Division of Cell Growth and Proliferation

Prof. Dr. Bruce Edgar

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The precise control of cell proliferation is essential for development in growing animals and plants, and for tissue homeostasis in adults. Loss of this control is a pre-requisite for carcinogenesis. Research in Dr. Edgar’s group focuses on the mechanisms that control cell growth and proliferation using the Drosophila model system. They use diverse molecular, genetic and cytological approaches to discover, and then characterize, genes and pathways that regulate the growth and proliferation of cells in vivo in several different organs and tissue types in this small fruit fly. Genes discovered in this way often prove to be oncogenes or tumor suppressors in humans, and thus these basic studies fuel more applied cancer research. Ongoing projects address the control of cell proliferation by the E2F, Retinoblastoma, and APC/C complexes, the mechanism of growth-dependent endoreplication cell cycles, nutrient-regulated cell growth via the insulin-TOR signaling network, and the regulation of homeostatic and neoplastic growth in the fly’s gut by intestinal stem cells.

FUTURE OUTLOOK
The laboratory continues to focus on the regulation of the cell growth and proliferation in several cell types in Drosophila.
The main projects concern:
• Regulation of cell cycle exit during differentiation
• Cell cycle control by Hsp90 and the APC/C ubiquitin ligase
• Control of Endocycles by E2F and the CRL4 ubiquitin ligase
• Growth regulation of the Endocycle
• Mechanism of endocycling in murine trophoblast giant cells
• Intestinal stem cell control by cell signaling pathways including Jak/Stat, EGFR/Ras/MAPK, Hippo, and others
• Whole-genome screens for regulators of intestinal stem cell proliferation and differentiation
• Cell cycle controls in intestinal stem cells and their progeny
• Development of an in vitro intestinal stem cell culture model

Prof. Edgar's Homepage at ZMBH

Contact

Prof. Dr. Bruce Edgar
Cell Growth and Proliferation (A220)
Deutsches Krebsforschungszentrum
ZMBH
Im Neuenheimer Feld 282
69120 Heidelberg
Tel: +49 6221 54 6827

Selected Publications

  • Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, and Edgar BA: Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137, 1343-55, 2009.
  • Jiang H, Grenley MO, Bravo MJ, Blumhagen RZ, Edgar BA: EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 8: 84-95, 2011.
  • Shibutani ST, de la Cruz AF, Tran V, Turbyfill WJ, Reis T, Edgar BA, and Duronio RJ.: Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell 15: 890-900, 2008.
  • Shaw RL, Kohlmaier A, Polesello C, Veelken C, Edgar BA, Tapon N: The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development 137: 4147-58, 2010.
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