Publications with contributions of the GPCF
Co-authorships of GPCF staff are indicated in bold.
- Castro F., Dirks W. G., Fahnrich S., Hotz-Wagenblatt A., Pawlita M., Schmitt M., (2013) High-throughput SNP-based authentication of human cell lines. Int J Cancer, 132:308-14
link to online source - Garding A., Bhattacharya N., Claus R., Ruppel M., Tschuch C., Filarsky K., Idler I., Zucknick M., Caudron-Herger M., Oakes C., Fleig V., Keklikoglou I., Allegra D., Serra L., Thakurela S., Tiwari V., Weichenhan D., Benner A., Radlwimmer B., Zentgraf H., Wiemann S., Rippe K., Plass C., Dohner H., Lichter P., Stilgenbauer S., Mertens D., (2013) Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB. PLoS Genet, 9:e1003373
link to online source - Issa A., Gill J. W., Heideman M. R., Sahin O., Wiemann S., Dey J. H., Hynes N. E., (2013) Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. Breast Cancer Res, 15:R8
link to online source - Klika K. D., (2013) Chiral Solid Solutions for the NMR Analysis of Enantiomers: A Potential New Approach to Chiral Analysis. Journal of Spectroscopy, 2013:
- Luo C., Tetteh P. W., Merz P. R., Dickes E., Abukiwan A., Hotz-Wagenblatt A., Holland-Cunz S., Sinnberg T., Schittek B., Schadendorf D., Diederichs S., Eichmuller S. B., (2013) miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes. J Invest Dermatol, 133:768-75
link to online source - Popanda O., Seibold P., Nikolov I., Oakes C. C., Burwinkel B., Hausmann S., Flesch-Janys D., Plass C., Chang-Claude J., Schmezer P., (2013) Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk. Int J Cancer, 132:55-62
link to online source - Ward A., Balwierz A., Zhang J. D., Kublbeck M., Pawitan Y., Hielscher T., Wiemann S., Sahin O., (2013) Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene, 32:1173-82
link to online source - Weischenfeldt J., Simon R., Feuerbach L., Schlangen K., Weichenhan D., Minner S., Wuttig D., Warnatz H. J., Stehr H., Rausch T., Jager N., Gu L., Bogatyrova O., Stutz A. M., Claus R., Eils J., Eils R., Gerhauser C., Huang P. H., Hutter B., Kabbe R., Lawerenz C., Radomski S., Bartholomae C. C., Falth M., Gade S., Schmidt M., Amschler N., Hass T., Galal R., Gjoni J., Kuner R., Baer C., Masser S., von Kalle C., Zichner T., Benes V., Raeder B., Mader M., Amstislavskiy V., Avci M., Lehrach H., Parkhomchuk D., Sultan M., Burkhardt L., Graefen M., Huland H., Kluth M., Krohn A., Sirma H., Stumm L., Steurer S., Grupp K., Sultmann H., Sauter G., Plass C., Brors B., Yaspo M. L., Korbel J. O., Schlomm T., (2013) Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell, 23:159-70
link to online source - Zeisel A., Yitzhaky A., Koerner C., Lauriola M., Cohen-Dvashi H., Kostler W. J., Yarden Y., Wiemann S., Domany E., (2013) qCMA: a desktop application for quantitative collective cell migration analysis. J Biomol Screen, 18:356-60
link to online source - Abba M., Laufs S., Aghajany M., Korn B., Benner A., Allgayer H., (2012) Look who's talking: deregulated signaling in colorectal cancer. Cancer Genomics Proteomics, 9:15-25
link to online source - Bahtz R., Seidler J., Arnold M., Haselmann-Weiss U., Antony C., Lehmann W. D., Hoffmann I., (2012) GCP6 is a substrate of Plk4 and required for centriole duplication. J Cell Sci, 125:486-96
link to online source - Balasubramanian P. G., Beckmann A., Warnken U., Schnolzer M., Schuler A., Bornberg-Bauer E., Holstein T. W., Ozbek S., (2012) Proteome of Hydra nematocyst. J Biol Chem, 287:9672-81
link to online source - Bierhaus A., Fleming T., Stoyanov S., Leffler A., Babes A., Neacsu C., Sauer S. K., Eberhardt M., Schnolzer M., Lasitschka F., Neuhuber W. L., Kichko T. I., Konrade I., Elvert R., Mier W., Pirags V., Lukic I. K., Morcos M., Dehmer T., Rabbani N., Thornalley P. J., Edelstein D., Nau C., Forbes J., Humpert P. M., Schwaninger M., Ziegler D., Stern D. M., Cooper M. E., Haberkorn U., Brownlee M., Reeh P. W., Nawroth P. P., (2012) Methylglyoxal modification of Na(v)1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat Med, 18:926-33
link to online source - Blauenburg B., Metsä-Ketelä M., Klika K. D., (2012) Formation of 5-Hydroxy-3-methoxy-1,4-naphthoquinone and 8-Hydroxy-4-methoxy-1,2-naphthoquinone from Juglone. ISRN Organic Chemistry, 2012:Article ID 274980
- Bocker M. T., Tuorto F., Raddatz G., Musch T., Yang F. C., Xu M., Lyko F., Breiling A., (2012) Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster. Nat Commun, 3:818
