Epigenomics and Cancer Risk Factors

PD Dr. Dieter Weichenhan

PD Dr. Dieter Weichenhan

PD Dr. Dieter Weichenhan

Position:

Scientist

Phone:

+49 6221 42 3305

Fax:

+49 6221 42 3359

CURRICULUM VITAE


EDUCATION

1977-1983:
Study of biology at the University of Oldenburg

1984-1989:
PhD thesis (magna cum laude)
Supervisor: Prof. W. Wackernagel, Department of Genetics at the University of Oldenburg
Thesis title: Physiological and genetic examinations with the cloned recBCD gene regions of the Enterobacteriaceae Escherichia coli, Proteus mirabilis und Serratia marcescens

1988-2001:
Group leader at the Institute of Biology (Director: Prof. W. Traut) at the University of Lübeck

1996-1997: (interim)
Visiting Research Assistant Professor at the Department of Human Genetics (Head: Prof. P. de Jong) at the Roswell Park Cancer Institute, Buffalo, USA

1998:
Habilitation
Thesis title: Gene fusion and gene amplification: the complex evolution of a young gene cluster in the genome of the house mouse
Venia legendi for Biology at the University of Lübeck

2001-2002:
Group leader at the Medical Clinic II (Director: Prof. H.A. Katus) at the University Clinic of Lübeck

2002-2008:
Group leader at the Medical Clinic III (Director: Prof. H.A. Katus) at the University Clinic of Heidelberg

since April 2008:
Senior scientist at the Division of Epigenomics and Cancer Risk Factors (Head: Prof. C. Plass) at the German Cancer Research Center (DKFZ) Heidelberg


RESEARCH INTEREST

Epigenetics in differentiation, aging and disease
Technical platforms for epigenetic research

PROFESSIONAL AFFILIATIONS

1986-1999: American Society of Microbiology
since 1989: German Society of Genetics
2005-2009: German Society of Cardiology
2006-2011: Consortium of Gene Diagnostics


  
LIST OF PUBLICATIONS

Weichenhan D, Wang Q, Adey A, Wolf S, Shendure J, Eils R, and Plass C. Tagmentation-based library preparation for low DNA input whole genome bisulfite sequencing. DNA Methylation Protocols, Methods in Molecular Biology, vol. 1708. J. Tost, ed. Springer Science & Business Media; 2017, in press.

Yoo Y, Park JH, Weigel C, Liesenfeld DB, Weichenhan D, Plass C, Seo DG, Lindroth AM, and Park YJ. TET-mediated hydroxymethylcytosine at the Ppargamma locus is required for initiation of adipogenic differentiation. Int J Obes (Lond). 2017;41(4):652-9. Abstract

Wolf C, Garding A, Filarsky K, Bahlo J, Robrecht S, Becker N, Zucknick M, Rouhi A, Weigel A, Claus R, Weichenhan D, Eichhorst B, Fischer K, Hallek M, Kuchenbauer F, Plass C, Dohner H, Stilgenbauer S, Lichter P, and Mertens D. NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib. Int J Cancer. 2017. Abstract

Meder B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Frese K, Lai A, Nietsch R, Scheiner C, Mester S, Bordalo DM, Amr A, Dietrich C, Pils D, Siede D, Hund H, Bauer A, Holzer DB, Ruhparwar A, Mueller-Hennessen M, Weichenhan D, Plass C, Weis T, Backs J, Wuerstle M, Keller A, Katus HA, and Posch AE. Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure. Circulation. 2017;136 Abstract(16):1528-44. Abstract

Jahreis S, Trump S, Bauer M, Bauer T, Thurmann L, Feltens R, Wang Q, Gu L, Grutzmann K, Roder S, Averbeck M, Weichenhan D, Plass C, Sack U, Borte M, Dubourg V, Schuurmann G, Simon JC, von Bergen M, Hackermuller J, Eils R, Lehmann I, and Polte T. Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications. J Allergy Clin Immunol. 2017. Abstract

