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Dr. Dieter Weichenhan

Dr. Dieter Weichenhan

Position: Scientist


Contact: Contact Form


Phone: +49 6221 42 3305

Fax: +49 6221 42 3359

CURRICULUM VITAE


EDUCATION

1977-1983:
Study of biology at the University of Oldenburg

1984-1989:
PhD thesis (magna cum laude)
Supervisor: Prof. W. Wackernagel, Department of Genetics at the University of Oldenburg
Thesis title: Physiological and genetic examinations with the cloned recBCD gene regions of the Enterobacteriaceae Escherichia coli, Proteus mirabilis und Serratia marcescens

1988-2001:
Group leader at the Institute of Biology (Director: Prof. W. Traut) at the University of Lübeck

1996-1997: (interim)
Visiting Research Assistant Professor at the Department of Human Genetics (Head: Prof. P. de Jong) at the Roswell Park Cancer Institute, Buffalo, USA

1998:
Habilitation
Thesis title: Gene fusion and gene amplification: the complex evolution of a young gene cluster in the genome of the house mouse
Venia legendi for Biology at the University of Lübeck

2001-2002:
Group leader at the Medical Clinic II (Director: Prof. H.A. Katus) at the University Clinic of Lübeck

2002-2008:
Group leader at the Medical Clinic III (Director: Prof. H.A. Katus) at the University Clinic of Heidelberg

since April 2008:
Senior scientist at the Division of Epigenomics and Cancer Risk Factors (Head: Prof. C. Plass) at the German Cancer Research Center (DKFZ) Heidelberg


RESEARCH INTEREST

Epigenetics in differentiation, aging and disease
Technical platforms for epigenetic research

PROFESSIONAL AFFILIATIONS

1986-1999: American Society of Microbiology
since 1989: German Society of Genetics
2005-2009: German Society of Cardiology
2006-2011: Consortium of Gene Diagnostics



LIST OF PUBLICATIONS

2014

1.Sonnet M, Claus R, Becker N, Zucknick M, Petersen J, Lipka DB, Oakes CC, Andrulis M, Lier A, Milsom MD, Witte T, Gu L, Kim-Wanner SZ, Schirmacher P, Wulfert M, Gattermann N, Lubbert M, Rosenbauer F, Rehli M, Bullinger L, Weichenhan D, and Plass C. Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia. Genome Med. 2014;6(4):34.

2.Rutschow D, Bauer R, Gohringer C, Bekeredjian R, Schinkel S, Straub V, Koenen M, Weichenhan D, Katus HA, and Muller OJ. S151A delta-sarcoglycan mutation causes a mild phenotype of cardiomyopathy in mice. Eur J Hum Genet. 2014;22(1):119-25.

3.Meder B, Ruhle F, Weis T, Homuth G, Keller A, Franke J, Peil B, Lorenzo Bermejo J, Frese K, Huge A, Witten A, Vogel B, Haas J, Volker U, Ernst F, Teumer A, Ehlermann P, Zugck C, Friedrichs F, Kroemer H, Dorr M, Hoffmann W, Maisch B, Pankuweit S, Ruppert V, Scheffold T, Kuhl U, Schultheiss HP, Kreutz R, Ertl G, Angermann C, Charron P, Villard E, Gary F, Isnard R, Komajda M, Lutz M, Meitinger T, Sinner MF, Wichmann HE, Krawczak M, Ivandic B, Weichenhan D, Gelbrich G, El-Mokhtari NE, Schreiber S, Felix SB, Hasenfuss G, Pfeufer A, Hubner N, Kaab S, Arbustini E, Rottbauer W, Frey N, Stoll M, and Katus HA. A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy. Eur Heart J. 2014;35(16):1069-77.

4.Lipka D, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Haas S, Brocks D, Gu L, Essers M, Brors B, Eils R, Trumpp A, Milsom M, and Plass C. Whole-genome bisulfite sequencing of HSCs and their immediate progeny identifies novel regulatory elements involved in self-renewal and early hematopoietic commitment. Exp Hematol. 2014;42(8 Suppl):S20.