link to online source - Brodde A., Teigler A., Brugger B., Lehmann W. D., Wieland F., Berger J., Just W. W., (2012) Impaired neurotransmission in ether lipid-deficient nerve terminals. Hum Mol Genet, 21:2713-24
link to online source - Bronneke S., Bruckner B., Peters N., Bosch T. C., Stab F., Wenck H., Hagemann S., Winnefeld M., (2012) DNA methylation regulates lineage-specifying genes in primary lymphatic and blood endothelial cells. Angiogenesis, 15:317-29
link to online source - Campa D., Butterbach K., Slager S. L., Skibola C. F., de Sanjose S., Benavente Y., Becker N., Foretova L., Maynadie M., Cocco P., Staines A., Kaaks R., Boffetta P., Brennan P., Conde L., Bracci P. M., Caporaso N. E., Strom S. S., Camp N. J., Cerhan J. R., Consortium G., Canzian F., Nieters A., (2012) A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk. Int J Cancer, 131:803-12
link to online source - Dolnik A., Engelmann J. C., Scharfenberger-Schmeer M., Mauch J., Kelkenberg-Schade S., Haldemann B., Fries T., Kronke J., Kuhn M. W., Paschka P., Kayser S., Wolf S., Gaidzik V. I., Schlenk R. F., Rucker F. G., Dohner H., Lottaz C., Dohner K., Bullinger L., (2012) Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing. Blood, 120:e83-92
link to online source - Eichhorn T., Schloissnig S., Hahn B., Wendler A., Mertens R., Lehmann W. D., Krauth-Siegel R. L., Efferth T., (2012) Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells. Mol Biosyst, 8:1311-8
link to online source - Forster F., Beisser D., Grohme M. A., Liang C., Mali B., Siegl A. M., Engelmann J. C., Shkumatov A. V., Schokraie E., Muller T., Schnolzer M., Schill R. O., Frohme M., Dandekar T., (2012) Transcriptome analysis in tardigrade species reveals specific molecular pathways for stress adaptations. Bioinform Biol Insights, 6:69-96
link to online source - Fredebohm J., Boettcher M., Eisen C., Gaida M. M., Heller A., Keleg S., Tost J., Greulich-Bode K. M., Hotz-Wagenblatt A., Lathrop M., Giese N. A., Hoheisel J. D., (2012) Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PLoS One, 7:e48503
link to online source - Hagemann S., Kuck D., Stresemann C., Prinz F., Brueckner B., Mund C., Mumberg D., Sommer A., (2012) Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation. PLoS One, 7:e36125
link to online source - Jones D. T., Jager N., Kool M., Zichner T., Hutter B., Sultan M., Cho Y. J., Pugh T. J., Hovestadt V., Stutz A. M., Rausch T., Warnatz H. J., Ryzhova M., Bender S., Sturm D., Pleier S., Cin H., Pfaff E., Sieber L., Wittmann A., Remke M., Witt H., Hutter S., Tzaridis T., Weischenfeldt J., Raeder B., Avci M., Amstislavskiy V., Zapatka M., Weber U. D., Wang Q., Lasitschka B., Bartholomae C. C., Schmidt M., von Kalle C., Ast V., Lawerenz C., Eils J., Kabbe R., Benes V., van Sluis P., Koster J., Volckmann R., Shih D., Betts M. J., Russell R. B., Coco S., Tonini G. P., Schuller U., Hans V., Graf N., Kim Y. J., Monoranu C., Roggendorf W., Unterberg A., Herold-Mende C., Milde T., Kulozik A. E., von Deimling A., Witt O., Maass E., Rossler J., Ebinger M., Schuhmann M. U., Fruhwald M. C., Hasselblatt M., Jabado N., Rutkowski S., von Bueren A. O., Williamson D., Clifford S. C., McCabe M. G., Collins V. P., Wolf S., Wiemann S., Lehrach H., Brors B., Scheurlen W., Felsberg J., Reifenberger G., Northcott P. A., Taylor M. D., Meyerson M., Pomeroy S. L., Yaspo M. L., Korbel J. O., Korshunov A., Eils R., Pfister S. M., Lichter P., (2012) Dissecting the genomic complexity underlying medulloblastoma. Nature, 488:100-5
link to online source - Jurmeister S., Baumann M., Balwierz A., Keklikoglou I., Ward A., Uhlmann S., Zhang J. D., Wiemann S., Sahin O., (2012) MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F. Mol Cell Biol, 32:633-51
link to online source - Keklikoglou I., Koerner C., Schmidt C., Zhang J. D., Heckmann D., Shavinskaya A., Allgayer H., Guckel B., Fehm T., Schneeweiss A., Sahin O., Wiemann S., Tschulena U., (2012) MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kappaB and TGF-beta signaling pathways. Oncogene, 31:4150-63
link to online source - Klika K. D., (2012) Differentiation Between 6- and 7-Membered Rings Based on Theoretical Calculation of NMR Parameters. ISRN Spectroscopy, 2012:Article 697156
- Klika K. D., (2012) Suggested New Terms for Describing Chiral States and the State-Dependent Behavior of Chiral Systems. International Journal of Organic Chemistry, 2:224-32
