Cellomics

Definition: „Cellomics“ investigates quantitative cell analysis on a genome wide scale using bioimaging methods and informatics.

Most animal models only incompletely recapitulate the complex interplay of genetic and non-genetic factors in common human diseases and fail to encompass this essential complexity. Advanced cellular models, including those derived from patient-specific induced pluripotent stem cells (iPSC), which will be generated as described below, may be able to model multiple risk factors in complex gene networks, if problems of reproducibility and standardization are solved and high throughput is combined with high-content analysis of molecular read-outs. Therefore, the DZNE has invested in major “cellomics” platforms at two sites (Bonn and Tübingen), which allow highly automated cell culture with the detection of multiple read-outs, enabling efficient compound screening under strictly standardized conditions.

 

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