Selected publications

2017

Schuenke P, Koehler C, Korzowski A, Windschuh J, Bachert P, Ladd ME, Mundiyanapurath S, Paech D, Bickelhaupt S, Bonekamp D, Schlemmer H-P, Radbruch A, Zaiss M. Adiabatically prepared spin-lock approach for T1ρ-based dynamic glucose enhanced MRI at ultrahigh fields. Magn. Reson. Med. 78: 215-225 (2017). doi: 10.1002/mrm.26370.

Korzowski A, Bachert P. High-resolution 31P echo-planar spectroscopic imaging in vivo at 7T. Magn. Reson. Med. (2017). doi: 10.1002/mrm.26785 [Epub ahead of print].

Schuenke P, Paech D, Koehler C, Windschuh J, Bachert P, Ladd ME, Schlemmer H-P, Radbruch A, Zaiss M. Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI. Sci. Rep. 7,42093 (2017). doi: 10.1038/srep42093.

Goerke S, Milde KS, Bukowiecki R, Kunz P, Klika KD, Wiglenda T, Mogk A, Wanker EE, Bukau B, Ladd ME, Bachert P, Zaiss M. Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins. NMR Biomed. 30: e3665 (2017). doi: 10.1002/nbm.3665.

Zaiss M, Windschuh J, Goerke S, Paech D, Meissner J-E, Burth S, Kickingereder P, Wick W, Bendszus M, Schlemmer H-P, Ladd ME, Bachert P, Radbruch A. Downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provides a unique contrast in human glioblastoma. Magn. Reson. Med. 77: 196-208 (2017). doi: 10.1002/mrm.26100.

Schuenke P, Windschuh J, Roeloffs V, Ladd ME, Bachert P, Zaiss M. Simultaneous mapping of water shift and B1 (WASABI) - Application to field-inhomogeneity correction of CEST MRI data. Magn. Reson. Med. 77: 571-580 (2017). doi: 10.1002/mrm.26133.

2015

Rerich E, Zaiss M, Korzowski A, Ladd ME, Bachert P: Relaxation–compensated CEST–MRI at 7 T for mapping of creatine content and pH – preliminary application in human muscle tissue in vivo. NMR Biomed. 28: 1402–1412 (2015). doi: 10.1002/nbm.3367.

Meissner J–E, Goerke S, Rerich E, Klika KD, Radbruch A, Ladd ME, Bachert P, Zaiss M: Quantitative pulsed CEST–MRI using Ω–plots. NMR Biomed. 28: 1196–1208 (2015). doi: 10.1002/nbm.3362.

Zaiss M, Windschuh J, Paech D, Meissner JE, Burth S, Schmitt B, Kickingereder P, Wiestler B, Wick W., Bendszus M,  Schlemmer HP, Ladd ME, Bachert P, Radbruch A: Relaxation-compensated CEST-MRI of the human brain at 7 T: Unbiased insight into NOE and amide signal changes in human glioblastoma. Neuroimage. 112: 180–188 (2015). doi:10.1016/j.neuroimage.2015.02.040.

Goerke S, Zaiss M, Kunz P, Klika K, Windschuh J, Mogk A, Bukau B, Ladd M, Bachert P: Signature of protein unfolding in chemical exchange saturation transfer imaging. NMR Biomed. 28: 906–913 (2015). doi: 10.1002/nbm.3317.

Windschuh J, Zaiss M, Meissner JE, Paech D, Radbruch A., Ladd ME, Bachert P: Correction of B1–inhomogeneities for relaxation-compensated CEST imaging at 7 T. NMR Biomed. 28: 529–537 (2015). doi: 10.1002/nbm.3283.

Bodet O, Goerke S, Behl NGR, Roeloffs VB, Zaiss M, Bachert P: Amide proton transfer in carnosine in aqueous solution studied in vitro by WEX and CEST experiments. NMR Biomed. 28: 1097–1103 (2015). doi: 10.1002/nbm.3343.

Paech D, Burth S, Windschuh J, Meissner J–E, Zaiss M, Eidel O, Kickingereder P, Nowosielski M, Wiestler B, Sahm F, Floca R, Wick W, Heiland S, Bendszus M, Schlemmer H–P, Ladd ME, Bachert P, Neumann Jan–O, Radbruch A: Nuclear–Overhauser–enhancement imaging of glioblastoma at 7 Tesla: Region–specific correlation with apparent diffusion coefficient and histology. PLoS One 10: e0121220 (2015). doi: 10.1371/journal.pone.0121220.

