Influence of apple juice constituents on biomarkers of colon carcinogenesis in vitro and in vivo



The project is aimed at the characterization of low- and high-molecular weight cancer chemopreventive components in apple juice extracts, fecal water and fermentation supernatants of apple juice extracts by activity-guided fractionation, and to elucidate their mechanisms of action.

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Based on the results of in vitro experiments, we will also investigate the influence of apple juice ingredients on intestinal carcinogenesis in the APCMin/+ mouse model to evaluate the relevance of our in vitro findings in vivo.

Further, we will analyze the potential of fecal water fractions to modulate biomarkers in in vitro test systems.

These investigations will help to better understand biological modifications which occur during colon carcinogenesis, to identify possibilities for their prevention, and to develop strategies for the transfer of the results to the human situation.

These studies are part of the BMBF-funded Nutrition Net:
Role of dietary components on the genesis of intestinal disorders and possibilities of their prevention by nutritional intervention



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