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BEGIN:VEVENT
UID:entry-335@www.dkfz.de
DTSTAMP:20260929T153041Z
DTSTART:20250210T120000Z
DTEND:20250210T130000Z
SUMMARY:Khaoula El Marzkioui "Size determination and role of the steroid ho
 rmone ecdysone during wing growth of Drosophila"
DESCRIPTION:Khaoula El Marzkioui obtained her master in cell biology at the
  university of Cergy (France). Then\, she pursued her PhD in developmental
  biology at the Curie Institute (France)\, in the team of Pierre Léopold 
 in which she focused on understanding organ growth control. Understanding 
 how organs achieve their final size during development is a fundamental ye
 t unresolved question in biology. This process involves both mass increase
  and growth cessation\, but the mechanisms driving growth arrest are not f
 ully understood. Studies on Drosophila imaginal tissues suggest that the c
 urrent model is that size determination is accomplished at the end of the 
 larval phase\, coinciding with the decline in cell proliferation during th
 e larva-to-pupa transition (LPT)\, our research shows that tissue growth c
 ontinues into the pupal stage. We found that discs double in mass after LP
 T\, with growth shifting from coupled cell growth and proliferation to cel
 l growth alone\, therefore uncoupling proliferation arrest from growth. Fu
 rther analysis emphasizes the Insulin/IGF pathway's role\, indicating that
  the current wing development model needs revision and providing new insig
 hts into growth arrest and organ size regulation. Additionally\, we explor
 ed the role of the steroid hormone ecdysone in growth control. Our finding
 s align with recent studies indicating that ecdysone is essential for tiss
 ue growth during the larval stage\, especially when ecdysone levels are lo
 w. At the end of larval development\, rising ecdysone levels trigger proli
 feration arrest and we show that growth becomes independent of ecdysone si
 gnaling suggesting a functional-dose dependent switch in ecdysone signalin
 g.
LOCATION:Buchleither-Seminarraum\, TP3 (INF 580\, Technology Park)
URL:https://www.dkfz.de/aktuelles/veranstaltungen/detail/49-khaoula-el-marz
 kioui-size-determination-and-role-of-the-steroid-hormone-ecdysone-during-w
 ing-growth-of-drosophila/a335
CATEGORIES:Vorträge und Seminare
ORGANIZER;CN="Andrea Kahlich":mailto:a.kahlich@dkfz-heidelberg.de
STATUS:CONFIRMED
SEQUENCE:1790690401
LAST-MODIFIED:20260929T140001Z
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