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Joseph Costello - University of California San Francisco (UCSF)

January 16 2012
11:00 DKFZ Main Auditorium
Host: Christoph Plass


Biosketch Joseph Costello

The Costello laboratory focuses on genetic and epigenetic mechanisms in gene regulation, and their aberrations in stem cells and brain cancer.   As the Director of one of the three NIH-funded Roadmap Epigenome Mapping Centers in the United States, Joseph Costello is applying next-generation sequencing to study DNA methylation, histone methylation, and RNA expression.  The goal of the Mapping Centers is to comprehensively map epigenomes of select human cells with significant relevance to complex human disease, and to make them available to the research community.  His center has developed a dynamic new epigenome browser (http://vizhub.wustl.edu/) that currently houses the epigenomes of hundreds of samples from human tissue and purified cell types. Costello's laboratory also has a long standing interest in how methylation in gene bodies regulates transcription, and how genetic and epigenetic mechanisms drive brain tumor formation.

Joseph Costello is Director of the Epigenetics Division of the UCSF CCC Program in Cell Cycling and Signaling, and is on the External Advisory Boards of University of Tokyo and UAB Heflin Center for Human Genetics.