Original- und Übersichtsarbeiten im Jahr 2018 und im Druck

Jansen H, Jänsch A, Breitling LP, Hoppe L, Dallmeier D, Schmucker R, Brenner H, König W, Rothenbacher D.
Hs-cTroponins for the prediction of recurrent cardiovascular events in patients with established CHD – A comparative analysis from the KAROLA study.
International Journal of Cardiology 2018; 250:247-252.

Jansen L, Buttmann-Schweiger N, Listl S, Ressing M, Holleczek B, Katalinic A, Luttmann S, Kraywinkel K, Brenner H, for the GEKID Cancer Survival Working Group.
Differences in incidence and survival of oral cavity and pharyngeal cancers between Germany and the United States depend on the HPV-association of the cancer site.
Oral Oncology 2018; 76:8-15.

Campa D, Pastore M, Capurso G, Hackert T, Di Leo M,…, Brenner H,…, Oliverius M, Pezzilli R, Landi S, Canzian F.
Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.
International Journal of Cancer 2018; 142:290-296.

Chen C, Stock C, Hoffmeister M, Brenner H.
Public health impact of colonoscopy use on colorectal cancer mortality in Germany and the United States.
Gastrointestinal Endoscopy 2018; 87:213-221.

Seibert TM, Fan CC, Wang Y, Zuber V, Karunamuni R,…, Brenner H,…, Andreassen OA, Dale AM, The PRACTICAL Consortium.
Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large-scale cohorts.
BMJ 2018; 360:j5757.

Gigic B, Boeing H, Toth R, Böhm J, Habermann N, Scherer D, Schrotz-King P, Abbenhardt-Martin C, Skender S, Brenner H, Chang-Claude J, Hoffmeister M, Syrjala K, Jacobsen PB, Schneider M, Ulrich A, Ulrich CM.
Associations between dietary patterns and longitudinal quality of life changes in colorectal cancer patients: the ColoCare study.
Nutrition and Cancer 2018; 70:51-60.

Gies A, Cuk K, Schrotz-King P, Brenner H.
Direct comparison of diagnostic performance of 9 quantitative fecal immunochemical tests for colorectal cancer screening.
Gastroenterology 2018; 154:93-104.

Weigl K, Chang-Claude J, Knebel P, Hsu L, Hoffmeister M, Brenner H.
Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score.
Clinical Epidemiology 2018; 10:143-152.

Klein AP, Wolpin BM, Risch HA, Stolzenberg-Solomon RZ, Mocci E,…, Brenner H,…, Chanock S, Obazee O, Petersen GM, Amundadottir TL.
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Nature Communications 2018; 9:556.

Babaei M, Balavarca Y, Jansen L, Lemmens V, van Erning FN, van Eycken L, Vaes E, Sjövall A, Glimelius B, Ulrich CM, Schrotz-King P, Brenner H.
Administration of adjuvant chemotherapy for stage II-III colon cancer patients: an European population-based study.
International Journal of Cancer 2018; 142:1480-1489.

Boakye D, Rillmann B, Walter V, Jansen L, Hoffmeister M, Brenner H.
Impact of comorbidity and frailty on prognosis in colorectal cancer patients: a systematic review and meta-analysis.
Cancer Treatment Reviews 2018; 64:30-39.

Ordóñez-Mena JM, Walter V, Schöttker B, Jenab M, O’Doherty MG, Kee F, Bueno-de-Mesquita B, Peeters PHM, Stricker BH, Ruiter R, Hofman A, Söderberg S, Jousilahti P, Kuulasmaa K, Freedman ND, Wilsgaard T, Wolk A, Nilsson LM, Tjonneland A, Quirós JR, van Duijnhoven FJB, Siersema PD, Boffetta P, Trichopoulou A, Brenner H, on behalf of the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES).
Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium.
Annals of Oncology 2018; 29:472-483.