- Klika K. D., (2012) Application of the PROJECT concept for suppression of J modulation to DEPT for 13C-multilabeled analytes. Org Lett, 14:524-7
link to online source - Klika K. D., Tähtinen P., Mäntsälä P., Niemi J., Metsä-Ketelä M., (2012) The potential of VCD to resolve the epimer vs. inverse epimer quandary. Computational and Theoretical Chemistry, 992:156-163
- Koch C. M., Joussen S., Schellenberg A., Lin Q., Zenke M., Wagner W., (2012) Monitoring of cellular senescence by DNA-methylation at specific CpG sites. Aging Cell, 11:366-9
link to online source - Koch C. M., Reck K., Shao K., Lin Q., Joussen S., Ziegler P., Walenda G., Drescher W., Opalka B., May T., Brummendorf T. H., Zenke M., Saric T., Wagner W., (2012) Pluripotent stem cells escape from senescence-associated DNA methylation changes. Genome Res, 23:248-59
link to online source - Kwon H. S., Lim H. W., Wu J., Schnolzer M., Verdin E., Ott M., (2012) Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol, 188:2712-21
link to online source - Lemke D., Pfenning P. N., Sahm F., Klein A. C., Kempf T., Warnken U., Schnolzer M., Tudoran R., Weller M., Platten M., Wick W., (2012) Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness. Clin Cancer Res, 18:105-17
link to online source - Lisauskas T., Matula P., Claas C., Reusing S., Wiemann S., Erfle H., Lehmann L., Fischer P., Eils R., Rohr K., Storrie B., Starkuviene V., (2012) Live-cell assays to identify regulators of ER-to-Golgi trafficking. Traffic, 13:416-32
link to online source - Mohr K., Koegl M., (2012) High-throughput yeast two-hybrid screening of complex cDNA libraries. Methods Mol Biol, 812:89-102
link to online source - Oja T., Klika K. D., Appassamy L., Sinkkonen J., Mantsala P., Niemi J., Metsa-Ketela M., (2012) Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage. Proc Natl Acad Sci U S A, 109:6024-9
link to online source - Oja T., Tähtinen P., Dreiack N., Mäntsälä P., Niemi J., Metsä-Ketelä M., Klika K. D., (2012) Alnumycins A2 and A3: new inverse-epimeric pairs stereoisomeric to alnumycin A1. Tetrahedron-Asymmetry, 23:670-682
- Palani S., Meitinger F., Boehm M. E., Lehmann W. D., Pereira G., (2012) Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation. J Cell Sci, 125:3091-6
link to online source - Patrikainen P., Kallio P., Fan K., Klika K. D., Shaaban K. A., Mäntsälä P., Rohr J., Yang K., Niemi J., Metsä-Ketelä M., (2012) Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities. Chem Biol, 19:647-55
link to online source - Pipkorn R., Wiessler M., Waldeck W., Hennrich U., Nokihara K., Beining M., Braun K., (2012) Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging. Int J Med Sci, 9:1-10
link to online source - Rausch V., Liu L., Apel A., Rettig T., Gladkich J., Labsch S., Kallifatidis G., Kaczorowski A., Groth A., Gross W., Gebhard M. M., Schemmer P., Werner J., Salnikov A. V., Zentgraf H., Buchler M. W., Herr I., (2012) Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment. J Pathol, 227:325-35
link to online source - Schleich K., Warnken U., Fricker N., Ozturk S., Richter P., Kammerer K., Schnolzer M., Krammer P. H., Lavrik I. N., (2012) Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model. Mol Cell, 47:306-19
link to online source - Schokraie E., Warnken U., Hotz-Wagenblatt A., Grohme M. A., Hengherr S., Forster F., Schill R. O., Frohme M., Dandekar T., Schnolzer M., (2012) Comparative proteome analysis of Milnesium tardigradum in early embryonic state versus adults in active and anhydrobiotic state. PLoS One, 7:e45682
link to online source - Schroder S., Cho S., Zeng L., Zhang Q., Kaehlcke K., Mak L., Lau J., Bisgrove D., Schnolzer M., Verdin E., Zhou M. M., Ott M., (2012) Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem, 287:1090-9
link to online source - Shamu C. E., Wiemann S., Boutros M., (2012) On target: a public repository for large-scale RNAi experiments. Nat Cell Biol, 14:115
link to online source - Shao K., Koch C., Gupta M. K., Lin Q., Lenz M., Laufs S., Denecke B., Schmidt M., Linke M., Hennies H. C., Hescheler J., Zenke M., Zechner U., Saric T., Wagner W., (2012) Induced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-derived Differences in DNA Methylation Profiles. Mol Ther, 21:240-50
link to online source - Simpson J. C., Joggerst B., Laketa V., Verissimo F., Cetin C., Erfle H., Bexiga M. G., Singan V. R., Heriche J. K., Neumann B., Mateos A., Blake J., Bechtel S., Benes V., Wiemann S., Ellenberg J., Pepperkok R., (2012) Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nat Cell Biol, 14:764-74
