Table of Contents

Publications

Fleming, Th.H., Theilen, T.-M., Wunderle, M., Karimi, J., Vittas, S., Bernauer, R., Bierhaus, A., Rabbani, N., Thornalley, P.J., Kroll, J., Tyedmers, J., Nawrotzki, R., Herzig, S., Brownlee, M., Nawroth, P.P. 2013. Aging-dependent reduction in Glyoxalase-I delays wound healing. Gerontology: in print

Rohm, M., Sommerfeld, A., Strzoda, D., Jones, A., Sijmonsma, T., Rudofsky, G., Wolfrum, C., Sticht, C., Gretz, N., Zeyda, M., Leitner, L.,  Nawroth, P., Stulnig, Th., Berriel Diaz, M., Vegiopoulos, A., and Herzig, S. 2013. Transcriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue. Cell Metab 17: 1-11

Becker, J., Dittner, C., Barysch, S.V., Karaca, S., Hsiao, H.-H., Berriel Diaz, M., Herzig, S., Urlaub, H., Melchior, F. 2013. Detecting endogenous SUMO targets in mammalian cells and tissues. Nat. Struct Mol. Biol: doi:10.1038/nsmb.2526

Jones, A., Friedrich, K., Rohm, M., Schäfer, M., Algire, C., Kulozik, P., Seibert, O., Müller-Decker, K., Sijmonsma, T., Strzoda, D., Sticht, C., Gretz, N., Dallinga-Thie, G.M., Leuchs, B., Kögl, M., Stremmel, W., Berriel Diaz, M., and Herzig, S. 2012. Transforming growth factor-beta1 Stimulated Clone-22 D4 is a molecular output of hepatic wasting metabolism. EMBO Mol. Med. Jan 11. doi: 10.1002/emmm.201201869

Eichelbaum, K., Winter, M., Berriel Diaz, M., Herzig, S., and Krijgsveld, J. 2012. Selective enrichment of newly synthesized proteins for quantitative secretome analysis. Nat. Biotechnol. 10: 984-990

Lützner, N., Kalbacher, H., Krones-Herzig, A., Rösl, F. 2012. FOXO3 is a Glucocorticoid Receptor Target and Regulates LKB1 and its own Expression Based on Cellular AMP Levels Via a Positive Autoregulatory Loop. PLOS One 7(7): e42166.  doi: 10.1371/journal.pone.0042166

Djuric, Z., Muhammed, K., Fleming, Th., Murikinati, S., Piel, D., von Bauer, R., Bea, F., Herzig, S., Zeier, M., Liou, H., Pizzi, M., Isermann, B., Schwanninger, M., Hecker, M., Bierhaus, A., Nawroth, P. 2012. Targeting NFκB subunit-specific activation prevents stress-dependent atherothrombotic gene expression. Molecular Medicine Dec 20,18:1375-86. doi: 10.2119

Fassl, A., Tagscherer, K.E., Richter, J., Berriel Diaz, M., Alcantara Llaguno, S.R., Campos, B., Kopitz, J., Herold-Mende, C., Herzig, S., Schmidt, M. HH, Parada, L.F., Wiestler, O.D. and Roth, W. 2012. Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1. Oncogene 31: 4698-708

Lee, A. W. S., Hengstler, H., Schwald, K., Berriel-Diaz, M., Loreth, D., Kirsch, M., Kretz, O., Haas, C. A., Hrabě de Angelis, M., Herzig, S., Brümmendorf, T., Klingenspor, M., Rathjen, F. G., Rozman, Nicholson, J. G., Cox, R. D.and Schäfer, M. K. E. 2012. Functional Inactivation of the Genome-wide Association Study Obesity Gene Neuronal4 Growth Regulator 1 in Mice Causes a Body Mass Phenotype. PLoS ONE 7: e41537

