Publications 2003

Becker N., Nieters A., Rittgen W.: Single nucleotide polymorphism-disease relationships: statistical issues for the performance of association studies. Mut.Res. 525 (1-2) 11-18, 2003.

Benner A., Heinzl H.: Sample size computation for two-sided test procedures. Contr.Clin.Trials 24(3, Suppl.1), p.200S, 2003.

Bonora E., Beyer K.S., Lamb J.A., Parr J.R., Klauck S.M., Benner A., Paolucci M., Abbott A., Ragoussis I., Poustka A., Bailey A.J., Monaco A.P.: Analysis of reelin as a candidate gene for autism. Mol.Psychiat. 8 (10) 885-892, 2003.

Breitkreutz I., Cremer F.W., Benner A., Raab M.S., Möhler T., Christensen O., Herrmann D., Ho A.D., Goldschmidt H.: Peripheral blood stem cell collection after CAD plus G-CSF in multiple myeloma: no influence of previous thalidomide administration. Onkol. 26(S5), p.131 (P718), 2003.

Breitkreutz I., Benner A., Möhler T., Glasmacher A., Martin H., Hölzer M., Salwender H., Ho A.D., Goldschmidt H.: Initial therapy with thalidomide in multiple myeloma: no increase of adverse events compared to standard therapy. Onkol. 26(S5), p.127 (P705), 2003.

Buchholz E., Drings P., Pilz L., Manegold C.: Final results from a single center, controlled study of standard versus dose intensified chemotherapy with sequential reinfusion of haematopoetic progenitor cells in small cell lung cancer. Proc.ASCO , p.No.2572, 2003.

Buchholz E., Drings P., Pilz L., Manegold C.: A single, center, controlled study of standard versus dose intensified chemotherapy with sequential reinfusion of hematopoetic progenitor cells in small cell lung cancer, final results. Onkol. 26(S5), p.26 (V305), 2003.

Dally H., Edler L., Jäger B.: Genvariante erhöht Risiko für kleinzelligen Lungenkrebs auf das Doppelte: Starke Raucherinnen besonders gefährdet. InFoOnkologie 6 (6) 385, 2003.

Dally H., Edler L., Jäger B., Schmezer P., Spiegelhalder B., Dienemann H., Drings P., Schulz V., Kayser K., Bartsch H., Risch A.: The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose. Pharmacogen. 13 (10) 607-618, 2003.

Dähn S., Schwalbach P., Wöhleke F., Benner A., Kuntz C.: Influence of different gases used for laparoscopy (helium, carbon dioxide, room air, xenon) on tumor volume, proliferation, and apoptosis. Surg.Endosc. (17) 1653-1657, 2003.

Dreger P., Stilgenbauer S., Benner A., Ritgen M., Kröber A., Kneba M., Schmitz N., Döhner H.: The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on on the VH gene mutational status. Onkol. 26(S5), p.8 (V182), 2003.

Edler L., Kopp-Schneider A.: Phase III clinical trial: myths around elementary statistical principles. Contr.Clin.Trials 24(3, Suppl.1), p.128S, 2003.

Edler L.: Chemotherapie mit komplementärer Misteltherapie. Wie evident ist ihre Wirksamkeit wirklich? Internist.Prax. 43 895-904, 2003.

Edler L., Kopp-Schneider A.: Randomized clinical trial: Myths around elementary statisitcal principles. Onkol. 26 (6) 551-556, 2003.

Edler L., Heinzl H.: Toxicokinetic modeling for environmental health problems. Environmetrics 14 (2) 193-202, 2003.

Edler L., Ittrich C.: Biostatistical methods for the validation of alternative methods for the in vitro toxicity testing. ATLA 31 (Suppl.1) 5-41, 2003.

Fogel M., Gutwein P., Mechtersheimer S., Riedle S., Stöck A., Smirnov A., Edler L., Ben-Arie A., Huszar M., Altevogt P.: L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Lancet 362 869-875, 2003.

Freier K., Bosch F.X., Flechtenmacher C., Devens F., Benner A., Lichter P., Joos S., Hofele C.: Distinct site-specific oncoprotein overexpression in head and neck squamous cell carcinoma: a tissue microarray analysis. Anticanc.Res. 23 (5A) 3971-3977, 2003.

Freier K., Joos S., Flechtenmacher C., Devens F., Benner A., Bosch F.X., Lichter P., Hofele C.: Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma. Cancer Res. 63 (6) 1179-1182, 2003.

Fröhling S., Schlenk R., Stolze I., Bihlmayr J., Kreitmeier S., Tobis K., Benner A., Döhner H.: CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. Onkol. 26(S5), p.18 (V224), 2003.

