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Functional Genome Analysis  (B070)
Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580
D-69120 Heidelberg, Germany.
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Publications Apart from publications in scientific journals, the division filed a total of 42 patents since 1995.
  





   2011 to 1994  (to 1986)
  1. Keller, A., Leidinger, P., Bauer, A., ElSharawi, A., Haas, J., Backes, C., Wendschlag, A., Giese, N., Tjaden, C., Ott, K., Werner, J., Hackert, T., Ruprecht, K., Huwer, H., Huebers, J., Jacobs, G., Rosenstiel, P., Dommisch, H., Schäfer, A., Müller-Quernheim, J., Wullich, B., Keck, B., Graf, N., Reichrath, J., Vogel, B., Nebel, A., Jager, S.U., Staehler, P., Amarantos, I., Boisguerin, V., Staehler, C., Beier, M., Scheffler, M., Büchler, M.W., Wischhusen, J., Häusler, S.F.M., Dietl, J., Hofmann, S., Lenhof, H.P., Schreiber, S., Katus, H.A., Rottbauer, W., Meder, B., Hoheisel, J.D., Franke, A. & Meese, E. (2011). Towards discovering the blood-born miRNome of human diseases. Nature Meth. 8, 841-843.
  2. Friedrich, A., Hoheisel, J.D., Knemeyer, J.-P. & Marmé, N. (2011). A universally applicable process for preparing stoichiometrically 1:1 labelled functional proteins. Proteomics 11, 3757-3760.
  3. Rizzato, C., Campa, D., Giese, N.,Werner, J., Rachakonda, S.P., Kumar, R., Schanné, M., Greenhalf, W., Costello, E., Khaw, K.T., Key, T.J., Siddiq, A., Lorenzo-Bermejo, J., Burwinkel, B., Neoptolemos, J.P., Büchler, M.W., Hoheisel, J.D., Bauer, A. & Canzian, F. (2011). Pancreatic cancer susceptibility loci and their role in survival. PLoS ONE, in press.
  4. Moskalev, E.A., Schubert, M. & Hoheisel, J.D. (2011). RNA-directed epigenomic reprogramming – an emerging principle of a more targeted cancer therapy? Genes Chrom. Cancer 51, 105-110.
  5. Dorer, D.E., Holtrup, F., Fellenberg, K., Engelhardt, E., Hoheisel, J.D. & Nettelbeck, D.M. (2011). Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells – differences of relevance for adenoviral oncolysis. PLoS ONE 6, e27934.
  6. Hoheisel, J.D. (2011). DNA-Microarray Technologie. Bioanalytik (Lottspeich, E. & Engels, J.W., eds.), Elsevier, Heidelberg, in press.
  7. Moskalev, E.A., Zavgorodnij, M.G., Majorova, S.P., Vorobjev, I.A., Jandaghi, P., Bure, I.V. & Hoheisel, J.D. (2011). Correction of PCR-bias in quantitative DNA methylation studies by means of cubic polynomial regression. Nucleic Acids Res. 39, e77.
  8. Mustafa, S.A., Hoheisel, J.D. & Alhamdani, M.S.S. (2011). Secretome profiling with antibody microarrays. Mol. Biosyst. 7, 1795-1801.
  9. Yepes, D., Jacob, A., Dauber, M., Costina, V., Hofheinz, R., Neumaier, M. & Findeisen, P. (2011). Substrate optimization and clinical validation of reporter peptides for MS-based protease profiling in serum specimens: a new approach for diagnosis of malignant diseases. Int. J. Oncol. 39, 145-154.
  10. de Souza Rocha Simonini, P., Riazalhosseini, Y. & Hoheisel, J.D. (2011). Eine kleine Ribonukleinsäure mit großer Wirkung bei hormonsensitiven Brusttumoren. Geburtsh. & Frauenheilk. 71, 878-879.
  11. Nibret, E., Youns, M., Krauth-Siegel, R.L. & Wink, M. (2011). Biological activities of Xanthatin from Xanthium strumarium leaves. Phytother. Res., in press.
  12. Bondar, A.N., Knapp-Mohammady, M., Suhai, S., Fischer, S. & Smith, J.C. (2011). The ground-state properties of the retinal revisited: quantum mechanical and classical mechanical computations of retinal proteins. Theor. Chem. Acc., in press.
  13. March, N.H. & Knapp-Mohammady, M. (2011). The inhomogeneous electron liquid in the ligand estradiol compared and contrasted with that in estrone. Phys. Chem. Liq., in press.
  14. Piva, J.A.A.C., Silva, J.L.R., Raniero, L., Jalkanen, K.J., Martin, A.A. & Bohr, H.G. (2011). Overview of the use of theoriy to understand infrared and Raman spectra and images of biomolecules: colorectal cancer as an example. Theor. Chem. Acc., in press.
  15. Schmidt, R., Jacak, J., Schirwitz, C., Stadler, V., Michel, G., Marmé, N., Schütz, G.J., Hoheisel, J.D. & Knemeyer, J.-P. (2011). Single-molecule detection on a protein-array assay platform for the exposure of a tuberculosis antigen. J. Proteome Res.10, 1316-1322.
  16. Holtrup, F., Bauer, A., Fellenberg, K., Hilger, R.A., Wink, M. & Hoheisel, J.D. (2011). Nemorosone specifically inhibits growth of pancreatic cancer cells and induces apoptosis via activation of the unfolded protein response (UPR). Brit. J. Pharmacol. 162, 1045-1059.
  17. Alhamdani, M.S. & Hoheisel, J.D. (2011). Antibody microarrays in proteome profiling. Molecular Analysis and Genome Discovery (Rapley, R & Harbron, S., eds.), Wiley, 219-243.
  18. Youns, M., Hoheisel, J.D. & Efferth, T. (2011). Therapeutic and diagnostic applications of nanoparticles. Curr. Drug Targets 12, 357-365.
  19. March, N.H. & Knapp-Mohammady, M. (2011). Molecular versus tissue liquids: an atomic length? Phys. Chem. Liq. 49, 830-834.
  20. March, N.H. & Knapp-Mohammady, M. (2011). Aqueous microdroplet encapsulation of normal or cancerous single cells. Phys. Chem. Liq. 49, 409-413.
  21. Torres Salazar, A., Hoheisel, J.D., Youns, M. & Wink, M. (2011). Anti-inflammatory and anti-cancer activities of essential oils and their biological constituents. Int. J. Clin. Pharmacol. Ther. 49, 93-95.
  22. March, N.H. & Knapp-Mohammady, M. (2011). The inhomogeneous electron liquid in some bioinorganic assemblies studied by density functional methods. Phys. Chem. Liq. 49, 259-269.
  23. Youns, M., Bauer, A., Reichling, J., Fellenberg, K., Efferth, T. & Hoheisel, J.D. (2010). Gene expression profiling identifies novel key players involved in chemopreventive effect of NS-398 on pancreatic cancer cells. Eur. J. Pharmacol. 650, 170-177.
  24. Schröder, C., Alhamdani, M.S.S., Fellenberg, K., Bauer, A., Jacob, A. & Hoheisel, J.D. (2011). Robust protein profiling with complex antibody microarrays in a dual-colour mode. Proteinarray Technology (Korf, U., ed.), Humana/Springer, 203-221.

