CHS Research Group Neuropeptides

Dr. Valéry Grinevich

The Image depicts virus-mediated cell-type specific fluorescent labeling of hypothalamic oxytocin neurons, as revealed by immunohistochemistry (green: Venus, red and blue: oxytocin and vasopressin-immunoreactivity, respectively), and represents the targets for oxytocin axons originate from the hypothalamic paraventricular nucleus in the rat forebrain. Image illustrated by Julia Kuhl.
© dkfz.de

Our laboratory is focused on the dissection of the mechanisms of neuropeptide action in the brain, from molecular – via anatomical – to the whole organism level. We employ genetic, molecular, anatomical, viral, optogenetic and behavioral approaches to study the effects of “addressed” axonal release of various neuropeptides within the distinct brain regions controlling stress and fear responses, maternal and social behavior. Furthermore, our group uses animal models of psychiatric diseases, including anxiety disorders and autism, to study the possible contribution of neuropeptides to the pathogenesis of the respective human diseases.

FUTURE OUTLOOK
In the future, we will focus on translational studies for oxytocin treatment of neurodevelopmental diseases such as autism spectrum disorders and Prader-Willi syndrome, as well as exploring the physiology of the oxytocin system in primates.

This Junior Research Group is generously supported by the Chica and Heinz Schaller Foundation (CHS) From December 2015 Dr. Grinevich's team has been cross affiliated with Central Institute of Mental Health in Mannheim and will relocate there in 2018.

Contact

Dr. Valéry Grinevich
Neuropeptides (V078)

CHS Research Group at CellNetworks Heidelberg University and DKFZ
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg

Tel: +49 6221 42 1581
Fax: +49 6221 42 1559
E-Mail: v.grinevich@dkfz.de

Selected Publications

  • Eliava M. et al. (2016). A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing. Neuron, 89(6), 1291-1304.
  • Grinevich V. et al. (2016). Assembling the puzzle: Pathways of oxytocin signaling in the brain. Biol Psychiatry, 79(3), 155-164.
  • Knobloch H. S. & Grinevich, V. (2014). Evolution of central oxytocin pathways in vertebrates. Front. Behav. Neurosci, 8:31.
  • Knobloch, S., Charlet, A., Hoffmann, L.C., Eliava, M., Khrulev, S., Cetin, A.H., Osten, P., Schwarz, M. K., Seeburg, P.H., Stoop, R. & Grinevich, V. (2012). Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron, 73, 553-566
to top