Gastl G., Berdel W., Edler L., Jaehde U., Port R.E., Mross K.B., Scheulen M.E., Sindermann H., Dittrich C.: Standard operating procedures for clinical trials of the CESAR - Central European Society for Anticancer Drug Research - EWIV. Onkol. 26 (Suppl.6) , 2003.

Goldschmidt H., Sonneveld P., Cremer F.W., van der Holt B., Westveer P., Breitkreutz I., Benner A., Glasmacher A., Schmidt-Wolf I.G.D., Martin H., Hölzer D., Ho A.D., Lokhorst H.M.: Joint HOVON-50/GMMG-HD3 randomized trial on the effect of thalidomide as part of a high-dose therapy regimen and as maintenance treatment for newly diagnosed myeloma patients. Ann.Hemtol. 82 (10) 654-659, 2003.

Görner M., Weber-Nordt R., Höpfner S., Benner A., Luft T., Ho A.D.: Addition of a low fixed number of CD3+ cells to CD34-enriched allografts: effects on engraftment, graft-versus-host disease, and survival after related und unrelated peripheral stem cell transplantation. J.Hematother.Stem Cell Res. 12 (3) 309-320, 2003.

Greim H., Gelbke H.P., Reuter U., Thielmann H.W., Edler L.: Evaluation of historical control data in carcinogenicity studies. Hum.Exp.Toxicol. 22 (10) 541-549, 2003.

Groos J., Kopp-Schneider A.: Biologically based stochastic modeling of hepatocarcinogenesis. Vol. LX, pp.429-430, 2003. Bull.Int.Statist.Inst. Contributed Papers 54th Session Book 1.

Hauer K., Hildebrandt W., Sehl Y., Edler L., Oster P., Dröge W.: Improvement in muscular performance and decrease in tumor necrosis factor level in old age after antioxidant treatment. J.Mol.Med. 81 (2) 118-125, 2003.

Heinzl H., Edler L., Mittlböck M.: Assessing uncertainty in toxicokinetic models exemplified by the case of human life long exposure to TCDD. Vol. LX, pp.477-478, 2003. Bull.Int.Statist.Inst. Contributed Papers 54th Session Book 1.

Heinzl H., Edler L.: Evaluating and assessing uncertainty of large-scaled statistical analyses exemplified at the Boehringer TCDD cohort. Ader H. J. & Mellenbergh G. J. Paper #52, pp.87-94, 2003. Amsterdam, Netherlands, Inst.Res.Extramural Med., VU Univ. Proc. of the 2nd Workshop on Research Methodoloy
http://www.knaw.nl/rm2003/

Höpfner S., Görner M., Benner A., Henning P., Ho A.D.: Unrelated donor transplantation after reduced intensity conditioning as an approach for patients lacking related donors for allogeneic stem cell transplantation. J.Hematother.Stem Cell Res. 12 (3) 331-339, 2003.

Ittrich C., Deml E., Österle D., Küttler K., Mellert W., Brendler-Schwaab S., Enzmann H., Schladt L., Bannasch P., Härtel T., Mönnikes O., Schwarz M., Kopp-Schneider A.: Prevalidation of a rat liver foci bioassay (RLFB) based on results from 1600 rats: a study report. Toxicol.Pathol. 31 (1) 60-79, 2003.

Ittrich C., Kopp-Schneider A.: Statistical analysis of an interlaboratory prevalidation study in carcinogenic risk assessment. Vol. LX, pp.541-542, 2003. Bull.Int.Statist.Inst. Contributed Papers 54th Session Book 1.

Ittrich C., Benner A., Edler L.: Statistical issues in design and analysis of clinical studies using functional genomic data. Onkol. 26, p.383 (L4), 2003.

Ittrich C., Deml E., Österle D., Küttler K., Mellert W., Brendler-Schwaab S., Enzmann H., Schladt L., Bannasch P., Härtel T., Mönnikes O., Schwarz M., Kopp-Schneider A.: Prevalidation of a rat liver foci bioassay (RLFB) as medium-term test system for carcinogenic risk. Naunyn-Schmiedeb.Arch.Pharmacol. 367(Suppl.1), p.R163 (638), 2003.

Kienle D., Kröber A., Katzenberger T., Otto G., Leupolt E., Barth T., Möller P., Benner A., Habermann A., Müller-Hermelink H.K., Bentz M., Lichter P., Döhner H., Stilgenbauer S.: VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics and outcome. Onkol. 26(S5), p.162 (P825), 2003.

Kienle D., Kröber A., Katzenberger T., Otto G., Leupolt E., Barth T.F.E., Möller P., Benner A., Habermann A., Müller-Hermelink H.K., Bentz M., Lichter P., Döhner H., Stilgenbauer S.: VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome. Blood 102 (8) 3003-3009, 2003.

