Molecular Genome Analysis


PhD Student



Ihre Aufgaben:

We are looking for a PhD candidate in biosciences for the project "Investigation of the Influence of Breast Cancer Drugs on HER2 Dimerization at the Molecular Level in Individual Cells Aiming to Find Clues for Causes of Drug Resistance" funded by the Else Kröner-Fresenius Foundation. This project is in collaboration with the Innovate Electron Microscopy group at the Leipniz-Institute for New Materials (Saarbrücken).

The Division of Molecular Genome Analysis at the DKFZ aims to understand the complex molecular mechanisms that regulate signalling networks controlling cancer development, metastasis, and drug response as prerequisite to advance personalized treatment. Visit to learn more about the group.

The HER2/ErbB2 receptor tyrosine kinase is overexpressed in 10-20% of breast cancer patients. Even though this subtype is efficiently treated with HER2-targeted antibody drugs, like trastuzumab, primary or acquired drug resistance is often inevitable, presumably also as a consequence of cancer cell heterogeneity. Other receptors of the HER/ErbB-family, like EGFR and ErbB3, are strongly expressed in other breast cancer subtypes, and form homo- as well as heterodimers upon activation. We plan studying the influence of drugs at the single cell level while taking cancer cell heterogeneity into account. This will be done using also liquid-phase scanning transmission electron microscopy (STEM) and established tumor cell lines as well as cells from clinical specimen. The project will cover the establishment of primary cells and testing surface expression of HER/ErbB-proteins as well as their functional impact towards response to targeted therapeutics. Subpopulations of tumor cells shall be identified and characterized at the molecular and functional levels, also to potentially identify predictors of drug response.

Ihr Profil:

We are looking for highly motivated candidates with a vivid interest in cellular signalling and translating in vitro-concepts to clinical application. Applicants should have graduated in a life sciences subject and have a strong background in cell and molecular biology. Experiences in the handling of clinical samples, microdissection and/or immunohistochemistry, cell culture, molecular biology techniques would be a plus. The candidates should enjoy working in an international and interdisciplinary environment that involves clinical aspects as well as theoretical approaches. Submit your complete application with cover letter, curriculum vitae, University diploma and thesis summary, as well as contact information for two references via the DKFZ online application system.

Wir bieten:

  • Interessanten, vielseitigen Arbeitsplatz
  • Internationales Umfeld
  • Vergütung nach TV-L
  • Möglichkeiten zur Teilzeitarbeit
  • Flexible Arbeitszeiten
  • Gute Fort- und Weiterbildung


January 2018


The position is limited to 3 years.


November 6, 2017

Weitere Informationen:

Prof. Dr. Stefan Wiemann
phone +49 6221 42-4702

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