Press and Public Relations

Honey Bees: Genetic Labeling Decides About Blue Blood

No. 61 | 03/11/2010 | by (Koh)

Queen bees and worker bees share the same genome, but they are different in the chemical labeling of about 550 genes. This has been discovered by scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), jointly with colleagues in Australia. The cancer researchers had chosen the bee as a study object in order to understand how development can be so different in organisms with identical sequence of genetic material. After all, healthy cells and cancer cells also share the same genome, but they develop diverging properties.


It is hard to believe that they belong to the same species: The large, long-lived queen bee is busy producing offspring throughout her lifetime. The much smaller worker bees, on the other hand, gather food, take care of the beehive, look after and feed the brood – but they are infertile.

“The honey bee is an extreme example of different larval development,” Professor Frank Lyko explains. Lyko, a scientist at DKFZ, studies how genes are regulated by chemical labeling with methyl groups. This type of regulation is part of what are called epigenetic regulation mechanisms – chemical alterations in the genetic material which do not change the sequence of DNA building blocks. This regulation mechanism enables the cell to adapt to changing environmental conditions.

Why is a cancer researchers interested in bees? “Cancer cells and healthy cells have identical genomes, but they behave very differently. To a large extent this is due to differences in the methylation of genes. Queen bees and worker bees also share the same genome, despite all differences in appearance. Here, too, methyl labels could be responsible for different larval development,” says Lyko.

In a beehive, it is the food alone which determines the future of the offspring: If the larvae are fed pollen, they develop into worker bees. If they are to grow into queen bees, their only food is royal jelly, which is rich in fat and protein. Australian researchers have recently imitated the effects of this power food by turning off the enzyme that labels DNA with methyl groups in bee larvae. These larvae all turned into queens – completely without any royal jelly.

This was a clear indication that it is methyl labels that determine the larvae’s fate by influencing the activity of particular genes. In their current work, Lyko and his team have investigated which genes turn a bee into a queen. While previous epigenetic investigations concentrated on the methyl labeling of individual genes, the Heidelberg researchers, jointly with bee experts from Australia, have been the first to compare methylation of the whole genomes of queens and workers. “The bee with its small genome has served as a model for us to test the method. By now, we are able to perform such investigations also in the human genome,” Frank Lyko explains.

Other than the richly methylated human genome, the bee genome carries considerably less methyl labels. In more than 550 genes the investigators found clear differences between worker bees and queen bees. These genes have often remained largely unchanged in the course of evolution, which is an indication for researchers that they fulfill important tasks of the cell.

Moreover, Lyko’s team identified a previously unknown mechanism by which gene methylation might influence character production. In bees, methyl labels are frequently found at so-called splice sites of genes where the blueprint for protein production is cut. If these recognition sites are made unrecognizable by chemical labels, the cell may possibly produce an altered protein with a different function. “So far, the theory has been that methyl labels block gene activity at the gene switches and thus produce diverging characteristics,” Frank Lyko says. “But now we have found evidence to suggest that the mechanism discovered in bees may also play a role in cancer cells.” This would mean that epigenetic factors in cancer not only turn genes on or off, but may also be responsible for production of proteins of a completely different kind.

Frank Lyko, Sylvain Foret, Robert Kucharski, Stephan Wolf, Cassandra Falckenhayn and Ryszard Maleszka: The Honey Bee Epigenomes: Differential Methylation of Brain DNA in Queens and Workers. PLoS Biology 2010, DOI: 10.1371/journal.pbio.1000506

A picture for this press release is available at:

Picture Source: Tobias Schwerdt, Deutsches Krebsforschungszentrum

The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 3,000 employees is the largest biomedical research institute in Germany. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg, where promising approaches from cancer research are translated into the clinic. In the German Consortium for Translational Cancer Research (DKTK), one of six German Centers for Health Research, DKFZ maintains translational centers at seven university partnering sites. Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients. DKFZ is a member of the Helmholtz Association of National Research Centers, with ninety percent of its funding coming from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Württemberg.


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