link to online source - Spaich S., Will R. D., Just S., Spaich S., Kuhn C., Frank D., Berger I.M., Wiemann S., Korn B., Koegl M., Backs J., Katus H. A., Rottbauer W., Frey N., (2012) Fbxl22, A Cardiac-Enriched F-Box Protein, Regulates Sarcomeric Protein Turnover and is Essential for Maintenance of Contractile Function In Vivo. Circ Res, 111:Epub ahead of print
link to online source - Sturm D., Witt H., Hovestadt V., Khuong-Quang D. A., Jones D. T., Konermann C., Pfaff E., Tonjes M., Sill M., Bender S., Kool M., Zapatka M., Becker N., Zucknick M., Hielscher T., Liu X. Y., Fontebasso A. M., Ryzhova M., Albrecht S., Jacob K., Wolter M., Ebinger M., Schuhmann M. U., van Meter T., Fruhwald M. C., Hauch H., Pekrun A., Radlwimmer B., Niehues T., von Komorowski G., Durken M., Kulozik A. E., Madden J., Donson A., Foreman N. K., Drissi R., Fouladi M., Scheurlen W., von Deimling A., Monoranu C., Roggendorf W., Herold-Mende C., Unterberg A., Kramm C. M., Felsberg J., Hartmann C., Wiestler B., Wick W., Milde T., Witt O., Lindroth A. M., Schwartzentruber J., Faury D., Fleming A., Zakrzewska M., Liberski P. P., Zakrzewski K., Hauser P., Garami M., Klekner A., Bognar L., Morrissy S., Cavalli F., Taylor M. D., van Sluis P., Koster J., Versteeg R., Volckmann R., Mikkelsen T., Aldape K., Reifenberger G., Collins V. P., Majewski J., Korshunov A., Lichter P., Plass C., Jabado N., Pfister S. M., (2012) Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma. Cancer Cell, 22:425-37
link to online source - Tähtinen P., Oja T., Dreiack N., Mäntsälä P., Niemi J., Metsä-Ketelä M., Klika K. D., (2012) Epimers vs. inverse epimers: the C-1 configuration in alnumycin A1. Rsc Advances, 2:5098-5100
- Uhlmann S., Mannsperger H., Zhang J. D., Horvat E. A., Schmidt C., Kublbeck M., Henjes F., Ward A., Tschulena U., Zweig K., Korf U., Wiemann S., Sahin O., (2012) Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. Mol Syst Biol, 8:570
link to online source - Winnefeld M., Brueckner B., Gronniger E., Stab F., Wenck H., Lyko F., (2012) Stable ethnic variations in DNA methylation patterns of human skin. J Invest Dermatol, 132:466-8
link to online source - Adamczyk K. A., Klein-Scory S., Tehrani M. M., Warnken U., Schmiegel W., Schnolzer M., Schwarte-Waldhoff I., (2011) Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. Life Sci, 89:304-12
link to online source - Amann P. M., Schadendorf D., Owen R. W., Korn B., Eichmuller S. B., Bazhin A. V., (2011) Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT. Exp Dermatol, 20:373-5
link to online source - Bachmann J., Raue A., Schilling M., Bohm M. E., Kreutz C., Kaschek D., Busch H., Gretz N., Lehmann W. D., Timmer J., Klingmuller U., (2011) Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Mol Syst Biol, 7:516
link to online source - Bai S.W., Herrera-Abreu M.T., Rohn J., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J., (2011) A novel strategy to identify and characterize a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. BMC Biology, 9:54
link to online source - Bartholomae C. C., Arens A., Balaggan K. S., Yanez-Munoz R. J., Montini E., Howe S. J., Paruzynski A., Korn B., Appelt J. U., Macneil A., Cesana D., Abel U., Glimm H., Naldini L., Ali R. R., Thrasher A. J., von Kalle C., Schmidt M., (2011) Lentiviral vector integration profiles differ in rodent postmitotic tissues. Mol Ther, 19:703-10
link to online source - Bender C., Heyde S., Henjes F., Wiemann S., Korf U., Beissbarth T., (2011) Inferring signalling networks from longitudinal data using sampling based approaches in the R-package 'ddepn'. BMC Bioinformatics, 12:291
link to online source - Blomberg J., Sheikholvaezin A., Elfaitouri A., Blomberg F., Sjosten A., Mattson Ulfstedt J., Pipkorn R., Kallander C., Ohrmalm C., Sperber G., (2011) Phylogeny-directed search for murine leukemia virus-like retroviruses in vertebrate genomes and in patients suffering from myalgic encephalomyelitis/chronic fatigue syndrome and prostate cancer. Adv Virol, 2011:341294
link to online source - Bocker M. T., Hellwig I., Breiling A., Eckstein V., Ho A. D., Lyko F., (2011) Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood, 117:e182-9
link to online source - Breitling L. P., Yang R., Korn B., Burwinkel B., Brenner H., (2011) Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet, 88:450-7
