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Dr. Dieter Weichenhan

Dr. Dieter Weichenhan

Position: Scientist

Contact: Contact Form

Phone: +49 6221 42 3305

Fax: +49 6221 42 3359



Study of biology at the University of Oldenburg

PhD thesis (magna cum laude)
Supervisor: Prof. W. Wackernagel, Department of Genetics at the University of Oldenburg
Thesis title: Physiological and genetic examinations with the cloned recBCD gene regions of the Enterobacteriaceae Escherichia coli, Proteus mirabilis und Serratia marcescens

Group leader at the Institute of Biology (Director: Prof. W. Traut) at the University of Lübeck

1996-1997: (interim)
Visiting Research Assistant Professor at the Department of Human Genetics (Head: Prof. P. de Jong) at the Roswell Park Cancer Institute, Buffalo, USA

Thesis title: Gene fusion and gene amplification: the complex evolution of a young gene cluster in the genome of the house mouse
Venia legendi for Biology at the University of Lübeck

Group leader at the Medical Clinic II (Director: Prof. H.A. Katus) at the University Clinic of Lübeck

Group leader at the Medical Clinic III (Director: Prof. H.A. Katus) at the University Clinic of Heidelberg

since April 2008:
Senior scientist at the Division of Epigenomics and Cancer Risk Factors (Head: Prof. C. Plass) at the German Cancer Research Center (DKFZ) Heidelberg


• Mouse models for complex genomic rearrangements
• Molecular genetics of heart muscle diseases (cardiomyopathies)
• Epigenetic changes in cancer development


1986-1999: American Society of Microbiology
since 1989: German Society of Genetics
since 2005: German Society of Cardiology
since 2006: Consortium of Gene Diagnostics


1. Luedde M, Ehlermann P, Weichenhan D, Will R, Zeller R, Rupp S, Müller A, Steen H, Ivandic BT, Ulmer HE, Kern M, Katus HA, Frey N. (2010) Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation. Cardiovasc Res. 2010 Jun 1;86(3):452-60.

1. Hassel D, Dahme T, Erdmann J, Meder B, Huge A, Stoll M, Just S, Hess A, Ehlermann P, Weichenhan D, Grimmler M, Liptau H, Hetzer R, Regitz-Zagrosek V, Fischer C, Nürnberg P, Schunkert H, Katus HA, Rottbauer W. (2009) Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nat Med. 15(11):1281-1288.

2. Goehringer, C., Rutschow, D., Bauer, R., Schinkel, S., Weichenhan, D., Bekeredjian, R., Straub, V., Kleinschmidt, J.A., Katus, H.A., and Muller, O.J. 2009. Prevention of cardiomyopathy in delta-sarcoglycan knock-out mice after systemic transfer of targeted adeno-associated viral vectors. Cardiovasc Res., 82:404-410.

3. Friedrichs, F., Zugck, C., Rauch, G.J., Ivandic, B., Weichenhan, D., Muller-Bardorff, M., Meder, B., El Mokhtari, N.E., Regitz-Zagrosek, V., Hetzer, R., Schäfer A., Schreiber S., Chen J., Neuhaus I., Ji R., Siemers N.O., Frey N., Rottbauer W., Katus H.A., and Stoll M. 2009. HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome Res 19:395-403.

1. Geiger, S.K., Bär, H., Ehlermann, P., Walde, S., Rutschow, D., Zeller, R., Ivandic, B.T., Zentgraf, H., Katus, H.A., Herrmann, H., and Weichenhan, D. 2008. Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. J Mol Med. 86:281-289.

2. Weichenhan, D., Traut, W., Gongrich, C., Himmelbauer, H., Busch, L., Monyer, H., and Winking, H. 2008. A mouse translocation associated with Caspr5-2 disruption and perinatal lethality. Mamm Genome 19:675-686.

3. Ehlermann, P., Weichenhan, D., Zehelein, J., Steen, H., Pribe, R., Zeller, R., Lehrke, S., Zugck, C., Ivandic, B.T., and Katus, H.A. 2008. Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene. BMC Med Genet 9:95.

1. Schoensiegel, F., Bekeredjian, R., Schrewe, A., Weichenhan, D., Frey, N., Katus, H.A., and Ivandic, B.T. 2007. Atrial natriuretic peptide and osteopontin are useful markers of cardiac disorders in mice. Comp Med. 57:546-553.