           2010
  25. de Souza Rocha Simonini, P., Breiling, A., Gupta, N., Malekpour, M., Youns, M., Omranipour, R., Malekpour, F., Volinia, S., Croce, C.M., Najmabadi, H., Diederichs, S., Sahin, Ö., Mayer, D., Lyko, F., Hoheisel, J.D. & Riazalhosseini, Y. (2010). Epigenetically de-regulated microRNA-375 activates Estrogen Receptor alpha activity in breast cancer. Cancer Res. 70, 9175-9184.
  26. Alhamdani, M.S., Schröder, C. & Hoheisel, J.D. (2010). Analysis conditions for proteomic profiling of mammalian tissue and cell extracts with antibody microarrays. Proteomics 10, 3203-3207.
  27. Schröder, C., Jacob, A., Tonack, S., Radon, T., Sill, M., Zucknick, M., Rüffer, S., Costello, E., Neoptolemos, J., Crnogorac-Jurcevic, T., Bauer, A., Fellenberg, K. & Hoheisel, J.D. (2010). Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-specific antibodies. Mol. Cell. Prot. 9, 1271-1280. pdf icon
  28. Alhamdani, M.S.S., Schröder, C., Giese, N., Bauer, A. & Hoheisel, J.D. (2010). Single-step procedure for the isolation of proteins at near-native conditions from mammalian tissue for proteomic analysis on antibody microarrays. J. Prot. Res. 9, 963-971.
  29. Schröder, C., Jacob, A., Rüffer, S., Fellenberg, K. & Hoheisel, J.D. (2010). Antibody microarrays for expression analysis. Antibody Engineering, Vol. 2 (Dübel, S., ed.), Springer Verlag, 429-445. pdf icon
  30. Sill, M., Schröder, C., Hoheisel, J.D., Benner, A. & Zucknick, M. (2010). Assessment and optimisation of normalisation methods for dual-colour antibody microarrays. BMC Bioinformatics 11, 556. pdf icon
  31. Gloriam, D.E., Orchard, S., Bertinetti, D., Bjorling, E., Bongcam-Rudloff, E., Bourbeillon, J., Bradbury, A.R., de Daruvar, A., Dübel, S., Frank, R., Gibson, T.J., Haslam, N., Herberg, F.W., Hiltke, T., Hoheisel, J.D., Kerrien, S., Koegl, M., Konthur, Z., Korn, B., Landegren, U., van der Maarel, S., Montecchi-Palazzi, L., Palcy, S., Rodriguez, H., Schweinsberg, S., Sievert, V., Stoevesandt, O., Taussig, M.J., Uhlen, M., Wingren, C., Gold, L., Woollard, P., Sherman, D.J. & Hermjakob, H. (2010). A community standard for the representation of protein affinity reagents. Mol. Cell. Prot. 9, 1-10. pdf icon
  32. Helwa, R. & Hoheisel, J.D. (2010). Analysis of DNA-protein interactions; from nitrocellulose filter-binding assays to microarray studies. Anal. Bioanal. Chem. 398, 2551-2561. pdf icon
  33. Böttcher, M., Kischkel, F. & Hoheisel, J.D. (2010). High-definition DNA methylation profiles from breast and ovarian carcinoma cell lines with differing doxorubicin resistance. PloS ONE 5, e11002. pdf icon
  34. Bythell, B.J., Knapp-Mohammady, M., Paizs, B. & Harrison, A.G. (2010). Effect of the His residue on the cyclization of b ions. J. Am. Soc. Mass Spectrom. 21, 1352-1363.
  35. Uhlmann, S., Zhang, J.D., Schwager, A., Mannsperger, H., Riazalhosseini, Y., Burmester, S., Ward, A., Korf, U., Wiemann, S. & Sahin, O. (2010). miR-200bc/429 cluster targets PLCc1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene 29, 4297-4306.
  36. Khan, M.S., Haas, F.H., Samami, A.A., Gholami, A.M., Bauer, A., Fellenberg, K., Reichelt, M., Hänsch, R., Mendel, R.R., Meyer, A.J., Wirtz, M. & Hell R. (2010). Sulfite reductase defines a newly discovered bottleneck for assimilatory sulfate reduction and is essential for growth and development in Arabidopsis thaliana. Plant Cell 22, 1216-1231. pdf icon
  37. Mraheil, M.A., Billion,, A., Kuenne, C., Pischimarov, J., Kreikemeyer, B., Engelmann, S., Hartke, A., Giard, J.-C., Rupnik, M., Vorwerk, S., Beier, M., Retey, J., Hartsch, T., Jacob, A., Cemic, F., Hemberger, J., Chakraborty1, T. & Hain, T. (2010). Comparative genome-wide analysis of small RNAs of major Gram-positive pathogens: from identification to application. Microb. Biotechnol. 3, 634-657. pdf icon
  38. Müller, P., Schmitt, E., Jacob, A., Hoheisel, J.D., Kaufmann, R., Cremer, C. & Hausmann, M. (2010). COMBO-FISH enables high precision localization microscopy as a prerequisite for nanostructure analysis of genome loci. Int. J. Mol. Sci. 11, 4094-4105. pdf icon
  39. Youns, M., Hoheisel, J.D. & Efferth, T. (2010). Toxicogenomics for the prediction of toxicity related to herbs from traditional chinese medicine. Planta Med. 76, 2019-2025.
  40. Pinto, L., Efferth, T., Torres, A., Hoheisel, J.D. & Youns, M. (2010). Berberine selectively inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells. Planta Med. 76, 1155-1161.
  41. Mulyaningsih, S., Youns, M., El-Readi, M.Z., Ashour, M.L., Nibret, E., Sporer, F., Herrmann, F., Reichling, J. & Wink, M. (2010). Biological activity of the essential oil of Kadsura longipedunculata (Schisandraceae) and its major components. J. Pharm. Pharmacol. 62, 1037-1044.
  42. Hoheisel, J.D. (2010). Zellulären Übeltätern auf der Spur; Funktionelle Genom- und Proteomanalyse in der Krebsforschung. Labor & More 3.10, 29-32.
  43. Keller, A., Lenhof, H.-P., Amarantos, I., Bauer, A., Giese, N., Hoheisel, J.D., Leidinger, P. & Meese, E. (2010). MicroRNA-Profile als vielversprechende Diagnosemethode. Laborwelt 1/10, 33.
  44. Moghaddas Gholami, A.M. & Fellenberg, K. (2010). Cross-species common regulatory network inference without requirement for prior gene affiliation. Bioinformatics 26, 1082-1090. pdf icon
  45. Böttcher, M. & Hoheisel, J.D. (2010). Pooled RNAi screens - technical and biological aspects. Curr. Genom. 11, 162-167.
  46. Böttcher, M., Fredebohm, J., Moghaddas Gholami, A., Hachmo, Y., Dotan, I., Canaani, D. & Hoheisel, J.D. (2010). Decoding pooled RNAi screens by means of barcode tiling arrays. BMC Genomics 11, 7. pdf icon
  47. Knapp-Mohammady, M. & March, N.H. (2010). Quantum-chemical study of the potential anti-cancer drug Ru-NAMI-A in complex with estrogen and the simulated VA and VCD spectra of estrogen, the Ru-NAMI-A drug, and possible/proposed estrogen-Ru-NAMI-A complexes. Theor. Chem. Acc. 125, 1-3.
  48. Youns, M., Hoheisel, J.D. & Efferth, T. (2010). Applications of microarray technology in ethnomedicinal plant research. Curr. Adv. Ethnomed. Plants (Rios, J.L., ed.), 424-443.
  49. Youns, M., Hoheisel, J.D. & Efferth, T. (2010). Traditional Chinese medicine (TCM) for molecular targeted therapies of tumors. Curr. Drug Discov. Technol. 7, 37-45.
  50. Kramer, S., Queiroz, R., Ellis, L., Hoheisel, J.D., Clayton, C. & Carrington, M. (2010). The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes. J. Cell Sci. 123, 699-711. pdf icon
  51. Simo, G., Herder, S., Cuny, G. & Hoheisel, J.D. (2010). Identification of subspecies specific genes differentially expressed in procyclic forms of Trypanosoma brucei subspecies. Infect. Genet. Evol. 10, 229-237.
  52. Soza-Ried, J., Hotz-Wagenblatt, A., Glatting, K.H., del Val, C., Fellenberg, K., Bode, H.R., Frank, U., Hoheisel, J.D. & Frohme, M. (2010). The transcriptome of the colonial marine hydroid Hydractinia echinata. FEBS J. 277, 197-209. pdf icon

           2009
  53. Archer, S., Luu, V.-D., Queiroz, R., Brems, S. & Clayton, C. (2009). Trypanosoma brucei PUF9 regulates mRNAs for proteins involved in replicative processes over the cell cycle. PLoS Pathogen 5, e1000565. pdf icon
  54. Hoheisel, J.D. (2009). Zurück in die Zukunft der Sequenzierung (Editorial). BIOforum 6, 3. pdf icon
  55. Youns, M., Efferth, T. & Hoheisel, J.D. (2009). Microarray analysis of gene expression in medicinal plant research. Drug Discov. Ther. 3, 200-207. pdf icon
  56. Queiroz, R., Benz, C., Fellenberg, K., Schindler, V., Hoheisel, J.D. & Clayton, C. (2009). Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons. BMC Genomics 10, 495. pdf icon
  57. Pfannschmidt, J., Bade, S., Hoheisel, J.D., Muley, T., Dienemann, H., Herpel, E. (2009). Identification of immunohistochemical prognostic markers for survival after resection of pulmonary metastases from colorectal carcinoma. Thorac. Cardiov. Surgeon 57, 403–408. pdf icon
  58. Alhamdani, M.S.S., Schröder, C. & Hoheisel, J.D. (2009). Oncoproteomic profiling with antibody microarrays. Genome Medicine 1, 68. pdf icon
  59. Ashour, M., El-readi, M., Youns, M., Mulyaningsih, S., Sporer, F., Efferth, T. & Wink, M. (2009). Chemical composition and biological activities of the essential oil obtained from Bupleurum marginatum (Apiaceae). J. Pharm. Pharmacol. 61, 1079-1087.
  60. Youns, M., Efferth, T., Reichling, J., Fellenberg, K., Bauer, A. & Hoheisel, J.D. (2009). Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells. Biochem. Pharmacol. 78, 273-283. pdf icon
  61. Börner, A., Warnken, U., Schnölzer, M., von Hagen, J., Giese, N., Bauer, A. & Hoheisel, J.D. (2009). Subcellular protein extraction from human pancreatic cancer tissues. BioTechniques 46, 297-304. pdf icon
  62. Ketterer, K., Kong, B., Frank, D., Giese, N., Bauer, A., Hoheisel, J.D., Korc, M., Kleeff, J., Michalski, C. & Friess, H. (2009). Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. Cancer Lett. 277, 72-81. pdf icon
  63. Bau, S., Schracke, N., Kränzle, M., Wu, H., Hoheisel, J.D., Beier, M. & Summerer, D. (2009). Targeted next-generation-sequencing by specific capture of multiple genomic loci using low-volume microfluidic DNA-arrays. Anal. Bioanal. Chem. 393, 171-175. pdf icon
  64. Wurst, M., Robles, A., Po, J., Luu, V.-D., Brems, S., Marentije, M., Stoitsova, S., Quijada, L., Hoheisel, J.D., Stewart, M., Hartmann, C. & Clayton, C. (2009). An RNAi screen of the RRM-domain proteins of Trypanosoma brucei. Mol. Biochem. Parasit. 163, 61-65. pdf icon
  65. Dannewitz, B., Tomakidi, P., Syagailo, Y., Kohl, A., Staehle, H.J., Eickholz, P., Komposch, G. & Steinberg, T. (2009). Elevation of collagen type I in fibroblast–keratinocyte cocultures emphasizes the decisive role of fibroblasts in the manifestation of the phenotype of cyclosporin A-induced gingival overgrowth. J. Period. Res. 44, 62-72. pdf icon
  66. Bauer, A., Kleeff, J., Bier, M., Wirtz, M., Kayed, H., Esposito, I., Korc, M., Hafner, M., Hoheisel, J.D. & Friess, H. (2009). Identification of malignancy factors by analysing cystic tumours of the pancreas. Pancreatology 9, 34-44. pdf icon

           2008
  67. Riazalhosseini, Y. & Hoheisel, J.D. (2008). Do we use the appropriate controls for the identification of informative methylation markers for early cancer detection? Genome Biol. 9, 405. pdf icon
  68. Clayton, C., Schwede, A., Stewart, M., Robles, A., Benz, C., Po, J., Wurst, M., Queiroz, R. & Archer, S. (2008). Control of mRNA degradation in trypanosomes. Biochem Soc. Trans. 36, 520-521.
  69. Beatriz Bermúdez, B., López, S., Pacheco, Y.M., Villar, J., Muriana, F.J.G., Hoheisel, J.H., Bauer, A. & Abia, R. (2008). The influence of postprandial triclyceride-rich lipoproteins on lipid-mediated gene expression in smooth muscle cells of the human coronary artery. Cardiovasc. Res. 79, 294-303. pdf icon
  70. Vorwerk, S., Ganter, K., Cheng, Y., Hoheisel, J.D., Stähler, P.F. & Beier, M. (2008). Microfluidic-based enzymatic on-chip labeling of miRNAs. New Biotechnol. 25, 142-149. pdf icon
  71. Selak, N., Bachrati, C.Z., Shevelev, I., Dietschy, T., Jacob, A., Hübscher, U., Hoheisel, J.D., Hickson, I.D. & Stagljar, I. (2008). The Bloom’s syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta. Nucleic Acids Res. 36, 5166-5179. pdf icon
  72. Pullat, J., Kusnezow, W., Jakson, K., Beier, M., Hoheisel, J.D. & Metspalu, A. (2008). Mutational analysis and SNP typing by an Arrayed Primer Extension (APEX) reaction on an in situ-synthesised 5'-3' oligonucleotide microarray. New Biotechnol. 25, 131-141. pdf icon
  73. Haas, F.H., Heeg, C., Queiroz, R., Bauer, A., Wirtz, M. & Hell, R. (2008). Mitochondrial serine acetyltransferase functions as a pacemaker of cysteine synthesis in plant cells. Plant Physiol. 148, 1055-1067. pdf icon
  74. Kramer, S., Queiroz, R., Ellis, L., Webb, H., Hoheisel, J.D., Clayton, C. & Carrington, M. (2008). Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2alpha phosphorylation at Thr169. J. Cell Sci. 121, 3002-3014. pdf icon
  75. Schanné, M. , Bodem, J., Gerhold-Ay, A., Jacob, A., Fellenberg, K., Kräusslich, H.-G. & Hoheisel, J.D. (2008). Genotypic resistance testing in HIV by Arrayed Primer Extension. Anal. Bioanal. Chem. 391, 1661-1669. pdf icon
  76. Litovkin, K.V., Ivanova, O.V., Bauer, A., Hoheisel, J.D., Bubnov, V.V. & Zaporozhan, V.N. (2008). Microarray study of gene expression in uterine leiomyoma. Exp. Oncol. 30, 106-111. pdf icon
  77. Hoheisel, J.D. (2008). Microarray-Technologie; funktionelle Analysen der genetischen Information. Praxis Naturwiss. Biol. 2/57, 6-8.
  78. Beier, V. & Hoheisel, J.D. (2008). MicroRNAs; small molecules with big impact in cancer. Bioforum Eur. 12/08, 2-3. pdf icon
  79. Friedrich, A., Müller, M., Nolte, O., Wolfrum, J., Sauer, M., Hoheisel, J.D., Knemeyer, J.P. & Marmé, N. (2008). Highly specific identification of single nucleic polymorphism in M. tuberculosis using smart probes and single-molecule fluorescence spectroscopy in combination with blocking oligonucleotides. Proc. SPIE. 6867, 68670N (8 pages).
  80. Marmé, N., Lee, H., Friedrich, A., Park, C.W., Fiore, J., Nesbitt, D.J. & Knemeyer, J.P. (2008). Suppressing nonspecific adsorption of proteins on the single-molecular level.  Proc. SPIE 6862, 686212 (7 pages).

