The research groups of ERC grant holders - Prof. Dr. Bruno Kyewski and Dr. Markus Feuerer at the German Cancer Research Centre, Heidelberg (DKFZ) - study immune tolerance. Both, central and peripheral tolerance are essential features of the immune system. Any leakiness can result in autoimmune diseases or immune disorders.

One aspect of our studies is to understand fundamental principles of epigenetic gene regulation, which leads to promiscuous gene expression in the thymus and the phenotype of regulatory immune cells. To this end, we use genome-wide arrays and RNA sequencing from both bulk-population and single-cells, measure global DNA methylation and perform ChIP-sequencing experiments.

To support the bioinformatics part of these projects we are looking for a highly motivated, diligent and enthusiastic team player with a strong background in:

  • R / Bioconductor
  • Analysis of next-generation sequencing data
  • Epigenetics and gene regulation
  • Linux and Windows environments
  • Knowledge in scripting languages (Perl, python) would be a plus

A successful candidate should be experienced in handling such big data sets and can independently contribute to the scientific in depth analysis of these data.

The person will work in close contact with Prof. Dr. Benedikt Brors, Division Applied Bioinformatics, and his team.

For further information kindly contact and send you applications to:

Prof. Dr. Benedikt Brors, Phone: +49 6221 42 3614, E-mail:

Dr. Markus Feuerer, Phone:+ 49-6221 42 1530, E-mail:

Dr. Sheena Pinto, Phone:+49 6221 42 3818, E-mail:

Application deadline: 13st November, 2015

Contract duration: initially for 1 year, can be extended for another year

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