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2017

Hirche C., Frenz T., Haas S., Döring M., Borst K. Tegtmeyer P., Brizic I., Jordan S., Keyser K., Chhatbar C., Pronk E., Lin S., Messerle M., Jonjic S., Falk C.S., Trumpp A., Essers M.A.G., Kalinke U. (2017). Systemic Virus Infections differentially modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports 19: 2345-56

Wang W., Stiehl T., Raffel S., Hoang V.T., Hoffmann I., Poisa-Beiro L., Saeed B.R., Blume R., Manta L., Eckstein V., Bochtler T., Wuchter P., Essers M., Jauch A., Trumpp A., Marciniak-Czochra A., Ho A.D., Lutz C. (2017). Reduced hematopoietic stem cell frequency predicts outcome in acute myeloid leukemia. Haematologica 102: 1567-77

Brocks D., Schmidt C.R., Daskalakis M., Jang H.S., Shah N.M., Li D., Li J., Zhang B., Hou Y., Laudato S., Lipka D.B., Schott J., Bierhoff H., Assenov Y.,Helf M., Ressnerova A., Islam M.S., Lindroth A.M., Haas S., Essers M., Imbusch C.D., Brors B., Oehme I., Witt O., Lübbert M., Mallm J.-P., Rippe K., Will R., Weichenhan D.,Stoecklin G., Gerhäuser C., Oakes C.C., Wang T., Plass C. (2017). DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat. Genet. 49: 1052-60 

Velten L.*, Haas S.F.*, Raffel S.*, Blaszkiewicz S., Islam S., Hennig B.P., Hirche C., Lutz C., Buss E.C., Nowak D., Boch T., Hofmann W.-K. Ho A.D., Huber W., Trumpp A.#,Essers M.A.G.#, Steinmetz L.M.#. (2017). Human haematopoietic stem cell lineage commitment is a continuous process. Nat. Cell Biol. 19: 271-281
* shared first author, #shared last and corresponding author        

Schreck C., Istvánffy R., Ziegenhain C., Sippenauer T., Ruf F., Henkel L., Gärtner F., Vieth B., Florian M.C., Mende N., Taubenberger A., Prendergast Á., Wagner A., Pagel C., Grziwok S., Götze K.S., Guck J., Dean D.C., Massberg S., Essers M., Waskow C., Geiger H., Schiemann M., Peschel C., Enard W., Oostendorp R.A. (2017). Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp. Med. 214: 165-181

Prendergast A.M., Kuck A., van Essen M., Haas S., Blaszkiewicz S., Essers M.A. (2017). IFNα mediated remodeling of endothelial cells in the bone marrow niche. Haematologica, 102: 445-453

2016

Uckelmann H., Blaszkiewicz S., Nicolae C., Haas S., Schnell A., Wurzer S., Wagener R., Aszodi A., Essers M.A.(2016). Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4. J Exp. Med. 213: 1961-1971

Scognamiglio R., Cabezas-Wallscheid N., Thier M.C., Altamura S., Reyes A., Prendergast Á.M., Baumgärtner D., Carnevalli L.S., Atzberger A., Haas S., von Paleske L., Boroviak T., Wörsdörfer P., Essers M.A., Kloz U., Eisenman R.N., Edenhofer F., Bertone P., Huber W., van der Hoeven F., Smith A., Trumpp A. (2016). Myc depletion induces a pluripotent dormant state mimicking diapause. Cell 164: 668-80

Weisser M., Demel U.M., Stein S., Chen-Wichmann L., Touzot F., Santilli G., Sujer S., Brendel C., Siler U., Cavazzana M., Thrasher A.J., Reichenbach J., Essers M.A., Schwäble J., Grez M. (2016). Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions. J. Allergy Clin. Immunol. 138: 219-228

Essers M.A.(2016). Stressed-out HSCs turn up p38aand purine to proliferate. Cell Stem Cell 19: 143-144

Essers M.A.(2016). A role for IFN during embryonic hematopoiesis. Blood 128: 150-152

Flores-Figueroa E., Essers M. and Bowman T.V. (2016). Hematopoiesis ‘awakens’: Evolving technologies, the force behind them. Exp. Hematol. 44: 101-105

2015

Haas S., Hansson J., Klimmeck D., Loeffler D., Velten L., Uckelmann H., Wurzer S., Prendergast Á.M., Schnell A., Hexel K., Santarella-Mellwig R., Blaszkiewicz S., Kuck A., Geiger H., Milsom M.D., Steinmetz L.M., Schroeder T., Trumpp A., Krijgsveld J., Essers M.A. (2015). Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors. Cell Stem Cell 17: 422-34

Walter D., Lier A., Geiselhart A., Thalheimer F.B., Huntscha S., Sobotta M.C., Moehrle B., Brocks D., Bayindir I., Kaschutnig P., Muedder K., Klein C., Jauch A., Schroeder T., Geiger H., Dick T.P., Holland-Letz T., Schmezer P., Lane S.W., Rieger M.A., Essers M.A., Williams D.A., Trumpp A., Milsom M.D. (2015). Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature 520: 549-52

