Metabolomics

Definition: „Metabolomics“ means the systematic identification and quantification of all metabolites of a cell, tissue, organ or organism under different conditions. The metabolome of a cell or an organism is a dynamic collection of metabolites, which are the actual response to current conditions.

Metabolites are the true endpoints of most biological processes and can be considered as functional intermediate phenotypes. Recent studies described inborn variation of metabolite concentrations that are linked to biomedically and pharmaceutically relevant genetic variants.  Quantitative measurement of metabolites provides a snapshot of an individual’s physiological state resulting from genetic and environ-mental factors. This data can form the basis for personalized therapy decisions.

iMed will help to:

  • Establish an online catalog of all available metabolomics technologies and expertise within the iMed Metabolomics Platform;
  • Establish regular meetings to foster scientific exchange between metabolomics experts from different centers;
  • Support projects in planning metabolomics analyses;
  • Perform metabolomics analyses of samples from iMed projects while optimizing the utilization of samples and resources;
  • Support iMed projects and the Systems Medicine Platform in analyzing and integrating platform-specific metabolomics data.

Investigators:
HMGU: Jerzy Adamski, Gabi Kastenmüller, Hans-Werner Mewes, Fabian Theis,  Philippe Schmitt-Kopplin, Römisch-Margl
MDC: Stefan Kempa, Matthias Selbach
UFZ: Martin von Bergen, Irina Lehmann

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