Dr. Adam Rose - Protein metabolism in health and disease

Research

In our group we aim to identify novel mechanisms of how protein and amino acid metabolism is regulated. In particular, we use mouse models as well as ex vivo tissue incubation and cell culture combined with novel molecular and biochemical techniques to gain new insights into the molecular physiology of  systemic and tissue specific protein turnover, amino acid metabolism, and interactions of amino acid with carbohydrate/fat metabolism.

Currently, we have two mains branches of research:

  • Role of dietary protein/amino acids in mammalian metabolic function
  • Novel stress signalling pathways in adaptive metabolic function

Publications

Selected Original articles

  • Okun JG, Conway S, Schmidt K, Schumacher J, Seibert O, Wang X, de Guia RM, Zota A, Maida A, Herzig S, Rose AJ*. Molecular control of systemic urea cycle function by the liver glucocorticoid receptor. Mol Metab, 4, 732-740.
  • Jiang Y, Rose AJ, Sijmonsma TP, Bröer A, Pfenninger A, Herzig S, Schmoll D, Bröer S (2015). Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control. Mol Metab, 4(5):406-17.
  • de Guia R, Rose AJ, Sommerfeld, A, Seibert O, Strzoda D, Zota A, Feuchter Y, Krones-Herzig A, Sijmonsma T, Kirilov M, Sticht C, Gretz N, Dallinga-Thie G, Diederichs S, Klöting N, Blüher M, Berriel-Diaz M, Herzig S (2015). microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis. EMBO J, 34(3): 344-60.
  • Rose AJ*, Berriel Díaz M,Reimann A, Klement J, Walcher T, Krones-HerzigA, Strobel O, Werner J, Peters A, Kleyman A, Tuckermann JP, Vegiopoulos A, Herzig S (2011). Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor. Cell Metab, 14(1):123-30.
  • KulozikP, JonesA, MattijssenF, RoseAJ, Reimann A, StrzodaD, Kleinsorg S, Raupp C, Kleinschmidt J, Müller-Decker K, Wahli W, Sticht C, Gretz N, von Loeffelholz C, StockmannM, PfeifferA, StöhrS, Dallinga-ThieGM, NawrothPP, Berriel DíazM, Herzig S (2011). Hepatic deficiency in transcriptional co-factor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab, 13(4):389-400.
  • Ostertag A, Rose AJ, Jones A, Liebert M, Kleinsorg S, Reimann A, Vegiopoulos A, Berriel Diaz M, Strzoda D, Yamamoto M, Satoh T, Akira S, Herzig S (2010). Control of adipose tissue inflammation through TRB1. Diabetes, 59: 1991-2000.
  • Rose AJ*, Alsted TJ, Kobberø JB, Maarbjerg SJ, Jensen TE, Jensen J, Richter EA (2009). A Ca2+-calmodulin-eEF2K-eEF2 signaling cascade, but not AMPK, contributes to the blunting of skeletal muscle protein synthesis during contractions. J Physiol, 587: 1547-63.
  • Rose AJ, Howlett KF, King DS, Hargreaves M (2001). Effect of prior exercise on glucose metabolism in trained men. Am J Physiol Endocrinol Metab 281: E766-71.

 

Reviews/Perspectives

  • Rose AJ, Herzig S (2013). Metabolic control through glucocorticoid hormones: an update. Mol Cell Endocrinol. 380(1-2): 65-78.
  • Rose AJ, Richter EA (2009). Regulatory mechanisms of skeletal muscle protein turnover during exercise. J Appl Physiol 106: 1702-11.
  • Rose AJ, Richter EA (2005). Skeletal muscle glucose uptake during exercise: how is it regulated? Physiology 20: 260-70.

 

*Corresponding author.

Staff

Current staff:

Annika Zota, Technical Assistant

 

Former staff:

Sahika Cingir, Masters Student

Jessica Fuhrmeister, Doctoral Student

Adriano Maida, Post-Doctoral Scientist

Jonas Schumacher, Masters Student

Jessica Chan, Doctoral Student

Thomas Gantert, Masters Student

Nicola Vallon, Bachelor Student

Joshua Mouatt, Guest Intern

Sean Conway, Guest Intern

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