Table of Contents

Due to their central biological relevance, cell death-regulating proteins are decisive for the progression and the therapy response in cancer. Therefore, we study the expression of cell death-regulating proteins in the primary human cancer tissue to identify prognostic and predictive tumor markers for cancer patients. This predictive approach in molecular pathology aims at the identification of tumor markers which is a prerequisite for a individualized therapy for cancer patients.

Projects

• Prognostic relevance of death ligands and death receptors in renal cancer.
  
• Expression and prognostic relevance of apoptosis-regulating proteins in colon cancer.
  
• G proteins as novel biomarkers in malignant brain tumors.

Selected recent publications

• Funke V, Lehmann-Koch J, Bickeböller M, Benner A, Tagscherer KE, Grund K, Pfeifer M, Herpel E, Schirmacher R, Chang-Claude J, Brenner H, Hoffmeister M, Roth W. The PEA-15/PED preotein regulates cellular survival and invasiveness in colorectal carcinomas. Cancer Letters, in press
• Macher-Goeppinger S, Aulmann S, Tagscherer KE, Wagener N, Haferkamp A, Penzel R, Brauckhoff A, Hohenfellner M, Sykora J, Walczak H, Teh BT, Autschbach F, Herpel E, Schirmacher P, Roth W Prognostic value of Tumor Necrosis Factor-Related Apoptosis-inducing ligand (TRAIL) and TRAIL receptors in renal cell cancer. Clinical Cancer Research 15, 650-9, 2009
  
• Macher-Goeppinger S, Aulmann S, Wagener N, Funke B, Tagscherer KE, Haferkamp A, Hohenfellner M, Kim S, Autschbach F, Schirmacher P, Roth W Decoy Receptor 3 is a prognostic factor in renal cell cancer. Neoplasia 10, 1049-56, 2008