Supplementary Table 5: Human homologues of Drosophila genes with JAK/STAT phenotypes [pdf]
 
Drosophila Gene BlastP Identity [%] Human Gene RefSeq
Art2 1.60E-77 44.2 protein arginine N-methyltransferase 4 NP_062828.2
asf1 3.20E-68 61.7 ASF1 anti-silencing function 1 homolog A NP_054753.1
bin3 8.80E-49 34.3 hypothetical protein FLJ20257 NP_062552.2
bon 3.60E-45 30.5 tripartite motif-containing 33 protein NP_056990.2
Caf1 0 91.9 retinoblastoma binding protein 4 NP_005601.1
CG10007 8.80E-50 34.5 chromosome 2 open reading frame 18 NP_060347.2
CG10077 7.00E-171 67.7 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 NP_004387.1
CG10960 3.40E-78 36.9 solute carrier family 2, (facilitated glucose transporter) member 8 NP_055395.2
CG11696 5.10E-33 29.9 zinc finger protein 502 NP_149987.2
CG12460 1.80E-17 54.0 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) NP_005057.1
CG13473 3.90E-17 34.9 thioredoxin 2 precursor NP_036605.2
CG15306 3.30E-27 45.1 microtubule-associated protein, RP/EB family, member 1 NP_036457.1
CG15418 1.40E-10 41.1 tissue factor pathway inhibitor 2 NP_006519.1
CG15434 1.60E-17 50.6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa NP_002479.1
CG15706 6.60E-20 20.0 FLJ20160 protein NP_060164.2
CG16903 2.00E-100 63.1 cyclin L1 NP_064703.1
CG16975 4.00E-123 49.4 l(3)mbt-like 2 isoform a NP_113676.2
CG17492 0 48.3 zinc finger, ZZ type with ankyrin repeat domain 1 NP_543151.1
CG18112 1.80E-20 27.8 chromosome 14 open reading frame 133 NP_071350.2
CG30122 7.20E-42 40.9 E1B-55kDa-associated protein 5 isoform a NP_008971.2
CG3058 2.60E-80 95.8 thioredoxin-like 4 XP_499552.1
CG31005 9.00E-100 52.5 trans-prenyltransferase NP_055132.2
CG31132 0 49.9 bromo domain-containing protein disrupted in leukemia NP_694984.2
CG31358 2.10E-51 44.2 stomatin-like 3 NP_660329.1
CG31694 2.00E-66 36.3 interferon-related developmental regulator 2 NP_006755.3
CG32406 5.50E-15 37.8 C1 domain-containing phosphatase and tensin-like protein isoform 3 NP_938072.1
CG3281 4.00E-41 31.7 zinc finger protein 91 NP_003421.1
CG40351 2.20E-94 56.6 PREDICTED: KIAA1076 protein XP_037523.9
CG4349 4.60E-35 45.2 ferritin, heavy polypeptide 1 NP_002023.2
CG4446 1.90E-66 47.2 pyridoxal kinase NP_003672.1
CG4653 8.80E-23 30.7 protease, serine, 2 preproprotein NP_002761.1
CG4781 2.00E-17 33.8 PREDICTED: similar to KIAA0644 protein XP_379800.1
CG4907 1.10E-47 28.9 phosphatidylinositol glycan, class N NP_036459.1
CG6422 1.30E-71 53.8 YTH domain family, member 1 NP_060268.2
CG6434 6.20E-69 71.2 retinoblastoma binding protein 5 NP_005048.2
CG6946 4.00E-39 46.2 heterogeneous nuclear ribonucleoprotein F NP_004957
CG7635 2.90E-76 62.1 stomatin isoform a NP_004090.4
CG9086 0 32.0 ubiquitin protein ligase E3 component n-recognin 1 NP_777576.1
CkIIalpha 4.00E-163 88.7 casein kinase II alpha 1 subunit isoform a NP_001886.1
CkIIbeta 5.00E-107 89.2 casein kinase 2, beta polypeptide NP_001311.3
CtBP 8.00E-152 72.4 C-terminal binding protein 2 isoform 1 NP_001320.1
dome 7.60E-15 28.2 sidekick 2 NP_061937.2
dre4 0 59.9 chromatin-specific transcription elongation factor large subunit NP_009123.1
eIF-4B 4.70E-32 27.2 eukaryotic translation initiation factor 4B NP_001408.1
enok 1.80E-94 33.4 MYST histone acetyltransferase (monocytic leukemia) 3 NP_006757.1
HDC01676 2.80E-15 61.0 cholinergic receptor, nicotinic, alpha polypeptide 7 precursor NP_000737.1
hop 1.60E-59 26.7 Janus kinase 2 NP_004963.1
Ipk2 1.80E-26 33.6 inositol polyphosphate multikinase NP_689416.1
jbug 5.30E-45 27.6 filamin B, beta (actin binding protein 278) NP_001448.1
kn 0 69.7 early B-cell factor NP_076870.1
l(1)G0084 7.40E-28 31.5 PHD finger protein 10 isoform a NP_060758.1
larp 2.00E-103 48.1 KIAA0731 protein NP_056130.2
lig 5.50E-25 32.8 ubiquitin associated protein 2 isoform 2 NP_065918.1
mask 0 74.0 multiple ankyrin repeats, single KH-domain protein isoform 1 NP_060217.1
mst 7.00E-52 29.7 misato NP_060586.2
nonA 1.80E-60 40.6 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) NP_005057.1
Nup154 0 32.6 nucleoporin 155kDa isoform 1 NP_705618.1
par-1 0 54.1 MAP/microtubule affinity-regulating kinase 3 NP_002367.4
Pp1alpha-96A 8.00E-169 88.9 protein phosphatase 1, catalytic subunit, alpha isoform 1 NP_002699.1
PP2A-B' 0 78.9 delta isoform of regulatory subunit B56, protein phosphatase 2A isoform 1 NP_006236.1
Ptp61F 5.00E-32 37.9 hypothetical protein LOC9671 NP_055468
Rab5 4.90E-85 75.0 RAB5A, member RAS oncogene family NP_004153.2
Rrp1 6.10E-82 55.2 APEX nuclease NP_542380.1
Socs36E 4.80E-65 68.0 suppressor of cytokine signaling 5 NP_054730.1
Stat92E 6.40E-86 41.6 signal transducer and activator of transcription 5B NP_036580.2
Taf2 0 52.5 TBP-associated factor 2 NP_003175.1
TSG101 4.30E-98 48.7 tumor susceptibility gene 101 NP_006283.1
 
