Press and Public Relations

Personalized cancer immunotherapy

No. 09a | 01/03/2017 | by Koh

The new Helmholtz Institute HI-TRON is a collaboration of the German Cancer Research Center (DKFZ) in Heidelberg and the Research Institute for Translational Oncology (TRON) at the University Medical Center of the Johannes Gutenberg University in Mainz. The goal of the partnership is to develop effective immunotherapies and to identify novel biomarkers for assessing the effectiveness of treatment.

© dkfz.de

In recent times, physicians have achieved spectacular clinical successes with cancer immunotherapies. There have even been cases of long-term regression in advanced stage cancers where until now medicine failed to be effective. Cancer researchers aim to adjust these treatments still more precisely to the individual disease. Advanced methods of molecular high-throughput analysis facilitate identifying the targets on cancer cells specifically and thus tailoring immunotherapies to the individual patient.

At the new Helmholtz Institute HI-TRON, the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) has now teamed up in this seminal research field with the Research Institute for Translational Oncology (TRON) at the University Medical Center Mainz.

Prof. Dr. Michael Baumann, Chairman of the Management Board of the German Cancer Research Center, said: "For developing novel cancer therapies successfully, it is crucial that researchers, researching physicians and clinicians should all be working hand in hand. In order to make this possible, the German Cancer Research Center relies on collaborations and intensive networking with excellent partner institutions. In TRON we have found an internationally renowned partner with whom we are joining forces to achieve further advances in the principal and seminal area of cancer immunotherapy. We will now be able to join up the strengths of both institutions – in order to offer more effective treatments to cancer patients as swiftly as possible."

Following the start-up phase, HI-TRON will receive annual funding of more than €5 million from the Helmholtz Association. The state of Rhineland-Palatinate and the DKFZ will additionally provide substantial initial financing.

TRON in Mainz is one of the world's leading institutes in research on the identification of biomarkers and personalized immunotherapy. The collaboration with the DKFZ is aimed above all at accelerating the translation of excellent immunology research and innovative therapy approaches into the clinic. Up to now, little is known why immunotherapies are effective in some patients and fail in others. Therefore, another major aim of the new research alliance is to identify biomarkers that facilitate assessing the prospects of success of an immunotherapy before starting treatment.

The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 3,000 employees is the largest biomedical research institute in Germany. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg, where promising approaches from cancer research are translated into the clinic. In the German Consortium for Translational Cancer Research (DKTK), one of six German Centers for Health Research, DKFZ maintains translational centers at seven university partnering sites. Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients. DKFZ is a member of the Helmholtz Association of National Research Centers, with ninety percent of its funding coming from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Württemberg.

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