5.Kuhmann C, Li C, Kloor M, Salou M, Weigel C, Schmidt CR, Ng LW, Tsui WW, Leung SY, Yuen ST, Becker N, Weichenhan D, Plass C, Schmezer P, Chan TL, and Popanda O. Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer. Hum Mol Genet. 2014;23(8):2043-54.

6.Goeppert B, Konermann C, Schmidt CR, Bogatyrova O, Geiselhart L, Ernst C, Gu L, Becker N, Zucknick M, Mehrabi A, Hafezi M, Klauschen F, Stenzinger A, Warth A, Breuhahn K, Renner M, Weichert W, Schirmacher P, Plass C, and Weichenhan D. Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway. Hepatology. 2014;59(2):544-54.

7.Gaedcke J, Leha L, Claus R, Weichenhan D, Jung K, Kitz J, Grade M, Wolff HA, Jo P, Doyen J, Gérard J-P, Johnsen SA, Plass C, Beißbarth T, and Ghadimi M. Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer. Oncotarget. 2014; advance online.

8.Dutruel C, Bergmann F, Rooman I, Zucknick M, Weichenhan D, Geiselhart L, Kaffenberger T, Rachakonda PS, Bauer A, Giese N, Hong C, Xie H, Costello JF, Hoheisel J, Kumar R, Rehli M, Schirmacher P, Werner J, Plass C, Popanda O, and Schmezer P. Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development. Oncogene. 2014;33(26):3401-10.

9.Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wunsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, and Trumpp A. Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis. Cell Stem Cell. 2014;15:1-16.

10.Arab K, Park YJ, Lindroth AM, Schafer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, and Plass C. Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A. Mol Cell. 2014;55(4):604-14.

2013

1.Wiestler B, Claus R, Hartlieb SA, Schliesser MG, Weiss EK, Hielscher T, Platten M, Dittmann LM, Meisner C, Felsberg J, Happold C, Simon M, Nikkhah G, Papsdorf K, Steinbach JP, Sabel M, Grimm C, Weichenhan D, Tews B, Reifenberger G, Capper D, Muller W, Plass C, Weller M, Wick W, and Neuro-oncology Working Group of the German Cancer S. Malignant astrocytomas of elderly patients lack favorable molecular markers: an analysis of the NOA-08 study collective. Neuro-Oncol. 2013;15(8):1017-26.

2.Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jager N, Gu L, Bogatyrova O, Stutz AM, Claus R, Eils J, Eils R, Gerhauser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Falth M, Gade S, Schmidt M, Amschler N, Hass T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sultmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, and Schlomm T. Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer cell. 2013;23(2):159-70.

3.Weichenhan D, and Plass C. The evolving epigenome. Hum Mol Genet. 2013;22(R1):R1-6.

4.Wang Q, Gu L, Adey A, Radlwimmer B, Wang W, Hovestadt V, Bahr M, Wolf S, Shendure J, Eils R, Plass C, and Weichenhan D. Tagmentation-based whole-genome bisulfite sequencing. Nature Protocols. 2013;8(10):2022-32.

5.Sonnet M, Baer C, Rehli M, Weichenhan D, and Plass C. Enrichment of methylated DNA by methyl-CpG immunoprecipitation. Meth Mol Biol. 2013;971:201-12.

6.Kostareli E, Holzinger D, Bogatyrova O, Hielscher T, Wichmann G, Keck M, Lahrmann B, Grabe N, Flechtenmacher C, Schmidt CR, Seiwert T, Dyckhoff G, Dietz A, Hofler D, Pawlita M, Benner A, Bosch FX, Plinkert P, Plass C, Weichenhan D, and Hess J. HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas. J Clin Invest. 2013;123(6):2488-501.

7.Jager N, Schlesner M, Jones DT, Raffel S, Mallm JP, Junge KM, Weichenhan D, Bauer T, Ishaque N, Kool M, Northcott PA, Korshunov A, Drews RM, Koster J, Versteeg R, Richter J, Hummel M, Mack SC, Taylor MD, Witt H, Swartman B, Schulte-Bockholt D, Sultan M, Yaspo ML, Lehrach H, Hutter B, Brors B, Wolf S, Plass C, Siebert R, Trumpp A, Rippe K, Lehmann I, Lichter P, Pfister SM, and Eils R. Hypermutation of the inactive X chromosome is a frequent event in cancer. Cell. 2013;155(3):567-81.