Zaiss M, Zu Z, Xu J, Schuenke P, Gochberg DF, Gore JC, Ladd ME, Bachert P: A combined analytical solution for chemical exchange saturation transfer and semi–solid magnetization transfer. NMR Biomed. 28: 217–230 (2015). doi: 10.1002/nbm.3237.

2014

Ivchenko O, Whittleston CS, Carr JM, Imhof P, Goerke S, Bachert P, Wales DJ: Proton transfer pathways, energy landscape, and kinetics in creatine–water systems. J. Phys. Chem. B. 118: 1969–1975 (2014). doi: 10.1021/jp410172k.

Ivchenko O, Bachert P, Imhof P: Umbrella sampling of proton transfer in a creatine–water system. Chem. Phys. Lett. 600: 51–55 (2014). doi: 10.1016/j.cplett.2014.03.045.

Benkhedah N, Bachert P, Nagel AM: Two–pulse biexponential–weighted 23Na imaging. J. Magn. Reson. 240: 67–76 (2014). doi: 10.1016/j.jmr.2014.01.007.

Zaiss M, Xu J, Goerke S, Khan IS, Singer RJ, Gore JC, Gochberg DF, Bachert P: Inverse Z–spectrum analysis for spillover–, MT–, and T1–corrected steady–state pulsed CEST–MRI – application to pH–weighted MRI of acute stroke. NMR Biomed. 27: 240–252 (2014). doi: 10.1002/nbm.3054.

Goerke S, Zaiss M, Bachert P: Characterization of creatine guanidinium proton exchange by water–exchange (WEX) spectroscopy for absolute–pH CEST imaging in vitro. NMR Biomed. 27: 507–518 (2014). doi: 10.1002/nbm.3086.

Roeloffs V, Meyer C, Bachert P, Zaiss M: Towards quantification of pulsed spinlock and CEST at clinical MR scanners: An analytical interleaved saturation–relaxation approach. NMR Biomed. 28: 40–53 (2014). doi: 10.1002/nbm.3192.

Paech D, Zaiss M, Meissner J–E, Windschuh J, Wiestler B, Bachert P, Neumann J–O, Kickingereder P, Schlemmer H–P, Wick W, Nagel AM, Heiland S, Ladd ME, Bendszus M, Radbruch A: Nuclear–Overhauser–enhancement–mediated chemical exchange saturation transfer imaging at 7 Tesla in glioblastoma patients. PLoS One 9: e104181 (2014). doi: 10.1371/journal.pone.0104181.

2013

Zaiss M, Bachert P: Chemical exchange saturation transfer (CEST) and MR Z–spectroscopy in vivo: a review of theoretical approaches and methods (TOPICAL REVIEW). Phys. Med. Biol. 58: R221–R269 (2013 Nov 21). doi:10.1088/0031-9155/58/22/R221.

Zaiss M, Bachert P: Exchange–dependent relaxation in the rotating frame for slow and intermediate exchange – Modeling off–resonant spin–lock and chemical exchange saturation transfer. NMR Biomed. 26: 507–518 (2013). doi: 10.1002/nbm.2887. Epub 2012 Dec 28.

Zaiss M, Kunz P, Goerke S, Radbruch A, Bachert P: MR imaging of protein folding in vitro employing nuclear–Overhauser–mediated saturation transfer. NMR Biomed. 26: 1815–1822 (2013). doi: 10.1002/nbm.3021. Epub 2013 Sep 25.

Kuder TA, Bachert P, Windschuh J, Laun FB: Diffusion pore imaging by hyperpolarized xenon–129 nuclear magnetic resonance. Phys. Rev. Lett. 111, Art. Nr. 028101 (2013).
URL:    http://link.aps.org/doi/10.1103/PhysRevLett.111.028101
DOI:    10.1103/PhysRevLett.111.028101
PACS:    87.61.-c, 61.43.Gt, 66.30.je, 82.56.Lz

Benkhedah N, Bachert P, Semmler W, Nagel AM: Three–dimensional biexponential–weighted 23Na imaging of the human brain with higher SNR and shorter acquisition time. Magn. Reson. Med. 70: 754–765 (2013). doi: 10.1002/mrm.24417.