link to online source - Campa D., Husing A., Stein A., Dostal L., Boeing H., Pischon T., Tjonneland A., Roswall N., Overvad K., Ostergaard J. N., Rodriguez L., Sala N., Sanchez M. J., Larranaga N., Huerta J. M., Barricarte A., Khaw K. T., Wareham N., Travis R. C., Allen N. E., Lagiou P., Trichopoulou A., Trichopoulos D., Palli D., Sieri S., Tumino R., Sacerdote C., van Kranen H., Bueno-de-Mesquita H. B., Hallmans G., Johansson M., Romieu I., Jenab M., Cox D. G., Siddiq A., Riboli E., Canzian F., Kaaks R., (2011) Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). PLoS One, 6:e16914
link to online source - Capper D., Preusser M., Habel A., Sahm F., Ackermann U., Schindler G., Pusch S., Mechtersheimer G., Zentgraf H., von Deimling A., (2011) Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol, 122:11-9
link to online source - Chiocchetti A., Pakalapati G., Duketis E., Wiemann S., Poustka A., Poustka F., Klauck S. M., (2011) Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. Am J Med Genet A, 155A:1472-5
link to online source - Dafinger C., Liebau M. C., Elsayed S. M., Hellenbroich Y., Boltshauser E., Korenke G. C., Fabretti F., Janecke A. R., Ebermann I., Nurnberg G., Nurnberg P., Zentgraf H., Koerber F., Addicks K., Elsobky E., Benzing T., Schermer B., Bolz H. J., (2011) Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J Clin Invest, 121:2662-7
link to online source - Edelson-Averbukh M., Shevchenko A., Pipkorn R., Lehmann W. D., (2011) Discrimination between peptide O-sulfo- and O-phosphotyrosine residues by negative ion mode electrospray tandem mass spectrometry. J Am Soc Mass Spectrom, 22:2256-68
link to online source - Faber K., Glatting K. H., Mueller P. J., Risch A., Hotz-Wagenblatt A., (2011) Genome-wide prediction of splice-modifying SNPs in human genes using a new analysis pipeline called AASsites. BMC Bioinformatics, 12 Suppl 4:S2
link to online source - Felix K., Fakelman F., Hartmann D., Giese N. A., Gaida M. M., Schnolzer M., Flad T., Buchler M. W., Werner J., (2011) Identification of serum proteins involved in pancreatic cancer cachexia. Life Sci, 88:218-25
link to online source - Gabriel R., Lombardo A., Arens A., Miller J. C., Genovese P., Kaeppel C., Nowrouzi A., Bartholomae C. C., Wang J., Friedman G., Holmes M. C., Gregory P. D., Glimm H., Schmidt M., Naldini L., von Kalle C., (2011) An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol, 29:816-23
link to online source - Giordano F. A., Sorg U. R., Appelt J. U., Lachmann N., Bleier S., Roeder I., Kleff V., Flasshove M., Zeller W. J., Allgayer H., von Kalle C., Fruehauf S., Moritz T., Laufs S., (2011) Clonal inventory screens uncover monoclonality following serial transplantation of MGMT P140K-transduced stem cells and dose-intense chemotherapy. Hum Gene Ther, 22:697-710
link to online source - Hagemann S., Heil O., Lyko F., Brueckner B., (2011) Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PLoS One, 6:e17388
link to online source - Hahn B., Bohm M., Raia V., Zinn N., Moller P., Klingmuller U., Lehmann W. D., (2011) One-source peptide/phosphopeptide standards for accurate phosphorylation degree determination. Proteomics, 11:490-4
link to online source - Kalay E., Yigit G., Aslan Y., Brown K. E., Pohl E., Bicknell L. S., Kayserili H., Li Y., Tuysuz B., Nurnberg G., Kiess W., Koegl M., Baessmann I., Buruk K., Toraman B., Kayipmaz S., Kul S., Ikbal M., Turner D. J., Taylor M. S., Aerts J., Scott C., Milstein K., Dollfus H., Wieczorek D., Brunner H. G., Hurles M., Jackson A. P., Rauch A., Nurnberg P., Karaguzel A., Wollnik B., (2011) CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat Genet, 43:23-6
link to online source - Kaltner H., Kubler D., Lopez-Merino L., Lohr M., Manning J. C., Lensch M., Seidler J., Lehmann W. D., Andre S., Solis D., Gabius H. J., (2011) Toward comprehensive analysis of the galectin network in chicken: unique diversity of galectin-3 and comparison of its localization profile in organs of adult animals to the other four members of this lectin family. Anat Rec (Hoboken), 294:427-44
link to online source - Karskela T., Klika K. D., Lonnberg H., (2011) SYNTHESIS OF 7-SUBSTITUTED 3-beta-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES. Collection of Czechoslovak Chemical Communications, 76:1043-1054
- Klika K. D., (2011) Proposed Extension to the Natta Projection Notation System for Enabling an Indication of Relative Stereochemistry and the Stereochemical State. International Journal of Organic Chemistry, 1:215-7