Kienle P., Koch M., Autschbach F., Benner A., Treiber M., Wannenmacher M., v.Knebel-Doeberitz M., Büchler M.W., Herfarth C., Weitz J.: Decreased detection rate of disseminated tumor cells of rectal cancer patients after preoperative chemoradiation: a first step towards a molecular surrogate marker for neoadjuvant treatment in colorectal cancer. Ann.Surg. 238 (3) 324-331, 2003.

Kienle P., Weitz J., Benner A., Herfarth C., Schmidt J.: Laparoscopically assisted colectomy and ileoanal pouch procedure with and without protective ileostomy. Surg.Endosc. 17 (5) 716-720, 2003.

Kienle P., Weitz J., Koch M., Benner A., Herfarth C., Schmidt J.: Biofeedback versus electrostimulation in treatment of anal sphincter insufficiency. Digest.Dis.Sci. 48 (8) 1607-1613, 2003.

Kim B.S., Park J.J., Edler L., Fournier D.v., Haase W., Sautter-Bihl M.L., Gotzes F., Thielmann H.W.: The second derivative of the dose-time-response surface as a measure of DNA repair kinetics in the comet assay. Environmetrics 14 169-182, 2003.

Kinscherf R., Cafaltzis K., Röder F., Hildebrandt W., Edler L., Deigner H.P., Breitkreutz R., Feussner G., Kreuzer J., Werle E., Michel G., Metz J., Dröge W.: Cholesterol levels linked to abnormal plasma thiol concentrations and thiol/disulfide redox status in hyperlipidemic subjects. Free Radic.Bio.Med. 35 (10) 1286-1292, 2003.

Kopp-Schneider A.: Biostatistical evaluation of focal hepatic preneoplasia. Toxicol.Pathol. 31 (1) 121-125, 2003.

Kopp-Schneider A.: Contributions of stochastic carcinogenesis modelling to probabilistic risk assessment. Vol. LX, pp.145-148, 2003. Bull.Int.Statist.Inst. Proceedings 54th Session Book 2.

Korshunov A., Neben K., Wrobel G., Tews B., Benner A., Hahn M., Golanov A., Lichter P.: Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age. Am.J.Pathol. 163 (5) 1721-1727, 2003.

Krämer A., Schweizer S., Neben K., Giesecke C., Kalla J., Katzenberger T., Benner A., Müller-Hermelink H.K., Ho A.D., Ott G.: Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin's lymphoma. Leukem. 17 (11) 2207-2213, 2003.

Laufs S., Gentner B., Nagy K.Z., Jauch A., Benner A., Naundorf S., Kühlcke K., Schiedlmeier B., Ho A.D., Zeller W.J., Frühauf S.: Retroviral vector integration occurs into preferred genomic targets of human bone marrow repopulating cells. Blood 101 (6) 2191-2198, 2003.

Liebisch P., Erne S., Scheck D., Wellmann A., Einsele H., Straka C., Goldschmidt H., Benner A., Stilgenbauer S., Döhner H.: In multiple myeloma, five common genomic aberrations (+1q, +9q, +11q, 13q-, t14q) display a non-random distribution and suggest novel pathogenetic pathways. Onkol. 26(S5), p.121 (P684), 2003.

Manegold C., Mezger J., Pilz L.R., Schott K., Koschel G., Hruska D.: Single-agent gemcitabine and docetaxel given sequentially every 3 weeks in advanced NSCLC: final results of a randomized phase-II-study show effective treatment. Onkol. 26(S5), p.140 (P753), 2003.

Markowetz F., Edler L., Vingron M.: Support vector machines for protein fold class prediction. Biometr.J. 45 (3) 377-389, 2003.

Möhler T., Hillengass J., Höpfner S., Benner A., Schlenzka J., Neben K., Egerer G., Görner M., Ho A.D., Goldschmidt H.: Thalidomide and CED chemotherapy followed by stem cell transplantation for poor prognosis multiple myeloma. Onkol. 26(S5), p.132 (P720), 2003.

Neben K., Korshunov A., Wrobel G., Tews B., Benner A., Hahn M., Golanov A., Lichter P.: Gene expression patterns in ependymoma correlate with tumor location and patient age. Onkol. 26(S5), p.203 (P981), 2003.

Neben K., Korshunov A., Benner A., Wrobel G., Hahn M., Golanov A., Lichter P.: Identification of novel prognostic markers in medulloblastoma by gene expression experiments. Onkol. 26(S5), p.37 (V352), 2003.

