Research
Transcriptional regulation of gene expression at the genetic and epigenetic level
Transcription factors required for initiation and termination of rDNA transcription by RNA polymerase I (Pol I).
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Regulation of ribosomal gene transcription is a key factor in controlling cell growth and balances the effects of growth inducers to prevent uncontrolled cell proliferation. The research activities of our group focus on the elucidation of the molecular mechanisms that coordinate ribosomal gene transcription with changes in cell growth. Since transcription of ribosomal RNA genes (rDNA) by RNA polymerase I (Pol I) is a highly regulated process, it serves as a model system for the elucidation of the processes that link gene expression with cell growth and proliferation.
last update: 16/10/2008
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