Dr. Adam J. Rose
Position: Group Leader
Affiliation: DKFZ Molecular Metabolic Control A170
E-mail: a.rose@dkfz.de
Phone: +49-(0)6221-42 3599
Fax: +49-(0)6221-42 3595
Building: DKFZ Main Building
Room: HH2.01.032
EDUCATION
1999
Honours degree by Research, Applied Science
School of Health Sciences
Deakin University, Melbourne, Australia
2000-2004
PhD by research, Applied Science (Physiology)
Deakin University, Melbourne, Australia
EMPLOYMENT
Since November 2008
Post-Doctoral scientist
Joint Research Division Molecular Metabolic Control
German Cancer Research Centre, Heidelberg, Germany
May 2004 - October 2008
Post-Doctoral scientist
Section of Human Physiology
University of Copenhagen, Copenhagen, Denmark
AWARDS
1998
Griffith University Award for Academic Excellence
2005 & 2006
Copenhagen Muscle Research Centre presentation competition: 1st place
2011
Best poster presentation: FASEB SRC on Nutrient control of metabolism and cell signaling
MEMBERSHIPS/PROFESSIONAL ACTIVITIES
Member
The Physiological Society, London
The Biochemical Society, UK
SELECTED ORIGINAL ARTICLES
• Rose AJ, Howlett KF, King DS, Hargreaves M (2001). Effect of prior exercise on glucose metabolism in trained men. Am J Physiol Endocrinol Metab 281: E766-71.
• Rose AJ, Hargreaves M (2003). Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle. J Physiol 553: 303-9.
• Rose AJ, Kiens B, Richter EA (2006). Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise. J Physiol 574: 889-903.
• Rose AJ, Alsted TJ, Kobberø JB, Richter EA (2007). Regulation and function of Ca2+-calmodulin-dependent protein kinase II of rat skeletal muscle. J Physiol 574: 889-903.
• Jensen TE, Rose AJ, Jørgensen SB, Brandt NB, Schjerling P, Wojtaszewski JF, Richter EA (2007). Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction. Am J Physiol Endocrinol Metab 292: E1308-17.
• Frøsig C, Rose AJ, Treebak JT, Kiens B, Richter EA, Wojtaszewski JF (2007). Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. Diabetes 56: 2093-102.
• Rose AJ, Alsted TJ, Kobberø JB, Maarbjerg SJ, Jensen TE, Jensen J, Richter EA (2009). A Ca2+-calmodulin-eEF2K-eEF2 signaling cascade, but not AMPK, contributes to the blunting of skeletal muscle protein synthesis during contractions. J Physiol 587: 1547-63.
• Højlund K, Birk JB, Klein DK, Levin K, Rose AJ, Hansen BF, Nielsen JN, Beck-Nielsen H, Wojtaszewski JF (2009). Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus. J Clin Endocrinol Metab 94: 4547-56.
• Ostertag A, Jones A*, Rose AJ*, Liebert M, Kleinsorg S, Reimann A, Vegiopoulos A, Berriel Diaz M, Strzoda D, Yamamoto M, Satoh T, Akira S, Herzig S (2010). Control of adipose tissue inflammation through TRB1. Diabetes 59: 1991-2000.
• Jeppesen J, Albers PH, Rose AJ, Birk JB, Schjerling P, Dzamko N, Steinberg GR, Kiens B (2011). Contraction induced skeletal muscle FAT/CD36 trafficking and fatty acid uptake is AMPK independent. J Lipid Res 52: 699-711.
• Kulozik P, Jones A, Mattijssen F, Rose AJ, Reimann A, Strzoda D, Kleinsorg S, Raupp C, Kleinschmidt J, Müller-Decker K, Wahli W, Sticht C, Gretz N, von Loeffelholz C, Stockmann M, Pfeiffer A, Stöhr S, Dallinga-Thie GM, Nawroth PP, Berriel Diaz M, Herzig S (2011). Hepatic deficiency in transcriptional co-factor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab 13: 389-400.
• Rose AJ, Berriel Díaz M, Reimann A, Klement J, Walcher T, Krones-Herzig A, Strobel O, Werner J, Peters A, Kleyman A, Tuckermann JP, Vegiopoulos A, Herzig S (2011). Molecular control of systemic bile Acid homeostasis by the liver glucocorticoid receptor. Cell Metab 14: 123-30.
*equal contribution
REVIEWS/PERSPECTIVES
• Rose AJ, Richter EA (2005). Skeletal muscle glucose uptake during exercise: how is it regulated? Physiology 20: 260-70.
• Jørgensen SB, Rose AJ (2008). How is AMPK activity regulated in skeletal muscles during exercise? Front Biosci 13: 5589-604.
• Rose AJ, Richter EA (2009). Regulatory mechanisms of skeletal muscle protein turnover during exercise. J Appl Physiol 106: 1702-11.
• Rose AJ, Vegiopoulos A, Herzig S (2010). Role of glucocorticoids and the glucocorticoid receptor in metabolism: Insights from genetic manipulations. J Steroid Biochem Mol Biol. 122: 10-20.