Proteomics

Definition: „Proteomics“ means the systematic analysis of the whole group of proteins (proteome) in the organisms.

Since proteins are the chief actors in most diseases, individualized medicine depends on comprehensive information about disease states at the protein level. This requires quantitative technologies capable of measuring disease-associated changes in protein levels, posttranslational modifications (PTMs) and protein-protein interactions (PPIs). Quantitative shotgun proteomics can be used to identify and quantify thousands of proteins in a few hours of measurement time. This enables in depth characterization of selected samples. Targeted proteomics can be used to characterize selected proteins with a very high throughput. This facilitates analysis of a large number of samples. Within iMed the existing infrastructure and expertise will be bundled with the aim to provide state-of-the-art proteomic analysis for researchers at all Helmholtz Centers.

Investigators:
MDC: Gunnar Dittmar, Stefan Kempa, Matthias Selbach
HMGU: Stefanie Hauck, Marius Ueffing
HZI: Lothar Jänsch
UFZ: Martin von Bergen

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