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link to online source - Raia V., Schilling M., Bohm M., Hahn B., Kowarsch A., Raue A., Sticht C., Bohl S., Saile M., Moller P., Gretz N., Timmer J., Theis F., Lehmann W. D., Lichter P., Klingmuller U., (2011) Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets. Cancer Res, 71:693-704
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link to online source - Seidler J., Zinn N., Haaf E., Boehm M. E., Winter D., Schlosser A., Lehmann W. D., (2011) Metal ion-mobilizing additives for comprehensive detection of femtomole amounts of phosphopeptides by reversed phase LC-MS. Amino Acids, 41:311-20
link to online source - Swiersy A., Wiek C., Reh J., Zentgraf H., Lindemann D., (2011) Orthoretroviral-like prototype foamy virus Gag-Pol expression is compatible with viral replication. Retrovirology, 8:66
link to online source - Tahoun A., Siszler G., Spears K., McAteer S., Tree J., Paxton E., Gillespie T. L., Martinez-Argudo I., Jepson M. A., Shaw D. J., Koegl M., Haas J., Gally D. L., Mahajan A., (2011) Comparative analysis of EspF variants in inhibition of Escherichia coli phagocytosis by macrophages and inhibition of E. coli translocation through human- and bovine-derived M cells. Infect Immun, 79:4716-29
link to online source - Wiessler M., Hennrich U., Pipkorn R., Waldeck W., Cao L., Peter J., Ehemann V., Semmler W., Lammers T., Braun K., (2011) Theranostic cRGD-BioShuttle Constructs Containing Temozolomide- and Cy7 For NIR-Imaging and Therapy. Theranostics, 1:381-94
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link to online source - Andrulis M., Capper D., Luft T., Hartmann C., Zentgraf H., von Deimling A., (2010) Detection of isocitrate dehydrogenase 1 mutation R132H in myelodysplastic syndrome by mutation-specific antibody and direct sequencing. Leuk Res, 34:1091-3
link to online source - Andrulis M., Capper D., Meyer J., Penzel R., Hartmann C., Zentgraf H., von Deimling A., (2010) IDH1 R132H mutation is a rare event in myeloproliferative neoplasms as determined by a mutation specific antibody. Haematologica, 95:1797-8
link to online source - Barbosa S., Pratte D., Schwarz H., Pipkorn R., Singer-Kruger B., (2010) Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex. Traffic, 11:1092-106
link to online source - Beckhove P., Warta R., Lemke B., Stoycheva D., Momburg F., Schnolzer M., Warnken U., Schmitz-Winnenthal H., Ahmadi R., Dyckhoff G., Bucur M., Junger S., Schueler T., Lennerz V., Woelfel T., Unterberg A., Herold-Mende C., (2010) Rapid T cell-based identification of human tumor tissue antigens by automated two-dimensional protein fractionation. J Clin Invest, 120:2230-42
link to online source - Bedlovicova Z., Imrich J., Kristian P., Danihel I., Bohm S., Sabolova D., Kozurkova M., Paulikova H., Klika K. D., (2010) Novel Carbohydrazide and Hydrazone Biomarkers Based on 9-Substituted Acridine and Anthracene Fluorogens. Heterocycles, 80:1047-1066
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link to online source - Bock B. C., Tagscherer K. E., Fassl A., Kramer A., Oehme I., Zentgraf H. W., Keith M., Roth W., (2010) The PEA-15 protein regulates autophagy via activation of JNK. J Biol Chem, 285:21644-54
link to online source - Bork S., Pfister S., Witt H., Horn P., Korn B., Ho A. D., Wagner W., (2010) DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell, 9:54-63
link to online source - Bourbeillon J., Orchard S., Benhar I., Borrebaeck C., de Daruvar A., Dubel S., Frank R., Gibson F., Gloriam D., Haslam N., Hiltker T., Humphrey-Smith I., Hust M., Juncker D., Koegl M., Konthur Z., Korn B., Krobitsch S., Muyldermans S., Nygren P. A., Palcy S., Polic B., Rodriguez H., Sawyer A., Schlapshy M., Snyder M., Stoevesandt O., Taussig M. J., Templin M., Uhlen M., van der Maarel S., Wingren C., Hermjakob H., Sherman D., (2010) Minimum information about a protein affinity reagent (MIAPAR). Nat Biotechnol, 28:650-3
link to online source - Braun K., Dunsch L., Pipkorn R., Bock M., Baeuerle T., Yang S., Waldeck W., Wiessler M., (2010) Gain of a 500-fold sensitivity on an intravital MR contrast agent based on an endohedral gadolinium-cluster-fullerene-conjugate: a new chance in cancer diagnostics. Int J Med Sci, 7:136-46