           2007
  81. Marmé, N., Sauer, M., Wolfrum, J., Hoheisel, J.D. & Knemeyer, J.-P. (2007). Smart Probes – a novel class of self-quenching DNA probes. Res. Adv. Nucleic Acids Res. 1, 1-10.
  82. Schanné, M., Beier, M. & Hoheisel, J.D. (2007). Unravelling the epigenetic code. Science Inside 2, 52-53. pdf icon
  83. Schanné, M., Riazalhosseini, Y., Beier, V., Gröne, H.-J., Waha, A., Schuster, M., Stähler, P., Lyko, F. & Hoheisel, J.D. (2007). Ein Programm für jeden Zelltyp. GenomXPress 2/07, 35-37.
  84. Hartmann, C., Benz, C., Brems, S., Ellis, L., Luu, V.-D., Stewart, M., D'Orso, I., Busold, C., Fellenberg, K., Frasch, A.C.C., Carrington, M., Hoheisel, J.D. & Clayton, C.E. (2007). The small trypanosome RNA-binding proteins TbUBP1 und TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes. Eucaryotic Cell 6, 1964-1978. pdf icon
  85. Staudt, T.M., Kräusslich, H.G., Marmé, N. & Knemeyer, J.P. (2007). Self-quenching peptide substrates for ultra-sensitive HIV-protease assays. Int. J. Environ. Anal. Chem. 87, 731-743.
  86. Bauer, A., Solinas-Toldo, S. & Hoheisel, J.D. (2007). Gendiagnostik; methodische Grundlagen. Grundlagen der Molekularen Medizin; 3. Auflage (Ganten, D. & Ruckpaul, K., eds.), Springer Verlag, 346-362.
  87. Moskalyov, E.A., Eprintsev, A.T. & Hoheisel, J.D. (2007). DNA methylation profiling in cancer: from single nucleotides towards the methylome. Molekulyarnaya Biologiya 41, 793-807. (in Russian)  Mol. Biol. 41, 723-736. (in English)  pdf icon
  88. Marmé, N. & Knemeyer, J.P. (2007). Sensitive bioanalytics: combining single-molecule spectroscopy with mono-labelled, self-quenching probes. Anal. Bioanal. Chem. 388, 1075-1085. pdf icon
  89. Pullat, J., Fleischer, R., Becker, N., Beier, M., Metspalu, A. & Hoheisel, J.D. (2007). Optimisation of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays: analysing variations in immune regulator genes of hay-fever samples. BMC Genomics 8, 282. pdf icon
  90. Kusumawidjaja, G., Kayed, H., Giese, N., Bauer, A., Erkan, M., Giese, T., Hoheisel, J.D., Friess, H. & Kleeff, J. (2007). Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. Cancer Biol. Ther. 6, 367-376. pdf icon
  91. Loos, M., Bergmann, F., Bauer, A., Hoheisel, J.D., Esposito, I., Kleeff, J., Schirmacher, P., Büchler, M.W., Klöppel, G. & Friess, H. (2007). Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature. Virchows Arch. 450, 719-726. pdf icon
  92. Kusnezow, W., Banzon, V., Schröder, C., Schaal, R., Hoheisel, J.D., Rüffer, S., Luft, P., Duschl, A. & Syagailo, Y.V. (2007). Comparison of various labeling substances for antibody microarray based profiling of clinical specimens. Proteomics 7, 1786-1799. pdf icon
  93. Knemeyer, J.P. & Marmé, N. (2007). Recent patents on self-quenching DNA probes. Recent Pat. DNA Gene Seq. 1, 145-157. pdf icon
  94. Denninger, V., Figarella, K. Schönfeld, C., Brems, S., Busold, C., Lang, F., Hoheisel, J.D. & Duszenko, M. (2007). Troglitazone induces differentiation in Trypanaosoma brucei. Exp. Cell Res. 313, 1805-1819. pdf icon
  95. Marmé, N., Friedrich, A., Hoheisel, J.D. & Knemeyer, J.-P. (2007). Smart Probes for the highly sensitive identification of single nucleic polymorphism on the single molecular level. FEBS Lett. 581, 1644-1648. pdf icon
  96. Jesnowski, R., Zubakov, D., Faissner, R., Ringel, J., Hoheisel, J.D., Lösel, R., Schnölzer; M. & Löhr, M. (2007). Genes and proteins differentially expressed during in vitro malignant transformation of bovine pancreatic duct cells. Neoplesia 9, 136-146. pdf icon
  97. Beier, V., Mund, C. & Hoheisel, J.D. (2007). Monitoring methylation changes in cancer. Adv. Biochem. Eng. Biotechnol. 104, Volume: Analytics of Protein-DNA Interactions (Seitz, H., Hrsg.), Springer Verlag, 1-11.
  98. Giordano, F.A., Hotz-Wagenblatt, A., Lauterborn, D., Appelt, J.U., Fellenberg, K., Nagy, K.Z., Zeller, W.J., Suhai, S., Fruehauf, S.& Laufs, S. (2007). New bioinformatic strategies to rapidly characterize retroviral integration sites of gene therapy vectors. Meth. Inform. Med. 46, 542-547.
  99. Friedrich, A., Habl, G., Sauer, M., Wolfrum, J., Hoheisel, J.D., Marmé, N. & Knemeyer, J.P. (2007). New hairpin-structured DNA probes: alternatives to classical molecular beacons. Proc. SPIE 6444, 64440M.
  100. Schliwka, J., Pullat, J., DeVilliers, E.-M., Hoheisel, J.D. & Beier, M. (2007). Mit der Geniom-Microarray Technologie HPV-Genotypen auf der Spur. Biospectrum 01.07, 52-53.
  101. Taussig, M.J., Stoevesandt, O., Borrebaeck, C., Bradbury, A., Cahill, D., Cambillau, C., de Daruvar, A., Dübel, S., Eichler, J., Frank, R., Gibson, T., Gloriam, D., Gold, L., Herberg, F., Hermjakob, H., Hoheisel, J.D., Joos, T., Kallioniemi, O., Koegl, M., Konthur, Z., Korn, B., Kremmer, E., Krobitsch, S., Landegren, U., van der Marel, S., McCafferty, J., Muyldermans, S., Nygren, P.A., Palcy, S., Plückthun, A., Polic, B., Przybylski, M., Saviranta, P., Sawyer, A., Sherman, D.J., Skerra, A., Templin, M., Ueffing, M. & Uhlén, M. (2007). ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nature Meth. 4, 13-17. pdf icon
  102. Hauser, M., Horn, P., Tournu, H., Hauser, N.C., Hoheisel, J.D., Brown, A.J.P. & Dickinson, J.R. (2007). A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. FEMS Yeast Res. 7, 84-92. pdf icon
  103. Marmé, N., Knemeyer, J.P. & Hoheisel, J.D. (2007). Imaging of single molecules in living cells. Anal. Bioanal. Chem. 387, 37-40. pdf icon