2012

Kelm BM, Kaster FO, Henning A, Weber M–A, Bachert P, Boesiger P, Hamprecht FA, Menze BH: Using spatial prior knowledge in the spectral fitting of MRS images. NMR Biomed. 25: 1–13 (2012). doi: 10.1002/nbm.1704.

Zechmann CM, Menze BH, Kelm BM, Zamecnik P, Ikinger U, Giesel FL, Thieke C, Delorme S, Hamprecht FA, Bachert P: Automated vs. manual pattern recognition of 3D 1H MRSI data of patients with prostate cancer. Academic Radiology 19: 675–684 (2012)

Zaiss M, Schnurr M, Bachert P: Analytical solution for the depolarization of hyperpolarized nuclei by chemical exchange saturation transfer between free and encapsulated xenon (HyperCEST). The Journal of Chemical Physics 136: 144106 1–10 (2012).

2011

Schmitt B, Zaiss M, Zhou J, Bachert P: Optimization of pulse train presaturation for CEST imaging in clinical scanners. Magnetic Resonance in Medicine 65: 1620–1629 (2011). PMID: 21337418, doi: 10.1002/mrm.22750.

Zaiss M, Schmitt B, Bachert P: Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian–line–fit analysis of z–spectra. Journal of Magnetic Resonance 211: 149–155 (2011).

Schmitt B, Zamecnik P, Zaiss M, Rerich E, Schuster L, Bachert P, Schlemmer H–P: A new contrast in MR mammography by means of chemical exchange saturation transfer (CEST) imaging at 3 Tesla: Preliminary results. Fortschr. Röntgenstr. 183: 1030–1036 (2011). PMID: 220340086.

2000 - 2010

Wilhelm T, Bachert P: In vivo 31P echo-planar spectroscopic imaging of human calf muscle. Journal of Magnetic Resonance 149: 126–130 (2001).

Schlemmer H–P, Bachert P, Herfarth KK, Zuna I, Debus J, van Kaick G: Proton MR spectroscopic evaluation of suspicious brain lesions after stereotactic radiotherapy. AJNR Am. J. Neuroradiol. 22: 1316–1324 (2001).

Schröder L, Bachert P: Evidence for a dipolar–coupled AM system in carnosine in human calf muscle from in vivo 1H NMR spectroscopy. Journal of Magnetic Resonance 164: 256–269 (2003).

Schulze A, Bachert P, Schlemmer H, Harting I, Polster T, Salomons GS, Verhoeven NM, Jakobs C, Fowler B, Hoffmann GF, Mayatepek E: Lack of creatine in muscle and brain in an adult with GAMT deficiency. Ann. Neurol. 53: 248–251 (2003).

Schröder L, Schmitz C, Bachert P: Phase modulation in dipolar–coupled A2 spin systems: effect of maximum state mixing in 1H NMR in vivo. Journal of Magnetic Resonance 171: 207–212 (2004).

Schröder L, Schmitz C, Bachert P: Molecular dynamics and information on possible sites of interaction of intramyocellular metabolites in vivo from resolved dipolar couplings in localized 1H NMR spectra. Journal of Magnetic Resonance 171: 213–224 (2004).

Schröder L, Schmitz C, Bachert P: Cumulative „roof effect“ in high–resolution in vivo 31P NMR spectra of human calf muscle and the Clebsch–Gordan coefficients of ATP at 1.5 T. Journal of Magnetic Resonance 174: 68–77 (2005).

Port RE, Schuster C, Port CR, Bachert P: Simultaneous sustained release of fludarabine monophosphate and Gd–DTPA from an interstitial liposome depot in rats: potential for indirect monitoring of drug release by magnetic resonance imaging. Cancer Chemother. Pharmacol. 58: 607–617 (2006).

Menze BH, Lichy MP, Bachert P, Kelm BM, Schlemmer H–P, Hamprecht FA: Optimal classification of long echo time in vivo magnetic resonance spectra in the detection of recurrent brain tumors. NMR in Biomedicine 19: 599–609 (2006).

Ulrich M, Wokrina T, Ende G, Lang M, Bachert P: 31P–{1H} echo–planar spectroscopic imaging of the human brain in vivo. Magnetic Resonance in Medicine 57: 784–790 (2007).

Kirsch S, Bachert P: Diffraction–like phenomena in a periodic magnetization distribution at 1.5 T using the distant dipolar field (DDF). Journal of Magnetic Resonance 185: 183–190 (2007).

