The Alliance Immunotherapy of Cancer has the major goal to translate basic research findings in immunology into innovative strategies for immunodiagnosis and immunotherapy. The Alliance wants to close a gap between basic research, pre-clinical research in murine models and translation of results from this research into clinical trials. To this end, the Helmholtz Alliance forms a strong matrix of translational infrastructure. The research activities are subdivided into four research topics that are closely connected:
Immunotherapy of Leukemia and Lymphoma
Immunotherapy of Hepatocellular Carcinoma
Immunotherapy of Melanoma
The topic Immunomonitoring plays a special role, as it is a connecting technical platform that establishes standardized, validated assay protocols delivering reliable quantitative monitoring of clinical relevance on patient material. The research topics are sorted according to the therapy of model diseases. Besides that, work packages could be also grouped into technical platforms according to the methodical approach that is used:
Adoptive T Cell Therapy
Breaking Apoptosis Resistance
Similar to the immunomonitoring platform these technical platforms comprehensively connect the research topics that are geared to tumor entities.