Dewi DL, Mohapatra SR, Blanco Cabanes S, Adam I, Somarribas Patterson LF, Berdel B, Kahloon M, Thurmann L, Loth S, Heilmann K, Weichenhan D, Mucke O, Heiland I, Wimberger P, Kuhlmann JD, Kellner KH, Schott S, Plass C, Platten M, Gerhauser C, Trump S, and Opitz CA. Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer. Oncoimmunology. 2017;6(2):e1274477. Abstract

Delacher M, Imbusch CD, Weichenhan D, Breiling A, Hotz-Wagenblatt A, Trager U, Hofer AC, Kagebein D, Wang Q, Frauhammer F, Mallm JP, Bauer K, Herrmann C, Lang PA, Brors B, Plass C, and Feuerer M. Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nat Immunol. 2017;18(10):1160-72. Abstract

Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lubbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhauser C, Oakes CC, Wang T, and Plass C. DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet. 2017;49(7):1052-60. Abstract

Trump S, Bieg M, Gu Z, Thurmann L, Bauer T, Bauer M, Ishaque N, Roder S, Gu L, Herberth G, Lawerenz C, Borte M, Schlesner M, Plass C, Diessl N, Eszlinger M, Mucke O, Elvers HD, Wissenbach DK, von Bergen M, Herrmann C, Weichenhan D, Wright RJ, Lehmann I, and Eils R. Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation. Sci Rep. 2016;6:28616. Abstract

Schliesser MG, Claus R, Hielscher T, Grimm C, Weichenhan D, Blaes J, Wiestler B, Hau P, Schramm J, Sahm F, Weiss EK, Weiler M, Baer C, Schmidt-Graf F, Schackert G, Westphal M, Hertenstein A, Roth P, Galldiks N, Hartmann C, Pietsch T, Felsberg J, Reifenberger G, Sabel MC, Winkler F, von Deimling A, Meisner C, Vajkoczy P, Platten M, Weller M, Plass C, and Wick W. Prognostic relevance of miRNA-155 methylation in anaplastic glioma. Oncotarget. 2016;7(50):82028-45. Abstract

Oakes CC, Seifert M, Assenov Y, Gu L, Przekopowitz M, Ruppert AS, Wang Q, Imbusch CD, Serva A, Koser SD, Brocks D, Lipka DB, Bogatyrova O, Weichenhan D, Brors B, Rassenti L, Kipps TJ, Mertens D, Zapatka M, Lichter P, Dohner H, Kuppers R, Zenz T, Stilgenbauer S, Byrd JC, and Plass C. DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia. Nat Genet. 2016;48(3):253-64. Abstract

Mock A, Geisenberger C, Orlik C, Warta R, Schwager C, Jungk C, Dutruel C, Geiselhart L, Weichenhan D, Zucknick M, Nied AK, Friauf S, Exner J, Capper D, Hartmann C, Lahrmann B, Grabe N, Debus J, von Deimling A, Popanda O, Plass C, Unterberg A, Abdollahi A, Schmezer P, and Herold-Mende C. LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients. Int J Cancer. 2016;139(2):424-32. Abstract

Kostareli E, Hielscher T, Zucknick M, Baboci L, Wichmann G, Holzinger D, Mucke O, Pawlita M, Del Mistro A, Boscolo-Rizzo P, Da Mosto MC, Tirelli G, Plinkert P, Dietz A, Plass C, Weichenhan D, and Hess J. Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients. Epigenetics. 2016;11(1):61-73. Abstract

Junge KM, Bauer T, Geissler S, Hirche F, Thurmann L, Bauer M, Trump S, Bieg M, Weichenhan D, Gu L, Mallm JP, Ishaque N, Mucke O, Roder S, Herberth G, Diez U, Borte M, Rippe K, Plass C, Hermann C, Stangl GI, Eils R, and Lehmann I. Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms. J Allergy Clin Immunol. 2016;137(2):610-3. Abstract

Goeppert B, Ernst C, Baer C, Roessler S, Renner M, Mehrabi A, Hafezi M, Pathil A, Warth A, Stenzinger A, Weichert W, Bahr M, Will R, Schirmacher P, Plass C, and Weichenhan D. Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma. Epigenetics. 2016;11(11):780-90. Abstract