1. Zeller, R., Ivandic, B.T., Ehlermann, P., Mücke, O., Zugck, C., Remppis, A., Giannitsis, E., Katus, H.A., and Weichenhan, D. 2006. Large-scale mutation screening in patients with dilated or hypertrophic cardiomyopathy: a pilot study using DGGE. J Mol Med. 84:682-691.

2. Traut, W., Weichenhan, D., Himmelbauer, H., and Winking, H. 2006. New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene. Mamm Genome. 17:723-731.

3. Korff, S., Schoensiegel, F., Riechert, N., Weichenhan, D., Katus, H.A., and Ivandic, B.T. 2006. Fine mapping of Dyscalc1, the major genetic determinant of dystrophic cardiac calcification in mice. Physiol Genomics. 25:387-392.

4. Korff, S., Riechert, N., Schoensiegel, F., Weichenhan, D., Autschbach, F., Katus, H.A., and Ivandic, B.T. 2006. Calcification of myocardial necrosis is common in mice. Virchows Arch. 448:630-638.

5. Ehlermann, P., Eggers, K., Bierhaus, A., Most, P., Weichenhan, D., Greten, J., Nawroth, P.P., Katus, H.A., and Remppis, A. 2006. Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products. Cardiovasc Diabetol. 5:6.

1. Pleger, S.T., Remppis, A., Heidt, B., Völkers, M., Chuprun, J.K., Kuhn, M., Zhou, R.H., Gao, E., Szabo, G., Weichenhan, D., et al. 2005. S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. Mol Ther. 12:1120-1129.

2. Jäger, J., Weichenhan, D., Ivandic, B., and Spang, R. 2005. Early diagnostic marker panel determination for microarray based clinical studies. Stat Appl Genet Mol Biol. 4:Article9.

1. Remppis, A., Pleger, S.T., Most, P., Lindenkamp, J., Ehlermann, P., Schweda, C., Löffler, E., Weichenhan, D., Zimmermann, W., Eschenhagen, T., et al. 2004. S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts. J Gene Med. 6:387-394.

2. Most, P., Pleger, S.T., Volkers, M., Heidt, B., Boerries, M., Weichenhan, D., Löffler, E., Janssen, P.M.L., Eckhart, A.D., Martini, J., et al. 2004. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J Clin Invest. 114:1550-1563.

3. Aherrahrou, Z., Axtner, S.B., Kaczmarek, P.M., Jurat, A., Korff, S., Doehring, L.C., Weichenhan, D., Katus, H.A., and Ivandic, B.T. 2004. A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice. Am J Pathol. 164:1379-1387.

4. Motiwala, T., Ghoshal, K., Das, A., Majumder, S., Weichenhan, D., Wu, Y.Z., Holman, K., James, S.J., Jacob, S.T., and Plass, C. 2003. Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene. 22:6319-6331.

1. Dai, Z.Y., Weichenhan, D., Wu, Y.Z., Hall, J.L., Rush, L.J., Smith, L.T., Raval, A., Yu, L., Kroll, D., Muehlisch, J., et al. 2002. An AscI boundary library for the studies of genetic and epigenetic alterations in CpG islands. Genome Research 12:1591-1598.

1. Weichenhan, D., Kunze, B., Winking, H., van Geel, M., Osoegawa, K., de Jong, P.J., and Traut, W. 2001. Source and component genes of a 6-200 Mb gene cluster in the house mouse. Mamm Genome. 12:590-594.

2. Traut, W., Rahn, I.M., Winking, H., Kunze, B., and Weichenhan, D. 2001. Evolution of a 6-200 Mb long-range repeat cluster in the genus Mus. Chromosoma 110:247-252.

1. Kunze, B., Hellwig-Bürgel, T., Weichenhan, D., and Traut, W. 2000. Transcription and proper splicing of a mammalian gene in yeast. Gene. 246:93-102.

2. Frengen, E., Zhao, B.H., Howe, S., Weichenhan, D., Osoegawa, K., Gjernes, E., Jessee, J., Prydz, H., Huxley, C., and de Jong, P.J. 2000. Modular bacterial artificial chromosome vectors for transfer of large inserts into mammalian cells. Genomics 68:118-126.