           2006
  104. Fellenberg, K., Busold, C., Witt, O., Bauer, A., Beckmann, B., Hauser, N.C., Frohme, M., Winter, S., Dippon, J. & Hoheisel, J.D. (2006). Systematic interpretation of microarray data using experiment annotations. BMC Genomics 7, 319. pdf icon
  105. Hauser, N.C., Martinez, R., Jacob, A., Rupp, S., Hoheisel, J.D. & Matysiak, S. (2006). Utilising the left-helical conformation of L-DNA for analysing different marker types on a single universal microarray platform. Nucleic Acids Res. 34, 5101-5111. pdf icon
  106. Luu, V.-D., Brems, S., Hoheisel, J.D., Burchmore, R., Guilbride, D.L. & Clayton, C.E. (2006). Functional analysis of Trypanosoma brucei PUF1. Mol. Biochem. Parasit. 150, 340-349.
  107. Gruegelsiepe, H., Brandt, O. & Hartmann, R.K. (2006). Antisense Inhibition of RNase P; mechanistic aspects and application to live bacteria. J. Biol. Chem. 281, 30613–30620. pdf icon
  108. Marmé, N., Friedrich, A., Müller, M., Nolte, O., Wolfrum, J., Hoheisel, J.D., Sauer, M. & Knemeyer, J.P. (2006). Identification of single-point mutations in mycobacterial 16S rRNA sequences by confocal single-molecule fluorescence spectroscopy. Nucleic Acids Res. 34, e90. pdf icon
  109. Kusnezow, W., Syagailo, Y.V., Rüffer, S., Baudenstiel, N., Gauer, C., Hoheisel, J.D., Wild, D.G. & Goychuk, I.(2006). Optimal design of microarray immunoassays to compensate for kinetic limitations – theory and experiment. Mol. Cell. Prot. 5, 1681-1696. pdf icon
  110. Angenendt, P., Kreutzberger, J., Glökler, J. & Hoheisel, J.D. (2006). Generation of high-density protein-microarrays by cell-free in situ expression of unpurified PCR products. Mol. Cell. Prot. 5, 1658-1666. pdf icon
  111. Schütz, S., Chemnitz, J., Spillner, C., Frohme, M., Hauber, J. & Kehlenbach; R.H. (2006). Stimulated expression of mRNAs in activated T cells depends on a functional CRM1 nuclear export pathway. J. Mol. Biol. 358, 997-1009. pdf icon
  112. Marmé, N., Friedrich, A., Denapaite, D., Hakenbeck, R. & Knemeyer, J.-P. (2006). Single nucleotide polymorphism analysis using different colored dye dimer probes. Chem. Phys. Lett. 428, 440–445. pdf icon
  113. Hoheisel, J.D. (2006). Microarrays; an overview. Encyclop. Genet. Genomics Proteomics Bioinf. (Dunn, M., Jorde, L., Little, P. & Subramaniam, S., eds.), Wiley-VHC, ISBN-10:0-470-84974-6.
  114. Altenhein, B., Becker, A., Busold, C., Beckmann, B., Hoheisel, J.D. & Technau, G.M. (2006). Expression profiling of glial genes during Drosophila embryogenesis. Develop. Biol. 296, 545-560. pdf icon
  115. Jacob, A., Brandt, O. & Hoheisel, J.D. (2006). PNA Chips. Encyclop. Ref. Genomics Proteomics Mol. Med. (Ganten, D. & Ruckpaul, K., eds.), 1422-1425. pdf icon
  116. Nolte, O., Müller, M., Häfner, B., Knemeyer, J.P., Stöhr, K., Wolfrum, J., Hakenbeck, R., Denapaite, D., Schwarz-Finsterle, J., Stein, S., Herten, D.P., Hausmann, M. & Sauer, M. (2006) Novel singly labeled probes for identification of micro-organisms, detection of antibiotic resistance genes and mutations, and tumor diagnosis (Smart Probes). Biophotonics: visions for a better health care (Popp, J., ed.), WILEY-VCH, Weinheim.
  117. Brandt, O., Feldner, J., Hellweg, S., Schröder, M., Stephan, A., Arlinghaus, H.F., Hoheisel, J.D. & Jacob, A. (2006). Development towards label and amplification-free genotyping of genomic DNA. Appl. Surface Sci. 252, 6935-6940.
  118. Hellweg, S., Jacob, A., Hoheisel, J.D., Grehl, T. & Arlinghaus, H.F. (2006). Mass spectrometric characterization of DNA microarrays as a function of primary ion species. Appl. Surface Sci. 252, 6742-6745. pdf icon
  119. Hoheisel, J.D. (2006). DNA-Microarray Technologie. Bioanalytik (Lottspeich, E. & Engels, J.W., eds.), Elsevier, Heidelberg, 967-978.
  120. Hoheisel, J.D. (2006). Microarray technology; beyond transcript profiling and genotype analysis. Nature Rev. Genet. 7, 200-210. pdf icon
  121. Reva, O.N., Weinel, C., Weinel, M., Böhm, K., Stjepandic, D., Hoheisel, J.D. & Tümmler, B. (2006). Functional genomics of stress response in Pseudomonas putida KT2440. J. Bacteriol. 188, 4079-4092. pdf icon
  122. Sobek, J., Bartscherer, K., Jacob, A., Hoheisel, J.D. & Angenendt, P. (2006). Microarray technology as a universal tool for high-throughput analysis of biological systems. Comb. Chem. High-Throughput Screening 9, 365-380. pdf icon
  123. Stähler, P., Beier, M., Gao, X. & Hoheisel, J.D. (2006). Another side of genomics: synthethic biology as a means for the exploitation of whole-genome sequence information. J. Biotechnol. 124, 206-212. pdf icon
  124. Kusnezow, W., Syagailo, Y.V., Goychuk, I., Hoheisel, J.D. & Wild, D.G. (2006). Antibody microarrays: the crucial impact of mass transport on assay kinetics and sensitivity. Expert Rev. Mol. Diagn. 6, 111-124. pdf icon
  125. Kusnezow, W., Syagailo, Y.V., Rüffer, S., Klenin, K., Sebald, W., Hoheisel, J.D., Gauer, C. & Goychuk, I. (2006). Kinetics of antigen binding to antibody microspots: strong limitation by mass transport to the surface. Proteomics 6, 794-803. pdf icon
  126. Syagailo, Y.V., Kusnezow, W. & Hoheisel, J.D. (2006). Microarray-based expression profiling; from technological basics to diagnostic perspectives. Apoptosis and Cancer Therapy (Debatin, K.M. & Fulda, S., eds.), Wiley-VHC, 60-85.
  127. Steinberg, T., Dannewitz, B., Tomakidi, P., Hoheisel, J.D., Mussig, E., Kohl, A. & Nees, M. (2006). Analysis of interleukon-1beta-modulated mRNA gene transcription in human gingival keratinocytes by epithelia-specific cDNA microarrays. J. Periodontal Res. 41, 426-446. pdf icon
  128. Möhrlen, F., Maniura, M., Plickert, G., Frohme, M. & Frank, U. (2006). Evolution of astacin-like metalloproteases in animals and their function in development. Evolut. Develop. 8, 223-231. pdf icon.
  129. Mali, B., Soza Ried, J., Frohme, M. & Frank, U. (2006). Structural but not functional conservation of an immune molecules: a tachylectin-like gene in Hydractinia. Dev. Comp. Immunol. 30, 275-281. pdf icon
  130. Frohme, M. & Hoheisel, J.D. (2006). Representational difference analysis; a methodology to study differential gene expression. Cell Biology: A Laboratory Handbook. 3rd Ed. (Celis, J., ed.), Elsevier, 113-120.

           2005
  131. Nees, M., Kusnezow, W. & Woodworth, C.D. (2005). Microarrays: small spots produce major advances in pharmacogenomics. Novel Anticancer Agents: Strategies for Discovery and Clinical Testing (Adej, A., Buolamwini, J.K., eds.), Elsevier Inc..
  132. Buchholz, M., Kestler, H.A., Bauer, A., Böck, W., Rau, B., Leder, G., Kratzer, W., Bommer, M., Adler, G., Hoheisel, J.D. & Gress, T.M. (2005). Specialized DNA arrays for the differentiation of pancreatic tumors: a solution for a common diagnostic dilemma. Clin. Cancer Res. 11, 8048-8054. pdf icon
  133. Klenin, K.V., Kusnezow, W. & Langowski, J. (2005). Kinetics of protein binding in solid-phase immunoassays: theory. J. Chem. Phys. 122, Art. No. 214715. pdf icon
  134. Rapp, B., Herrmann, D., Guber, A., Welle, A., Schild, D., Jacob, A., Dauber, M. & Hoheisel, J.D. (2005). Mikrotiterplatte mit integrierter funktionalisierter Filterstruktur. Proceed. Mikrosystemtechnik Kongress 2005 (ISBN 3-8007-2926-1), VDE Verlag GmbH, Berlin und Offenbach, 773-776.
  135. Kersten, B., Wanker, E.E., Hoheisel, J.D. & Angenendt, P. (2005). Multiplex approaches in protein microarray technology. Expert Rev. Proteomics 2, 499-510. pdf icon
  136. Marmé, N., Habl, G. & Knemeyer, J.-P. (2005). Aggregation behavior of the red-absorbing oxazine derivative MR 121: A new method for determination of pure dimer spectra. Chem. Phys. Lett. 408, 221-225. pdf icon
  137. Habl, G. Böhm, H., Marmé, N. & Knemeyer, J.-P. (2005). A new assay for single nucleotide polymorphism analysis based on displacement reactions in PNA-DNA double helices. Int. J. Environ. Anal. Chem. 85, 613-623.
  138. Schäfer, G., Müller, M., Hafner, B., Habl, G., Molte, O., Marme, N., Knemeyer, J.-P. (2005). Self-quenching DNA probes based on aggregation of fluorescent dyes. Proc. SPIE 5704, 30.
  139. Staudt, T.M., Knemeyer, L., Kräusslich, H.-G., Knemeyer, J.-P., & Marme, N. (2005). Novel fluorescently labeled enzyme substrates for the sensitive detection of HIV-protease. Proc. SPIE 5704, 112.
  140. Busold, C., Winter, S., Hauser, N., Bauer, A., Dippon, J., Hoheisel, J.D. & Fellenberg, K. (2005). GO-annotations in correspondence analysis facilitate interpretation of microarray data. Bioinformatics 21, 2424-2429. pdf icon
  141. Mund, C., Beier, V., Bewerunge, P., Dahms, M., Lyko, F. & Hoheisel, J.D. (2005). Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16 promoter in colon carcinoma cell lines. Nucleic Acids Res. 33, e73. pdf icon
  142. Angenendt, P. (2005). Progress in protein and antibody microarray technology. Drug Discovery Today 10, 503-511. pdf icon
  143. Beier, V., Mund, C., Schanne, M., Lyko, F. & Hoheisel, J.D. (2005). Characterisation of genomic methylation patterns in tumours. Exocrine Pancreas Cancer (Gress, T.M., Neoptolemos, J.P., Lemoine, N.R. & Real, F.X., eds.), Solvay, 252-258. pdf icon
  144. Buchholz, M., Kestler, H.A., Bauer, A., Hoheisel, J.D. & Gress, T.M. (2005). Development of diagnostic arrays for the differential diagnosis of a pancreatic mass. Exocrine Pancreas Cancer (Gress, T.M., Neoptolemos, J.P., Lemoine, N.R. & Real, F.X., eds.), Solvay, 394-401. pdf icon
  145. Schanne, M., Bodem, J., Kräusslich, H.G., Jacob, A. & Hoheisel, J.D. (2005). Microarray-basierte Resistenzbestimmung in HIV. LaborMedizin & Diagnostik 01.05, 19.
  146. Kusnezow, W., Pulli, T., Syagailo, Y. & Hoheisel, J.D. (2005). Microarray immunoassay of complex specimens; problems and technological challenges. Handbook of Immunohistochemistry & In Situ Hybridisation of Human Carcinomas, Vol. 2 (Hayat, M.A., ed.), 23-35.
  147. Brems, S., Guilbruide, L., Gundlesdodjir-Planck, D., Busold, C., Luu, V.-D., Schanne, M., Hoheisel, J.D. & Clayton, C. (2005). The transcriptomes of Trypanosoma brucei Lister 427 and TREU927 bloodstrem and procyclic trypomastigotes. Mol. Biochem. Parasit. 139, 163-172. pdf icon
  148. Beier, M. & Hoheisel, J.D. (2005). DNA-microarray preparation by light-controlled in situ synthesis. Curr. Protocols Nucleic Acid Chem., Unit 12.5.