Filarsky K, Garding A, Becker N, Wolf C, Zucknick M, Claus R, Weichenhan D, Plass C, Dohner H, Stilgenbauer S, Lichter P, and Mertens D. Kruppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling. Haematologica. 2016;101(6):e249-53. Abstract

BLUEPRINT Consortium. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications. Nat Biotechnol. 2016;34(7):726-37. Abstract

Bauer T, Trump S, Ishaque N, Thurmann L, Gu L, Bauer M, Bieg M, Gu Z, Weichenhan D, Mallm JP, Roder S, Herberth G, Takada E, Mucke O, Winter M, Junge KM, Grutzmann K, Rolle-Kampczyk U, Wang Q, Lawerenz C, Borte M, Polte T, Schlesner M, Schanne M, Wiemann S, Georg C, Stunnenberg HG, Plass C, Rippe K, Mizuguchi J, Herrmann C, Eils R, and Lehmann I. Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Mol Syst Biol. 2016;12(3):861. Abstract

Sonnet M, Claus R, Becker N, Zucknick M, Petersen J, Lipka DB, Oakes CC, Andrulis M, Lier A, Milsom MD, Witte T, Gu L, Kim-Wanner SZ, Schirmacher P, Wulfert M, Gattermann N, Lubbert M, Rosenbauer F, Rehli M, Bullinger L, Weichenhan D, and Plass C. Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia. Genome Medicine. 2014;6(4):34. Abstract

Rutschow D, Bauer R, Gohringer C, Bekeredjian R, Schinkel S, Straub V, Koenen M, Weichenhan D, Katus HA, and Muller OJ. S151A delta-sarcoglycan mutation causes a mild phenotype of cardiomyopathy in mice. European Journal of Human Genetics : EJHG. 2014;22(1):119-25. Abstract

Meder B, Ruhle F, Weis T, Homuth G, Keller A, Franke J, Peil B, Lorenzo Bermejo J, Frese K, Huge A, Witten A, Vogel B, Haas J, Volker U, Ernst F, Teumer A, Ehlermann P, Zugck C, Friedrichs F, Kroemer H, Dorr M, Hoffmann W, Maisch B, Pankuweit S, Ruppert V, Scheffold T, Kuhl U, Schultheiss HP, Kreutz R, Ertl G, Angermann C, Charron P, Villard E, Gary F, Isnard R, Komajda M, Lutz M, Meitinger T, Sinner MF, Wichmann HE, Krawczak M, Ivandic B, Weichenhan D, Gelbrich G, El-Mokhtari NE, Schreiber S, Felix SB, Hasenfuss G, Pfeufer A, Hubner N, Kaab S, Arbustini E, Rottbauer W, Frey N, Stoll M, and Katus HA. A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy. European Heart Journal. 2014;35(16):1069-77. Abstract

Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wunsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, and Plass C. Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing. Cell Cycle. 2014; 13(22): 3476-87. Abstract 

Lipka D, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Haas S, Brocks D, Gu L, Essers M, Brors B, Eils R, Trumpp A, Milsom M, and Plass C. Whole-genome bisulfite sequencing of HSCs and their immediate progeny identifies novel regulatory elements involved in self-renewal and early hematopoietic commitment. Experimental Hematology. 2014;42(8 Suppl):S20. Abstract

Kuhmann C, Li C, Kloor M, Salou M, Weigel C, Schmidt CR, Ng LW, Tsui WW, Leung SY, Yuen ST, Becker N, Weichenhan D, Plass C, Schmezer P, Chan TL, and Popanda O. Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer. Human Molecular Genetics. 2014;23(8):2043-54. Abstract

Goeppert B, Konermann C, Schmidt CR, Bogatyrova O, Geiselhart L, Ernst C, Gu L, Becker N, Zucknick M, Mehrabi A, Hafezi M, Klauschen F, Stenzinger A, Warth A, Breuhahn K, Renner M, Weichert W, Schirmacher P, Plass C, and Weichenhan D. Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway. Hepatology. 2014;59(2):544-54. Abstract 

Gaedcke J, Leha A, Claus R, Weichenhan D, Jung K, Kitz J, Grade M, Wolff HA, Jo P, Doyen J, Gerard JP, Johnsen SA, Plass C, Beissbarth T, and Ghadimi M. Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer. Oncotarget. 2014. Abstract