1. Traut, W., Weichenhan, D., Eickhoff, U., and Winking, H. 1999. Origin of the chromosome 1 HSR of the house mouse detected by CGH. Chromosome Res. 7:649-653.

2. Kunze, B., Traut, W., Garagna, S., Weichenhan, D., Redi, C.A., and Winking, H. 1999. Pericentric satellite DNA and molecular phylogeny in Acomys (Rodentia). Chromosome Res. 7:131-141.

3. Frengen, E., Weichenhan, D., Zhao, B.H., Osoegawa, K., van Geel, M., and de Jong, P.J. 1999. A modular, positive selection bacterial artificial chromosome vector with multiple cloning sites. Genomics 58:250-253.

1. Weichenhan, D., Kunze, B., Traut, W., and Winking, H. 1998. Evolution by fusion and amplification: the murine Sp100-rs gene cluster. Cytogenet Cell Genet. 80:226-231.

2. Weichenhan, D., Kunze, B., Traut, W., and Winking, H. 1998. Restoration of the Mendelian transmission ratio by a deletion in the mouse chromosome 1 HSR. Genet Res. 71:119-125.

1. Weichenhan, D., Kunze, B., Zacker, S., Traut, W., and Winking, H. 1997. Structure and expression of the murine Sp100 nuclear dot gene. Genomics. 43:298-306.

2. Plass, C., Weichenhan, D., Catanese, J., Costello, J.F., Yu, F., Yu, L., Smiraglia, D., Cavenee, W.K., Caligiuri, M.A., deJong, P., et al. 1997. An arrayed human Not I-EcoRV boundary library as a tool for RLGS spot analysis. DNA Res. 4:253-255.

1. Weichenhan, D., Traut, W., Kunze, B., and Winking, H. 1996. Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects. Genet Res. 68:125-129.

2. Kunze, B., Weichenhan, D., Virks, P., Traut, W., and Winking, H. 1996. Copy numbers of a clustered long-range repeat determine C-band staining. Cytogenet Cell Genet. 73:86-91.

3. Carlisle, C., Winking, H., Weichenhan, D., and Nagamine, C.M. 1996. Absence of correlation between Sry polymorphisms and XY sex reversal caused by the M.m. domesticus Y chromosome. Genomics 33:32-45.

1. Weichenhan, D., Kunze, B., Plass, C., Hellwig, T., Winking, H., and Traut, W. 1995. A transcript family from a long-range repeat cluster of the house mouse. Genome. 38:239-245.

2. Plass, C., Weichenhan, D., Kunze, B., Hellwig, T., Schneider, C., Bautz, F.A., Grzeschik, K.H., Traut, W., and Winking, H. 1995. A member of the mouse LRR transcript family with homology to the human SP100 gene. Hereditas. 122:245-256.

1. Rohwedel, J., Weichenhan, D., Meier, C., and Traut, W. 1993. Different modes of hypervariability in (GATA)n simple sequence repeat loci. Insect Mol Biol. 2:49-58.

1. Traut, W., Epplen, J.T., Weichenhan, D., and Rohwedel, J. 1992. Inheritance and mutation of hypervariable (GATA)n microsatellite loci in a moth, Ephestia kuehniella. Genome 35:659-666.

1. Weichenhan, D. 1991. Fast recovery of DNA from agarose gels by centrifugation through blotting paper. Trends in Genetics 7:109-109.

2. Rinken, R., Devries, J., Weichenhan, D., and Wackernagel, W. 1991. The RecA-RecBCD dependent recombination pathways of Serratia marcescens and Proteus mirabilis in Escherichia coli - functions of hybrid enzymes and hybrid pathways. Biochimie 73:375-384.

1. Weichenhan, D., and Wackernagel, W. 1989. Functional analyses of Proteus mirabilis wild-type and mutant RecBCD enzymes in Escherichia coli reveal a new mutant phenotype. Mol Microbiol. 3:1777-1784.

1. Weichenhan, D., and Wackernagel, W. 1988. Cloning of the recB, recC, and recD genes from Proteus mirabilis in Escherichia coli: in vivo formation of active hybrid enzymes. J Bacteriol. 170:1412-1414.

last update: 11/11/2010 back to top