Rose, A.J., Berriel Diaz, M., Reimann, A., Klement, J., Walcher, T., Krones-Herzig, A., Strobel, O., Werner, J., Peters, A., Kleyman, A., Tuckermann, J.P., Vegiopoulos, A. and Herzig, S. 2011. Molecular Control of Systemic Bile Acid Homeostasis by the Liver Glucocorticoid Receptor. Cell Metab. 14: 123–130

Kulozik, Ph., Jones, A., Mattijssen, F., Rose, A. J., Reimann, A., Strzoda, D., Kleinsorg, S., Raupp, Ch., Kleinschmidt, J., Müller-Decker, K., Wahli, W., Sticht, C., Gretz, N., von Loeffelholz, Ch., Stockmann, M., Pfeiffer, A., Stöhr, S., Dallinga-Thie, G. M., Nawroth, P. P., Berriel Diaz M. and Herzig, S. 2011. Hepatic deficiency in transcriptional co-factor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab. 13: 389–400

Jeppesen,J., Albers,P.H., Rose,A.J., Birk,J.B., Schjerling,P., Dzamko,N., Steinberg,G.R., Kiens,B. 2011. Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent. J. Lipid Res. 52 (4): 699-711
 
Vegiopoulos, A., Müller-Decker, K., Strzoda, D., Schmitt, I., Chichelnitskiy, E., Ostertag, A., Berriel Diaz, M., Rozman, J., Hrabe de Angelis, M., Nüsing, R.M., Meyer, C., Wahli, W., Klingenspor, M., and Herzig, S. 2010. COX-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328: 1158-1161

Comment in:

Beige can be slimming. Ishibashi, J., Seale, P. 2010. Science May 6

Scientists find a way to trigger fat-burning fat. TIME Magazine May 11, 2010

Kiss,E., Popovic,Z.V., Bedke,J., Adams,J., Bonrouhi,M., Babelova,A., Schmidt,C., Edenhofer,F., Zschiedrich,I., Domhan,S., Abdollahi,A., Schaefer,L., Gretz,N., Porubsky,S., Groene,H.J. 2010. Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage. American Journal of Pathology 176 (5): 2150-2162

Ostertag, A., Jones, A., Rose, A.J., Liebert, M., Kleinsorg, S., Reimann, A., Vegiopoulos, A., Berriel Diaz, M., Strzoda, D., Yamamoto, M., Satoh, T., Akira, S., and Herzig, S. 2010. Control of adipose tissue inflammation through TRB1. Diabetes 59:1991-2000

Haas, B., Mayer, P., Jenissen, K., Ahmad, M., Bloch, W., Berriel Diaz, M., Herzig, S., Fässler, R., and Pfeifer, A. 2009. Protein Kinase G controls insulin-induced brown fat cell differentiation and mitochondrial biogenesis. Sci. Signal. 2: ra78

Chichelnitskiy, E., Vegiopoulos, A., Berriel Diaz, M., Ziegler, A., Kleiman, A., Rauch, A., Tuckermann, J., and Herzig, S. 2009. In vivo PEPCK promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice. Hepatology 50: 1963-1971

Scherneck, S., Nestler, M., Vogel, H., Blüher, M., Block, M.D., Berriel Diaz, M., Herzig, S., Schulz, N., Teichert, M., Tischer, S., Al-Hasani, H., Kluge, R., Schürmann, A., and Joost, H.G. 2009. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes caused by mouse locus Nidd/SJL. PLOS Genet. 5: e1000541

Narvekar, P., Berriel Diaz, M., Krones-Herzig, A., Hardeland, U., Strzoda, D., Stöhr, S., Frohme, M., and Herzig, S. 2009. Liver-specific Loss of Lipolysis-Stimulated Lipoprotein Receptor Triggers Systemic Hyperlipidemia in Mice. Diabetes 58: 1040-1049

