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Joint International Journal of Cancer and Klaus Tschira Stiftung Lecture at DKFZ

Tuesday, April 15, 2014 - Prof. C. Richard Boland

Rick Boland is Chief of the  Division of Gastroenterology at Baylor University Medical Center in Dallas, Texas. He was educated at Notre Dame and Yale and the University of California at San Francisco where he received clinical training in Internal Medicine and Gastroenterology. His research efforts have focused on colorectal cancer (CRC). The majority of the papers he has published are experiments that attempt to gain insights that are translational or clinical in nature. He has had an interest in the familial forms of CRC since medical school and helped define the non-polyposis form of hereditary CRC (Lynch Syndrome). His lab developed in vitro models for the study of the DNA mismatch repair (MMR) system that led to novel insights into the nature of that disease. The first part of his laboratory career was focused upon complex carbohydrates, but in 1990, Boland undertook sabbatical training in molecular genetics and redirected his interest into tumor genetics. In 1994, his group discovered the presence of the polyomavirus JC virus in CRC, which initiated investigations into the role of JCV in causing genomic instability. In 2002, the work was extended into DNA methylation, miRNA and epigenetics, which was a natural outgrowth of the prior work, helping to explain alterations in CRC that did not fit into prior conceptual models. Each change in direction has been a logical extension from what he was doing into new, but relevant areas of investigation. His lab is now using insights into the initial development of colorectal neoplasia to find noninvasive diagnostics and novel means of preventing the disease. Prof. Boland’s interests continue to be focused on carcinogenesis of the gastrointestinal tract, the early detection and diagnosis of these tumors, and developing approaches to cancer prevention.

Rick Boland has an impressive list of nearly 350 publications and he has served on the editorial board of top journals in the field, including Gastroenterology and the International Journal of Cancer. He is a highly sought-after speaker and, therefore, we are pleased to invite you to our first presentation in this year’s lectureship.


Prof. C. Richard Boland interviewed by Dr. Stefanie Seltmann

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