Babaei M, Balavarca Y, Jansen L, Sjövall A, Bos A, Van de Velde T, Moreau M, Gabriel L, Goncalves AF, Bento MJ, Ulrich CM, Schrotz-King P, Lemmens V, Glimelius B, Brenner H.
Neoadjuvant therapy in rectal cancer patients with clinical stage II-III across European countries: variations and outcomes.
Clinical Colorectal Cancer 2018; 17; e129-e142.

Hajek A, Bock JO, Saum KU, Matschinger H, Brenner H, Holleczek B, Haefeli WE, Heider D, König HH.
Frailty and health care costs – longitudinal results of a prospective cohort study.
Age and Ageing 2018; 47:233-241.

Niedermaier T, Weigl K, Hoffmeister M, Brenner H.
Fecal immunochemical tests in combination with blood tests for colorectal cancer and advanced ademona detection - systematic review.
United European Gastroenterology Journal 2018; 6:13-21.

Erben V, Carr PR, Holleczek B, Stegmaier C, Hoffmeister M, Brenner H.
Dietary patterns and risk of advanced colorectal neoplasms: a large population based screening study in Germany.
Preventive Medicine 2018; 111:101-109.

Büchele G, Günther KP, Brenner H, Puhl W, Stürmer T, Rothenbacher D, Brenner RE.
Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement.
Scientific Reports 2018; 8:5253.

Minicozzi P, Walsh PM, Sánchez MJ, Trama A, Innos K, Marcos-Gragera R, Dimitrova N, Botta L, Johannesen TB, Rossi S, Sant M, EUROCARE-5 Working Group*.
Is low survival for cancer in Eastern Europe due principally to late stage at diagnosis?
European Journal of Cancer 2018; 93:127-137.
*Collaborators from DKFZ: Brenner H

Hajek A, Bock JO, Saum KU, Schöttker B, Brenner H, Heider D, König HH.
Unterschiede in der Morbidität nach Krankenversichertenstatus im Alter.
Das Gesundheitswesen (im Druck).

Pulte D, Jansen L, Brenner H.
Disparities in colon cancer survival by insurance type: a population based analysis.
Diseases of the Colon & Rectum (im Druck).

Gündert M, Edelmann D, Benner A, Jansen L, Jia M, Walter V, Knebel P, Herpel E, Chang-Claude J, Hoffmeister M, Brenner H, Burwinkel B.
Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier).
Gut (im Druck).

Rahbari NN*, Carr PR*, Jansen L, Chang-Claude J, Weitz J, Hoffmeister M, Brenner H.
Time of metastasis and outcome in colorectal cancer.
Annals of Surgery (im Druck).
*contributed equally

Rudolph A, Song M, Brook MN, Milne RL, Mavaddat N,…, Brenner H, Arndt V,…, Easton DF, Chatterjee N, Chang-Claude J, Garcia-Closas M.
Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium.
International Journal of Epidemiology (im Druck).

Huang L, Jansen L, Balavarca Y, Molina-Montes E, Babaei M, van der Geest L, Lemmens V, Van Eycken L, De Schutter H, Johannesen TB, Fristrup CW, Mortensen MB, Zakelj MP, Zadnik V, Becker N, Hackert T, Mägi M, Cassetti T, Sassatelli R, Grützmann R, Merkel S, Goncalves AF, Bento MJ, Hegyi P, Lakatos G, Szentesi A, Moreau M, van de Velde T, Broeks A, Sant M, Minicozzi P, Mazzaferro V, Real FX, Carrato A, Molero X, Besselink MG, Malats N, Büchler MW, Schrotz-King P, Brenner H.
Resection of pancreatic cancer in Europe and the US: an international large-scale study highlighting large variations.
Gut (im Druck).

Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M,..., Brenner H,..., Henderson BE, Kote-Jarai Z, Haiman CA, Eeles RA.
Prostate cancer meta-analysis of more than 140,000 men identifies 63 novel prostate cancer susceptibility loci.
Nature Genetics (im Druck).

