The structure of the scientific program will be mechanism- and process-oriented and will focus on three major tumor entities:

Topic 1: Joint Action on Tumors of the Digestive System
Topic 2: Joint Action on Brain Tumors
Topic 3: Joint Action on Hematological Malignancies

Tumor initiation and progression will not only be investigated from a cancer cell centric view but also include microenvironmental cues such as angiogenesis, inflammation and fibroblastic response. Cross-entity comparison will uncover common targetable nodes within the three tumor entities and their individual subtypes.

The three research topics are structured into 10 work packages giving the PCCC consortium the following overall thematic and structural organization:

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Topic 1: Joint Action on Tumors of the Digestive System

WP 1: Oncogenic Pathways in Tumor Initiation, Progression and Treatment Resistance
WP 2: Tumor Cell Extravasation and Metastasis
WP 3: Stroma and Tumor Microenvironment
WP 4: Preclinical Discovery and Validation Platform

Topic 2: Joint Action on Brain Tumors

WP 5: Preclinical Studies and Somatic Gene Transfer-based Mouse Models for Childhood Brain Tumors
WP 6: Advanced Mouse Models for Glioblastoma multiforme

Topic 3: Joint Action on Hematological Malignancies

WP 7: Preclinical Models for AML and ALL
WP 8: Preclinical Mouse Models for B and T Cell Lymphoma
WP 9: Synthetic Lethality Approaches for Personalized Treatment
WP 10: Generation of a Collaborative Platform between the Consortium and Major Clinical Leukemia and Lymphoma Study Groups

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