Werdegang

1975 BSc in Biologie, Chemie und Physik, Universität Kaschmir
1979 Msc in Chmie, Universität Kaschmir
1981 MPhil in "Chemie von Naturprodukten", Universität Kaschmir
1985 PhD in "Chemie von Naturprodukten", Universität Kaschmir
2001 Dozent für Genetik des Krebses, Karolinska Institut
2005 Habilitation in Molekulargenetischer Epidemiologie, Universität Heidelberg

Forschungsgebiet

Melanoma, Krebsgenetik, somatische Mutationen, Genexpression

Ausgewählte Publikationen

Stacey SN, Sulem P, Jonasdottir A, Masson G, Gudmundsson J, Gudbjartsson DF, Magnusson OT, Gudjonsson SA, Sigurgeirsson B, Thorisdottir K, Ragnarsson R, Benediktsdottir KR, Nexø BA, Tjønneland A, Overvad K, Rudnai P, Gurzau E, Koppova K, Hemminki K, Corredera C, Fuentelsaz V, Grasa P, Navarrete S, Fuertes F, García-Prats MD, Sanambrosio E, Panadero A, Juan AD, Garcia A, Rivera F, Planelles D, Soriano V, Requena C, Aben KK, Rossum MM, Cremers RG, Oort IM, van Spronsen DJ, Schalken JA, Peters WH, Helfand BT, Donovan JL, Hamdy FC, Badescu D, Codreanu O, Jinga M, Csiki IE, Constantinescu V, Badea P, Mates IN, Dinu DE, Constantin A, Mates D, Kristjansdottir S, Agnarsson BA, Jonsson E, Barkardottir RB, Einarsson GV, Sigurdsson F, Moller PH, Stefansson T, Valdimarsson T, Johannsson OT, Sigurdsson H, Jonsson T, Jonasson JG, Tryggvadottir L, Rice T, Hansen HM, Xiao Y, Lachance DH, O Neill BP, Kosel ML, Decker PA, Thorleifsson G, Johannsdottir H, Helgadottir HT, Sigurdsson A, Steinthorsdottir V, Lindblom A; Swedish Low-risk Colorectal Cancer Study Group, Sandler RS, Keku TO, Banasik K, Jørgensen T, Witte DR, Hansen T, Pedersen O, Jinga V, Neal DE, Catalona WJ, Wrensch M, Wiencke J, Jenkins RB, Nagore E, Vogel U, Kiemeney LA, Kumar R, Mayordomo JI, Olafsson JH, Kong A, Thorsteinsdottir U, Rafnar T, Stefansson K. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. Nat Genet 2011 Sep 25. doi: 10.1038/ng.926. [Epub ahead of print]

Gast A, Bermejo JL, Claus R, Brandt A, Weires M, Weber A, Plass C, Sucker A, Hemminki K, Schadendorf D, Kumar R.Association of inherited variation in toll-like receptor genes with malignant melanoma susceptibility and survival. PLoS One 2011;6(9):e24370.

Gast A, Scherer D, Chen B, Bloethner S, Melchert S, Sucker A Lordick F, Becker K, Langer R, Buechler M, Hemminki K, Kumar R. DNA Repair Gene and MTHFR Gene Polymorphisms as Prognostic Markers in Locally Advanced Adenocarcinoma of the Esophagus or Stomach Treated with Cisplatin and 5-Fluorouracil-Based Neoadjuvant Chemotherapy. Ann Surg Oncol 2011 Feb 24.

Schrama D, Scherer D, Schneider M, Zapatka M, Broecker E-B, Schadendorf D, Ugurel S, Kumar R, Becker JC. ERCC5 p.Asp1104His and ERCC2 p.Lys751Gln polymorphisms are independent prognostic factors for clinical course of melanoma. J Invest Dermatol 2011;131(6):1280-90.

Scherer D, Rachakonda PS, Angelini S, Mehnert F,Sucker A, Hauschild A, Hemminki K, Egberts F , Schadendorf D, Kumar R. Association between the germline MC1R variants and somatic BRAF/NRAS mutations in melanoma tumors. J Invest Dermatol 2010;130(12):2844-8.

Gast A, Scherer D, Chen B, Bloethner S, Melchert S, Sucker A, Hemminki K, Schadendorf D, Kumar R. Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study. Genes Chromosomes Cancer 2010;49:733-45.

Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Gonzalez Neira A, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves M, Houlston RS. Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. Nat Genet 2010;42:492-4.

Scherer D, Kumar R. Genetics of pigmentation in skin cancer - A review. Mutat Res 2010;705(2):141-53.