Heim E, Seitel A, Andrulis J, Isensee F, Stock C, Ross T, Maier-Hein L.
Clickstream analysis for crowd-based objects segmentation with confidence.
IEEE Trans Pattern Anal Mach Intell (im Druck).

Gies A, Bhardwaj M, Stock C, Schrotz-King P, Brenner H.
Quantitative fecal immunochemical tests for colorectal cancer screening.
International Journal of Cancer (im Druck).

Brenner H, Qian J, Werner S.
Variation of diagnostic performance of fecal immunochemical testing for hemoglobin by sex and age: results from a large screening cohort.
Clinical Epidemiology (im Druck).

Niedermaier T, Weigl K, Hoffmeister M, Brenner H.
Diagnostic performance of once-only flexible sigmoidoscopy combined with fecal immunochemical test in a large colorectal cancer screening population.
Epidemiology (im Druck).

Painter J, O’Mara T, Morris A, Cheng T, Gorman M,…, Brenner H,…, Tomlinson I, Easton D, Thompson D, Spurdle A.
Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.
Cancer Medicine (im Druck).

Brück K, Jager KJ, Zoccali C, Bello A, Minutolo R,…, Brenner H,…, De Nicola L, Heinze G, Van Biesen W, Stel VS on behalf of the European CKD Burden Consortium.
Progression and mortality in patients with CKD attending outpatient nephrology clinics across Europe: A novel analytic approach.
Kidney International (im Druck).

Alwers E, Jia M, Kloor M, Bläker H, Brenner H, Hoffmeister M.
Associations between molecular classifications of colorectal cancer and patient survival: a systematic review.
Clinical Gastroenterology and Hepatology (im Druck).

Abubakar M, Chang-Claude J, Raza Ali H, Chatterjee N, Coulson P, Daley F, Blows F, Benitez J, Milne R, Brenner H, Stegmaier C, Mannermaa A, Rudolph A, Sinn P, Couch FJ, Devilee P, Tollenaar RAEM, Seynaeve C, Figueroa J, Lissowska J, Hewitt S, Hooning MJ, Hollestelle A, Foekens R, Koppert LB, kConFab Investigators, Bolla MK, Wang Q, Jones ME, Schoemaker MJ, Keeman R, Easton DF, Swerdlow AJ, Sherman ME, Schmidt MK, Pharoah PD, Garcia-Closas M.
Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation.
International Journal of Cancer (im Druck).

Ose J, Botma A, Balavarca Y, Buck K, Scherer D, Habermann N, Beyerle J, Pfütze K, Seibold P, Kap EJ, Benner A, Jansen L, Butterbach K, Hoffmeister M, Brenner H, Ulrich A, Schneider M, Chang-Claude J, Burwinkel B, Ulrich CM.
Pathway analysis of genetic variants in folate-mediated one-carbon metabolism related genes and survival of colorectal cancer patients.
Cancer Medicine (im Druck).

NCD Risk Factor Collaboration (NCD-RisC)*.
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants.
International Journal of Epidemiology (im Druck).
*Collaborators on behalf of the ESTHER study: Brenner H, Saum KU, Schöttker B

Emerging Risk Factors Collaboration / EPIC-CVD / UK Biobank Alcohol Study Group*.
Risk thresholds for alcohol consumption: combined analysis of individual-participant data on 599,912 current drinkers in 83 prospective studies.
Lancet (im Druck).
*Member of the writing committee on behalf of the ESTHER study: Brenner H

Pulte D, Weberpals J, Schröder CC, Emrich K, Holleczek B, Katalinic A, Luttmann S, Sirri E, Jansen L, Brenner H for the GEKID Cancer Survival Working Group.
Survival of patients with hepatobiliary tract and duodenal cancer sites in Germany and the United States in the early 21st century.
International Journal of Cancer (im Druck).