8.Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Kohler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dosch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, and Meder B. Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med. 2013;5(3):413-29.

9.Garding A, Bhattacharya N, Haebe S, Muller F, Weichenhan D, Idler I, Ickstadt K, Stilgenbauer S, and Mertens D. TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q. Haematologica. 2013;98(2):269-73.

10.Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, Idler I, Zucknick M, Caudron-Herger M, Oakes C, Fleig V, Keklikoglou I, Allegra D, Serra L, Thakurela S, Tiwari V, Weichenhan D, Benner A, Radlwimmer B, Zentgraf H, Wiemann S, Rippe K, Plass C, Dohner H, Lichter P, Stilgenbauer S, and Mertens D. Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. PLoS Genet. 2013;9(4):e1003373.

2012

1.Faryna M, Konermann C, Aulmann S, Bermejo JL, Brugger M, Diederichs S, Rom J, Weichenhan D, Claus R, Rehli M, Schirmacher P, Sinn HP, Plass C, and Gerhauser C. Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. FASEB J. 2012;26(12):4937-50.

2.Baer C, Claus R, Frenzel LP, Zucknick M, Park YJ, Gu L, Weichenhan D, Fischer M, Pallasch CP, Herpel E, Rehli M, Byrd JC, Wendtner CM, and Plass C. Extensive promoter DNA hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia. Cancer Res. 2012;72(15):3775-85.

2011

1.Park YJ, Claus R, Weichenhan D, and Plass C. Genome-wide epigenetic modifications in cancer. Progress Drug Res. 2011;67(25-49.

2.Meder B, Haas J, Keller A, Heid C, Just S, Borries A, Boisguerin V, Scharfenberger-Schmeer M, Stahler P, Beier M, Weichenhan D, Strom TM, Pfeufer A, Korn B, Katus HA, and Rottbauer W. Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathies. Circulation Cardiovasc Genet. 2011;4(2):110-22.

3.Kuhmann C, Weichenhan D, Rehli M, Plass C, Schmezer P, and Popanda O. DNA methylation changes in cells regrowing after fractioned ionizing radiation. Radiotherapy Oncol. 2011;101(1):116-21.

4.Arab K, Smith LT, Gast A, Weichenhan D, Huang JP, Claus R, Hielscher T, Espinosa AV, Ringel MD, Morrison CD, Schadendorf D, Kumar R, and Plass C. Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma. Carcinogenesis. 2011;32(10):1467-73.

2010

1.Luedde M, Ehlermann P, Weichenhan D, Will R, Zeller R, Rupp S, Muller A, Steen H, Ivandic BT, Ulmer HE, Kern M, Katus HA, and Frey N. Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation. Cardiovasc Res. 2010;86(3):452-60.

2009

1.Hassel D, Dahme T, Erdmann J, Meder B, Huge A, Stoll M, Just S, Hess A, Ehlermann P, Weichenhan D, Grimmler M, Liptau H, Hetzer R, Regitz-Zagrosek V, Fischer C, Nurnberg P, Schunkert H, Katus HA, and Rottbauer W. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nature Med. 2009;15(11):1281-8.

2.Goehringer C, Rutschow D, Bauer R, Schinkel S, Weichenhan D, Bekeredjian R, Straub V, Kleinschmidt JA, Katus HA, and Muller OJ. Prevention of cardiomyopathy in delta-sarcoglycan knockout mice after systemic transfer of targeted adeno-associated viral vectors. Cardiovasc Res. 2009;82(3):404-10.

3.Friedrichs F, Zugck C, Rauch GJ, Ivandic B, Weichenhan D, Muller-Bardorff M, Meder B, El Mokhtari NE, Regitz-Zagrosek V, Hetzer R, Schafer A, Schreiber S, Chen J, Neuhaus I, Ji R, Siemers NO, Frey N, Rottbauer W, Katus HA, and Stoll M. HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome Res. 2009;19(3):395-403.

2008

1.Weichenhan D, Traut W, Gongrich C, Himmelbauer H, Busch L, Monyer H, and Winking H. A mouse translocation associated with Caspr5-2 disruption and perinatal lethality. Mamm Genome. 2008;19(10-12):675-86.