Schröder L, Schmitz CHJ, Bachert P: Carnosine as molecular probe for sensitive detection of Cu(II) ions using localized 1H NMR spectroscopy. Journal of Inorganic Biochemistry 102: 174–183 (2008).

Menze BH, Kelm BM, Weber M–A, Bachert P, Hamprecht FA: Mimicking the human expert: pattern recognition for an automated assessment of data quality in MR spectroscopic images. Magnetic Resonance in Medicine 59: 1457–1466 (2008).

Kirsch S, Bachert P: Visualization of the distant dipolar field: a numerical study. Concepts Magn. Reson. Part A 34A: 357–364 (2009).

Zechmann Ch, Zamecnik P, Bachert P: V–2.13.1 Radiologische Diagnostik des Prostatakarzinoms. In: "Onkologie - Grundlagen • Diagnostik • Therapie • Entwicklungen" (Zeller WJ, zur Hausen H, eds.), 26. Erg. Lfg. 9/09, p. 1–23, ecomed Medizin, Hüthig Jehle Rehm, Heidelberg, 2009.

Matthies C, Nagel AM, Schad LR, Bachert P: Reduction of B0 inhomogeneity effects in triple–quantum–filtered sodium imaging. Journal of Magnetic Resonance 202: 239–244 (2010).

1991 - 1999

Port RE, Bachert P, Semmler W: Kinetic modeling of in vivo nuclear magnetic resonance spectroscopy data: 5–Fluorouracil in liver and liver tumors. Clin. Pharmacol. Ther. 49: 497–505 (1991).

Bachert P, Bellemann ME, Layer G, Koch T, Semmler W, Lorenz WJ: In vivo 1H, 31P–{1H} and 13C–{1H} magnetic resonance spectroscopy of malignant histiocytoma and skeletal muscle tissue in man. NMR in Biomedicine 5: 161–170 (1992).

Bachert P, Bellemann ME: Kinetics of the in vivo 31P–1H nuclear Overhauser effect of the human–calf–muscle phosphocreatine resonance. Journal of Magnetic Resonance 100: 146–156 (1992).

Ende G, Bachert P: Dynamic 13C–1H nuclear polarization of lipid methylene resonances applied to broadband proton–decoupled in vivo 13C MR spectroscopy of human breast and calf tissue. Magnetic Resonance in Medicine 30: 415–423 (1993).

Krems B, Bachert P, Zabel H–J, Lorenz WJ: 19F–{1H} nuclear Overhauser effect and proton decoupling of 5–fluorouracil and alpha–fluoro–beta–alanine. Journal of Magnetic Resonance B 108: 155–164 (1995).

Bachert P, Schad LR, Bock M, Knopp MV, Ebert M, Großmann T, Heil W, Hofmann D, Surkau R, Otten EW: Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized 3He. Magnetic Resonance in Medicine 36: 192–196 (1996).

Ebert M, Großmann T, Heil W, Otten EW, Surkau R, Leduc M, Bachert P, Knopp MV, Schad LR, Thelen M: Nuclear magnetic resonance imaging with hyperpolarised helium–3. Lancet 347: 1297–1299 (1996).

Schulze A, Hess T, Wevers R, Mayatepek E, Bachert P, Marescau B, Knopp MV, De Deyn PP, Bremer HJ, Rating D: Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: Diagnostic tools for a new inborn error of metabolism. J. Pediatr. 131: 626–631 (1997).

Bachert P: Kinetics of heteronuclear cross–relaxation in dipolar coupled–spin systems: Applications to in vivo measurements. Concepts Magn. Reson. 9: 227–245 (1997).

Bachert P: Pharmacokinetics using fluorine NMR in vivo. Progress in Nuclear Magnetic Resonance Spectroscopy 33: 1–56 (1998).

Becker M, Port RE, Zabel H–J, Zeller WJ, Bachert P: Monitoring local disposition kinetics of carboplatin in vivo after subcutaneous injection in rats by means of 195Pt NMR. Journal of Magnetic Resonance 133: 115–122 (1998).

Schlemmer H–P, Becker M, Bachert P, Dietz A, Rudat V, Vanselow B, Wollensack P, Zuna I, Knopp MV, Weidauer H, Wannenmacher M, van Kaick G: Alterations of intratumoral pharmacokinetics of 5–fluorouracil in head and neck carcinoma during simultaneous radiochemotherapy. Cancer Research 59: 2363–2369 (1999).

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