Dutruel C, Bergmann F, Rooman I, Zucknick M, Weichenhan D, Geiselhart L, Kaffenberger T, Rachakonda PS, Bauer A, Giese N, Hong C, Xie H, Costello JF, Hoheisel J, Kumar R, Rehli M, Schirmacher P, Werner J, Plass C, Popanda O, and Schmezer P. Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development. Oncogene. 2014;33(26):3401-10. Abstract

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wunsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, and Trumpp A. Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis. Cell Stem Cell. 2014;15(4):507-22. Abstract 

Arab K, Park YJ, Lindroth AM, Schafer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, and Plass C. Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A. Molecular Cell. 2014;55(4):604-14. Abstract

Wiestler B, Claus R, Hartlieb SA, Schliesser MG, Weiss EK, Hielscher T, Platten M, Dittmann LM, Meisner C, Felsberg J, Happold C, Simon M, Nikkhah G, Papsdorf K, Steinbach JP, Sabel M, Grimm C, Weichenhan D, Tews B, Reifenberger G, Capper D, Muller W, Plass C, Weller M, Wick W, and Neuro-oncology Working Group of the German Cancer S. Malignant astrocytomas of elderly patients lack favorable molecular markers: an analysis of the NOA-08 study collective. Neurooncology. 2013;15(8):1017-26. Abstract

Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jager N, Gu L, Bogatyrova O, Stutz AM, Claus R, Eils J, Eils R, Gerhauser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Falth M, Gade S, Schmidt M, Amschler N, Hass T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sultmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, and Schlomm T. Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell. 2013;23(2):159-70. Abstract

Weichenhan D, and Plass C. The evolving epigenome. Human Molecular Genetics. 2013;22(R1):R1-6. Abstract 

Wang Q, Gu L, Adey A, Radlwimmer B, Wang W, Hovestadt V, Bahr M, Wolf S, Shendure J, Eils R, Plass C, and Weichenhan D. Tagmentation-based whole-genome bisulfite sequencing. Nature Protocols. 2013;8(10):2022-32. Abstract

Sonnet M, Baer C, Rehli M, Weichenhan D, and Plass C. Enrichment of methylated DNA by methyl-CpG immunoprecipitation. Methods in Molecular Biology. 2013;971:201-12. Abstract

Kostareli E, Holzinger D, Bogatyrova O, Hielscher T, Wichmann G, Keck M, Lahrmann B, Grabe N, Flechtenmacher C, Schmidt CR, Seiwert T, Dyckhoff G, Dietz A, Hofler D, Pawlita M, Benner A, Bosch FX, Plinkert P, Plass C, Weichenhan D, and Hess J. HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas. The Journal of Clinical Investigation. 2013;123(6):2488-501. Abstract

Jager N, Schlesner M, Jones DT, Raffel S, Mallm JP, Junge KM, Weichenhan D, Bauer T, Ishaque N, Kool M, Northcott PA, Korshunov A, Drews RM, Koster J, Versteeg R, Richter J, Hummel M, Mack SC, Taylor MD, Witt H, Swartman B, Schulte-Bockholt D, Sultan M, Yaspo ML, Lehrach H, Hutter B, Brors B, Wolf S, Plass C, Siebert R, Trumpp A, Rippe K, Lehmann I, Lichter P, Pfister SM, and Eils R. Hypermutation of the inactive X chromosome is a frequent event in cancer. Cell. 2013;155(3):567-81. Abstract

Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Kohler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dosch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, and Meder B. Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Molecular Medicine. 2013;5(3):413-29. Abstract

Garding A, Bhattacharya N, Haebe S, Muller F, Weichenhan D, Idler I, Ickstadt K, Stilgenbauer S, and Mertens D. TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q. Haematologica. 2013;98(2):269-73. Abstract

Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, Idler I, Zucknick M, Caudron-Herger M, Oakes C, Fleig V, Keklikoglou I, Allegra D, Serra L, Thakurela S, Tiwari V, Weichenhan D, Benner A, Radlwimmer B, Zentgraf H, Wiemann S, Rippe K, Plass C, Dohner H, Lichter P, Stilgenbauer S, and Mertens D. Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. PLoS Genetics. 2013;9(4):e1003373. Abstract