2.Geiger SK, Bar H, Ehlermann P, Walde S, Rutschow D, Zeller R, Ivandic BT, Zentgraf H, Katus HA, Herrmann H, and Weichenhan D. Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. J Mol Med. 2008;86(3):281-9.

3.Ehlermann P, Weichenhan D, Zehelein J, Steen H, Pribe R, Zeller R, Lehrke S, Zugck C, Ivandic BT, and Katus HA. Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene. BMC Med Genet. 2008;9(95.

2007

1.Schoensiegel F, Bekeredjian R, Schrewe A, Weichenhan D, Frey N, Katus HA, and Ivandic BT. Atrial natriuretic peptide and osteopontin are useful markers of cardiac disorders in mice. Comp Med. 2007;57(6):546-53.

2006

1.Zeller R, Ivandic BT, Ehlermann P, Mucke O, Zugck C, Remppis A, Giannitsis E, Katus HA, and Weichenhan D. Large-scale mutation screening in patients with dilated or hypertrophic cardiomyopathy: a pilot study using DGGE. J Mol Med. 2006;84(8):682-91.

2.Traut W, Weichenhan D, Himmelbauer H, and Winking H. New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene. Mamm Genome. 2006;17(7):723-31.

3.Korff S, Schoensiegel F, Riechert N, Weichenhan D, Katus HA, and Ivandic BT. Fine mapping of Dyscalc1, the major genetic determinant of dystrophic cardiac calcification in mice. Physiol Genomics. 2006;25(3):387-92.

4.Korff S, Riechert N, Schoensiegel F, Weichenhan D, Autschbach F, Katus HA, and Ivandic BT. Calcification of myocardial necrosis is common in mice. Virchows Archiv. 2006;448(5):630-8.

5.Ehlermann P, Eggers K, Bierhaus A, Most P, Weichenhan D, Greten J, Nawroth PP, Katus HA, and Remppis A. Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products. Cardiovasc Diabetol. 2006;5(6.

2005

1.Pleger ST, Remppis A, Heidt B, Volkers M, Chuprun JK, Kuhn M, Zhou RH, Gao E, Szabo G, Weichenhan D, Muller OJ, Eckhart AD, Katus HA, Koch WJ, and Most P. S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. Mol Therapy. 2005;12(6):1120-9.

2.Jaeger J, Weichenhan D, Ivandic B, and Spang R. Early diagnostic marker panel determination for microarray based clinical studies. Stat Appl Genet Mol Biol. 2005;4(Article9).

2004

1.Remppis A, Pleger ST, Most P, Lindenkamp J, Ehlermann P, Schweda C, Loffler E, Weichenhan D, Zimmermann W, Eschenhagen T, Koch WJ, and Katus HA. S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts. J Gene Med. 2004;6(4):387-94.

2.Most P, Pleger ST, Volkers M, Heidt B, Boerries M, Weichenhan D, Loffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, and Koch WJ. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J Clin Invest. 2004;114(11):1550-63.

3.Aherrahrou Z, Axtner SB, Kaczmarek PM, Jurat A, Korff S, Doehring LC, Weichenhan D, Katus HA, and Ivandic BT. A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice. American J Pathol. 2004;164(4):1379-87.

2003

1.Motiwala T, Ghoshal K, Das A, Majumder S, Weichenhan D, Wu YZ, Holman K, James SJ, Jacob ST, and Plass C. Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene. 2003;22(41):6319-31.

2002

1.Dai Z, Weichenhan D, Wu YZ, Hall JL, Rush LJ, Smith LT, Raval A, Yu L, Kroll D, Muehlisch J, Fruhwald MC, de Jong P, Catanese J, Davuluri RV, Smiraglia DJ, and Plass C. An AscI boundary library for the studies of genetic and epigenetic alterations in CpG islands. Genome Res. 2002;12(10):1591-8.

2001

1.Weichenhan D, Kunze B, Winking H, van Geel M, Osoegawa K, de Jong PJ, and Traut W. Source and component genes of a 6-200 Mb gene cluster in the house mouse. Mamm Genome. 2001;12(8):590-4.

2000

1.Kunze B, Hellwig-Burgel T, Weichenhan D, and Traut W. Transcription and proper splicing of a mammalian gene in yeast. Gene. 2000;246(1-2):93-102.