link to online source - Braun K., Wiessler M., Pipkorn R., Ehemann V., Bauerle T., Fleischhacker H., Muller G., Lorenz P., Waldeck W., (2010) A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv "Click Chemistry" targeted to alphavbeta3 integrin for therapy. Int J Med Sci, 7:326-39
link to online source - Busse C., Feederle R., Schnolzer M., Behrends U., Mautner J., Delecluse H. J., (2010) Epstein-Barr viruses that express a CD21 antibody provide evidence that gp350's functions extend beyond B-cell surface binding. J Virol, 84:1139-47
link to online source - Capper D., Weissert S., Balss J., Habel A., Meyer J., Jager D., Ackermann U., Tessmer C., Korshunov A., Zentgraf H., Hartmann C., von Deimling A., (2010) Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol, 20:245-54
link to online source - Chin R., Nachbur U., Earnest-Silveira L., Bankovacki A., Koeberlein B., Zentgraf H., Bock C. T., Silke J., Torresi J., (2010) Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus. Virus Res, 147:7-16
link to online source - Dani D., Shimokawa I., Komatsu T., Higami Y., Warnken U., Schokraie E., Schnolzer M., Krause F., Sugawa M. D., Dencher N. A., (2010) Modulation of oxidative phosphorylation machinery signifies a prime mode of anti-ageing mechanism of calorie restriction in male rat liver mitochondria. Biogerontology, 11:321-34
link to online source - Derrer B., Windeisen V., Guedez Rodriguez G., Seidler J., Gengenbacher M., Lehmann W. D., Rippe K., Sinning I., Tews I., Kappes B., (2010) Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase. FEBS Lett, 584:4169-74
link to online source - Dietz L., Esser P. R., Schmucker S. S., Goette I., Richter A., Schnolzer M., Martin S. F., Thierse H. J., (2010) Tracking human contact allergens: from mass spectrometric identification of peptide-bound reactive small chemicals to chemical-specific naive human T-cell priming. Toxicol Sci, 117:336-47
link to online source - Eck W., Nicholson A. I., Zentgraf H., Semmler W., Bartling S., (2010) Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice. Nano Lett, 10:2318-22
link to online source - Emerson V., Holtkotte D., Pfeiffer T., Wang I. H., Schnolzer M., Kempf T., Bosch V., (2010) Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein. J Virol, 84:1355-65
link to online source - Erlbruch A., Hung C. W., Seidler J., Borrmann K., Gesellchen F., Konig N., Kubler D., Herberg F. W., Lehmann W. D., Bossemeyer D., (2010) Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. Proteomics, 10:2890-900
link to online source - Gdynia G., Keith M., Kopitz J., Bergmann M., Fassl A., Weber A. N., George J., Kees T., Zentgraf H. W., Wiestler O. D., Schirmacher P., Roth W., (2010) Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria. Cancer Res, 70:8558-68
link to online source - Gloriam D. E., Orchard S., Bertinetti D., Bjorling E., Bongcam-Rudloff E., Borrebaeck C. A., Bourbeillon J., Bradbury A. R., de Daruvar A., Dubel S., Frank R., Gibson T. J., Gold L., Haslam N., Herberg F. W., Hiltke T., Hoheisel J. D., Kerrien S., Koegl M., Konthur Z., Korn B., Landegren U., Montecchi-Palazzi L., Palcy S., Rodriguez H., Schweinsberg S., Sievert V., Stoevesandt O., Taussig M. J., Ueffing M., Uhlen M., van der Maarel S., Wingren C., Woollard P., Sherman D. J., Hermjakob H., (2010) A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics, 9:1-10
link to online source - Gronniger E., Weber B., Heil O., Peters N., Stab F., Wenck H., Korn B., Winnefeld M., Lyko F., (2010) Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet, 6:e1000971
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link to online source - Klika K. D., Budovska M., Kutschy P., (2010) NMR spectral enantioresolution of spirobrassinin and 1-methoxyspirobrassinin enantiomers using (S)-(-)-ethyl lactate and modeling of spirobrassinin self-association for rationalization of its self-induced diastereomeric anisochromism (SIDA) and enantiomer self-disproportionation on achiral-phase chromatography (ESDAC) phenomena. Journal of Fluorine Chemistry, 131:467-476
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link to online source - Mali B., Grohme M. A., Forster F., Dandekar T., Schnolzer M., Reuter D., Welnicz W., Schill R. O., Frohme M., (2010) Transcriptome survey of the anhydrobiotic tardigrade Milnesium tardigradum in comparison with Hypsibius dujardini and Richtersius coronifer. BMC Genomics, 11:168
link to online source - Meitinger F., Petrova B., Lombardi I. M., Bertazzi D. T., Hub B., Zentgraf H., Pereira G., (2010) Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast. J Cell Sci, 123:1851-61