           2004
  149. Guduric-Fuchs, J., Möhrlen, F., Frohme, M., Frank, U. (2004). A fragile X mental retardation-like gene in a cnidarian. Gene 343, 231–238. pdf icon
  150. Mali, B., Möhrlen, F., Frohme, M. & Frank, U. (2004). A putative double role of a chitinase in a cnidarian: pattern formation and immunity. Develop. Comp. Immunol. 28, 973–981.
  151. Malanchi, I., Accardi, R., Diehl, F., Smet, A., Androphy, E., Hoheisel, J.D. & Tommasino, M. (2004). Human papillomavirus type 16 E6 promotes retinoblastoma protein phosphorylation and cell cycle progression. J. Virol. 78, 13769-13778.
  152. Bey, M., Stüber, K., Fellenberg, K., Schwarz-Sommer, Z., Sommer, H., Saedler, H. & Zachgo, S. (2004). Characterization of Antirrhinum petal development and identification of target genes of the class B MADS-box Gene DEFICIENS. Plant Cell 16, 3197-3215.
  153. Brandt, O. & Hoheisel, J.D. (2004). Peptide nucleic acids on microarrays and other biosensors. Trends Biotechnol. 22, 617-622.
  154. Beier, M. & Hoheisel, J.D. (2004). Synthesis of 3’-O-NPPOC-protected 5’-O-phosphoramidites. Curr. Protocols Nucleic Acid Chem., Unit 12.3.
  155. Beier, M. & Hoheisel, J.D. (2004). Derivatization of solid supports. Curr. Protocols Nucleic Acid Chem., Unit 12.4.
  156. Brandt, R., Grützmann, R., Bauer, A., Jesnowski, R., Ringel, J., Löhr, M., Pilarsky, C. & Hoheisel, J.D. (2004). DNA-microarray analysis of pancreatic malignancies. Pancreatology 4, 587-597.
  157. Brors, B. & Fellenberg, K. (2004). Bioinformatik. Molekulare Biotechnologie; Konzepte und Methoden (Wink, M., ed.), Wiley-VCH Verlag, Weinheim, 409-440.
  158. Frohme, M. & Wiemann, S. (2004). Funktionelle Genomik. Molekulare Biotechnologie; Konzepte und Methoden (Wink, M., ed.), Wiley-VCH Verlag, Weinheim, 339-384.
  159. Frohme, M. & Wiemann, S. (2004). Genomik. Molekulare Biotechnologie; Konzepte und Methoden (Wink, M., ed.), Wiley-VCH Verlag, Weinheim, 287-338.
  160. Arlinghaus, H.F., Schröder, M., Feldner, J.C., Brandt, O., Hoheisel, J.D. & Lipinsky, D. (2004). Development of PNA microarrays for gene diagnostics with TOF-SIMS. Appl. Surface Sci. 231–232, 392–396. pdf icon
  161. Jacob, A., Brandt, O., Stephan, A. & Hoheisel, J.D. (2004). PNA Microarrays. Methods in Molecular Biology (Niemeyer, C., ed.), Humana Press, Totowa, 283-294.
  162. Beier, V., Bauer, A., Baum, M. & Hoheisel, J.D. (2004). Fluorescent sample labelling for DNA-microarray analyses. Methods in Molecular Biology (Niemeyer, C., ed.), Humana Press, Totowa, 127-136.
  163. Hollich, V., Johnson, E., Furlon, E.E., Beckmann, B., Celinker, S. & Hoheisel, J.D. (2004). Creation of a minimal tiling path of genomic clones for Drosophila: provision of a common resource. Biotechniques 37, 282-284.
  164. Kusnezow, W., Pulli, T., Witt, O. & Hoheisel, J.D. (2004). Solid support for protein microarrays and related devices. Protein Microarrays (Schena, M., Hrsg.), Jones and Bartlett, Sudbury, MA, 247-284.
  165. Fleischer, R., Frohme, M. & Hoheisel, J.D. (2004) Komplexe Microarrays in Krebsforschung und -diagnose. BIOspektrum 04/04, 434-436.
  166. Hagen, I., Ecker, M., Lagorce, A., Francois, J.M., Sestak, S., Rachel., R., Grossmann, G., Hauser, N.C., Hoheisel, J.D., Tanner, W. & Strahl, S. (2004). Sed1p and Srl1p are required to compensate for cell wall instability in Saccharomyces cerevisiae mutants defective in multiple GPI-anchored mannoproteins. Mol. Microbiol. 52, 1413-1425.
  167. Esposito, I., Bauer, A., Hoheisel, J.D., Kleeff, J., Friess, H., Büchler, M.W., Bergmann, F., Rieker, R.J., Otto, H.F., Klöppel, G., & Penzel, R. (2004). Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity. Virchows Arch. 444, 447-453.
  168. Beier, V. & Hoheisel, J.D. (2004). Charakterisierung von DNA-Methylierungsmustern mit Hilfe von Oligonukleotid-Microarrays. BIOforum 05/04, 31-33.
  169. Boutros, M., Kiger, A.A., Armknecht, S., Kerr, K., Hild, M., Koch, B., Haas, S.A., Beckmann, B., Vingron, M., Sauer, F., Hoheisel, J.D., Paro, R. and Perrimon, N. (2004). Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303, 382-385.

           2003
  170. Beckmann, B., Hild, M., Haas, S.A., Koch, B., Solovjev, V., Busold, C., Fellenberg, K, Boutros, M., Vingron, M., Sauer, F., Hoheisel, J.D. & Paro, R. (2003). An integrated gene annotation and transcriptional profiling approach towards the full gene content of the Drosophila genome. Genome Biol. 5, R3.
  171. Yuan, L., An, H.X., Deng, X.L.& Li, Z.Y. (2003). Regulation of leptin on insulin secretion and sulfonulurea receptor 1 transcription level in isolated rats pancreatic islets. Chinese Med. J. 116, 868-872.
  172. Yuan, L., An, H.X., Deng, X.L., Chen, L.L. & Li, Z.Y. (2003). Rosiglitazone reverses insulin secretion altered by chronic exposure to free fatty acid via IRS-2-associated phosphatidylinositol 3-kinase pathway. Acta Pharmacol. Sinica 24, 429-434.
  173. Parker, N.B., Yang, X.D., Hanke, J., Mason, K.A., Schowen, R.L., Borchardt, R.T. & Yin, D.H. (2003). Trypanosoma cruzi: molecular cloning and characterization of the S-adenosylhomocysteine hydrolase. Exp. Parasitol. 105, 149-158.
  174. Hoheisel, J.D. (2003). DNA-Microarrays in der Routine. Forschung & Diagnostik 1, 34-35.
  175. Bauer, A., Beckmann, B., Busold, C., Brandt, O., Kusnezow, W., Pullat, J., Aign, V., Fellenberg, K., Fleischer, R., Jacob, A., Frohme, M. & Hoheisel, J.D. (2003). Use of complex DNA- and antibody-microarrays as tools in functional analyses. Comp. Funct. Genom. 4, 520-524.
  176. Aign, V. & Hoheisel, J.D. (2003). Analysis of nutrient-dependent transcript variations in Neurospora crassa. Fungal Genet. Biol. 40, 225-233.
  177. Jacob, A., Brandt, O., Würtz, S., Stephan, A., Schnölzer, M. & Hoheisel, J.D. (2003). Production of PNA-arrays for nucleic acid detection. Peptide Nucleic Acids; Protocols and Applications (Nielsen, P.E., ed.), Horizon Bioscience, Wymondham, 261-279.
  178. Brandt, O., Feldner, J., Stephan, A., Schröder, M., Schnölzer, M. Arlinghaus, H.F., Hoheisel, J.D. & Jacob, A. (2003). PNA-microarrays for hybridisation of unlabelled DNA-samples. Nucleic Acids Res. 31, e119.
  179. Becerra, M., Lombardía, L.J., González-Siso, M.I., Rodriguez-Belmonte, E., Hauser, N.J., & Cerdán, M.E. (2003). Genome-wide analysis of the yeast transcriptome upon heat and cold shock. Comp. Funct. Genom. 4, 366-375.
  180. Zubakov, D., Hoheisel, J.D., Kluxen, F.-W., Brändle, M., Ehring, T., Hentsch, B. & Frohme, M. (2003). Late ischemic preconditioning of the myocardium alters the expression of genes involved in inflammatory response. FEBS Lett. 547, 51-55. 
  181. Fellenberg, K., Vingron, M., Hauser, N.C. & Hoheisel, J.D. (2003). Correspondence analysis with microarray data. Perspectives in Gene Expression (Appasani, K., ed.), Eaton Publishing, Westborough, 307-343.
  182. Kusnezow, W. & Hoheisel, J.D. (2003). Solid Support for Microarray Immunoassays. J. Mol. Recognit.16, 165-176. 
  183. Hoheisel, J.D. (2003). Humangenetik leicht gemacht. Forum DKG 2/03, 61. 
  184. Löhr, M. & Hoheisel, J.D. (2003). DNA-Chip Technologie beim Pankreaskarzinom. Z. Gastroenterol. 41, 623-624.
  185. Lagorce, A., Hauser, N.C., Labourdette, D., Rodriguez, C., Jasson, S., Arroyo, J., Hoheisel, J.D. & Francois, J.-M. (2003). Genome-wide analysis of the response to cell wall damage in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 278, 20345-20357. 
  186. Scheideler, M. & Hoheisel, J.D. (2003). Analyses de microréseaux d'ADN. Bioforum France 1/03, 24-27.
  187. Yin, Z., Wilson, S., Hauser, N.C., Tournu, H., Hoheisel, J.D. & Brown, A.J.P. (2003). Differential effects of high and low glucose signals upon global expression patterns in yeast. Mol. Microbiol. 48, 713-724. 
  188. Mannhaupt, G., Montrone, C., Haase, D., Mewes, W., Aign, V., Hoheisel, J.D., Fartmann, B., Nyakatura, G., Kempken, F., Maier, J. and Schulte, U. (2003). What‘s in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence. Nucleic Acids Res. 31, 1944-1954. 
  189. Kusnezow, W., Jacob, A., Walijew, A., Diehl, F. & Hoheisel, J.D. (2003). Antibody microarrays: an evaluation of production parameters. Proteomics 3, 254-264. 
  190. Würtz, S., Hanke, J., Solinas-Toldo, S. & Hoheisel, J.D. (2003). Genomanalyse und Gendiagnostik. Grundlagen der molekularen Medizin, 2. Auflage (Ganten, D. & Ruckpaul, K., Eds.); Springer Verlag, 391-440.