Faryna M, Konermann C, Aulmann S, Bermejo JL, Brugger M, Diederichs S, Rom J, Weichenhan D, Claus R, Rehli M, Schirmacher P, Sinn HP, Plass C, and Gerhauser C. Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. FASEB Journal : official publication of the Federation of American Societies for Experimental Biology. 2012;26(12):4937-50. Abstract

Baer C, Claus R, Frenzel LP, Zucknick M, Park YJ, Gu L, Weichenhan D, Fischer M, Pallasch CP, Herpel E, Rehli M, Byrd JC, Wendtner CM, and Plass C. Extensive promoter DNA hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia. Cancer Research. 2012;72(15):3775-85. Abstract

Park YJ, Claus R, Weichenhan D, and Plass C. Genome-wide epigenetic modifications in cancer. Progress in Drug Research, Fortschritte der Arzneimittelforschung, Progres des recherches pharmaceutiques. 2011;67:25-49. Abstract

Meder B, Haas J, Keller A, Heid C, Just S, Borries A, Boisguerin V, Scharfenberger-Schmeer M, Stahler P, Beier M, Weichenhan D, Strom TM, Pfeufer A, Korn B, Katus HA, and Rottbauer W. Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathies. Circulation Cardiovascular Genetics. 2011;4(2):110-22. Abstract

Kuhmann C, Weichenhan D, Rehli M, Plass C, Schmezer P, and Popanda O. DNA methylation changes in cells regrowing after fractioned ionizing radiation. Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. 2011;101(1):116-21. Abstract

Arab K, Smith LT, Gast A, Weichenhan D, Huang JP, Claus R, Hielscher T, Espinosa AV, Ringel MD, Morrison CD, Schadendorf D, Kumar R, and Plass C. Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma. Carcinogenesis. 2011;32(10):1467-73. Abstract

Luedde M, Ehlermann P, Weichenhan D, Will R, Zeller R, Rupp S, Muller A, Steen H, Ivandic BT, Ulmer HE, Kern M, Katus HA, and Frey N. Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation. Cardiovascular Research. 2010;86(3):452-60. Abstract

Hassel D, Dahme T, Erdmann J, Meder B, Huge A, Stoll M, Just S, Hess A, Ehlermann P, Weichenhan D, Grimmler M, Liptau H, Hetzer R, Regitz-Zagrosek V, Fischer C, Nurnberg P, Schunkert H, Katus HA, and Rottbauer W. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nature Medicine. 2009;15(11):1281-8. Abstract

Goehringer C, Rutschow D, Bauer R, Schinkel S, Weichenhan D, Bekeredjian R, Straub V, Kleinschmidt JA, Katus HA, and Muller OJ. Prevention of cardiomyopathy in delta-sarcoglycan knockout mice after systemic transfer of targeted adeno-associated viral vectors. Cardiovascular Research. 2009;82(3):404-10. Abstract

Friedrichs F, Zugck C, Rauch GJ, Ivandic B, Weichenhan D, Muller-Bardorff M, Meder B, El Mokhtari NE, Regitz-Zagrosek V, Hetzer R, Schafer A, Schreiber S, Chen J, Neuhaus I, Ji R, Siemers NO, Frey N, Rottbauer W, Katus HA, and Stoll M. HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome Research. 2009;19(3):395-403. Abstract 

Weichenhan D, Traut W, Gongrich C, Himmelbauer H, Busch L, Monyer H, and Winking H. A mouse translocation associated with Caspr5-2 disruption and perinatal lethality. Mammalian Genome : official journal of the International Mammalian Genome Society. 2008;19(10-12):675-86. Abstract

Geiger SK, Bar H, Ehlermann P, Walde S, Rutschow D, Zeller R, Ivandic BT, Zentgraf H, Katus HA, Herrmann H, and Weichenhan D. Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. Journal of Molecular Medicine. 2008;86(3):281-9. Abstract

Ehlermann P, Weichenhan D, Zehelein J, Steen H, Pribe R, Zeller R, Lehrke S, Zugck C, Ivandic BT, and Katus HA. Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene. BMC Medical Genetics. 2008;9:95. Abstract