Lemke, U., Krones-Herzig, A., Berriel Diaz, M., Narvekar, P., Ziegler, A., Vegiopoulos, A., Bohl, S., Klingmüller, U., Cato, A., Screaton, R., Müller-Decker, K., Kersten, S., and Herzig, S. 2008. The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. Cell Metab. 8: 212-223

Berriel Diaz, M., Krones-Herzig, A., Metzger, D., Ziegler, A., Vegiopoulos, A., Klingenspor, M., Müller-Decker, K. and Herzig, S. 2008. Nuclear receptor co-factor RIP140 controls lipid metabolism during wasting in mice. Hepatology 48: 782-791

Zschiedrich, I., Hardeland, U., Krones-Herzig, A., Vegiopoulos, A., Berriel Diaz, M., Müggenburg, J., Sombroek, D., Hofmann, T., Zawatzky, R., Yu, X., Gretz, N., Christian, M., White, R., Parker, M.G., and Herzig, S. 2008. Co-activator function of RIP140 for NFkB/RelA-dependent cytokine gene expression. Blood 112: 264-276

Krones-Herzig, A., Mesaros, A., Metzger, D., Ziegler, A., Lemke, U., Brüning, J.C, and Herzig, S. 2006. Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1. J. Biol. Chem. 281: 3025-3029

Dimova, E., Möller, U., Herzig, S., Fink, T., Zachar, V., Ebbesen, P., and Kietzmann, T. 2005. Transcriptional regulation of Plasminogen Activator Inhibitor-1 expression by Insulin-Like Growth Factor-1 via MAP kinases and Hypoxia-Inducible Factor –1 in HepG2 cells. Thromb. Haemost. 93: 1176-1184

Koo, S.-H., Satoh, H., Herzig, S., Lee, C.-H., Hedrick, S., Kulkarni, R., Evans, R.M., Olefsky, J., and Montminy, M. 2004. PGC-1 promotes insulin resistance in liver via the PPARa dependent induction of TRB3. Nat. Med. 10: 530-534

Sawka-Verhelle, D., Escoubet-Lozach, L., Fong, A.L., Hester, K.D., Herzig, S., Lebrun, P., and Glass, C.K. 2004. PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation. J. Biol. Chem. 279: 17772-17784
 
Herzig, S., Hedrick, S., Morantte, I., Koo, S.-H., Galimi, F., and Montminy, M. 2003. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPARg. Nature 426: 190-193

Comment in:

Why so many of us are getting diabetes. Gorman, C. 2003. Time Magazine 162, Dec 8

Herzig, S.*, Du, K.*, Kulkarni, R., and Montminy, M. 2003. TRB-3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300: 1574-1577

* Authors contributed equally to this work.

Comment in:

Highlights: A sugar fix for fasters. Bussell, K. 2003. Nat. Rev. Mol. Cell. Biol. 4, 512

Putting the brakes on insulin signaling. Saltiel, A.R. 2003. N. Engl. J. Med. 349, 2560-2562

Canettieri, G., Morantte, I., Guzman, E., Asahara, H., Herzig, S., Anderson, S.D., Yates III, J.R., and Montminy. M. 2003. Attenuation of a phosphorylation dependent activator by an HDAC:PP1 complex. Nat. Struc. Biol. 10: 175-181

Herzig, S., Long, F., Jhala, U.S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schütz, G., Yoon, C., Puigserver, P., Spiegelman, B., and Montminy, M. 2001. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413: 179-183

Comment in:

News and Views: Metabolism: Controlling the glucose factory. Vidal-Puig, A. and O'Rahilly. 2001. Nature 413, 125–126

Herzig, S., Füzesi, L., and Knepel, W. 2000. Heterodimeric Pbx-Prep1 homeodomain protein binding to the glucagon gene restricting transcription in a cell type-dependent manner. J. Biol. Chem. 275: 27989-27999
 
