Immune Microenvironment Team

Research interests

Identification of immunotherapeutic targets within the glioma microenvironment and of molecular and cellular mechanisms of immune escape with main focus on

  1. Tryptophan catabolism
  2. Immune checkpoint inhibition
  3. Myeloid cells
  4. Tumor blood vessels

 

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Team members

  • Katharina Ochs
  • Lukas Bunse
  • Mirco Friedrich
  • Jens Blobner
  • Frederik Cichon
  • Katrin Deumelandt
  • Edward Green
  • Jana Sonner

Publications

  • Sonner JK, Deumelandt K, Ott M et al. The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas. Oncoimmunology, 2016.
  • Ochs K, Ott M, Rauschenbach KJ et al. Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4. J Neurochem, 2015.
  • Ott M, Litzenburger UM, Rauschenbach KJ et al. Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. Glia, 2015.
  • Litzenburger UM, Opitz CA, Sahm F et al. Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR. Oncotarget, 2014.
  • Ochs K, Sahm F, Opitz CA et al. Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma. J Neuroimmunol, 2013.
  • Opitz CA, Litzenburger UM, Sahm F et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature, 2011.

 

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