           2002
  191. Kusnezow, W. & Hoheisel, J.D. (2002). Antibody Microarrays: Promises and Problems. BioTechniques 33 (suppl.), 14-23. 
  192. Stjepandic, D., Weinel, C., Hilbert, H., Nelson, K.E., Tümmler, B. & Hoheisel, J.D. (2002). The genome structure of Pseudomonas putida; high-resolution mapping and microarray analysis. Environ. Microbiol. 4, 819-823. 
  193. Nelson, K.E., Weinel, C., Paulsen, I.T., Dodson, R.J., Hilbert, H., Martins Dos Santos, V., Fouts, D.E., Gill, S.R., Pop, M., Holmes, M., Brinkac, L., Beanan, M., DeBoys, R., Daugherty, S., Kolonay, J., Madupu, R., Nelson, W., White, O., Peterson, J., Khouri, H., Hance, I., Chris Lee, P., Holtzapple, E., Scanlan, D., Tran, K., Moazzez, A., Utterback, T., Rizzo, M., Lee, K., Kosack, D., Moestl, D., Wedler, H., Lauber, J., Stjepandic, D., Hoheisel, J.D., Straetz, M., Heim. S., Kiewitz, C., Eisen, J., Timmis, K.N., Düsterhoft, A., Tümmler, B., & Fraser, C.M. (2002). The complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440. Environ. Microbiol.4, 799-808. 
  194. Diehl, S., Diehl, F., El-Sayed, N.M., Clayton, C. & Hoheisel, J.D. (2002). Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray. Mol. Biochem. Parasit. 123, 115-123. 
  195. Scheideler, M. & Hoheisel, J.D. (2002). DNA-Microarray Analyses; benefits, promises and problems. Screening 5/02, 22-25. 
  196. Diehl, F., Beckmann, B., Kellner, N., Hauser, N.C., Diehl, S. & Hoheisel, J.D. (2002). Manufacturing DNA-microarrays from unpurified PCR-products. Nucleic Acids Res. 30, e79. 
  197. Lombardía, L.J., Becerra, M., Rodríguez-Belmonte, E., Hauser, N.C. & Cerdán, M.E. (2002) Genome-wide analysis of yeast transcription upon calcium shortage. Cell Calcium 32, 83-91. 
  198. Hauser, N.C., Fellenberg, K. & Rupp, S. (2002). How to Discover Pathogenic Mechanisms - New Evaluation Tools Towards Drug Discovery. Screening 3, 28-31.
  199. Hayes, A., Zhang, N., Wu, J., Butler, P.R., Hauser, N.C., Hoheisel, J.D., Lim, F.L., Sharrocks, A.D., Oliver, S.G. (2002) Hybridisation array technology coupled with chemostat culture: tools to interrogate gene expression in Saccharomyces cerevisiae. Methods 26, 281-290. 
  200. Brazma, A., Robinson, A., Vilo, J., Vingron, M., Hoheisel, J.D., Fellenberg, K. & Muilu, J. (2002). ArrayExpress; establishing a public repository for DNA array-based gene expression data. DNA-Chip Technology; Adv. Biochem. Engineering/Biotechnol. 77, 113-139.
  201. Hoheisel, J.D. (ed.) (2002). DNA-Chip Technology; Adv. Biochem. Engineering/Biotechnol. 77.
  202. Beckers, J., Hoheisel, J.D., Mewes, W., Vingron, M. & Hrabé de Angelis, M. (2002). Molecular phenotyping of mouse mutant resources by RNA expression profiling. Curr. Genomics 3, 121-129. 
  203. Frohme, M., Zolk, O., Maurer, A., Kluxen, F.-W., Hentsch, B., Zubakov, D., Hoheisel, J.D., Zucker, I.H., Pepe, S. & Eschenhagen, T. (2002). Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure. Biochem. Biophys. Res. Commun. 293, 1377-1382. 
  204. Scheideler, M., Schlaich, N.L., Fellenberg, K., Beißbarth, T., Hauser, N., Vingron, M., Slusarenko, A.J. & Hoheisel, J.D. (2002). Monitoring the switch from housekeeping to pathogen defence metabolism in Arabidopsis thaliana. J. Biol. Chem. 277, 10555-10561. 
  205. Fellenberg, K., Hauser, N.C., Brors, B., Hoheisel, J.D. & Vingron, M. (2002). Microarray data warehouse allowing for the statistical analysis of experiment annotations. Bioinformatics 18, 423-433. 
  206. Becerra, M., Lombardía-Ferreira, L.J., Hauser, N.J., Hoheisel, J.D., Tizon, B. & Cerdán, M.E. (2002). The yeast transcriptome in aerobic and hypoxic conditions. Effects of HAP1 ROX1 ROX3 and SRB10 deletions. Mol. Microbiol. 43, 545-555.pdf icon
  207. Tauch, A., Homann, I., Mormann, S., Rüberg, S., Billaut, A., Bathe, B., Brand, S., Brockmann-Gretza, O., Rückert, C., Schischka, N., Wrenger, C., Hoheisel, J.D., Mockel, B., Huthmacher, K., Pfefferle, W., Pühler, A. & Kalinowski, J. (2002). Strategy to sequence the genome of Corynebacterium glutamicum ATCC 13032: use of a cosmid and a bacterial artificial chromosome library. J. Biotechnol. 95, 25-38. 
  208. Heber, S., Stoye, J., Frohme, M., Hoheisel, J.D. & Vingron, M. (2002). Resampling methods in physical mapping. Classification, Automation, and New Media; Studies in Classification, Data Analysis, and Knowledge Organization (Gaul, W. & Ritter, G., eds.), Springer Verlag, 437-444.
  209. Hoheisel, J.D. & Cahill, D. (Editorial) (2002). Proteomics and genomics; catching function in action. Curr Opin. Chem. Biol. 6, 11-12. 
  210. Beier, M. & Hoheisel, J.D. (2002). Use of NPE/NPEOC-protected 5'-phosphoramidites for inverse in situ synthesis of oligonucleotides on DNA-microarrays. J. Biotechnol. 94, 15-22. 

           2001
  211. Hoheisel, J.D., Fellenberg, K., Brors, B., Diehl, F., Hauser, N.C. & Vingron, M. (2001). Transkriptionelle Untersuchungen auf DNS-Microarrays; Aspekte der Daten-Evaluation und Interpretation. BIOforum 12/01, 908-910.
  212. Petersohn, A., Brigulla, M., Haas, S., Hoheisel, J.D., Völker, U.& Hecker, M. (2001). Global analysis of the general stress response of Bacillus subtilis. J. Bacteriol. 183, 5617-5631. pdf icon
  213. Hoheisel, J.D., Diehl, F., Scheideler, M., Hauser, N., Aign, V., Matysiak, S. & Beier, M. (2001). Improving DNA-chip technology; chemical aspects. Novel Approaches in Biosensors and Rapid Diagnostic Assays (Liron, Z., Brohmberg, A. and Fisher, M., eds.), Kluwer Academic/Plenum Publishers, London, 165-172. 
  214. Matysiak, S., Reuthner, F. & Hoheisel, J.D. (2001). Automating parallel peptide-synthesis for the production of PNA-library arrays. BioTechniques 31, 896-904. 
  215. Fellenberg, K., Hauser, N.C., Brors, B., Neutzner, A., Hoheisel, J.D. & Vingron, M. (2001). Microarray data analysis by correspondence analysis. Proc. Natl. Acad. Sci. USA 98, 10781-10786. 
  216. Beier, M., Stephan, A. & Hoheisel, J.D. (2001). Synthesis of photolabile 5'-O-phosphoramidites for the production of microarrays of inversely oriented oligonucleotides. Hel. Chim. Acta 84, 2089-2095. 
  217. Hauser, N.C., Fellenberg, K., Rosario, G., Bastuck, S., Hoheisel, J.D. & Perez-Ortin, J.E. (2001). Whole genome analysis of a wine yeast strain. Comp. Funct. Genom. 2, 69-79. 
  218. Frohme, M., Camargo, A., Czink, C., Matsukuma, A.Y., Simpson, A.J.G., Hoheisel, J.D. & Verjovski-Almeida, S. (2001). Directed gap closure in large scale sequencing projects. Genome Res. 11, 901-903. 
  219. Matysiak, S., Reuthner, F. & Hoheisel, J.D. (2001). New developments in Spot-synthesis of PNA-arrays. Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Chemical Libraries (Epton, R., ed.), Mayflower Worldwide, Birmingham, 71-74.
  220. Hoheisel, J.D. & Conway, P.J. (eds.) (2001). Analytical Biotechnology. Curr Opin. Biotechnol. 12 (1). 
  221. Aign, V., Schulte, U. & Hoheisel, J.D. (2001). Hybridisation mapping of Neurospora crassa linkage groups II and V. Genetics 157, 1015-1020. 
  222. Diehl, F., Grahlmann, S., Beier, M. & Hoheisel, J.D. (2001). Manufacturing DNA-microarrays of high spot homogeneity and reduced background signal. Nucleic Acids Res. 29, e38. 
  223. Shen, H.H., Huang, A.-M., Hoheisel, J.D. & Tsai, S.-F. (2001). Identification and characterization of a SET/NAP protein encoded by a brain-specific gene, MB20. Genomics 71, 21–33. 
  224. Hoheisel, J.D. (2001). DNA in me that‘s not my DNA. Trends Biotechnol. 19, 155-156.

           2000
  225. Beißbarth, T., Fellenberg, K., Brors, B., Arribas-Prat, R., Boer, J., Hauser, N.C., Scheideler, M., Hoheisel, J.D., Schütz, G., Poustka, A. & Vingron, M. (2000). Comparison and quality measures of DNA array hybridisation data. Bioinformatics16, 1014-1022. 
  226. Tümmler, B., Kiewitz, C., Weinel, C., Hoheisel, J.D., Düsterhöft, A., Hilbert, H., Moore, E., Strätz, M., Timmis, K.N., Nelson, K.E. & Fraser, C.M. (2000). Sequenzierung und Funktionsanalyse des Pseudomonas putida KT2440 Genoms: Methodik und Ressourcen. Biologische Sicherheit (Hartmann, A, ed.), Forschungszentrum Jülich (ISBN 3-89336-255-X), 251-257.
  227. Hoheisel, J.D. (2000). Das Humangenomprojekt. Humangenetisches Symposium 29, 11-16.
  228. Heber, S., Stoye, J., Frohme, M., Hoheisel, J.D. & Vingron, M. (2000). Contig selection in physical mapping. J. Comput. Biol. 7, 395-408. pdf icon
  229. Campbell, H.D., Fountain, S., Young, I.G., Weitz, S., Lichter, P. & Hoheisel, J.D. (2000). Fliih, the murine homologue of the Drosophila melanogaster flightless-I gene: genomic structure, chromosomal mapping and overlap with Llglh. DNA Sequence 11, 29-40.
  230. Heber, S., Hoheisel, J.D. & Vingron, M. (2000). Application of bootstrap-techniques to physical mapping. Genomics 69, 235-241. 
  231. Heber, S., Stoye, J., Hoheisel, J.D. & Vingron, M. (2000). Contig selection in physical mapping. Proc. Fourth Ann. Internat. Conf. Comput. Mol. Biol. (RECOMB 2000), 155-164.
  232. Hoheisel, J.D. (2000). Editorial on DNA-Chips. BIOforum12/00, 825. 
  233. Frohme, M., Camargo; A.A., Heber, S., Czink, C., Simpson, A.J.D., Hoheisel, J.D. & de Souza, A.P. (2000). Mapping analysis of the Xylella fastidiosa genome. Nucleic Acids Res. 28, 3100-3104. 
  234. Frohme, M., Scharm, B., Delius, H., Knecht, R. & Hoheisel, J.D. (2000). Use of representational difference analysis and cDNA-arrays for transcriptional profiling of tumour tissue. Ann. N.Y. Acad. Sci. 910, 85-104.
  235. Frohme, M., Hauser, N., Scheideler, M., Diehl, F., Beier, M., Würtz, S. & Hoheisel, J.D. (2000). Chips, arrays and other hybridisation based techniques for genome and transcriptome characterisation. Molecular Pathogenesis of Pancreatic Cancer (Gress, T., ed.), IOS Press, Amsterdam, 88-94.
  236. Hoheisel, J.D. & Vingron, M. (2000). Transcriptional profiling: is it worth the money? Res. Microbiol. 151, 113-119. 
  237. Simpson, A.J.G., et al., Hoheisel, J.D., et al. & Setubal, J.C. (2000). The genome sequence of the plant pathogen Xylella fastidiosa. Nature 406, 151-157. 
  238. Hoheisel, J.D. & Beier, M. (2000). DNS-Chips/elektronische Chips, grundverschieden und doch ähnlich. Dechema Tätigkeitsbericht.1999, 8-11.
  239. Hoheisel, J.D. (2000). ... and counting: DNA-microarrays. Proceedings Int. Conf. Genomics and Proteomics: Functional and Computational Aspects (Suhai, S., ed.), Plenum Publishing, New York, 1-3.
  240. Wambutt, R. et al., Hoheisel, J.D. et al. & Bevan, M. (2000). Progress in Arabidopsis genome sequencing and functional genomics. J. Biotechnol. 78, 281-292. 
  241. Beier, M. & Hoheisel, J.D. (2000). Production by quantitative photolithographic synthesis of individually quality-checked DNA microarrays. Nucleic Acids Res. 28, e11. 
  242. Beier, M., Matysiak, S., Hauser, N., Scheideler, M., Würtz, S., Fellenberg, K., Vingron, M. & Hoheisel, J.D. (2000). DNA microchips; transcriptional profiling and beyond. Chimia 54, 29-30.

