Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
- Epigenetics
- Redox Regulation
- Vascular Oncology and Metastasis
- Clinical Neurobiology
- Molecular Neurogenetics
- Chaperones and Proteases
- Vascular Signaling and Cancer
- Molecular Neurobiology
- Molecular Biology of Centrosomes and Cilia
- Stress-induced Activation of Hematopoietic Stem Cells
- Metastatic Niches
- DNA Repair Mechanisms and Cancer
- Neuronal Signaling and Morphogenesis
- Cell Signaling and Metabolism
- Metabolism and Stem Cell Plasticity
- Team
- Open positions
- Associated unit
- Cell Morphogenesis and Signal Transduction
- Helmholtz Professorship Molecular Biology of the Cell II
- Helmholtz Professorship Cell Biology
- Functional and Structural Genomics
- Biophysics of Macromolecules
- Molecular Genome Analysis
- Molecular Genetics
- Pediatric Neurooncology
- Cancer Genome Research
- Chromatin Networks
- Functional Genome Analysis
- Theoretical Bioinformatics
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- RNA Biology and Cancer
- Systems Biology of Signal Transduction
- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
- Pediatric Glioma Research
- Somatic Evolution and Early Detection
- Bioinformatics and Omics Data Analytics
- Mechanisms of Leukemogenesis
- Brain Tumor Translational Targets
- Molecular Genetics of Breast Cancer
- Functional Proteome Analysis
- Cancer Risk Factors and Prevention
- Epigenomics and Cancer Risk Factors
- About The Division
- Cancer Epigenomics
- Cancer Chemoprevention and Epigenomics
- DNA Repair and Epigenomics
- Regulation of Cellular Differentiation
- Computational Epigenomics
- Methods
- Contact
- News
- Open Positions
- How to find us
- Research Program Cancer Risk Factors & Prevention
- Cancer Epidemiology
- Molecular Genetic Epidemiology
- Clinical Epidemiology and Aging Research
- Biostatistics
- Genomic Epidemiology
- Cancer Survivorship
- Molecular Epidemiology
- Epigenomics and Cancer Risk Factors
- Tumor Immunology
- Imaging and Radiooncology
- Radiology
- Research
- Contrast Agents In Radiology Research Group
- Neuro-Oncologic Imaging Research Group
- Radiological Early Response Assessment Of Modern Cancer Therapies
- Imaging In Monoclonal Plasma Cell Disorders
- 7 Tesla MRI - Novel Imaging Biomarkers
- Functional Imaging
- Visualization And Forensic Imaging
- PET/MRI
- Computed Tomography And Dual Energy CT
- Radiomics Research Group
- Prostate Research Group
- Breast Imaging Research Group
- Bone marrow
- Musculoskeletal Imaging
- Staff
- Patients
- Research
- Medical Physics in Radiology
- X-Ray Imaging and Computed Tomography
- Radiopharmaceutical Chemistry
- Medical Physics in Radiation Oncology
- Faculty & Staff
- DKFZ PhD Programm
- Research
- Computational Patient Models
- Applied Medical Radiation Physics
- Therapy Planning - Development
- Current Projects
- Former Projects
- Adaptive Radiotherapy
- Registration
- Functional Imaging
- Knowledge based radiotherapy planning (TAPIR)
- New technologies for transferring therapeutical knowledge (IRIS)
- Planning System for proton therapy of eye tumors (OCTOPUS)
- Image Processing and Represenation (VIS-A-VIS)
- Stereotactic laser neurosurgery (STELA)
- Contact
- Research Interest
- Radiotherapy Optimization
- Medical Engineering
- Novel Detection Techniques for Ion Beams
- Physical Quality Assurance in Radiation Therapy
- Ion Beam Therapy
- MR-guided RadioTherapy
- Clinical Research Group
- Publications
- Vacancies
- Awards
- Education and Training
- Events
- Biomedical Physics in Radiation Oncology
- Computer Assisted Medical Interventions
- Medical Image Computing
- Optical Nanoscopy
- Radiooncology - Radiobiology
- Radiation Oncology
- Molecular Radiooncology
- Nuclear Medicine
- Translational Radiation Oncology
- Molecular Mechanisms of Head and Neck Tumors
- Radiology
- Infection, Inflammation and Cancer
- Tumor Virology
- Molecular Diagnostics of Oncogenic Infections
- Viral Transformation Mechanisms
- Pathogenesis of Virus-Associated Tumors
- Virus-associated Carcinogenesis
- Chronic Inflammation and Cancer
- Episomal-Persistent DNA in Cancer- and Chronic Diseases
- Immunotherapy and Immunoprevention
- Cell Plasticity and Epigenetic Remodeling
- Cellular Polarity and Viral Infection
- Noroviruses