Carr PR, Alwers E, Bienert S, Weberpals J, Kloor M, Brenner H, Hoffmeister M.
Lifestyle factors and risk of sporadic colorectal cancer by microsatellite instability status: a systematic review and meta-analyses.
Annals of Oncology (im Druck).

Jeon J, Du M, Schoen RE, Hoffmeister M, Newcomb PA,..., Brenner H, Hayes RB, White E, Peters U, Hsu L, on behalf of the Colorectal Transdisciplinary (CORECT) Study and Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO).
Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors.
Gastroenterology (im Druck).

Colombo M, Lopez-Perolio I, Meeks H, Caleca L, Parsons M,…, Arndt V,…, Brenner H,…, Spurdle A, Goldgar D, de la Hoya M, Radice P.
The BRCA2 c.68-7T>A variant is not pathogenic: a model for clinical calibration of spliceogenicity.
Human Mutation (im Druck).

Weberpals J, Jansen L, Müller OJ, Brenner H.
Long term heart-specific mortality among 347,476 breast cancer patients treated with radiotherapy or chemotherapy: A registry-based cohort study.
European Heart Journal (im Druck).

Amitay EL, Krilaviciute A, Brenner H.
Systematic review: Gut microbiota in fecal samples and detection of colorectal neoplasms.
Gut Microbes (im Druck).

Nabers A*, Perna L*, Lange J, Mons U, Schartner J, Güldenhaupt J, Saum KU, Janelidze S, Holleczek B, Rujescu D, Hansson O, Gerwert K, Brenner H.
Amyloid blood biomarker detects alzheimer’s disease.
EMBO Molecular Medicine (im Druck).
*shared first authorship

Zhang Y, Saum KU, Schöttker B, Holleczek B, Brenner H.
Methylomic survival predictors, frailty, and mortality.
Aging (im Druck).

Krilaviciute A, Stock C, Leja M, Brenner H.
Potential for non-invasive breath tests for preselecting individuals for invasive gastric cancer screening endoscopy.
Journal of Breath Research (im Druck).

Hoppe LK, Muhlack DC, König W, Carr PR, Brenner H, Schöttker B.
Association of abnormal serum potassium levels with arrhythmias and cardiovascular mortality: a systematic review and meta-analysis of observational studies.
Cardiovascular Drugs and Therapy (im Druck).

Weigl K, Thomsen H, Balavarca Y, Hellwege J, Shrubsole M, Brenner H.
Genetic risk score is associated with prevalence of advanced neoplasms in a colorectal cancer screening population.
Gastroenterology (im Druck).

Horne HN*, Oh H*, Sherman ME, Palakal M, Hewitt SM,…, Brenner H,…, Van Leeuwen FF, Van’t Veer LJ, Garcia-Closas M, Figueroa JD.
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.
Scientific Reports (im Druck).
*contributed equally

Raina P, Gilsing A, Freisling H, van den Heuvel E, Sohel N, Jenab M, Ferrari P, Tjonneland A, Benetou V, Picavet S, Eriksson S, Schöttker B, Brenner H, Saum KU, Perna L, Wilsgaard T, Trichopoulou A, Boffetta P, Griffith L.
The combined effect of cancer and cardio-metabolic conditions on the mortality burden in older adults.
The Journals of Gerontology: Series A (im Druck).

Wu L, Shi W, Long J, Guo X, Michailidou K,..., Arndt V,…, Brenner H,…, Kraft P, Easton DF, Chenevix-Trench G, Zheng W.
Identification of novel susceptibility loci and genes for breast cancer risk: a transcriptome-wide association study of 229,000 women of European descent.
Nature Genetics (im Druck).

Lauby-Secretan B, Vilahur N, Bianchini F, Guha N, Straif K, for the International Agency for Research on Cancer Handbook Working Group*.
The IARC perspective on colorectal cancer screening.
The New England Journal of Medicine (im Druck).
*Collaborator from DKFZ: Hoffmeister M

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