Beimesche, S., Neubauer, A., Herzig, S., Grzeskowiak, R., Diedrich, T., Cierny, I., Scholz, D., Alejel, T., and Knepel, W. 1999. Tissue-specifictranscriptional activity of a pancreatic islet cell-specific enhancersequence/Pax6-binding site determined in normal adult tissues in vivo using transgenic mice. Mol. Endocrinol. 13: 718-728

Reviews and Book Chapters

Herzig, S. and Rodenm, M. 2013. Diabetes and the liver. Dtsch Med Wochenschr 138:1-3

Herzig, S and Wolfrum, C. 2013. Brown and white fat: From signaling to disease. Biochim Biophys Acta 1831(5):895. doi: 10.1016/j.bbalip.2013.03.009

Rose, A.J. and Herzig, S. 2013. Metabolic control through glucocorticoid hormones: an update. Mol. Cell. Endocrinol.: in press

Klingenspor, M., Herzig, S., Pfeifer, A.. 2012. Brown fat develops a brite future. Obes. Facts 5: 890-896

Algire, C., Medrikova, D., Herzig, S. 2012. White and Brown Adipose stem cells: From Signaling to Clinical Implications. BBA - Molecular and Cell Biology of Lipids. Available online, DOI information: 10.1016/j.bbalip.2012.10.001

Herzig, S. 2012. Liver: A target of late diabetic complications. Exper. and Clin. Endocrinol. & Diabetes 120(4):202-4

Sommerfeld, A., Krones-Herzig, A., and Herzig. S. 2010. Transcriptional co-factors and hepatic energy metabolism. Mol. Cell. Endocrinol. 332(1-2):21-31

Rose, A.J., Vegiopoulos, A., and Herzig, S. 2010. Role of glucocorticoids and the glucocorticoid receptor in metabolism: insights from genetic manipulations. J. Steroid Biochem. Mol. Biol. 122: 10-20

Herzig, S. and Werner, Jens. 2009. Paraneoplastic syndromes. In: Handbook of Pancreatic Cancer. Ed.: John Neoptolemos, Markus Büchler, James Abbruzzese, Raul Urrutia, in press

Jones, A., Kulozik, P., Ostertag, A., and Herzig, S. 2008. Common pathological processes and transcriptional pathways in Alzheimer´s disease and type 2 diabetes. J. Alzheimers Dis. 16: 787-808

Hardeland, U., and Herzig, S. 2008. Molecular mechanisms of muscle atrophy. Bioforum 5: 28-29

Herzig, S. 2007. Molecular control of hepatic gluconeogenesis. Diabetologie 2: 1-3

Vegiopoulos, A. and Herzig, S. 2007. Glucocorticoids, metabolism and metabolic diseases. Mol. Cell. Endocrinol. 275: 43-61

Herzig, S. 2007. Transcription factors in metabolic disease. Dtsch. Med. Wochenschr. 132: 1121-1124

Kleeff, J., Beckhove, P., Esposito, I., Herzig, S., Huber, P.E., Löhr, J.M., and Friess, H. 2007. Pancreatic cancer microenvironment. Int. J. Cancer 121, 699-705
(*All authors contributed equally to this work.)

Berriel Diaz, M., Lemke, U., and Herzig, S. 2006. Discovering orphans’ sweet secret: NR4A receptors and glucose production. Cell Metab. 4: 339-340

Schmoll, D., Herzig, S., and Barthel, A. 2006. Forkhead proteins and the regulation of hepatic gene expression. In: New transcription factors and their role in diabetes and therapy. Advances in Molecular and Cellular Endocrinology, 1st Edition.

Herzig, S. 2005. Insulin resistance: Tracing molecular events. Diabetes Spezial 01/2005: 26-27 (German)

Herzig, S. 2005. Molecular metabolic control. Bioforum 7-8: 2-4 (German)

Barthel, A., Herzig, S., Muller, H.W., Harborth, J., Bornstein, S.R. 2005. RNA interference-based strategies for metabolic syndrome treatment. Horm. Metab. Res. 37: 59-62