2.Frengen E, Zhao B, Howe S, Weichenhan D, Osoegawa K, Gjernes E, Jessee J, Prydz H, Huxley C, and de Jong PJ. Modular bacterial artificial chromosome vectors for transfer of large inserts into mammalian cells. Genomics. 2000;68(2):118-26.

1999

1.Traut W, Weichenhan D, Eickhoff U, and Winking H. Origin of the chromosome 1 HSR of the house mouse detected by CGH. Chromos Res. 1999;7(8):649-53.

2.Kunze B, Traut W, Garagna S, Weichenhan D, Redi CA, and Winking H. Pericentric satellite DNA and molecular phylogeny in Acomys (Rodentia). Chromos Res. 1999;7(2):131-41.

3.Frengen E, Weichenhan D, Zhao B, Osoegawa K, van Geel M, and de Jong PJ. A modular, positive selection bacterial artificial chromosome vector with multiple cloning sites. Genomics. 1999;58(3):250-3.

1998

1.Weichenhan D, Kunze B, Traut W, and Winking H. Evolution by fusion and amplification: the murine Sp100-rs gene cluster. Cytogenet Cell Genet. 1998;80(1-4):226-31.

2.Weichenhan D, Kunze B, Traut W, and Winking H. Restoration of the Mendelian transmission ratio by a deletion in the mouse chromosome 1 HSR. Genet Res. 1998;71(2):119-25.

1997

1.Weichenhan D, Kunze B, Zacker S, Traut W, and Winking H. Structure and expression of the murine Sp100 nuclear dot gene. Genomics. 1997;43(3):298-306.

2.Plass C, Weichenhan D, Catanese J, Costello JF, Yu F, Yu L, Smiraglia D, Cavenee WK, Caligiuri MA, deJong P, and Held WA. An arrayed human not I-EcoRV boundary library as a tool for RLGS spot analysis. DNA Res. 1997;4(3):253-5.

1996

1.Weichenhan D, Traut W, Kunze B, and Winking H. Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects. Genet Res. 1996;68(2):125-9.

2.Kunze B, Weichenhan D, Virks P, Traut W, and Winking H. Copy numbers of a clustered long-range repeat determine C-band staining. Cytogenet Cell Genet. 1996;73(1-2):86-91.

3.Carlisle C, Winking H, Weichenhan D, and Nagamine CM. Absence of correlation between Sry polymorphisms and XY sex reversal caused by the M. m. domesticus Y chromosome. Genomics. 1996;33(1):32-45.

1995

1.Weichenhan D, Kunze B, Plass C, Hellwig T, Winking H, and Traut W. A transcript family from a long-range repeat cluster of the house mouse. Genome. 1995;38(2):239-45.

2.Plass C, Weichenhan D, Kunze B, Hellwig T, Schneider C, Bautz FA, Grzeschik KH, Traut W, and Winking H. A member of the mouse LRR transcript family with homology to the human Sp100 gene. Hereditas. 1995;122(3):245-56.

1993

1.Rohwedel J, Weichenhan D, Meier C, and Traut W. Different modes of hypervariability in (GATA)n simple sequence repeat loci. Insect Mol Biol. 1993;2(1):49-58.

1991

1.Weichenhan D. Fast recovery of DNA from agarose gels by centrifugation through blotting paper. Trends Genet. 1991;7:109.

2.Rinken R, de Vries J, Weichenhan D, and Wackernagel W. The recA-recBCD dependent recombination pathways of Serratia marcescens and Proteus mirabilis in Escherichia coli: functions of hybrid enzymes and hybrid pathways. Biochimie. 1991;73(4):375-84.

1989

1.Weichenhan D, and Wackernagel W. Functional analyses of Proteus mirabilis wild-type and mutant RecBCD enzymes in Escherichia coli reveal a new mutant phenotype. Mol Microbiol. 1989;3(12):1777-84.

1988

1.Weichenhan D, and Wackernagel W. Cloning of the recB, recC, and recD genes from Proteus mirabilis in Escherichia coli: in vivo formation of active hybrid enzymes. J Bact. 988;170(3):1412-4.



last update: 27/09/2014 back to top