Dr. Manuela Hummel

Dr. Manuela Hummel

Dr. Manuela Hummel

Position:

Scientist

Phone:

+49 6221 42 2135

Fax:

+49 6221 42 2397

Building:

TP 4

Room:

S4.224

Area of Work

I am part of the systems medicine CLIOMMICS project, which aims in personalizing the treatment for multiple myeloma patients. We develop and improve prognostic models for survival, response to treatment and side effects by integration of different “omics”, clinical, cytogenetic and imaging data.


Background

  • Biostatistics department at the DKFZ from October 2013
  • Senior analyst technician at the Centre for Genomic Regulation (CRG), Barcelona, Spain, 2008-2013
  • PhD, Institute for Medical Informatics, Biometry and Epidemiology (IBE), University of Munich, 2009
  • Diploma in Statistics, University of Munich, 2005

Selected Publications

  1. Hummel M, Edelmann D, Kopp-Schneider A. Clustering of samples and variables with mixed-type data. PLOS ONE 2017; 12(11):e0188274.
  2. Stoyan D, Pommerening A, Hummel M, Kopp-Schneider A. Multiple-rater Kappas for Binary Data: Models and Interpretation. Biometrical Journal 2017; doi: 10.1002/bimj.201600267
  3. Hummel M, Bonnin S, Lowy E, Roma G. TEQC: an R-package for quality control in target capture experiments. Bioinformatics 2011; 27 (9): 1316-1317. doi: 10.1093/bioinformatics/btr122
  4. Metzeler KH, Hummel M, Bloomfield CD, Spiekermann K, Braess J, Sauerland M-C, Heinecke A, Radmacher M, Marcucci G, Whitman SP, Maharry K, Paschka P, Larson RA, Berdel WE, Büchner T, Wörmann B, Mansmann U, Hiddemann W, Bohlander SK, Buske C. An 86 probe set gene expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood 2008; 112(10):4193-201. doi 10.1182/blood-2008-02-134411.
  5. Hummel M, Meister R, Mansmann U. GlobalANCOVA: Exploration and Assessment of Gene Group Effects. Bioinformatics 2008; 24 (1): 78-85.

Software

• R-package GlobalAncova for group testing 
• R-package TEQC for quality control in targeted sequencing
• R-package CluMix for plotting heatmaps with mixed-type data 

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