- Laboratory of Oncolytic Virus Immuno-Therapeutics
- Tumorvirus-specific Vaccination Strategies
- Mammalian Cell Cycle Control Mechanisms
- Molecular Therapy of Virus-Associated Cancers
- DNA Vectors
- Translational Cancer Research
- Translational Oncology
- Applied Functional Genomics
- Preventive Oncology
- Cellular and Molecular Pathology
- Molecular Oncology of Gastrointestinal Tumors
- Applied Bioinformatics
- Physical Activity, Prevention and Cancer
- Medical Informatics for Translational Oncology
- Molecular Therapy in Haematology and Oncology
- Health Economics
- Applied Tumor Biology
- Neuroimmunology and Brain Tumor Immunology
- Dermato-Oncology
- Molecular Hematology - Oncology
- Pediatric Oncology
- Neurooncology
- Neuropathology
- Experimental therapies for hematologic malignancies
- Adaptive Immunity and Lymphoma
- Molecular Leukemogenesis
- Neuropeptides
- Brain Cancer Metabolism
- GMP & T Cell Therapy
- Toxicology and Chemotherapy
- Immune Monitoring
- Cancer Drug Development
- Cell Biology and Tumor Biology
- Research Groups A-Z
- Junior Research Groups
- Core Facilities
- Center for Preclinical Research
- Chemical Biology Core Facility
- Genomics and Proteomics
- Imaging and Cytometry
- Information Technology
- Library
- Kataloge - Catalogues
- Zeitschriften - Journals
- E-Books - Ebooks
- Datenbanken - Databases
- Dokument-Lieferung - Document Delivery
- Publikationsdatenbank - Publication database
- DKFZ Archiv - DKFZ Archive
- Open Access
- Science 2.0
- Ansprechpartner - Contact
- More Information - Service
- Anschrift - Address
- Antiquariat - Second Hand
- Aufstellungssystematik - Shelf Classification
- Ausleihe - Circulation
- Benutzerhinweise - Library Use
- Beschaffungsvorschläge - Desiderata
- Fakten und Zahlen - Facts and Numbers
- Kooperationen, Konsortien - Cooperations, Consortia
- Kopieren, Scannen - Copying, Scans
- Kurse, Führungen - Courses, Introductions
- Öffnungszeiten - Opening Hours
- Neue Medien - New Media
- DEAL-Info
- DKFZ-Intern - internal only
- WHO Collaborating Centers
- Cooperations & Networks
- National Cooperations
- International Cooperations
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Program
- Call 2017
- Members of the Program Committee
- Generation of New Projects
- Publications
- Highlight-Projects
- 30th Anniversary of the Program
- Documentation
- Heidelberg - Israel, Science and Culture
- German-Israeli Cancer Research Schools
- Israel-Symposium, March 12, 2013
- 34th Meeting of the DKFZ-MOST Program
- DKFZ-MOST Cooperation 40th Anniversary
- Symposium 40 Years of German-Israeli Cooperation
- Helmholtz-Israel-Cooperation in Personalized Medicine
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Cooperations with industrial companies
- Helmholtz Alliances
- DKFZ PostDoc Network
- Cross Program Topic RNA@DKFZ
- Cross Program Topic Cancer Inflammation
- Cross Program Topic Epigenetics@dkfz
- Cross Program Topic Single Cell Sequencing
- iMed
- INFORM
- Baden-Württemberg Cancer Registry
Research Group Functional Proteome Analysis
Dr. Martina Schnölzer
Proteomes change qualitatively and quantitatively, reflecting the alterations in the physiological state of cells, body fluids, organelles and organisms. This is not only achieved by the expression of different genes and proteins, but also by a large number of posttranslational events giving rise to the high complexity on the protein level. In recent years, mass spectrometry has emerged to be one of the most powerful tools to study proteomes, protein networks and multiprotein platforms. In collaborative projects with clinical partners our research group “Functional Proteome Analysis” is participating in several long-term research activities including mainly three areas: (I) large scale investigation of so far unknown proteomes, (II) quantitative description of posttranslational modifications, and (III) relative and absolute quantification of proteins and protein complexes. To this end we are applying metabolic labeling with heavy isotopes as well as label-free approaches to obtain comprehensive information to uncover the dynamics and interactions of protein networks.
FUTURE OUTLOOK
Applying mass spectrometry to investigate and quantitatively describe protein interactions and networks.