Cross Program Topic Cancer Inflammation

Cross Topic Interaction Platform on CANCER INFLAMMATION

Inflammatory processes play a key role during tumourigenesis, tumour progression and metastasis. Thus, a major breakthrough in cancer treatment or prevention will be impossible without understanding basic mechanisms of inflammation in premalignant and malignant tissues. These processes are of tremendous complexity, affecting and involving multiple cells of the adaptive and innate immune system, of the tumour vasculature, stroma as well as tumour cells. Cellular and molecular mechanisms of their interactions and the resulting effects on tumour cell biology and prognosis and on treatment options are only poorly understood.

Principal Aims of the Platform:

  1. Exchange of scientific concepts across the borders of the research programs
  2. Establish collaboration and joint projects between the different programs within DKFZ but also with local universities and clinics
  3. Design joint model systems to analyze inflammatory processes
  4. Translate findings from animal models to human samples and clinical exploitations

Three main areas of research focus were selected to be investigated: 1) the impact of adaptive and innate immune responses on key signaling pathways in tumour cells. 2) Understanding the interplay between the regulation of chronic inflammation, metabolic disorders and tumour progression. 3) Assessing the role of immune infiltrates in tumours and their impact on tumour angiogenesis.

Coordinator:

Prof. Philipp Beckhove        Translational Immunology (D015)

Steering Commitee:

Prof. Hellmut Augustin        Vascular Oncology and Metastasis (A190)
Prof. Peter Angel                 Signal Transduction and Growth Control (A100)
Prof. Stephan Herzig           Molecular Metabolic Control (A170)
Dr. Jörg Hoheisel                 Functional Genome Analysis (B070)

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