2014

Lipka D.B., Wang Q., Cabezas-Wallscheid N., Klimmeck D., Weichenhan D., Herrmann C., Lier A., Brocks D., von Paleske L., Renders S., Wünsche P., Zeisberger P., Gu L., Haas S., Essers M.A., Brors B., Eils R., Trumpp A., Milsom M.D., Plass C. (2014). Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfate sequencing. Cell Cycle 13: 3476-87

Cabezas-Wallscheid N., Klimmeck D., Hansson J., Lipka D.B., Reyes A., Wang Q., Weichenhan D., Lier A., von Paleske L., Renders S., Wünsche P., Zeisberger P., Brocks D., Gu L., Herrmann C., Haas S., Essers M.A., Brors B., Eils R., Huber W., Milsom M.D., Plass C., Krijgsveld J., Trumpp A. (2014). Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA Methylome analysis. Cell Stem Cell 15: 507-22

Ehninger A., Boch T., Uckelmann H., Essers M.A., Müdder K., Sleckman B.P., Trumpp A. (2014). Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-a-induced stress response. Blood 123: 3909-13

Carnevalli L.S., Scognamiglio R., Cabezas-Wallscheid N., Rahmig S., Laurenti E., Masuda K., Jöckel L., Kuck A., Sujer S., Polykratis A., Erlacher M., Pasparakis M., Essers M.A., Trumpp A. (2014). Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B. J. Exp. Med. 211: 769-79

Becker M.S., Schmezer P., Breuer R., Haas S.F., Essers M.A., Krammer P.H., Li-Weber M. (2014). The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression. Cell Death Dis5, e1000

Prendergast A.M. and Essers M.A.(2014) Hematopoietic stem cells, infection, and the niche. Ann.N.Y.Acad.Sci. 1310: 51-7

2012

Glauche I., Horn K., Horn M., Thielecke L., Essers M.A., Trumpp A., Roeder I. (2012). Therapy of chronic myeloid leukaemia can benefit from the activation of stem cells: simulation studies of different treatment combinations. Br. J. Cancer 106:1742-52

Schemionek M., Spieker T., Kerstiens L., Elling C., Essers M., Trumpp A., Berdel W.E., Müller-Tidow C., Koschmieder S. (2012). Leukemic spleen cells are more potent than bone marrow-derived cells in a transgenic mouse model of CML. Leukemia 26: 1030-7

2011

Roeder I., Loeffler M., Glauche I.; other participants. (2011). Towards a quantitative understanding of stem cell-niche interaction: experiments, models, and technologies. Blood Cells Mol Dis. 46: 308-317

2010

Essers M.A., and Trumpp A. (2010). Targeting leukemic stem cells by breaking their dormancy. Mol. Oncol. 4: 443-450

Trumpp A., Essers M.A.G., and Wilson A. (2010). Awakening dormant hematopoietic stem cells. Nat Rev Immunol. 10: 201-209

2009

Essers M.A.G., Offner, S., Blanco-Bose W.E., Waibler Z., Kalinke U., Duchosal M.A., and Trumpp A. (2009). IFNα activates dormant HSCs in vivoNature 458:904-908

2008

Hoogeboom D., Essers M.A.G., Polderman P.E., Voets E., Smits L.M.M., and Burgering B.M.T. (2008). Interaction of FOXO with b-catenin inhibits b-catenin/T cell factor activity. J.Biol.Chem. 283: 9224-9230

2007

Wilson A., Oser G.M., Jaworski M., Blanco-Bose W.E., Laurenti E., Adolphe C., Essers M.A., Macdonald H.R., Trumpp A. (2007). Dormant and self-renewing hematopoietic stem cells and their niches. Ann N Y Acad Sci. 1106: 64-75

2006

Oskarsson T., Essers M.A.G., Dubois N., Offner S., Dubey C., Roger C., Metzger D., Chambon P., Hummler E., Beard P., and Trumpp A. (2006). Skin epidermis lacking the c-mycgene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes&Dev. 20: 2024-2029

2005

Essers M.A.G., de Vries-Smits A.M.M., Polderman P.E., Burgering B.M.T., and Korswagen, H.C. (2005). Functional interaction between b-catenin and FOXO in oxidative stress signalling. Science 308: 1181-1184

2004

Essers M.A.G., Weijzen S., de Vries-Smits A.M.M., Saarloos I., de Ruiter N.D., Bos J.L., and Burgering B.M.T. (2004). FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23: 4802-4812

2002

Kops G.J.P.L., Medema R.H., Glassford J., Essers M.A.G., Dijkers P.F., Coffer P.J., Lam E.W., and Burgering B.M.T. (2002). Control of cell cycle exit and entry by protein kinase B-regulated Forkhead transcription factors. Mol. Cell. Biol. 22: 2025-2036

2000

Smits V.A.J., van Peer M.A., Essers M.A.G., Klompmaker R., Rijksen G., and Medema R.H. (2000). Negative growth regulation of SK-N-MC cells by bFGF defines a growth factor-sensitive point in G2J. Biol. Chem. 275: 19375-19381

1999

Smits V.A., Essers M.A., Loomans D.S., Klompmaker R., Rijksen G., and Medema R.H. (1999). Inhibition of cell proliferation by lithium is associated with interference in cdc2 activation. FEBS Lett457: 23-7.

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