Shown are human homologues of Drosophila genes with a BlastP E value of 10E-10 or less.
 
 
 
 

Supplementary Table 6: Human disease homologues of Drosophila genes with JAK/STAT phenotypes [pdf]
 
Drosophila Gene BlastP Human Gene RefSeq Disease
CG10960 1,40E-39 erythrocyte/hepatoma glucose transporter NP_006507 Glucose transport defect, blood-brain barrier, 606777 (1)
CG11696 1,30E-11 "ikaros; ik1" NP_006051 Leukemia, acute lymphoblastic (1)
CG1391 2,80E-33 calcium-activated neutral protease 3 NP_000061 Muscular dystrophy, limb-girdle, type 2A, 253600 (1)
CG17492 1,00E-22 ankyrin, brain NP_001139 Long QT syndrome 4, 600919 (1)
CG17520 3,10E-17 cell division kinase 4 NP_000066 Melanoma (1)
CG18284 4,60E-46 acid cholesteryl ester hydrolase deficiency, type 2 NP_000226 Cholesteryl ester storage disease (1)
CG30092 6,00E-102 "actin-binding protein 280; abp280" NP_001447 Frontometaphyseal dysplasia, 304120 (1)
CG31780 3,70E-22 "enterokinase; entk" NP_002763 Enterokinase deficiency, 226200 (1)
CG31782 4,20E-13 "ikaros; ik1" NP_006051 Leukemia, acute lymphoblastic (1)
CG31783 1,20E-35 collagen receptor, platelet NP_000063 Platelet glycoprotein IV deficiency, 608404 (1)
CG3281 1,90E-18 "ikaros; ik1" NP_006051 Leukemia, acute lymphoblastic (1)
CG33106 1,80E-23 interferon-induced 2-5a-dependent rnase NP_066956 Prostate cancer 1, 176807, 601518 (1)
CG3664 4,70E-16 "oncogene nras; nras1" NP_002515 Colorectal cancer (1)
CG4236 9,90E-17 peroxin 7 NP_000279 Refsum disease, 266500 (1)
CG4349 3,50E-35 fth NP_002023 Iron overload, autosomal dominant (1)
CG7583 4,20E-24 "3-phosphogylcerate dehydrogenase; 3pgdh" NP_006614 Phosphoglycerate dehydrogenase deficiency, 601815 (1)
CG9181 1,00E-42 "protein-tyrosine phosphatase 2c; ptp2c" NP_002825 Leukemia, juvenile myelomonocytic, 607785 (1)
CG9712 4,40E-98 tumor susceptibility gene 101 NP_006283.1 Breast cancer (2)
CG9774 1,10E-11 lkb1 NP_000446 Melanoma, malignant sporadic (1)
HDC01676 2,90E-15 cholinergic receptor, nicotinic, alpha polypeptide-7 NP_000737.1 Schizophrenia (2)
Hop 8,40E-52 Janus kinase 3 NP_000206 SCID, autosomal recessive, T-negative/B-positive type (1)
Stat92E 6,50E-86 signal transducer and activator of transcription 5B NP_036580.2 Leukemia (2)
 
Shown are the relevant diseases of the human homologues with a BlastP E value of 10E-10 or less.
 
References
 
(1) data sets were downloaded from Homophila Version 2.1 (update 04.01.2005). Originally published:
Chien, S., Reiter, L. T., Bier, E. & Griboskov M. Homophila: human disease gene cognates in Drosophila. Nucleic Acids Research 30: 149-151 (2002)
 
(2) data sets from:
Online Mendelian Inheritance in Man, OMIM (TM). McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information, National Library of Medicine (Bethesda, MD), 2000.
World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/
 
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