Oberemm A., Querfurth N., Dieterich A., Meckert C., Brandenburger L., Herzig A., Lindner Y., Krause E., Ittrich C., Kopp-Schneider A., Richter-Reichhelm H.B., Gundert-Remy U.: Proteomic analysis of TCDD-mediated effects in marmoset liver and thymus. Naunyn-Schmiedeb.Arch.Pharmacol. 367(Suppl.1), p.R153 (599), 2003.

Oberemm A., Querfurth N., Meckert C., Brandenburger L., Herzig A., Kalenberg K., Krause E., Ittrich C., Kopp-Schneider A., Hellmann J., Bannasch P., Richter-Reichhelm H.B., Gundert-Remy U.: Proteomic investigation into n-nitrosomorpholine mediated changes in rat liver. Toxicol.Lett. 144(Suppl.1), p.s103 (379), 2003.

Öhm C., Ittrich C., Mezger J., Langenbuch T., Eckardt M.J., Lehban H., Rehm M., Schulz G., Seipelt G., Ehlert T., Stauch M., Wolters U., Edler L.: Gemcitabine and vindesin combination regimen in inoperable metastatic non-small cell lung cancer: a phase II study. Onkol. 26(S5), p.141 (P754), 2003.

Pauli T., Pilz L., Rittgen W.: A stochastic model of the human skin under consideration of cell proliferation and differentiation and its realization as a simulation model. Inf.Biom.Epidem.Med.Biol. 34(3), pp.309-311, 2003.

Renwick A.G., Barlow S.M., Hertz-Piccioto I., Boobis A.R., Dybing E., Edler L., Eisenbrand G., Greig J.B., Kleiner J., Lambe J., Müller D.J.G., Smith M.R., Tritscher A., Tuijtelaars S., van den Brandt P., Walker R., Kroes R.: Risk characterization of chemicals in food and diet. Final part of Food Safety in Europe (FOSIE): Risk assessment of chemicals in food and diet (EC concerted action QLK1-1999-00156). Food Chem.Toxicol. 41 (9 special issue) 1211-1271, 2003.

Schlenk R.F., Benner A., Hartmann F., del Valle F., Weber C., Pralle H., Fischer J., Gunzer U., Pezzutto A., Weber W., Grimminger W., Preiss J., Hensel M., Fröhling S., Döhner K., Haas R., Döhner H.: Risk-adapted postremission therapy in acute myeloid leukemia: results of the German multicenter AML HD93 treatment trial. Leukem. 17 (8) 1521-1528, 2003.

Schlenk R.F., Fröhling S., Benner A., Addamo B., Hartmann F., del Valle F., Pralle H., Fischer J.T., Kölbel C.B., Grimminger W., Mergenthaler H.G., Preiss J., Hensel M., Glasmacher A., Peschel C., Waterhouse C., Salwender H., Biedermann H.G., Kneba M., Kremers S., Koller E., Griesinger F., Döhner K., Haas R.: Phase III- study of all-trans retinoic acid in previously untreated patients 61 years or older with acute myeloid leukemia: AMLSG ULM study HD98B. Onkol. 26(S5), p.1 (V137), 2003.

Schmeding M., Schwalbach P., Reinshagen S., Autschbach F., Benner A., Kuntz C.: Helium pneumoperitoneum reduces tumor recurrence after curative laparoscopic liver resection in rats in a tumor-bearing small animal model. Surg.Endosc. 17 (6) 951-959, 2003.

Schmiechen A., Buckler F., Schmohl S., Ittrich C., Münzel P., Schwarz M.: Regulation of cytochrome P450 1A1 (CYP1A1) gene expression by TCDD. Naunyn-Schmiedeb.Arch.Pharmacol. 367(Suppl.1), p.R125 (486), 2003.

Stach D., Schmitz O.J., Stilgenbauer S., Benner A., Döhner H., Wiessler M., Lyko F.: Capillary electrophoretic analysis of genomic DNA methylation levels. Nucl.Acids Res. 31 (2) E2, 2003.

Twardella D., Popanda O., Helmbold I., Ebbeler R., Benner A., v.Fournier D., Haase W., Sautter-Bihl M.L., Wenz F., Schmezer P., Chang-Claude J.: Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy. Radiother.Oncol. 69 (2) 145-153, 2003.

Volm M., Koomägi R., Rittgen W.: Cellular predictive factors of drug resistance in non-small cell lung carcinomas. Meth.Mol.Med. 75 39-51, 2003.

Wörner S.M., Benner A., Sutter C., Schiller M., Yuan Y.P., Keller G., Bork P., v.Knebel-Doeberitz M., Gebert J.: Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative real common target genes. Oncogene 22 (15) 2226-2235, 2003.

Zehbe I., Mytilineos J., Wikström I., Henriksen R., Edler L., Tommasino M.: Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphisms in cervical cancer of Swedish women. Hum.Immunol. 64 (5) 538-542, 2003.

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