Professional Experience



Since November 2003

Scientist Molecular Metabolic Control A170

German Cancer Research Center Heidelberg, Germany


November 2002-November 2003: Maternity leave


April 2000-November 2002

Postdoctoral fellow, Sidney Kimmel Cancer Center, San Diego


April 1999-March 2000

Postdoctoral Associate, Department of Biochemistry and Molecular Cell Biology, Georg-August-University Göttingen, Germany


April 1999

Dr. rer.nat. (Ph.D.),

Faculty of Mathematics and Life Sciences, Georg-August-University Göttingen, Germany

Title of thesis: Zonation of the glucagon, insulin and 1B-adrenergic receptors in the liver. Differential expression on various cell types of the liver and modulation of gene expression by glucose and O2 in cultured rat hepatocytes.


November 1995

Diploma (equivalent to MA): Biochemistry, Human Genetics, Organic Chemistry


February 1993

Pre-Diploma (equivalent to BA): Zoology, Botany, Organic Chemistry, Physics



June 1990

Diploma of the German Abitur, Friedrich-Wilhelm-Schule and Ober-stufengymnasium Eschwege, Eschwege, Germany




Awards

March 2002

Scholar-in-Training Award for the 2002 AACR (American Association for Cancer Research) Annual Meeting in San Francisco, CA


April 2001-March 2002

Postdoctoral fellowship DAAD (Deutscher Akademischer Austausch Dienst)


January 1998

Awarded best poster on the occasion of the 14th annual meeting of the German Association for the study of the liver (GASL), Halle (Saale), Germany


Publications

Narvekar, P., Berriel Diaz, M., Krones-Herzig, A., Strzoda, D., Stöhr, S., Frohme, M., and Herzig, S. 2009. Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice. Diabetes, in press

Krones-Herzig, A., Lemke, U., Berriel Diaz, M., Narvekar, P., Ziegler, A., Vegiopoulos, A., Kirilov, M., Maier, J., Cato, A., Kersten, S., Screaton, R., and Herzig, S. 2008. The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. Cell Metab. 8: 212-223

Zschiedrich, I., Hardeland, U., Krones-Herzig, A., Vegiopoulos, A., Berriel Diaz, M., Müggenburg, J., Sombroek, D., Hofmann, T., Zawatzky, R., Yu, X., Gretz, N., Christian, M., White, R., Parker, M.G., and Herzig, S. 2008. Co-activator function of RIP140 for NFkB/RelA-dependent cytokine gene expression. Blood 112: 264-276

Berriel Diaz, M., Krones-Herzig, A., Metzger, D., Ziegler, A., Vegiopoulos, A., Klingenspor, M., Müller-Decker, K. and Herzig, S. 2008. Nuclear receptor co-factor RIP140 controls lipid metabolism during wasting. Hepatology 48: 782-791

Krones-Herzig, A., Mesaros, A., Metzger, D., Ziegler, A., Lemke, U., Brüning, J.C, and Herzig, S. 2006. Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1. J. Biol. Chem. 281: 3025-3029

A. Krones-Herzig, S. Mittal, K. Yule, H. Liang, C. English, R. Urcis, T. Soni E. Adamson and D. Mercola. Egr1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Research, accepted 2005

A. Krones-Herzig, E. Adamson and D. Mercola. EGR1, a novel upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence. Proceedings of the National Academy of Sciences, U.S.A., 100 (2003), 3233-3238.

T. Virolle, A. Krones-Herzig, V. Baron, G. De Gregorio, E.D. Adamson and D. Mercola. Egr1 promotes growth and survival of prostate cancer cells. Identification of novel Egr1 target genes. J Biol Chem. 278 (2003), 11802-11810

V. Baron, G. De Gregorio, A. Krones-Herzig, T. Virolle, A. Calogero, R. Urcis and D. Mercola. Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivo. Oncogene. 22 (2003), 4194-4204.

G.V. Glinsky, A. Krones-Herzig, A.B. Glinskii and G. Gebauer. Microarray analysis of xenograft-derived cancer cell lines representing multiple experimental models of human prostate cancer. Mol Carcinog. 37 (2003), 209-221.

G.V. Glinsky, A. Krones-Herzig and A.B. Glinskii. Malignancy-associated regions of transcriptional activation: gene expression profiling identifies common chromosomal regions of a recurrent transcriptional activation in human prostate, breast, ovarian, and colon cancers. Neoplasia. 5 (2003), 218-228.

T. Kietzmann, A. Krones-Herzig and K. Jungermann. Signalling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements.
Biochem. Pharmacol. 7308 (2002), 1-9

A. Krones, K. Jungermann and T. Kietzmann. Cross-Talk between the signals hypoxia and glucose at the glucose response element of the L-Type pyruvate kinase gene.
Endocrinology. 142 (2001), 2707-2718

A. Krones, T. Kietzmann and K. Jungermann. Perivenous localization of insulin receptor protein in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures. Biochem J. 348 (2000), 433-438

A. Krones, T. Kietzmann and K. Jungermann. Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures. FEBS Letters. 421 (1998), 136-140

T. Heise*, A. Krones*, A. Nath, K. Jungermann and B. Christ (* both authors
contributed equally to this work). Parallel acceleration of phosphoenolpyruvate carboxykinase mRNA degradation and increase in ribonuclease activity induced by insulin in
cultured rat hepatocytes. Biol. Chem. 379 (1998), 875-883