           1999
  243. Hanke, J. & Hoheisel, J.D. (1999). Construction and screening of cosmid libraries. The Nucleic Acids Protocols Handbook - Methods in Molecular Biology (Rapley, R., ed.), Humana Press, Totowa, 405-414.
  244. The European Union Arabidopsis Genome Sequencing Consortium (1999). Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature 402, 769-777. 
  245. Hoheisel, J.D. (1999). DNS-Chips - Technologie mit Zukunft. Biotechnologie-Agentur Baden-Württemberg 4, 6.
  246. Li, Z., Rossi, E.A., Hoheisel, J.D., Kalderon, D. & Rubin, C.S. (1999). Generation of a novel A kinase anchor protein and a myristoylated alanine-rich C kinase substrate-like analog from a single gene. J. Biol. Chem. 274, 27191-27200. 
  247. Wallrapp, C., Müller-Pillasch, F., Micha, A., Wenger, C., Geng, M., Solinas-Toldo, S., Lichter, P., Frohme, M., Hoheisel, J.D., Adler, G. & Gress, T.M. (1999). Strategies for the detection of disease genes in pancreatic cancer. Ann. N.Y. Acad. Sci. 880, 122-146.
  248. Wallrapp, C., Müller-Pillasch, F., Micha, A., Wenger, C., Geng, M., Solinas-Toldo, S., Lichter, P., Frohme, M., Hoheisel, J.D., Adler, G. & Gress, T.M. (1999). Novel technologies for detection of genomic and transcriptional alterations in pancreatic cancer. Ann. Oncology 10, suppl. 4, S64-S68. 
  249. Geng, M., Wallrapp, C., Müller-Pillasch, F., Frohme, M., Hoheisel, J.D. & Gress, T. (1999). Isolation of differentially expressed genes by combining representational difference analysis (RDA) and cDNA library arrays. Expression Genetics: Accelerated and High-Throughput Methods Book (McClelland, M. & Pardee, A., eds.), Biotechniques Books, Natick, 145-153.
  250. Matysiak, S., Hauser, N.C., Würtz, S. & Hoheisel, J.D. (1999). Improved solid supports and spacer/linker systems for the synthesis of spatially addressable PNA-libraries. Nucleosides & Nucleotides 18, 1289-1291.
  251. Beier, M. & Hoheisel, J.D. (1999). New developments in light-controlled synthesis of DNA-arrays. Nucleosides & Nucleotides 18, 1301-1304.
  252. Weiler, J., Matysiak, S., Gausepohl, H. & Hoheisel, J.D. (1999). New developments in hybridisation based DNA screening on oligomer arrays. Solid Phase Synthesis - Peptides, Proteins and Nucleic Acids (Epton, R., ed.), Mayflower Worldwide, 93-96.
  253. Beier, M. & Hoheisel, J.D. (1999). Versatile derivatisation of solid support media for covalent bonding on DNA-microchips. Nucleic Acids Res. 27, 1970-1977. 
  254. Matysiak, S., Würtz, S., Hauser, N., Gausepohl, H. & Hoheisel, J.D. (1999). PNA-arrays for nucleic acid detection. Peptide Nucleic Acids: Protocols and Applications (Nielsen, P. & Egholm, M., eds.), Horizon Scientific Press, Wymondham, 119-128.
  255. Hoheisel, J.D. (1999). DNS-Chip Technologie - eine Herausforderung. med. genetik 11, 4-5.
  256. Vingron, M. & Hoheisel, J.D. (1999). Computational aspects of expression data analysis. J. Mol. Med. 77, 3-7.

           1998
  257. Craig, A. & Hoheisel, J.D. (eds.) (1998). Methods in Microbiology 28 - Automation. Academic Press.
  258. Hauser, N.C., Scheideler, M., Matysiak, S., Vingron, S. & Hoheisel, J.D. (1998). DNA arrays for transcriptional profiling. Methods in Microbiology 28 - Automation (Craig, A. & Hoheisel, J.D., eds.), Academic Press, 193-204.
  259. Persson, K., Åslund, L., Grahn, B., Hanke, J. & Heby, O. (1998). Characterization of the Trypanosoma cruzi S-adenosylmethionine decarboxylase gene and the encoded enzyme. Biochem. J. 333, 527-537. pdf icon
  260. Geng, M., Wallrapp, C., Müller-Pillasch, F., Frohme, M., Hoheisel, J.D. & Gress, T. (1998). Isolation of differentially expressed genes by combining representational difference analysis (RDA) and cDNA library arrays. BioTechnique 25, 434-438. 
  261. Hoheisel, J.D. & Vingron, M. (1998). DNS-Chip Technologie. BioSpektrum 6, 17-20. (reprinted 1999 in Biochemica 3, 31-35.)
  262. Andersson, B., Åslund, L., Hoheisel, J.D. & Pettersson, U. (1998). 93.4 kb of complete sequence from chromosome 3 of Trypanosoma cruzi containing a strand switch region. Genome Res. 8, 809-816. 
  263. Hauser, N.C., Vingron, M., Scheideler, M., Krems, B., Hellmuth, K., Entian, K.-D. & Hoheisel, J.D. (1998). Transcriptional profiling on all open reading frames of Saccharomyces cerevisiae. Yeast 14, 1209-1221. 
  264. Chan, H.Y.E., Zhang, Y., Hoheisel, J.D. & O'Kane, C.J. (1998) Identification and characterisation of the gene for Drosophila L3 ribosomal protein. Gene 212, 119-125. 
  265. Hauser, N., Scheideler, M. & Hoheisel, J.D. (1998). DNS-Chip Technologie zur Untersuchung von Genaktivität. Krebsforschung heute 98 (Stamatiadis-Smidt, M.A., Ed.); Steinkopff Verlag, 190-193.
  266. Gausepohl, H., Weiler, J., Schwarz, S., Fitzpattrick, R. & Hoheisel, J.D. (1998). Synthesis of large PNA arrays on membranes using the SPOT method. Peptides 1996 - Proceedings of the 24th Symposium of the European Peptide Society (Ramage, R., and Epton, R., eds.), Mayflower Scientific Ltd., 411-412.
  267. Scholler, P., Heber, S. & Hoheisel, J.D. (1998). Optimisation and automation of fluorescence-based DNA hybridisation for high-throughput clone mapping. Electrophoresis 19, 504-508.
  268. Hanke, J., Frohme, M., Laurent, J.P., Swindle, J. & Hoheisel, J.D. (1998). Hybridisation mapping of Trypanosoma cruzi chromosomes III and IV. Electrophoresis 19, 482-485.
  269. Frohme, M., Hanke, J., Åslund, L., Pettersson, U. & Hoheisel, J.D. (1998). Selective generation of chromosomal cosmid libraries within the Trypanosoma cruzi genome project. Electrophoresis 19, 478-481.

           1997
  270. Krebber, H., Bastians, H., Hoheisel, J.D., Lichter, P., Ponstingl, H. & Joos, S. (1997). Localisation of the gene encoding the Ran-binding protein RanBP2 to human chromosome 2q11-13 by fluorescence in situ hybridisation. Genomics 43, 247-248. 
  271. Weiler, J. & Hoheisel, J.D. (1997). Picomole synthesis of high quality oligonucleotide primers in combination with the preparation of oligonucleotide arrays. Nucl. & Nucl. 16, 1793-1796.
  272. Hoheisel, J.D. (1997). Oligomer chip technology. Trends Biotechnol.15, 465-469. 
  273. Weiler, J., Hauser, N. & Hoheisel, J.D. (1997). New developments in oligomer array technologies. Nucl. & Nucl. 16, 777-780.
  274. Christodoulou, S., Lockyer, A.E., Foster, J.M., Hoheisel, J.D. & Roberts, D.B. (1997). Nucleotide sequence of a Drosophila melanogaster cDNA encoding a clanexin homologue. Gene 191, 143-148. 
  275. Weiler, J., Gausepohl, H., Hauser, N., Jensen, O.N. & Hoheisel, J.D. (1997). Hybridisation based DNA screening on peptide nucleic acid (PNA) oligonucleotide arrays. Nucleic Acids Res. 25, 2792-2799. 
  276. Hanke, J., Solinas-Toldo, S. & Hoheisel, J.D. (1997). Genomanalyse und Gendiagnostik. Handbuch der molekularen Medizin, Band 1 (Ganten, D. & Ruckpaul, K., Eds.); Springer Verlag, pp. 51-91.
  277. Ohkura, H., Török, T., Tick, G., Hoheisel, J.D., Kiss, I. & Glover, D.M. (1997). Mutation of a gene for a Drosophila kinesin like protein, Klp38B, leads to failure of cytokinesis. J. Cell Science 110, 945-954. 
  278. Bastians, H., Krebber, H., Hoheisel, J.D., Ohl, S., Lichter, P., Ponstingl, H. & Joos, S. (1997). Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11.2-12.1 by fluorescence in situ hybridisation. Genomics 42, 181-182. 
  279. Campbell, H.D., Fountain, S., Young, I.G., Claudianosll, C., Hoheisel, J.D., Chen, K.-S. & Lupski, J.R. (1997). Genomic structure, evolution and expression of human fli, a gelsolin and leucine-rich-repeat family member: linkage to HUGL. Genomics 42, 46-54. 
  280. Johnston, M., Hillier, L., Riles, L., Albermann, K., André, B., Ansorge, W., Benes, V., Brückner, M., Delius, H., Dubois, E., Düsterhöft, A., Entian, K.-D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kötter, P., Louis, E.J., Messenguy, F., Mewes, H.W., Miosga, T., Möstl, D., Müller-Auer, S., Nentwich, U., Obermaier, B., Piravandi, E., Pohl, T.M., Portetelle, D., Purnelle, B., Rechmann, S., Rieger, M., Rinke, M., Rose, M., Scharfe, M., Scherens, B., Scholler, P., Schwager, C., Schwarz, S., Underwood, A. P., Urrestarazu, L. A., Vandenbol, M., Verhasselt, P., Vierendeels, F., Voet, M., Volckaert, G., Voss, H., Wambutt, R., Wedler, E., Wedler, H., Zimmermann, F. K., Zollner, A., Hani, J. & Hoheisel, J.D. (1997). The complete sequence of Saccharomyces cerevisiae chromosome XII. Nature 387 (suppl.), 87-90.
  281. Jacq, C., et al., Hoheisel, J.D., et al. (1997). The nucleotide sequence of chromosome IV of Saccharomyces cerevisiae. Nature 387 (suppl.), 75-78.
  282. Goffeau, A. et al., Hoheisel, J.D., et al. (1997) Yeast Genome Directory. Nature 387 (suppl.), 5.
  283. Gress, T.M., Wallrapp, C., Frohme, M., Müller-Pillasch, F., Lacher, U., Friess, H., Büchler, M., Adler, G. & Hoheisel, J.D. (1997). Identification of genes with specific expression in pancreatic cancer by use of cDNA representational difference analysis. Genes Chrom. Cancer 19, 97-103. 
  284. Bastians, H., Krebber, H., Vetrie, D., Hoheisel, J.D., Lichter, P., Ponstingl, H. & Joos, S. (1997). Localisation of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3. Genomics 41, 296-297. 
  285. Werner, E., Holder, A.A. & Hoheisel, J.D. (1997). Growth and storage of YAC-clones in Hogness Freezing Medium. Nucleic Acids Res. 25, 1467-1468. 
  286. The Trypanosoma cruzi genome consortium: Zingales, B., Rondinelli, E., Degrave, W., da Silveira, J.F., Levin, M., Le Paslier, D., Modabber, F., Dobrokhotov, B., Swindle, J., Kelly, J. M., Åslund, L., Hoheisel, J.D., Ruiz, A.M., Cazzulo, J.J., Pettersson, U. & Frasch, A.C. (1997). The Trypanosoma cruzi genome initiative. Parasitol. Today 13, 16-21.