Schoensiegel F, Bekeredjian R, Schrewe A, Weichenhan D, Frey N, Katus HA, and Ivandic BT. Atrial natriuretic peptide and osteopontin are useful markers of cardiac disorders in mice. Comparative Medicine. 2007;57(6):546-53. Abstract

Zeller R, Ivandic BT, Ehlermann P, Mucke O, Zugck C, Remppis A, Giannitsis E, Katus HA, and Weichenhan D. Large-scale mutation screening in patients with dilated or hypertrophic cardiomyopathy: a pilot study using DGGE. Journal of Molecular Medicine. 2006;84(8):682-91. Abstract

Traut W, Weichenhan D, Himmelbauer H, and Winking H. New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene. Mammalian Genome : official journal of the International Mammalian Genome Society. 2006;17(7):723-31. Abstract

Korff S, Schoensiegel F, Riechert N, Weichenhan D, Katus HA, and Ivandic BT. Fine mapping of Dyscalc1, the major genetic determinant of dystrophic cardiac calcification in mice. Physiological Genomics. 2006;25(3):387-92. Abstract

Korff S, Riechert N, Schoensiegel F, Weichenhan D, Autschbach F, Katus HA, and Ivandic BT. Calcification of myocardial necrosis is common in mice. Virchows Archiv : an international journal of pathology. 2006;448(5):630-8. Abstract

Ehlermann P, Eggers K, Bierhaus A, Most P, Weichenhan D, Greten J, Nawroth PP, Katus HA, and Remppis A. Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products. Cardiovascular Diabetology. 2006;5:6. Abstract

Pleger ST, Remppis A, Heidt B, Volkers M, Chuprun JK, Kuhn M, Zhou RH, Gao E, Szabo G, Weichenhan D, Muller OJ, Eckhart AD, Katus HA, Koch WJ, and Most P. S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. Molecular Therapy : the journal of the American Society of Gene Therapy. 2005;12(6):1120-9. Abstract

Jaeger J, Weichenhan D, Ivandic B, and Spang R. Early diagnostic marker panel determination for microarray based clinical studies. Statistical Applications in Genetics and Molecular Biology. 2005;4: Article9. Abstract

Remppis A, Pleger ST, Most P, Lindenkamp J, Ehlermann P, Schweda C, Loffler E, Weichenhan D, Zimmermann W, Eschenhagen T, Koch WJ, and Katus HA. S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts. The Journal of Gene Medicine. 2004;6(4):387-94. Abstract

Most P, Pleger ST, Volkers M, Heidt B, Boerries M, Weichenhan D, Loffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, and Koch WJ. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. The Journal of Clinical Investigation. 2004;114(11):1550-63. Abstract 

Aherrahrou Z, Axtner SB, Kaczmarek PM, Jurat A, Korff S, Doehring LC, Weichenhan D, Katus HA, and Ivandic BT. A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice. The American Journal of Pathology. 2004;164(4):1379-87. Abstract

Motiwala T, Ghoshal K, Das A, Majumder S, Weichenhan D, Wu YZ, Holman K, James SJ, Jacob ST, and Plass C. Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene. 2003;22(41):6319-31. Abstract

Dai Z, Weichenhan D, Wu YZ, Hall JL, Rush LJ, Smith LT, Raval A, Yu L, Kroll D, Muehlisch J, Fruhwald MC, de Jong P, Catanese J, Davuluri RV, Smiraglia DJ, and Plass C. An AscI boundary library for the studies of genetic and epigenetic alterations in CpG islands. Genome Research. 2002;12(10):1591-8. Abstract

Weichenhan D, Kunze B, Winking H, van Geel M, Osoegawa K, de Jong PJ, and Traut W. Source and component genes of a 6-200 Mb gene cluster in the house mouse. Mammalian Genome : official journal of the International Mammalian Genome Society. 2001;12(8):590-4. Abstract

Kunze B, Hellwig-Burgel T, Weichenhan D, and Traut W. Transcription and proper splicing of a mammalian gene in yeast. Gene. 2000;246(1-2):93-102. Abstract