link to online source - Moosmeier M. A., Bulkescher J., Reed J., Schnolzer M., Heid H., Hoppe-Seyler K., Hoppe-Seyler F., (2010) Transtactin: a universal transmembrane delivery system for Strep-tag II-fused cargos. J Cell Mol Med, 14:1935-45
link to online source - Mora R., Dokic I., Kees T., Huber C. M., Keitel D., Geibig R., Brugge B., Zentgraf H., Brady N. R., Regnier-Vigouroux A., (2010) Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma. Glia, 58:1364-83
link to online source - Pagans S., Kauder S. E., Kaehlcke K., Sakane N., Schroeder S., Dormeyer W., Trievel R. C., Verdin E., Schnolzer M., Ott M., (2010) The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe, 7:234-44
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link to online source - Rickelt S., Rizzo S., Doerflinger Y., Zentgraf H., Basso C., Gerosa G., Thiene G., Moll R., Franke W. W., (2010) A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata. Mod Pathol, 23:1429-37
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link to online source - Roesch-Ely M., Schnolzer M., Nees M., Plinkert P. K., Bosch F. X., (2010) Reference spectra from squamous epithelium and connective tissue allow whole section proteomics analysis. Arch Physiol Biochem, 116:218-26
link to online source - Schokraie E., Hotz-Wagenblatt A., Warnken U., Mali B., Frohme M., Forster F., Dandekar T., Hengherr S., Schill R. O., Schnolzer M., (2010) Proteomic analysis of tardigrades: towards a better understanding of molecular mechanisms by anhydrobiotic organisms. PLoS One, 5:e9502
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link to online source - Sela N., Mersch B., Hotz-Wagenblatt A., Ast G., (2010) Characteristics of transposable element exonization within human and mouse. PLoS One, 5:e10907
link to online source - Soza-Ried J., Hotz-Wagenblatt A., Glatting K. H., del Val C., Fellenberg K., Bode H. R., Frank U., Hoheisel J. D., Frohme M., (2010) The transcriptome of the colonial marine hydroid Hydractinia echinata. FEBS J, 277:197-209
link to online source - Stirnnagel K., Luftenegger D., Stange A., Swiersy A., Mullers E., Reh J., Stanke N., Grosse A., Chiantia S., Keller H., Schwille P., Hanenberg H., Zentgraf H., Lindemann D., (2010) Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles. Retrovirology, 7:45
link to online source - Uhlmann S., Zhang J. D., Schwager A., Mannsperger H., Riazalhosseini Y., Burmester S., Ward A., Korf U., Wiemann S., Sahin O., (2010) miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene, 29:4297-306
link to online source - Volkmann M., Luithle D., Zentgraf H., Schnolzer M., Fiedler S., Heid H., Schulze-Bergkamen A., Strassburg C. P., Gehrke S. G., Manns M. P., (2010) SLA/LP/tRNP((Ser)Sec) antigen in autoimmune hepatitis: identification of the native protein in human hepatic cell extract. J Autoimmun, 34:59-65
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link to online source - Winter D., Seidler J., Hahn B., Lehmann W. D., (2010) Structural and mechanistic Information on c(1) ion formation in collision-induced fragmentation of peptides. J Am Soc Mass Spectrom, 21:1814-20
link to online source - Winter D., Seidler J., Kugelstadt D., Derrer B., Kappes B., Lehmann W. D., (2010) Minimally permutated peptide analogs as internal standards for relative and absolute quantification of peptides and proteins. Proteomics, 10:1510-4
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link to online source - Apel A., Zentgraf H., Buchler M. W., Herr I., (2009) Autophagy-A double-edged sword in oncology. Int J Cancer, 125:991-5
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link to online source - Bonemann G., Pietrosiuk A., Diemand A., Zentgraf H., Mogk A., (2009) Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion. EMBO J, 28:315-25
link to online source - Borner A., Warnken U., Schnolzer M., Hagen J., Giese N., Bauer A., Hoheisel J., (2009) Subcellular protein extraction from human pancreatic cancer tissues. Biotechniques, 46:297-304
link to online source - Braun A., Treede I., Gotthardt D., Tietje A., Zahn A., Ruhwald R., Schoenfeld U., Welsch T., Kienle P., Erben G., Lehmann W. D., Fuellekrug J., Stremmel W., Ehehalt R., (2009) Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis. Inflamm Bowel Dis, 15:1705-20
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