           1996
  287. Weiler, J. & Hoheisel, J.D. (1996). Combining the preparation of oligonucleotide arrays and synthesis of high quality primers. Anal. Biochem. 243, 218-227. pdf icon
  288. Goffeau, A., Barrell, B.G., Bussey, H., Davis, R.W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J.D., Jacq, C., Johnston, M., Louis, E.J., Mewes, H.W., Murakami, Y., Philippsen, P., Tettelin, H. & Oliver, S.G. (1996). Life with 6000 genes. Science 274, 546-567. pdf icon
  289. Scholler, P., Benes, V., Voss, H., Ansorge, W. & Hoheisel, J.D. (1996). Sequencing 39,350 bp of Saccharomyces cerevisiae chromosome XII utilising ordered shotgun libraries. DNA Sequence 6, 257-262.
  290. Hanke, J., Sánchez, D.O., Henriksson, J., Åslund, L., Pettersson, U., Frasch, A.C.C. & Hoheisel, J.D. (1996). Towards the mapping of the Trypanosoma cruzi genome; analyses on a representative cosmid library. BioTechniques 21, 686-693. pdf icon
  291. Hoheisel, J.D., Maier, E., Mott, R. & Lehrach, H. (1996). Integrated genome mapping by hybridization techniques. Analysis of Non-Mammalian Genomes - A Practical Guide (Birren, B. & Lai, E., Eds.), Academic Press, pp. 319-346.
  292. Hoheisel, J.D. (1996). Sequence-independent and linear variation of oligonucleotide DNA-binding stabilities. Nucleic Acids Res. 24, 430-432. pdf icon

           1995
  293. Scholler, P., Karger, A.E., Meier-Ewert, S., Lehrach, H., Delius, H. & Hoheisel, J.D. (1995). Fine-mapping of shotgun template-libraries; an efficient strategy for the systematic sequencing of genomic DNA. Nucleic Acids Res. 23, 3842-3849. pdf icon
  294. Lin, W.-H., Huang, L.-H., Yeh, J.-Y., Hoheisel, J.D., Lehrach, H., Sun, Y.H. & Tsai, S.-H. (1995). A Drosophila GATA transcription factor is expressed in multiple tissues in the developing embryos. J. Biol. Chem. 270, 25150-25158. pdf icon
  295. Stephen W. Scherer & Hoheisel, J.D. (1995). Genome analysis. Mol. Med. Today 1, 258-259. pdf icon
  296. Cornell, M.J., William, T.A., Coates, D., Corvol, R., Soubrier, F., Hoheisel, J.D., Lehrach, H. & Isaac, R.E. (1995). Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster. J. Biol. Chem. 270, 13613-13619. pdf icon
  297. Scholler, P., Schwarz, S. & Hoheisel, J.D. (1995). High-resolution cosmid mapping of the left arm of Saccharomyces cerevisiae chromosome XII; a first step towards an ordered sequencing approach. Yeast 11, 659-666. pdf icon
  298. Chen, K.-S., Nguyen, D., Hoheisel, J.D., Young, I.G., Miklos, G.L.G., Greenberg, F., Shaffer, L.G., Campbell, H.D. & Lupski, J.R. (1995). The Drosophila melanogaster flightless-I gene (fliI) human homologue maps within the Smith-Magenis microdeletion critical region in 17p11.2. Am. J. Hum. Genet. 56, 175-182.

           1994
  299. Hoheisel, J.D. (1994). Creation of a rare-cutter multiple-cloning site. BioTechniques 17, 456-460.
  300. Hoheisel, J.D., Ross, M.T., Zehetner, G. & Lehrach, H. (1994). Relational genome analysis using reference libraries and hybridisation fingerprinting. J. Biotechnol. 35, 121-134. pdf icon
  301. Hoheisel, J.D. (1994). Application of hybridisation techniques to genome mapping and sequencing. Trends Genet. 10, 79-83. pdf icon
  302. Maier, E., Hoheisel, J.D. & Lehrach, H. (1994). Ordered clone libraries as high resolution mapping tools. Proceedings of the 6th European Congress on Biotechnology (Alberghina, L., Frontali, L. & Sensi, P., eds.), Elsevier, pp. 191-194.

           1993    (Publications of Jörg D. Hoheisel prior to joining DKFZ)
  303. Hoheisel, J.D., Maier, E., Meier-Ewert, S. & Lehrach, H. (1993). Relational genome analysis based on hybridisation techniques. Ann. Biol. Clin. 50, 827-829.
  304. Hoheisel, J.D. & Lehrach, H. (1993). Use of reference libraries and hybridisation fingerprinting for relational genome analysis. FEBS Lett. 325, 118-122. pdf icon
  305. Mott, R., Grigoriev, A., Maier, E., Hoheisel, J.D. & Lehrach, H. (1993). Algorithms and software tools for ordering clone libraries; application to the mapping of the genome of Schizosaccharomyces pombe. Nucleic Acids Res. 21, 1965-1974. pdf icon
  306. Hoheisel, J.D., Maier, E., Mott, R., McCarthy, L., Grigoriev, A.V., Schalkwyk, L.C., Nizetic, D., Francis, F. & Lehrach, H. (1993). High-resolution cosmid and P1 maps spanning the 14-Mbp genome of the fission yeast Schizosaccharomyces pombe. Cell 73, 109-120.
  307. Hoheisel, J.D. (1993). On the activities of Escherichia coli Exonuclease III. Anal. Biochem. 209, 238-246. pdf icon

           1992
  308. Gress, T.M., Hoheisel, J.D., Lennon, G.G., Zehetner, G. & Lehrach, H. (1992). Hybridisation fingerprinting of high density cDNA-library arrays with cDNA pools derived from whole tissues. Mamm. Genomes 3, 609-619. pdf icon
  309. Maier, E., Hoheisel, J.D., McCarthy, L., Mott, R., Grigoriev, A.V., Monaco, A.P., Larin, Z. & Lehrach, H. (1992). Yeast artificial chromosome clones completely spanning the genome of Schizosaccharomyces pombe. Nature Genet. 1, 273-277. pdf icon
  310. Ross, M.T., Hoheisel, J.D., Monaco, A.P., Larin, Z., Zehetner, G. & Lehrach, H. (1992). High-density gridded YAC filters: their potential as genome mapping tools. Techniques for the Analysis of Complex Genomes (Anand, R. ed.), Academic Press, pp. 137-154.

           1991
  311. Freese, S., Hoheisel, J.D., Lehrach, H. & Wright, G. (1991). N2-substituted-2'-deoxyguanosine 5'-triphosphates as substrates for E. coli DNA polymerase I. Nucleosides & Nucleotides 10, 1507-1524.
  312. Hoheisel, J.D., Lennon, G.G., Zehetner, G. & Lehrach, H. (1991). Use of high coverage reference libraries of Drosophila melanogaster for relational data analysis; a step towards mapping and sequencing of the genome. J. Mol. Biol. 220, 903-914. pdf icon
  313. Hoheisel, J.D., Drmanac, R., Larin, Z., Lennon, G., Monaco, A.P., Nizetic, D., Ross, M., Zehetner, G. & Lehrach, H. (1991). Use of high coverage libraries for an integrated analysis of genomic DNA. Genome Analysis: From Sequence to Function (Collins, J. & Driesel, A.J. eds.), Advances Mol. Gen. 4, Hüthig Buch Verlag, pp. 125-132.

           1990
  314. Lehrach, H., Drmanac, R., Hoheisel, J.D., Larin, Z., Lennon, G., Monaco, A.P., Nizetic, D., Zehetner, G. & Poustka, A. (1990). Hybridisation fingerprinting in genome mapping and sequencing. Genome Analysis Volume 1: Genetic and Physical Mapping (Davies, K.E. & Tilghman, S. eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor (NY), pp. 39-81.
  315. Hoheisel, J.D. & Lehrach, H. (1990). Quantitative measurements on the duplex stability of 2.6-diaminopurine and 5-chloro-uracil nucleotides using enzymatically synthesized oligomers. FEBS Lett. 274, 103-106. pdf icon
  316. Hoheisel, J.D. (1990). Extension of a pUC18-like polylinker by the octanucleotide recognition sites of NotI, FseI, SfiI and PacI. Trends Genet. 6, 346.
  317. Hoheisel, J.D., Craig, A.G. & Lehrach, H. (1990). Effect of 5-bromo and 5-methyl deoxycytosine on duplex stability and discrimination of the NotI octadeoxynucleotide; quantitative measurements using thin-layer chromatography. J. Biol. Chem. 265, 16656-16660. pdf icon
  318. Craig, A., Nizetic, D., Hoheisel, J.D., Zehetner, G. & Lehrach, H. (1990). Ordering of cosmid clones covering the Herpes Simplex Virus Type I (HSV-I) genome: a test case for fingerprinting by hybridisation. Nucleic Acids Res. 18, 2653-2660. pdf icon

           1989
  319. Hoheisel, J.D., Nizetic, D. & Lehrach, H. (1989). Control of partial digestion combining the enzymes Dam methylase and MboI. Nucleic Acids Res. 17, 4571-4582. pdf icon
  320. Craig, A., Nizetic, D., Hoheisel, J.D., Monaco, A.P., Zehetner, G., Lennon, G., Young, B. & Lehrach, H. (1989). Long-range ordering of clones by probe fingerprinting. Polymerase Chain Reaction (Erlich, H.A., Gibbs, R.A. & Kazazian, H.H. eds.), Curr. Comm. Mol. Biol., Cold Spring Harbor Laboratory Press, Cold Spring Harbor (NY), pp. 205-210.
  321. Hoheisel, J.D. (1989). Ultrafast Microprep protocol for large-number preparations of recombinant plasmids and cosmids. Technique 1, 21-27. pdf icon
  322. Hoheisel, J.D. (1989). A cassette with seven unique restriction sites, including octanucleotide sequences: extension of multiple-cloning-site plasmids. Gene 80, 151-154. pdf icon

           1986-1988
  323. Hoheisel, J.D. (1988). Untersuchung verschiedener, topologisch induzierter DNS-Sekundärstrukturen. (Thesis) Hartung-Gorre Verlag, Konstanz.
  324. Hoheisel, J.D. & Pohl, F.M. (1987). Searching for potential Z-DNA in genomic Escherichia coli DNA. J. Mol. Biol. 193, 447-464. pdf icon
  325. Hoheisel, J.D. & Pohl, F.M. (1986). Simplified preparation of unidirectional deletion clones. Nucleic Acids Res. 14, 3605. pdf icon







  
Patents
 For further information, please, contact Dr. Jörg Hoheisel or the DKFZ Technology Transfer Office.
  






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