Frengen E, Zhao B, Howe S, Weichenhan D, Osoegawa K, Gjernes E, Jessee J, Prydz H, Huxley C, and de Jong PJ. Modular bacterial artificial chromosome vectors for transfer of large inserts into mammalian cells. Genomics. 2000;68(2):118-26. Abstract

Traut W, Weichenhan D, Eickhoff U, and Winking H. Origin of the chromosome 1 HSR of the house mouse detected by CGH. Chromosome Research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 1999;7(8):649-53. Abstract

 Kunze B, Traut W, Garagna S, Weichenhan D, Redi CA, and Winking H. Pericentric satellite DNA and molecular phylogeny in Acomys (Rodentia). Chromosome Research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 1999;7(2):131-41. Abstract

Frengen E, Weichenhan D, Zhao B, Osoegawa K, van Geel M, and de Jong PJ. A modular, positive selection bacterial artificial chromosome vector with multiple cloning sites. Genomics. 1999;58(3):250-3. Abstract

Weichenhan D, Kunze B, Traut W, and Winking H. Evolution by fusion and amplification: the murine Sp100-rs gene cluster. Cytogenetics and Cell Genetics. 1998;80(1-4):226-31. Abstract

Weichenhan D, Kunze B, Traut W, and Winking H. Restoration of the Mendelian transmission ratio by a deletion in the mouse chromosome 1 HSR. Genetical Research. 1998;71(2):119-25. Abstract 

Weichenhan D, Kunze B, Zacker S, Traut W, and Winking H. Structure and expression of the murine Sp100 nuclear dot gene. Genomics. 1997;43(3):298-306. Abstract

Plass C, Weichenhan D, Catanese J, Costello JF, Yu F, Yu L, Smiraglia D, Cavenee WK, Caligiuri MA, deJong P, and Held WA. An arrayed human not I-EcoRV boundary library as a tool for RLGS spot analysis. DNA Research : an international journal for rapid publication of reports on genes and genomes. 1997;4(3):253-5. Abstract

Weichenhan D, Traut W, Kunze B, and Winking H. Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects. Genetical Research. 1996;68(2):125-9. Abstract 

Kunze B, Weichenhan D, Virks P, Traut W, and Winking H. Copy numbers of a clustered long-range repeat determine C-band staining. Cytogenetics and Cell Genetics. 1996;73(1-2):86-91. Abstract

Carlisle C, Winking H, Weichenhan D, and Nagamine CM. Absence of correlation between Sry polymorphisms and XY sex reversal caused by the M. m. domesticus Y chromosome. Genomics. 1996;33(1):32-45. Abstract

Weichenhan D, Kunze B, Plass C, Hellwig T, Winking H, and Traut W. A transcript family from a long-range repeat cluster of the house mouse. Genome / National Research Council Canada = Genome / Conseil national de recherches Canada. 1995;38(2):239-45. Abstract

Plass C, Weichenhan D, Kunze B, Hellwig T, Schneider C, Bautz FA, Grzeschik KH, Traut W, and Winking H. A member of the mouse LRR transcript family with homology to the human Sp100 gene. Hereditas. 1995;122(3):245-56. Abstract

Rohwedel J, Weichenhan D, Meier C, and Traut W. Different modes of hypervariability in (GATA)n simple sequence repeat loci. Insect Molecular Biology. 1993;2(1):49-58. Abstract

Rinken R, de Vries J, Weichenhan D, and Wackernagel W. The recA-recBCD dependent recombination pathways of Serratia marcescens and Proteus mirabilis in Escherichia coli: functions of hybrid enzymes and hybrid pathways. Biochimie. 1991;73(4):375-84. Abstract

Weichenhan D, and Wackernagel W. Functional analyses of Proteus mirabilis wild-type and mutant RecBCD enzymes in Escherichia coli reveal a new mutant phenotype. Molecular Microbiology. 1989;3(12):1777-84. Abstract

Weichenhan D, and Wackernagel W. Cloning of the recB, recC, and recD genes from Proteus mirabilis in Escherichia coli: in vivo formation of active hybrid enzymes. Journal of Bacteriology. 1988;170(3):1412-4. Abstract

 

 

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