eur. Pat. 02 026 700.1
  • Braun K, Waldeck W, Pipkorn R, Bock M, Debus J, Wießler M, Dunsch L, Didinger B: 
    Intrazelluläres Kontrastmittel für die Hochfeld Kernspintomographie auf der Basis von Nitrid-Cluster Gd/Sc (in unterschiedlicher Verteilung am Beispiel von endohedraler GdxNx@C80x.

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