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Characterization of the molecular mechanisms by which rodent parvoviruses induce cell lysis and control antiviral defence mechanisms
The aim of this team is to unravel the pathways that are used or activated by rodent parvoviruses (PV) to induce cell lysis and to regulate antiviral defence mechanisms. The first project is focused on the interference of the PV non-structural protein NS1 with the activity and expression of cellular phospholipases A2, and on the role of this interplay in cell lysis. The second project deals essentially with the involvement of the PV non-structural proteins in the inhibition of the PKR and interferon signalling pathway which is activated by PV replication in infected host cells.